• 대한흉부심장혈관외과학회:학술대회논문집
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• 대한흉부외과학회 1998년도 제30차 추계학술대회 대한흉부외과학회
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• pp.13-13
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• 1998

• Journal of Chest Surgery
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• 제33권8호
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• pp.655-661
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• 2000

Backgound: This study was performed to evaluate the incidences, the risk factors, and the clinical course of the hyperamylasemia in patients who underwent open heart surgery under cardiopulmonary bypass. Material and Method: Thirty seven patients who underwent cardiopulmonary bypass were studied at Department of Thoracic & Cardiovascular Surgery, Yeungnam University Hospital, from July 1997 to June 1998. The thirty seven patients were divided into two groups, 13 patients in group I had normal serum amylase levels and 24 patients in group II had hyperamylasemia. Result: Mean serum amylase(IU/l) levels and 24 patients in group II had hyperamylasemia. Result: Mean serum amylase(IU/l) levels of gorup II showed 54.3$\pm$4.6, 78.0$\pm$9.2, 372.0$\pm$103.4, 460.5$\pm$80.4, 280.4$\pm$46.6, and 131.0$\pm$15.6, preoperative, immediate postoperative, at postoperative 1, 2, 3, and 7 days, respectively. In group II, serum amylase level of the postoperative day 2 was the highest and was significantly higher than that of the preoperative day(p<0.001). Serum amylase level started to decreased at postoperative day 3 and returned to the normal level at postoperative day 7. Significant clinical symtoms of overt pancreatitis were not shown in patients in group II. The following perioperative variable such as diagnosis, cardiopulmonary bypass time, aortic cross clamping time, mean systemic pressure during bypass, and administration of steroid were compared between groups. There were no significant differences between groups. In all patients, Serum amylase level of postoperative day 2 and aortic cross clamping time were correlated significantly(p=0.047). Conclusion: Serum amylase level after cardiopulmonary bypass could be elevated postoperatively and serum amylase level of POD 2 was considered to have significant correlation with aortic cross clamping time. Shortening of aortic cross clamping time will help in reducing the hyperamylsemia. In this study, although significant clinical symptoms and overt pancreatitis were not seen from hyperamylsemic patients, careful clinical observation of hyperamylasemia would be necessary.

• Clinical and Experimental Pediatrics
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• 제52권11호
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• pp.1283-1285
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• 2009

마크로아밀라아제혈증은 대개 혈중 아밀라아제 분자의 크기가 큰 양성 질환으로 1-2% 까지 보고된다. 마크로아밀라아제혈증에서는 아밀라아제가 면역 글로불린과 결합하여 고분자 복합체를 형성하여 소변을 통한 배출이 정상 혹은 저하되어 혈청 내 고아밀라아제혈증을 일으킨다. 소아에서는 매우 드문 질환이다. 본 저자들은 초기 급성 췌장염으로 오인된 4세 여아가 마크로아밀라아제혈증으로 진단되어 보고하는 바이다. 고아밀라아제혈증의 원인중 하나인 마크로아밀라아제혈증을 조기 진단하지 못하면 췌장질환과 감별을 위한 고 비용의 검사를 하게 되고 금식이나 정맥 영양과 같은 필요 없는 치료를 할 수 있다.