• Journal of the Korean Society of Radiology
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• v.9 no.6
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• pp.349-356
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• 2015

The study is to recognize the interactions with bone ages by measuring the length between the end of the bone and the growth plate on selected highest weight of regions of seven for bone maturity in TW3 method. The experiment is subjected on seventy-two children (36 males, 36 females) who have examined the growth plate test from March, 2014 to March, 2015 and implemented a regression analysis by measuring the length between the end of the bone and the growth plate in Hand AP image of the children. In result, each bone age has produced a mean value and a standard deviation corresponding to the specific range and as bone age increases the length between the end of the bone and the growth plate decreased. In addition, female children showed lower mean value in comparison to male and also the measurement of the length between the end of the bone and the growth plate and its bone age are shown to be statistically valid(p<0.001) according to the results of regression analysis using its result value. Therefore, the probability of prediction on the bone age read off through the applied TW3 method and regression equation in the Hand AP image of the children.

• Clinical and Experimental Pediatrics
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• v.50 no.7
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• pp.678-685
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• 2007

Purpose : Recent reports pointed out that gonadotropin releasing hormone analogue (GnRHa) therapy alone is not so promising for improving adult height in precocious puberty. So, that we studied the growth promoting effect of combined therapy with GnRHa and growth hormone (GH) in early pubertal girls. Methods : Twenty three early pubertal girls ($9.73{\pm}1.59yr$) with predicted adult heights (PAH) below-2 standard deviation score (SDS) were included. They were divided into two groups as follows; Group I before menarche (n=19) and Group II after menarche (n=4). After combined therapy, various growth parameters were compared between two groups and between the before and after therapy. Results : Between the two groups before therapy, chronologic age (CA), growth velocity (GV), body mass index (BMI), target height (TH), PAH and serum insulin-like growth factor binding protein-3 were not different, but BA, height and difference between bone age (BA) and CA were significantly higher and insulin-like growth factor-1 (IGF-1) was marginally higher in group II. After therapy, BA still remained higher in group II, but other parameters were not different. In both groups, after therapy, the difference between BA and CA, the ratio of BA over CA, and GV were significantly decreased, but PAH, height SDS and BMI were significantly increased. Regarding IGF-1 level, a significant increase was noted in group I, but not in group II. Conclusion : With combined therapy of GnRHa and GH, PAH in early pubertal girls might be improved significantly and even approach TH. Among them, those who were before menarche might have greater potential for the height gain than those after menarche in view of IGF-1 changes during therapy.

• Journal of the korean academy of Pediatric Dentistry
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• v.46 no.3
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• pp.233-238
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• 2019

This study aimed to assess the skeletal age of skeletal maturational indicator (SMI) and middle phalanx of the middle finger (MP3) stages and to predict the SMI and MP3 stages corresponding to pubertal growth spurt in boys and girls respectively. The skeletal age was assessed from hand-wrist radiographs of 363 children (182 boys, 181 girls) aged 7 to 16 years by radiologists using the Korean standard bone age chart. Also, SMI and MP3 stages were evaluated from the radiographs. From these records, the mean skeletal age of SMI and MP3 stages was calculated. The stages including pubertal growth spurt were SMI 4 - 5, MP3 FG - G stages in boys and SMI 3 - 4, MP3 F - FG stages in girls.

• Clinical and Experimental Pediatrics
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• v.52 no.12
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• pp.1370-1376
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• 2009

Purpose:Treatment of precocity with gonadotropin releasing hormone analogue (GnRHa) might theoretically exert a detrimental effect on the bone mass during pubertal development. We investigated the short-term changes in bone mineral density (BMD) during GnRHa treatment and the enhancement in the changes with the co-administration of GnRHa and human growth hormone (hGH). Methods:Forty girls with precocious or early puberty who were using GnRHa for more than 1 year were enrolled. Of them, 14 concurrently received hGH. Lumbar bone mineral density was measured before and after the treatment, and bone mineral density-standard deviation scores (BMD-SDSs) were compared according to chronologic age (CA) and bone age (BA), as well as according to the administration of GnRHa alone (Group I) or the co-administration of hGH and GnRHa (Group II). Results:BMDs before and after treatment were in the normal range according to CA but were significantly lower according to BA (P<0.05). During treatment, BMD-SDSs did not change according to CA but significantly increased according to BA (P<0.05). BMD-SDSs in group I did not change during treatment according to CA or BA, while those in group II increased significantly according to BA (P<0.05), but not according to CA. Conclusion:Lumbar BMD was adequate according to CA at initial manifestation of precocity but was lower if compared to BA, that is, BMD did not increase with BA. Because co-treatment with hGH significantly increased BMD-SDSs according to BA, hGH co-treatment could be considered during GnRHa therapy.

• Proceedings of the Korean Society of Computer Information Conference
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• 2022.01a
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• pp.153-154
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• 2022

본 논문에서는 역연령으로 구분되었던 기존 생물학적 성숙도에 기반한 체력 지표가 아닌 골성숙도를 활용한 생물학적 성숙도에 기반하여 유소년의 신체에 맞는 체계적인 운동을 추천하는 기법을 제안한다. 이를 통해 유소년의 성장기에 개인화된 운동능력 발달을 성취하게 함으로써 국민 체력 증진에 기여하고 체육 공교육 활성화 및 유소년 피트니스 관리 산업 발전에 도움이 될 것으로 기대한다.

• Journal of the Korea Convergence Society
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• v.9 no.9
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• pp.309-317
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• 2018

The purpose of this study was to investigate the effect of bone age on physique and physical fitness in elementary school students. For this purpose, the structural equation model test was conducted based on the three-year longitudinal study. The results were as follows. First, bone age in boys and girls (1st~3rd grade) has a direct effect on the change of body size, but it does not affect the change of physical strength. Second, the bone age of the senior male students(4~6 grade) gave a direct effect on the change of physique, 50m running, and sit-up. On the other hand, it gave an indirect effect on push-ups, sitting basketball throws, and standing long jump. Third, the bone age of the female students(grades 4~6) affected directly on body size change, sit-up, side step and indirect effect on 50m running, half squat jump, and standing long jump. These results indicated that the evaluation of the bone age of the subjects should be included in the exercise ability evaluation items for the male and female students in elementary school over the fourth grade in relation to the myofunction.

• Journal of the korean academy of Pediatric Dentistry
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• v.46 no.2
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• pp.139-146
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• 2019

This study aimed to analyze the association of midpalatal suture (MPS) maturation stages with skeletal maturation and age and to obtain references for establishing a treatment plan for rapid maxillary expansion (RME). Cone-Beam Computed Tomography (CBCT) images from 480 children (240 boys, 240 girls) aged 7 - 15 years were obtained. MPS maturation stages and cervical vertebral maturation indicator (CVMI) were evaluated, and the correlations between MPS maturation stages, CVMI, and age were determined using the Spearman's correlation test. The positive likelihood ratio (LHR) of CVMI for MPS maturation stages was calculated. MPS maturation stages and CVMI showed a strong correlation. Especially, CVMI 1 - 3 showed positive LHR greater than 10 for the diagnosis of stages A - C. MPS maturation stages and age were correlated strongly in girls and moderately in boys. Conventional RME produces the most favorable skeletal effect at CVMI 1 - 3 or those up to 12 years of age and fewer skeletal effects at CVMI 4 or at 13 years of age in girls and 13 - 15 years in boys. It is recommended to evaluate MPS maturation stages using CBCT before RME application at CVMI 5, 6 or at 14, 15 years of age in girls.

• Journal of the Korean Applied Science and Technology
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• v.38 no.6
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• pp.1627-1642
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• 2021

This study aims to evaluate physical fitness according to the bone age of youth, and ultimately provide basic data for balanced development of youth through physical fitness standard indicators according to the bone age. A total of 730 youth aged 11 to 13 years in bone age and 11 to 13 years in chronological age were selected as subjects; and after taking X-ray films to calculate the bone age, they were evaluated by using the TW3 method. A total of 2 components in physique, which were stature and weight, were measured using a stadiometer(Hanebio, Korea, 2021) and Inbody 270(Biospace, Korea, 2019). A total of 7 components in physical fitness were measured as well, which included muscular strength (Hand Grip Strength), balance (Bass Stick Test), agility (Plate Tapping), power (Standing Long Jump), flexibility (Sit&Reach), muscular endurance (Sit-Up), and cardiovascular endurance (Shuttle Run). Descriptive statistics and independent t-test were conducted for data processing using the SPSS PC/Program(Version 26.0), and it was considered significant at the level of p< .05. The results of this study may be summarized as follow. First, the result of comparing the bone age and the chronological age of 11 to 13 years old in physical fitness, males showed significant difference in muscular strength, power, muscular endurance, and cardiovasular endurance. In females, muscular strength, balance, agility, power, flexibility, muscular endurance, and cardiovascular endurance showed significant difference. Second, physical fitness standard indicators were presented for each gender and age (11-13 years old) of youth according to the bone age; and based on this, physical fitness standard indicators, which are basic data for physical fitness evaluation according to the bone age of youth, were presented.

• Proceedings of the Korea Information Processing Society Conference
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• 2019.10a
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• pp.630-632
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• 2019

정부는 IT기술을 활용하여 국민의 건강증진을 목적으로 체력 상태 측정 및 평가를 제공하는 체육복지 서비스가 수행하고 있다. 특히, 모든 성장발육발달이 이루어지는 유소년기는 성인의 생활체육과는 그 중요성이나 효과의 측면에서 다르게 다루어야 한다. 따라서, 본 연구는 골연령에 따른 발육단계별 체력을 분석하여 유소년들에게 적합한 신체활동 서비스를 효율적으로 제공하기 위한 피지컬 피트니스 관리 시스템을 제안한다. 이를 통해, 골연령 평가를 위한 영상처리기술은 한국형 골연령 측정의 정확도를 높여주고, 유소년들에게 적합한 피트니스 프로그램을 효율적으로 제공할 수 있다.

• Clinical and Experimental Pediatrics
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• v.50 no.2
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• pp.198-204
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• 2007

Purpose : The hope that arresting pubertal developement might increase final adult height has led to an attempt to use GnRH agonist (GnRHa) in children with early puberty and poor growth prognosis. We investigated the growth-promoting effect of GnRH agonists with or without growth hormone (GH) in girls with early puberty and decreased predicted adult height (PAH). Methods : Thirty five girls with advanced bone age and early pubertal signs were randomized for treatment for about 1 year with monthly GnRHa in group 1 (n=18), or with a combination of GH and GnRHa in group 2 (n=17). The following growth parameters were compared between groups, and the difference ($\Delta$) before and after treatment : chronological age (CA), bone age (BA), $\Delta$(BA-CA), height (HT), target height (TH), predicted adult height (PAH), $\Delta$ (TH-PAH), serum insulin-like growth factor (IGF-1) and insulin-like growth factor binding protein (IGFBP-3). Results : Before treatment, BA, TH, PAH Standard deviation scores (SDS), $\Delta$(TH-PAH) were not different between the two groups, but CA was higher in group 2 and $\Delta$(BA-CA) were higher in group 1 (P<0.05). After $1.06{\pm}0.93$ year of treatment, $\Delta$ (BA-CA) decreased and there were significant changes in PAH and $\Delta$ (TH-PAH), especially in group 2 (P<0.05 in group 1, and P<0.001 in group 2). In both groups, IGF-1 and IGFBP-3 were not different before and after treatment, but after treatment, IGF-1 level in group 2 was marginally higher than IGF-1 in group 1 (P<0.1). Conclusion : Compromised predicted adult height in girls with early puberty and advanced bone age was significantly improved with GnRH with/without GH treatment in the short-term period. The addition of GH to GnRHa results in a significant increase in PAH compared to GnRHa alone because GnRHa suppressed growth hormone-IGF-1 axis. For comparison of final adult height, further longitudinal follow-up will be needed.