• Korean Journal of Biological Psychiatry
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• v.28 no.2
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• pp.23-35
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• 2021

Fear conditioning and extinction, which are adaptive processes to learn and avoid potential threats, have essential roles in the pathophysiology of anxiety disorders. Experimental fear conditioning and extinction have been used to identify the mechanism of fear and anxiety in humans. However, the brain-based mechanisms of fear conditioning and extinction are yet to be established. In the current review, we summarized the results of neuroimaging studies that examined the brain changes-functional activity and structures-regarding fear conditioning or extinction in healthy individuals. The functional activity of the amygdala, insula, anterior cingulate gyrus, ventromedial prefrontal cortex, and hippocampus changed dynamically with both fear conditioning and extinction. This review may provide an up-to-date summary that may broaden our understanding of pathophysiological mechanisms of anxiety disorder. In addition, the brain regions that are involved in the fear conditioning and extinction may be considered as potential treatment targets in the future studies.

• Korean Journal of Biological Psychiatry
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• v.18 no.2
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• pp.80-89
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• 2011

Pavlovian fear conditioning has been extensively studied for the understanding of neurobiological basis of memory and emotion. Pavlovian fear conditioning is an associative memory which forms when conditioned stimulus (CS) is paired with unconditioned stimulus (US) once or repeatedly. This behavioral model is also important for the understanding of anxiety disorders such as posttraumatic stress disorder. Here we describe the neural circuitry involved in fear conditioning and the molecular mechanisms underlying fear memory formation. During consolidation some memories fade out but other memories become stable and concrete. Emotion plays an important role in determining which memories will survive. Memory becomes unstable and editable again immediately after retrieval. It opens the possibility for us of modulating the established fear memory. It provides us with very efficient tools to improve the efficacy of cognitive-behavior therapy and other exposure-based therapy treating anxiety disorders.

• (The)Study of the Eastern Classic
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• no.68
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• pp.439-472
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• 2017

The purpose of this paper is to confirm how traditional legends are changing and existing in modern times, and how they are inheriting and developing legendary values and meanings. The subject of the study is uncanny stories concerning army that is judged to be worthwhile alongside uncanny stories concerning school. The uncanny stories concerning army are urban legends that are active in the internet. It can be defined as 'a narrative story that raises fear with supernatural and strange experiences in the army'. In addition to the internet community sites, humor sites and game sites are actively handed down. Recently, ghost stories have appeared on the site, and uncanny stories concerning army are easily collected from these various sites. The uncanny stories concerning army can be divided into three types: ghost experience type, Bulgogi GP type, mystery radio type. The ghost experience type has the largest number of version, the contents are rich and varied. It does not deviate much from the traditional notion of ghosts. Bulgogi GP type has a frenzied horror from its name. It is related to actual events and raises horror. Mystery radio type is a romantic material used in movies and dramas. However, unlike movies and dramas, uncanny stories concerning army are perceived as fearsome. The uncanny stories concerning army continues to emphasize that the story is actually experienced in the title and content. It has presented concrete evidence. The emphasis on truthfulness is intended to make fear more realistic. This comes from the desire for safety. Uncanny stories concerning army focus on horror. So It tries to reveal the history and truthfulness of the story itself. As a result, the history of reality, the truth of reality, and the realistic ideology are erased. Historical and truthfulness of traditional legends has been varied in the case of uncanny stories concerning army.

• Journal of Korean Medical classics
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• v.18 no.4 s.31
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• pp.101-119
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• 2005

금원사대가적태두류완소(金元四大家的泰斗劉完素), 1110년생어하북성하간현(年生於河北省河間縣), 졸어(卒於)1200년(年), 향년(享年)90세(歲). 타통과연구(他通過硏究)${\ulcorner}$황제내경(黃帝內經)${\lrcorner}$화(和)${\ulcorner}$상한론(傷寒論)${\lrcorner}$, 저술료(著述了)${\ulcorner}$소문현기원병식(素問玄機原病式)${\lrcorner}$, ${\ulcorner}$황제소문선명론방(黃帝素問宣明論方)${\lrcorner}$, ${\ulcorner}$소문병기기의보명집(素問病機氣宜保命集)${\lrcorner}$, ${\ulcorner}$상한표본심법류췌(傷寒標本心法類萃)${\lrcorner}$, ${\ulcorner}$상한직격론(傷寒直格論)${\lrcorner}$등저작(等著作). 령외, 응용운기대이론진행연구(應用運氣對理論進行硏究), 주장(主張)‘화열론(火熱論)’, 제출이한량약물치료질병적방법, 사금원시대재의학상(使金元時代在醫學上), 형성료백가쟁명적국면(形成了百家爭鳴的局面). 필자통과대류완소적방제학설급임상경험적연구(筆者通過對劉完素的方劑學說及臨床經驗的硏究), 득출여하결론(得出如下結論): 재방제학설상(在方劑學說上), ${\ulcorner}$황제소문선명론방(黃帝素問宣明論方)${\lrcorner}$중(中), 기사용적(其使用的)${\ulcorner}$상한론(傷寒論)${\lrcorner}$화각가급기제자문운용방제(和各家及其弟子們運用方劑), 공포괄(共包括)366개(個). 대부분주장료이용신고적한약(大部分主張了利用辛苦的寒藥), 래개통울결(來開通鬱結), 조습제열(操濕除熱). ‘상복보양(常服保養)’시인위여기소거주적중국북방(是因爲與其所居住的中國北方), 기후건조(氣候乾操), 인문다식습성강(人們多食濕性强), 차교표한적식물(且較標悍的食物), 소이유사인체장위비조적경향(所以有使人體腸胃秘操的傾向). ${\ulcorner}$황제소문선명론방(黃帝素問宣明論方)${\lrcorner}$적(的)366개방중(個方中), 유산제(有散劑)126개(個), 탕제(湯劑)87개(個), 기중(其中), 지유(只有)18개방가칭지위진정적탕제, 기여도접근위자산(其餘都接近爲煮散). ${\ulcorner}$황제소문선명론방(黃帝素問宣明論方)${\lrcorner}$중소나열적주요방제유(中所羅列的主要方劑有)‘방풍통성산(防風通聖散)’, ‘삼화신우환(三花神佑丸)’, ‘쌍해산(雙解散)’, ‘삼일승기탕(三一承氣湯)’, ‘대금화환(大金花丸)’, ‘익원산(益元散)’, ‘대건중탕(大建中湯)’, ‘당귀룡담환(當歸龍膽丸)’, ‘비방다주조산(秘方茶酒調散)’, ‘계령감로산(桂零甘露散)’, ‘천궁석고탕(川弓石膏湯)’, ‘전성산(全聖散)’, ‘지유탕(地楡湯)’, ‘인참산(人參散)’, ‘작약탕(芍藥湯)’, ‘내통황연탕(內統黃連湯)’, ‘신궁환(神芎丸)’, ‘도환산(倒換散)’등(等). 재임상경험상(在臨床經驗上), 류씨유풍부치료경험(劉氏有豊富治療經驗), 단시유감적시몰유전하일부관우의안방면적저작(但是遺憾的是沒有傳下一部關于醫案方面的著作). 재질병적치료상(在疾病的治療上), 가간출기유독창적견해(可看出其有獨創的見解), 저일점도견우(這一點都見于)${\ulcorner}$소문현기원병식(素問玄機原病式)${\lrcorner}$등이론저작(等理論著作), 우기산견어(尤其散見於)${\ulcorner}$황제소문선명론방(黃帝素問宣明論方)${\lrcorner}$중(中).

• Korean Journal of Ichthyology
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• v.31 no.4
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• pp.201-207
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• 2019

Temperature is one of the most important criteria considered in species preference for aquaculture. Acute drop in temperature during winter is a cause of disease and mass mortality in farmed fish. This study was carried out the low water temperature tolerance, oxygen consumption, hematologic and histological responses to use as basic data for the management of fish farming which frequently cause death due to winter water temperature drop. Low-lethal water temperature for 4 days of file fish Thamnaconus modestus (4day-LT₅₀) was 6.97℃ (6.69~7.27℃). Oxygen consumption rate decreased with decreasing water temperature, showing a significant difference between water temperatures. SOD activity increased significantly at 6℃ experimental group than control group (10℃) (p<0.05), but CAT did not show any significant difference between experimental temperatures (p>0.05). Cortisol increased with decreasing experimental water temperature compared to control group. Histological changes in the liver include decreased blood vessels in the blood vessels, proliferation of acid cells, condensation of the nucleus, atrophy of pancreatic exocrine gland cells, and enzyme source granules.