• Korean Journal of Social Welfare
• /
• v.58 no.4
• /
• pp.291-312
• /
• 2006

Incentive-Therapy approach on substance abuser has a solid theoretical base in Behavior Psychology and shows the effectiveness empirically in US. The purpose of this exploratory study was to evaluate the effectiveness of Incentive-Therapy on two alcohol abusers using ABA Single System Design in a community welfare agency, Korea. It proceeded for 12 week-baseline stage, 6-week intervention stage and 4-week postintervention stage through scanning whether alcohol abuser drinks or not by the alcohol analyzer as a target behavior. As a results, this study showed that two abusers' drinking were decreased in the middle of intervention stage in incentive-therapy but they showed differently in the postintervention stage : One sustained his abstinence and the other recurred to drink. Thus, we concluded Incentive-Therapy had better adaptability in community welfare agency in that alcohol abusers were driven to motivate for abstinence and then had an opportunity for psycho-social counseling and social welfare intervention consistently.

• Journal of the Korean Institute of Intelligent Systems
• /
• v.22 no.6
• /
• pp.715-721
• /
• 2012

A threat evaluation is the technique which decides order of priority about tracks engaging with enemy by recognizing battlefield situation and making it efficient decision making. That is, in battle situation of multiple target it makes expeditious decision making and then aims at minimizing asset's damage and maximizing attack to targets. Threat value computation used in threat evaluation is calculated by sensor data which generated in battle space. Because Battle situation is unpredictable and there are various possibilities generating potential events, the damage or loss of data can make confuse decision making. Therefore, in this paper we suggest that substantial threat value calculation using learning bayesian network which makes it adapt to the varying battle situation to gain reliable results under given incomplete data and then verify this system's performance.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.9
• /
• pp.211-226
• /
• 2019

Pig CD45, the leukocyte common antigen, is encoded by the PTPRC gene and CD45 is a T cell-type specific tyrosine phosphatase with alternative splicing of its exons. The CD45 is a coordinated regulator of T cell antigen receptor (TCR) signal transduction achieved by dephosphorylating the phosphotyrosine of its substances, including $CD3{\zeta}$ chain of TCR, Lck, Fyn, and Zap-70 kinase. A dysregulation of CD45 is associated with a multitude of immune disease and has been a target for immuno-drug discovery. To characterize its key structural features with the effects of regulating TCR signaling, this study predicted the unknown structure of pig CD45RO (the smallest isoform) and the complex structure bound to the ITAM (REEpYDV) of $CD3{\zeta}$ chain via homology modeling and docking the peptide, based on the known human CD45 structures. These features were integrated into the structural plasticity of extracellular domains and functional KNRY and PTP signature motifs (the role of a narrow entrance into ITAM binding site) of the tyrosine phosphatase domains in a cytoplasmic region from pig CD45RO. This contributes to the selective recognition of phosphotyrosine from its substrates by adjusting the structural stability and binding affinity of the complex. The characterized features of pigCD45RO can be applied in virtual screening of the T-cell specific immunomodulator.