• Journal of Acupuncture Research
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• v.21 no.4
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• pp.225-236
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• 2004

본 실험에서는 녹용 약침액의 항 골재흡수 속성을 조사하였다. PTH, $1,25(OH)_2D_3$와 IL-1을 각각 골재흡수 인자로 사용하여 생쥐의 두개골에서 osteoblast 세포를 격리, 배양, 그리고 자극시켰을 때 collagenolysis의 증가를 보였다. 두 가지를 동시에 사용한 결과, IL-1은 골재흡수성을 촉진시키고 재 흡수력을 생산하였다. In vitro에서의 세포독성 결과는 $1-200{\mu}g/ml$의 녹용 약침액 농도 분포에서 무세포독성을 보였다. 또한 녹용 약침액은 생쥐의 두개골 골아세포 내에서 PTH (2 unit/ml), IL-$1{\alpha}$ (1 ng/ml), $1,25(OH)_2D_3$ (10 ng/ml), IL-$1{\alpha}$ 및 IL-$1{\beta}$로 인해 유발된 collagenolysis에 대해서 대항하는 보호활동성을 나타내었다. 녹용약침액은 IL-$1{\alpha}$ 와 IL-$1{\beta}$로 인해 유발된 collagenolysis에 대항하는 보호활동성을 지녔다. DAS는 IL-$1{\alpha}$와 IL-$1{\beta}$로 인해 촉진된 골재 흡수력을 억제하는 효과를 보였다. 이와 같은 결과는 녹용약침액이 골다공증과 연관된 질환에 대해서 매우 안정적인 임상적 사용이 가능한 것을 관찰할 수 있으므로 추후 이와 관련한 지속적인 연구가 필요할 것으로 사료되었다.

• Journal of Acupuncture Research
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• v.25 no.2
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• pp.119-127
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• 2008

목적 : 골관절염치료에 빈용되는 유근피 약침액의 처치가 생쥐의 파골세포에 있어서 골재흡수의 저해에 미치는 영향을 알아보고자 하였다 방법 : 생쥐에게 유근피 약침액을 두개골 세포에 전, 후 처치하여 골재흡수에 대한 유근피 약침액의 억제 활성능을 검토하였다. 결론 : 염증성 cytokine 중 $IL-1{\beta}$ 유도인자인 PGE와 LPS처리로 $IL-1{\beta}$생성이 증가되었으나, 유근피 약침액 처치군은 이를 억제하였다. 유근피 약침액 전처리군에서도 $IL-1{\beta}$ 생성이 억제되었다. 유근피 약침액 처치군은 PGE2유발 $IL-1{\beta}$ 전사를 억제하였으며, PGE2 유발 $IL-1{\beta}$ 유도는 cAMP antagonist인 Rp-cAMP와 protein kinase A(PKA)저해제에 의해서도 억제되어 $IL-1{\beta}$ 발현에 cAMP, PKA 신호전달경로가 관여함을 시사하였다. 본 연구에서 유근피 약침액은 강한 항 관절염효과와 골재흡수 저해 활성이 있으며, 관절염 치료, 예방에 유의함을 밝힌 것으로 사료된다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.4
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• pp.131-139
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• 2021

This study assessed the use of zeolite with high absorption performance in landscape paving concrete as a substitute for aggregate. The absorption performance and strength properties of paving concrete were investigated according to the replacement rate of the zeolite coarse aggregate, and the mechanical properties were investigated through strength tests. The absorption rate of the zeolite aggregate was 14%, which is 2.5 times higher than that of general aggregate. When zeolite coarse aggregate is applied to paving concrete, the absorption rate increases according to the replacement rate. The absorption rate was 5.2% at a replacement rate of 50%, which was 42% higher than that of general paving concrete. The compressive strength increased to 20% of the replacement rate and decreased at a higher replacement, but all the strengths in the construction standard code were satisfied. The flexural strength satisfied the code up to a replacement rate of 10%, but the strength decreased with increasing replacement rate, and the splitting tensile strength was greater than that of paving concrete using general aggregate up to a 20% replacement rate. Overall, zeolite coarse aggregate can be applied as a substitute.

• Journal of the Korea institute for structural maintenance and inspection
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• v.20 no.3
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• pp.122-129
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• 2016

In this study, we developed a pressing device which can reproduce the pressure of concrete inside the conveying pipe as a part of the basic study to development of high fluidity concrete under high pressure pumping. Using this pressing device, we evaluated a absorption properties of aggregate that are crushed coarse aggregate, river gravel and lightweight coarse aggregate according to pressure of coarse aggregate and aggregate inside a high fluidity concrete, focused on the reduction of unit water quantity by pressure. In addition, it was evaluated the compressive strength of high fluidity concrete about before and after of pressive. Test a result, case of condition under the high pressure of 250 bar, absorption ratio of crushed coarse aggregate and river gravel were not increased above the surface absorption, absorption ratio of lightweight coarse aggregate was increased than the surface absorption.

• Journal of the Korea Concrete Institute
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• v.13 no.6
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• pp.561-567
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• 2001

It is reported that a lot of sludge powder is produced during the process of manufacturing crushed fine aggregate in mines. However, there is a limitation on the its use that most of them are disposed and wasted, which cause environmental pollution. Therefore, in this paper, tests are carried out in order to recycle sludge powder as filler for cement mortar products. Kinds of aggregates and mix proportion of mortar are varied under various contents of sludge powder. According to test results, it is found that cement mortar products using sludge powder as substitution of fine aggregate about 10% have better qualities than those without sludge powder.

• Proceedings of the Korean Society of Disaster Information Conference
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• 2015.11a
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• pp.166-167
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• 2015

단열재를 생산하는 회사에서는 대부분 유기단열재를 사용하고 있다. 커튼윌 시스템은 경제적이면서 성능이 우수하지만 불연성이지 않다. 따라서 근래에 안전사고가 많아지고 있어서 타지 않는 무기 단열재가 필요하다. 또한 안전과 단열효과 및 소비자가 요구하는 친환경적인 무기단열재가 필요하므로 불연성 무기단열재의 개발이 시급하다. 본 논문은 무기단열재의 문제인 흡수성을 실험하기 위하여 가습기를 이용하여 흡수성 실험을 하였고 경량골재인 펄라이트와 바인더를 섞고 흡수방지제로 처리한 샘플과 그렇지 않은 샘플의 흡수율을 측정하여 에너지 효율 지속성 단열재의 기술연구를 목표로 한다.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.21 no.2
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• pp.82-86
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• 2011

Lightweight aggregate which is composed of sintered polycrystalline materials usually has a certain portion of pores inside of it. Because of such a structural characteristics, it tends to that movement of water in aggregate shows an abnormal behavior against the change of outside environment. In general, water movement behavior is controlled by porosity, distribution of pore size; however, dense surface layer will also affect water movement behavior in case of artificially sintered aggregates. Factors affecting water movement behavior in the aggregate are pore distribution, pore shape, pre-wetting method, etc. In this study, absorption characteristics of aggregate under the pressure and absorption rate according to water dipping time are analyzed for the basis of pressure pumping of lightweight concrete. Two kinds of aggregates were used for the test: one is made by 'L' company in Germany and the other is of our own made at the pilot plant in Kyonggi University. Absorption rate of aggregate is measured according to water dipping time, vacuum pressure, and quenching condition. Absorption rate of aggregate with $300^{\circ}C$ quenching is higher than that of aggregate with 24 hr water dipping. Generally the more vacuum the higher water absorption rate. Water absorption rate of 'L' aggregate under -300 mmHg is 54 % higher than that of aggregate with 24 hr water dipping; however, only 2 % increase in water absorption was measured for the K622 and K73 which were of our own.

• Journal of the Mineralogical Society of Korea
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• v.3 no.1
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• pp.18-33
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• 1990

각종 콘크리트 구조물의 기초공사에서 생기는 문제점 외에 시멘트와 골재자체의 반응, 즉 알카리-골재반응에 의한 물리, 화학적인 변화가 구조물에 피해를 주는 일차적인 요인으로 작용된 사례가 최근 10년간 외국에서는 잇달아 보고 되고 있다. 국내산 콘크리트 구조물에 대한 본 연구에 의하면 변성작용을 받은 이축성 석영, 자아석류가 시멘트로부터 공급된 알카리용매에 쉽게 반응, 붕괴되며 조립질보다 세립질 골재에 더 큰 영향이 나타난다. 골재와 시멘트 사이의 반응에 의하여 K, Na, Ca 및 Si 성분이 함량이 높은 부분으로부터 낮은 곳으로 상호 치환 이동되는데 그 과정에서 smectite와 illite같은 점토광물이 반응생성물로 정출된다. 이러한 광물은 구조물 내에서 수분의 흡수와 방출에 의하여 부피의 팽축이 거듭됨으로써 콘크리트 구조물에 심각한 손상을 야기시킨다.

• The Journal of Korean Obstetrics and Gynecology
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• v.15 no.4
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• pp.45-60
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• 2002

Mouse calvarial osteoblast cells were isolated and cultured. To examine whether the cells produce active gelatinases in culture medium or not,the cells were analyzed using by zymograsphic analysis on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). We show that mouse calvarial osteoblasts in culture constitutively synthesize progelatinase- A. Then, mouse osteoblasts, which were stimulated by PTH, $1,25(OH)_2D_3$, mononuclear cell conditioned medium (MCM) and IL-1 as bone resorption agent's, showed increased collagenolysis by producing the active gelatinase. However, treatment of indomethacin and dexamethasone significantly decreased those effects of collagenolysis in mouse osteoblastic cells. On the other hand, IL-1 in stimulating bone resorption was examined using fetal mouse long bone organ culture. IL-1 stimulated bone resorption and produced marked resorption when present simultaneously. Furthermore, when it was examined the effects of indomethacin and dexamethasone on the dose dependent responses of $IL-1{\alpha}$, indomethacin and dexametasone produced a rightward shift in the IL-1 dose response curve. The results of in vitro cytotoxicities showed that Taeyoungjon-Jahage water extracts(T.Y.J-J.H.G extracts) have no any cytotoxicities in concentrations of $1-200\;{\mu}g/ml$ and furthermore there is no any cytotoxicity even in concentration of $300\;{\mu}g/ml$ on mouse calvarial bone cells. T.Y.J.-J.H.G. extracts had protective activity against PTH (2 units/mI), or MCM (5%, v/v), or $rhIL-1{\alpha}$ (1 ng/mI) or $1,25(OH)_2D3$ (10 ng/ml) , $IL-1{\alpha}$ and $IL-1{\beta}-induced$ collagenolysis in the mouse calvarial cells. Pretreatment of the T.Y.J.-J.H.G.extracts for 1 h, which by itself had little effect on cell survival, did not enhance the collagenolysis, nor significantly reduced the collagenolysis by pretreatment. Furthermore. the medicinal extracts were shown to have the protective effects against collagenolysis induced by $IL-1{\alpha}$ and $IL-1{\beta}$. Pretreatment of the extracts for 1 h significantly reduced the collagenolysis. Interestingly, the T.Y.J.-J.H.G. extracts were shown to have the inhibiting effects against gelatinase enzyme and processing activity induced by the bone resortion agents of PTH, $1,25(OH)_2D_3$, $IL-1{\beta}$ and $IL-1{\alpha}$, with strong protective effect in pretreatment with the extracts. T.Y.J.-J.H.G. extracts were shown to have the inhibiting effects against $IL-1{\alpha}-$ and $IL-1{\beta}-stimulated$ bone resorption and the effect of the pretreatment with a various concentrations of the medicinal extracts were significant. The inhibition extent and phenomena of IL-1 stimulated bone resorption by nonsteroidal anti-inflammatory agents of indomethacin and dexamethasone were similar to those obtained by T.Y.J.-J.H.G. extracts treatment in the mouse calvarial tissue culture system. These results indicated that the T.Y.J.-J.H.G.-water extracts are highly stable and applicable to clinical uses in osteoporosis.

• Magazine of the Korea Concrete Institute
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• v.10 no.1
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• pp.125-132
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• 1998

경량골재 콘크리트의 내구성과 경제성에 대한 인식 부족으로 조경재료나 인공토양 둥 구조부재 이외의 분야에 사용되고 있는 국내 실정에 비해서, 구미 여러나라에서는 고강도 경량골재를 장지간 교량과 고충건물에 사용하고 있다. 경량골재 콘크리트는 구조물의 재료비 단순비교에 있어서도 경제성이 있을 뿐만 아니라, 자중감소로 인한 구조적, 기하학적 장점도 있으며, 또한 고강도 경량골재의 개발로 경량골재가 가지고 있는 여러 문제점을 해소하여 사용성과 내구성에 있어서 보통골재 콘크리트와 큰 차이가 없는 상황이다. 그러나국내에서 생산된 경량골재는 닫힌 공극보다 열린 공극을 많이 내포하고 있어 수분흡수가 많고, 특히, 동결융해에 대한 내구성에 취약한 문제점을 가지고 있다. 본 논문에서는 내동해성 향상을 위해 10종류의 고강도 경량골재 콘크리트 공시체를 제작하여 실리카 흄, 물.시멘트비, AE제, 강섬유 등을 실험 변수로 하여동결융해 실험을 수행하였다. 연구결과 실리카흄, 물.시멘트 비는 어느 정도 내동해성을 향상시키지만 근본적인 해결방안이 되지 못하며, AE제를 첨가한 공시체와 강섬유를 사용한 공시체는 동결융해 내구성 지수가 90%이상으로 측정되어 내동해성을 개선시킬 수 있는 요소로 나타났다.