• The Korean Journal of Pesticide Science
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• v.14 no.3
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• pp.183-190
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• 2010

To search the new potent herbicidal agents by receptor-based approach, the interactions between receptor and substrate molecules from molecular docking to acetyl-CoA carboxylase(PDB code: 3K8X) of 2-(4-(6-chloro-2-benzoxazolyl)oxy)phenoxy-N-phenylpropionamide analogues (1-38) as substrate molecules were performed and discussed quantitatively. The most of the substrate molecules were formated 2 H-bonds between carbonyl oxygen atom of the substrate molecules and the amino acid residues (Ala1627 and Ile1735) in binding site of acetyl-CoA carboxylase (ACCase). But, the substrate molecules such as $R_l$=Acetyl substituents (6 & P9) were formated 3 H-bonds between H-bond acceptors in the substrate molecules and the H-bond donors in three amino acid residues including the rest residue (Gly 1998). Therefore, the inhibitory activity factors of the substrate molecules against ACCase are due to the H-bonding characters that will be able to apply to the optimization of herbicidal agents.

• The Korean Journal of Zoology
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• v.38 no.4
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• pp.523-530
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• 1995

Specific affinity binding sites for atrial natriuretic peptide (ANP) were Investigated in the pig ovarian tissues by in vitro autoradiographic techniques. In the pig ovary, the highest binding sites for 12514abeiled rANP(l~28) were localized in the granulosa cell layer of the forncles. The binding sies on theca layer of the ovarian follicles were mainly localized in the external layer, but none was observed In the Internal layer. In the corpus luteum, the binding site was not observed. The specific bindings of 200 pM of l2Sl4abelled rANP(l~28) to granulosa and theca externa layers were reversed completely by excess concentration (1 ~4) of unlabelled rANP(l~28) but not by 10 ~ of unrelated peptides, human angiotensin II and arginine vasopressin. The binding was also displaced by 1 ~ of desiGIn18, Ser19, Gly2O, leu21, Gly22I ANP(4~2g) (C- ANF) as a spedfic ligand of the ANP clearance receptor. Therefore these results indicate ~hat the biological and the clearance ANP receptors exist in the theca externa and granulosa layer of the pig ovary, and suggest that the ANP receptors may be related with the regulatory lundion of the ovarian follicular development including oocyte maturation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.22 no.9
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• pp.1949-1956
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• 1997

The mode parameters of asymmetrical coupled microstrip lines on composite substrates are derived by using closed form expression. A 10 dB directional couplers, where the center frquency is 1.8 GHZ, are fabricated on a single-layer substrate and on compsite substrates respectively. It is shown that coupler on a single-layer substrate.

• Journal of IKEEE
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• v.20 no.2
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• pp.123-127
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• 2016

In this study, gamma radiation detectors are created by integrating the following combinations of different YSO scintillators and PMT(photomultiplier-tubes) respectively: $3mm{\times}3mm{\times}2mm$, $3mm(Dia){\times}15mm$, $3mm(Dia){\times}20mm$, $10mm(Dia){\times}20mm$. In addition, the scintillator with a 10mm diameter was integrated with a light guide with a 2mm thickness, 10mm entry and 3mm exit, using LightTools. The constructed detector used the standard gamma ray sources $^{137}Cs$(662keV) to analyze the spectral characteristics of gamma rays. The results indicate that at 662keV, the energy resolutions were 14.46%, 21.10%, and 10.71% for the first three combinations respectively. The best results were recorded for the $10mm(Dia){\times}20mm$ detector with light guide, which had an energy resolution of 7.48%.

• Journal of Life Science
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• v.15 no.6 s.73
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• pp.928-934
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• 2005

ATF2 is a cellular transcription factor which belongs to the CREB/ATF class and it is leucine zipper protein which generally binds to DNA as dimers. This paper presents the procedure for subcloning the ATF2 gene and the results of experiment used the expressed ATF2. The pET expression vector was used since it produced 6xHis fusion protein for easy purification using affinity column. The Nickel chelating chromatography was used for Purifying the expressed ATE2 from E- codi BL2l. Subsequen시y In vitro binding pull-down assay showed the binding specificity of ATF2 with AP-1 family factors such as BATF, c-Fos, c-Jun and ATF2 itselgf. ATF2 forms homodimer as well as strong heterodimer with BATF. It also forms stable dimer with c-Jun but barely binds with c-Fos.

• Journal of Nutrition and Health
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• v.24 no.4
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• pp.356-365
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• 1991

$L-Triiodothyronine(T_3)$ binding to purified plasma membrane and to isolated nuclei from the same liver in obese(ob/ob) mice and their lean littermates was examined. The maximal binding capacity(Bmax) for $T_3$ receptor of liver nuclei, as compared to lean control, was significantly lower in the obese mouse$(obese 527{\pm}80fmol/mg\;DNA ; lean 883{\pm}62fmol/mg\;DNA)$, without an apparent difference in dissociation constant(Kd). The finding that obese mice have fewer liver nuclear $T_3$ receptors confirms previous reports. The Bmax and Kd of liver plasma membrane $T_3$ receptor were not significantly different between obese and lean mouse, which suggests no defect to be occurring in the function of the plasma membrane $T_3$ receptor and reinforces the view that the peripherally impaired thyroid hormone action in obese mice is a post plasma membrane receptor event. These results further support the hypothesis that the major defect of the thyroid hormone metabolism in genetic obesity occurs at the level of the nuclear receptor.

• Journal of Life Science
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• v.31 no.10
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• pp.954-959
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• 2021

Apoptosis is an important mechanism that regulates cellular populations to maintain homeostasis, and the caspases, a family of cysteine proteases, are key mediators of the apoptosis pathway. Caspase-8 is an initiator caspase of the extrinsic apoptotic pathway, which is initiated by extracellular stimuli. Caspase-8 have two conserved domains, N-terminal tandem death effector domains (DED) and C-terminal two catalytic domain, which are important for this extrinsic apoptosis pathway. In extrinsic apoptosis pathway, death receptors which members of TNF superfamily are activated by binding of death receptor specific ligands from cell outside. After the activated death receptors recruit adaptor protein Fas-associated death domain protein (FADD), death domains (DD) of death receptor and FADD bind to each other and FADD combined with death receptor recruits procaspase-8, a precursor form of caspase-8. The DED of FADD and procaspase-8 bind to one another and FADD-bound procaspase-8 is activated by cleavage of the prodomain. This death receptor-FADD-caspase-8 complex called death inducing signaling complex (DISC). Cellular FLICE-inhibitory proteins (c-FLIPs) regulate caspase-8 activation by acting both anti- and pro-apoptotically, and caspase-8 activation initiates the activation of executioner caspases such as caspase-3. Finally activated executioner caspases complete the apoptosis by acting critically DNA degradation, nuclear condensation, plasma membrane blebbing, and the proteolysis of certain caspase substrates.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.11 no.1
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• pp.47-52
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• 2011

In this paper, to evaluate the design properties of 3D optical multimode interference (MMI) couplers with ultracompact width, modal transmission line theory and effective dielectric method are combined with together. A coupling efficiency based on the composed approach is defined, and the coupling length is numerically determined for the design of 3 dB coupler, cross coupler and bar coupler. The simulation result shows that the designed MMI coupler has a low insertion loss and a high splitting ratio.

• Electrical & Electronic Materials
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• v.2 no.1
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• pp.41-51
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• 1989

압전세라믹을 이용한 에너지포획형 단일체 대역통과필터는 '에너지포획'과 '탄생결합'이라는 두 중요한 원리를 사용한다. 본 연구의 주된 목적은 이중결합필터의 전극변수가 필터 특성에 미치는 영향을 규명하는 것이다. 예비단계로 에너지포획형 공진자의 부분전극의 단위 면적당 무게나 부분전극의 크기가 주파수특성에 미치는 영향을 조사하여 에너지포획을 야기시킬 수 있는 부분전극의 조건을 설정하였다.

• Journal of the Korean Chemical Society
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• v.49 no.5
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• pp.461-469
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• 2005