• Journal of radiological science and technology
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• v.31 no.1
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• pp.33-39
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• 2008

Abdominal obesity, especially, visceral obesity is thought to be a risk factor of type 2 diabetes and cardiovascular disease such as hypertension, hyperlipidemia, coronary artery disease. Based on previous studies visceral fat accumulation is highly related to these diseases compared to subcutaneous fat accumulation. The purpose of this study was to see the relation between abdominal obesity and lipid profiles in adult women. The included subjects were 25 adult women(BMI > $23\;kg/m^2$), who visited the obesity clinic in a general hospital from April 2006 to September 2007. Blood pressure, fasting glucose and lipid profiles were measured. The abdominal fat distribution had been assessed by CT scan at the level of L4-L5. From bivariate analyses, the visceral fat accumulation showed negative correlations with TC and TC/HDL. The BMI, total abdominal fat and Visceral fat/Subcutaneous fat ratio showed significant correlations with visceral fat accumulation. From linear regression analyses of all the study subjects, TC, TG and HDL were found to be determinants of the visceral fat accumulation($R^2\;=\;0.474$).

• Journal of Applied Biological Chemistry
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• v.64 no.3
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• pp.291-298
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• 2021

In this study, we investigated whether the combined administration of berberine (BBR) and silibinin (SBN) was effective in improving hyperlipidemia and anti-obesity efficacy using a high-fat diet (HFD)-fed obese mouse model. HFD-induced obese mice were supplemented with the BBR and SBN combination (BBR-SBN) along with the HFD administration for 8 weeks. During the experiment, body weight, food intake, and levels of total cholesterol, triglyceride and high-density lipoprotein (HDL)-cholesterol were analyzed. Consumption of HFD in the mice caused rapid increases in body weight and the levels of total cholesterol and triglycerides compared to the normal control (NC) group. However, supplementation of BBR-SBN in these obese mice significantly reduced body weight gain and suppressed the levels of total cholesterol and triglyceride with the increment of HDL cholesterol level. In the HFD-fed group, abdominal fat weight was significantly increased and the adipocytes within the epididymal adipose tissue were found to have expanded sizes compared to the NC group. However, in the BBR-SBN group, the sizes of the adipocytes were comparable to those of the NC group and abdominal fat weight was significantly reduced. Moreover, the deposition of giant vesicular fat cells in liver tissues seen in the HFD-fed group was considerably reduced in the BBR-SBN group. These results suggest that the BBR-SBN combination tends to have synergic potential as an anti-obesity agent by significantly reducing body weight gain as well as lowering serum lipid levels and thus improving anti-obesity efficacy in HFD-induced obese mice.

• Journal of Applied Biological Chemistry
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• v.62 no.1
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• pp.31-38
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• 2019

Scutellaria baicalensis Georgi (Scutellariae Radix) has been widely used as a dietary ingredient and traditional herbal medicine such as diuretic, hyperlipidemia, antibacterial, anti-allergy, anti-inflammatory and anticancer properties. In this study, the isolation of biomarkers or bioactive compounds from complex S. baicalensis extracts represents an essential step for de novo identification and bioactivity assessment. The bioactive fraction consisted of eight compounds which was chromatographed on an analytical high performance liquid chromatography column using two different gradient runs. A simulative replacement of the analytical column with a medium pressure liquid chromatography and open column allowed the determination of gradient profile to allow sufficient separation in the preparative scale. From the optimized method, eight standard compounds have been identified in the fractions. In addition, MS, UV, HRMS detection was provided by ultraperformance liquid chromatographyequadrupole time-of-flight mass spectrometry (UPLC-QTof-MS) of all fractions. Therefore, this scale up procedure was successfully applied to a S. baicalensis extract.

• Journal of the Korean Institute of Landscape Architecture
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• v.49 no.2
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• pp.113-127
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• 2021

Although planning techniques linking parks, green areas, and waterways have become common, there are frequent disruptions in the operation and management of landscape-use artificial channels (LuAC). Therefore, this study examined a design to promote the sustainable management and operation of a LuAC using rainwater for the streamlets of the Jeonju-Wanju Innovative City. In order to accomplish the purpose of this study, scenarios were set up by dividing the design into waterhead and waterway portions. First, the scenario regarding the waterhead was analyzed to calculate the water supply and storage required for the waterway and waterhead. The analysis showed that the waterway requires a water supply of 676.8 tons/months, 3,018 tons to 5,512 tons of storage space, and a water depth of 0.75 m to 1.37 m considering the ecological and landscape aspects. The second scenario is to select an effective system of facilities for the operation and management of the LuAC. To accomplish this, a single-circulation system (SCS), which transports water to a highland location was compared to a multi-circulation system (MCS), which supplied water separately to each water space and operated independently. The results showed that the MCS, which was operated independently by small power units, was more effective owing to the vast difference in water supply operation times.

• Journal of the Korea Society of Computer and Information
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• v.27 no.3
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• pp.165-171
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• 2022

In this paper, we suggest the Measures to improve the Act Bill for establishing the Game User Committee. The Act Bill has a lot of problems which are violations of criminal legalism due to unclear terms in administrative punishment and violations of The Human Right enjoying freedom of occupation and guaranting property due to not defining provisisons about The Duty of Confidentiality or The Legal Fiction as Public Officials for Purposes of Applying Penalty Provisions. also the duplicate regulations in the Act Bill disrupt game industry development. we have three results that were derived through analysis of Prior studies and precedents. The First is to define details of special reasons in enforcement ordinance and enforcement regulations. The Second is to define The Duty of Confidentiality or The Legal Fiction as Public Officials for Purposes of Applying Penalty Provisions in the act bill. The Third is to address managing the random reward items in the Game Rating and Administration Committee or is to give game user advance notice about the Comntent Dispute Mediation system.

• Journal of Life Science
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• v.29 no.1
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• pp.18-28
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• 2019

Recent studies reported that obesity upregulated the expression of neuronal nitric oxide synthase (nNOS) and regulated particular behavior patterns in animal models. They also reported that ameliorated the increase in nNOS expression and decreased depression and anxiolytic effects. Thus, exercise seems to be an effective strategy for improving brain function by downregulating nNOS. However, the immune response differs greatly, depending on the exercise intensity. The aim of the present study was to investigate differences in brain nNOS expression in obese C57BL/6 mice that performed exercise of different intensities. Obesity was induced in 6-wks-old mice (n=35) by feeding a 60%-fat diet for 6-wks. A control (CON) group (n=14) was fed a normal diet. At the end of the induction 6-wks period of obesity, seven animals in the CON group and obesity-induced group were sacrificed to confirm obesity induction (preliminary experiments and confirmation of visceral fat accumulation). The remaining animals were then used in an 8-wks exercise intervention. Other than the CON (n=7), the obesity-induced animals were divided into the following groups: high-fat diet (HFD, n=7), HFD-low intensity (HFD-LI, n=7, 12 m/min for 75 min), HFD-moderate intensity (HFD-MI, n=7, 15 m/min for 60 min), and HFD-high intensity (HFD-HI, n=7, 18 m/min for 50 min). The exercise was performed on an animal treadmill. The expression of the nNOS protein in the hippocampus was significantly higher in the HFD group as compared with that in the CON group (p<0.01). However, there was no difference in the hippocampal expression of the nNOS protein in the other exercise groups as compared with that in the CON group. In contrast, nNOS expression in the HFD-HI group was significantly lower than that in the HFD-LI group (p<0.05). The expression of phosphorylated Akt (pAkt) was significantly higher in all the exercise groups as compared with that in the CON and HFD groups. There was no difference in the expression of pAkt in the cerebral cortex among groups, and the expression of pAkt in the cerebellum was significantly higher in the HFD-HI group as compared with that in the CON group (p<0.05). There were also no between-group differences in pAkt expression in the cerebellum among the various exercise groups. In conclusion, nNOS seems to be overexpressed in response to obesity, and it appears to be downregulated by exercise. Relatively high-intensity exercise may be effective in improving brain function by downregulating nNOS.

• 월간 기계설비
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• no.11 s.220
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• pp.29-37
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• 2008

최근들어 국제 유가가 급등하고 지구 온난화 등 환경문제가 부각되면서 기존의 에너지를 대체하는 대안으로 신재생 에너지가 전 세계적으로 뜨거운 이슈로 떠오르고 있다. 더구나 온실가스 감축 등 본격적인 환경경제 시대가 도래하면서 환경친화적이고 고갈 염려가 없는 신재생에너지가 효과적인 대안으로 주목받고 있다. 또한 고유가 및 기술개발 가속화도 신재성에너지 시장 확대를 부채질하고 있어 신재생에너지에 대한 관심이 신성장동력으로 집중되고 있다. 이처럼 환경문제 해결에 대한 관심은 '선택'이 아닌 '필수'가 되었다. 우리나라도 국가 차원에서 이산화탄소 배출을 줄이기 위해 '저탄소 녹색성장' 정책을 마련하면서 신재생에너지 확대 보급을 위한 제도 및 대책이 새롭게 마련되고 있다. 건설산업은 대표적인 에너지 다소비업종에 속하기 때문에 이산화탄소 저감을 위해 에너지 저소비형 건축물 연구에 많은 투자를 하고 있으며, 신재생에너지를 이용한 생태토시 조성 등에 노력을 기울이고 있다. 특히 에너지를 다루는 기계설비는 이러한 신재생에너지와 밀접한 관련이 있기에 더욱 관심을 기울이고 있다. 태앙광을 비롯하며 지열, 풍력, 바이오 등 신재생에너지 개발은 물론 빗물이용 시스템 쓰레기 이송 설비와 같은 첨단과 환경이 조화를 이루는 아파트의 보급도 차츰 늘어나고 있는 추세다. '누구의 영역도 아닌' 곳이자 '누구의 영역도 될 수 있는' 신재생에너지가 설비건설업계에 확대, 보급되기 위해서는 설비건설업계의 관심이 집중되어야하며, 기술개발을 활발히 하여 선점경쟁에서 유리 한 고지를 접할 수 있을 것이다. 그렇다면 국내 신재생에너지의 개발 수준은 어디까지 왔을까? 이번 호는 그 현황을 집중 조명해 보고, 다음 호에는 풍력, 바이오에너지, 지열, 연료전자 수소 등을 하나씩 분석해 본다.

• Design Convergence Study
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• v.14 no.6
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• pp.29-55
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• 2015

This study aimed to examine and compare housing conditions and satisfaction degree of working college students in Seoul metropolitan area, depending on their stress level from economic burden and living housing type. The interview using the questionnaire was conducted. The subjects were 199 working college students aged between 19 and 35. The two-tier cluster sampling method were used, the region and representative university within the region. The comparison of satisfaction degree per type of housing of working college students has been conducted to find 3 characteristic patterns of satisfaction degree per housing condition from the stress of preparing the fund for rent, and students with high degree of stress from arranging rent showed relatively low degree of satisfaction in most items. 6 patterns have been identified in terms of housing types, and most of the students living in the Gosiwon, the poorest condition and housing type, showed the lowest degree of satisfaction, while those residing in the officetel turned out to the most satisfied. This study gives implications of housing welfare for working college students.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.14 no.2
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• pp.142-149
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• 2014

Purpose: There are 15 types of Glycogen storage disease (GSD) that have been identified, and GSD type Ia is the most common type. There are several studies of Korean GSD type Ia patients' long-term complications. The aim of this study to find out clinical symptoms and prognosis of GSD type Ia patients. Methods: We performed clinical, biochemical and genetic analysis retrospectively on five patients diagnosed with GSD type Ia in a Soonchunhyang University Hospital from July 2002 to July 2014. Results: All patients had hepatomegaly at diagnosis, and they were all confirmed to have fatty liver at abdomen USG. They had no developmental delay, but two of them had growth retardation. Elevated blood lactate, triglyceride, and uric acid levels can find out all patients, but only one patient had hypoglycemia. They are diagnosed with GSD through gene analysis, and by gene analysis, they have c.648G>T (homozygote, splicing mutation), c.122G>A/c.648G>T, c.248G>A/c.648G>T mutations. Treatment with three times meals, three times snacks and four to six times use of uncooked constarch for all patients. Following the progress, one of them resulted in hypothyroidism, other one had renal stones. A patient diagnosed at 16 years old had liver cirrhosis and started having hemodialysis for ESRD. Conclusion: GSD type Ia patients had hepatomegaly, hyperlipidemia, hyperuricemia, and lactacidemia. Therefore patients who have such these symptoms are recommended gene analysis. A patient diagnosed at 16-years-old had liver cirrhosis and ESRD in progress, early diagnosis and treatment are important for GSD type Ia patients.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2017.04a
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• pp.53-53
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• 2017

연구목적: 국내 과일 산업의 한 단계 도약과 대외 경쟁력을 높이기 위해서는 수확작업의 기계화가 시급함. 이 연구는 국내외 과일 수확 기계화 현황과 문제점을 분석하고, 향후 수확작업 기계화 방향을 제시하고자 수행 수확기계 실용화 현황 및 고찰 (국내) 과일을 직접 수확이 아닌 수확 작업을 보조해주는 고지 작업기(수동형, 모터 진동형)와 고소 작업차가 대부분임. 수동형은 사과 감 등을 수확하지만, 작업능률이 낮고 작업자가 쉽게 피로하여 장시간 작업이 불가능하므로 실질적인 대안이 되지 못함. 진동형은 자체 동력을 이용하여 나무에 진동을 가하여 주로 대추 매실 등 소과류 수확에 이용되고, 수확능률은 우수하나 충격 손상이 많아 개선이 요구됨. 고소작업차는 동력원에 따라 충전식과 엔진식으로 구분되고, 충전식은 엔진식에 비해 진동 소음이 적어 쾌적하지만, 작업시간이 배터리 용량에 제한을 받음. 또한 작업대 작동방식에 따라 리프트형과 붐형으로 구분함. 리프트형은 리프트를 이용하여 작업대를 상하로 구동하는 방식으로 높은 위치의 과실 수확이 어렵고, 작업대 넓이 만큼의 작업 공간(과수간의 거리)이 필요함. 붐형은 필요한 곳으로 접근성이 우수하나 무거운 무게를 지탱하기 어렵기 때문에 본체를 무겁게 하거나 수시로 수확된 과일을 하차시켜야 함. (국외) 수확 후 가공되는 과일류와 포도 올리브 오렌지 매실 등 소과류 수확이 기계화되었지만, 사과 복숭아 등 신선과일은 아직도 외국의 값싼 노동자들에 의존하여 수확되고 있음. 현재 실용화된 수확 기계는 진동식 수확기계와 터널식 수확기계가 대표적임. 진동식은 집게형의 부착기를 나무 줄기에 고정한 후 트랙터 동력원으로 나무에 진동을 가하여 수확하고, 올리브 대추 등과 같은 소과류와 과피가 두꺼운 오렌지 등에 적용되고, 수확 작업능률이 매우 높으나 과일의 낙하 상처를 피할 수 없는 단점이 있음. 터널형은 규격화(과수 크기 및 형태, 재식거리)된 과수원에 잘 적응하도록 설계 제작되어, 과수 위를 지나가면서 내부에 설치된 진동장치와 컨테이너로 과일을 수확하고, 와인용 포도 수확기가 대표적임. 기계수확이 가능하도록 과수원 조성단계에서부터 재배양식(과수 좌우 및 전후 거리)을 기계의 제원(바퀴 간격, 작업부 간격 등)에 맞추어 재배함. 과일 수확로봇에 관한 연구는 활발하고 일부에서 실증시험단계에 있음. 결론: 구체적인 추진방향을 제시하면, 단기적으로는 과일 수확작업자의 작업편이성과 노동강도를 줄일 수 있도록 소형 저가 범용성이 우수한 보조기구/기계의 보급을 확대하고, 중장기적으로는 수확기계/수확로봇 개발을 위한 연구개발비 투자를 늘리는 동시에, 기계/로봇이 과수원에 잘 적응할 수 있도록 수형 재식거리 등 재배양식의 표준화가 추진되어야 함.