• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.1
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• pp.78-95
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• 2023

목적 : 마이크로니들 패치는 피부장벽의 주요 구성성분인 각질층을 관통할 수 있어 일반적인 경피를 통한 약물 전달 수단보다 더 효율적으로 약물을 전달할 수 있다는 장점이 있어 다양한 분야에서 응용되고 있다. 본 임상연구는 아토피피부염 환자의 피부 건조 증상에 대하여 용해성 히알루론산 마이크로니들 패치와 외용제를 병행하여 용해성 마이크로니들 패치의 유효성과 안전성을 평가하였다. 방법 : 본 연구는 단일 기관, 연구자 주도, 평가자 눈가림, 인체 분할 연구로 설계된 무작위 배정 임상시험으로, 피부건조 증상이 있는 아토피피부염 환자 20명을 대상으로 임상연구를 수행하였다. 한 명의 피험자에서 2곳의 시험 병변을 선택한 후, 무작위 배정으로 각각 시험 병변과 대조 병변을 결정하여 2주 동안 매일 양측 병변에 모두 아로마 크림을 도포한 다음, 시험 병변에만 용해성 히알루론산 마이크로니들 패치를 추가로 부착하였다. 결과 : 1차 유효성 평가지표인 local scoring atopic dermatitis(L-SCORAD) index는 치료 후에 시험 병변이 대조 병변보다 유의성 있게 호전되었다. 2차 유효성 평가지표 중 피부 건조감 VAS와 피부 수분 함유량도 시험 병변이 대조 병변보다 유의성 있는 개선을 보였다. Investigator's Global Assessment scale, 소양감 VAS, 경피수분손실량에 있어서는 시험 병변과 대조 병변 모두 치료 후에 유의성 있게 호전되었으나, 두 병변 간의 차이에는 유의성이 없었다. 이상 반응은 나타나지 않았으므로 안전성도 확인되었다. 결론 : 용해성 히알루론산 마이크로니들 패치와 외용제 병행치료는 외용제만 사용하였을 때보다 L-SCORAD index 및 피부 건조감 VAS, 피부 수분 함유량에 있어서 아토피피부염의 증상을 유의성 있게 개선시켰다.

• The Journal of the Convergence on Culture Technology
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• v.8 no.6
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• pp.685-691
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• 2022

This study was based on the steel composite concrete box structure (Transfer girder) which was installed to support the skyscrapers directly above the subway line. In this study, it was analytically proved that the cause of cracks on the steel composite concrete box structure were the shrinkage cracks by comparing the results of crack investigation and numerical analysis. As the results, it was found that the internal temperature difference between concrete and steel members occurred according to the shape of the steel frame embedded in concrete, the location of vertical stiffener, and the closed section area. The narrower spacing of vertical stiffener was occurred the internal temperature concentration of the structure and the temperature difference increased. And the location of higher thermal strain and temperature were similar to the location of actual cracks by the visual inspection. Therefore, the internal temperature concentration parts were formed according to the presence and spacing of the vertical stiffeners and the inspection passage in the central part of the structure. The shrinkage cracks were occurred by the restrained of temperature expansion and contraction of the concrete. As the results of this study, it was important to separate and manage the non-structural cracks caused by shrinkage and the structural cracks in the maintenance of serviced steel-composite concrete structures.

• Korean Journal of Food Science and Technology
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• v.11 no.4
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• pp.264-272
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• 1979

The flat-plate and tubular soar collectors were designed and constructed for drying the rough rice, and the performance of the collectors and drying effect were investigated when rough rice was packed in grain bin connected to collectors. Average-monthly radiation on a horizontal surface based on bright sunshine in Daejeon area during 1978 was the highest as $16,814\;KJ/m^2{\cdot}day$ in May and the lowest as $4,254\;KJ/m^2{\cdot}day$ in December, and significane was not recognized between the calculated and recorded values. The thermal effciency of collectors were increased as radiation increased during drying period and the average thermal effciency of flat-plate and tubular collectors in 11 to 12 o'clock a.m were 28.12 and 16.75%, respectively. The average inlet temperature of grain bin at 12 o'clock was shown as 20.02 at control 40.5 at grain bin connected to tubular collector and $55.1^{\circ}C$ at grain bin connected to flat-plate collector. In 25 cm rough rice depth in grain bin, tim taken for drying from initial moisture content at 27.4 to decrease upto 17.0% (14.5 % on wet basis) were 32 in control, 18 in grain bin connected to tubular collector and 11 hrs to flat-plate collector, and grain depth influenced drying rate remarkably. In the view point of drying characteristics, drying pattern showed initially falling-rate to constant-rate period finally.

• The Journal of Engineering Geology
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• v.15 no.1
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• pp.41-55
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• 2005

This research is aimed at investigating the ground characterization of the Cheongju granite area using the geophysical methods. Test site was chosen from the building site in Chungbuk University, Chongju, Chungbuk province. Furthermore, geophysical methods are employed on the outcrops in the east to map the distribution of fault and intrusion and reveal the degree of weathering. The subsurface structure mapped from seismic re-fraction survey mainly consists of two units of weathered soil and rock. Threshold of the units were determined on the basis of seismic velocity of 800 m/s, supported from the standard classification table. From the results of standard penetrating test(SPT), these units are found to show medium-high and high density, respectively. Weathering soil is subdivided in unsaturated layer and saturated layer with thresholds of seismic velocity (500 m/s) and resistivity (200 ohm-m). In particular, unsaturated layer is again classified into dry and wet portions using the GPR section. The boundary between unsaturated and saturated weathering soils corresponds to the groundwater table at depth of approximately 5～6.2 m, which is well correlated with the one from drill-core data. However, bedrock is not delineated by geophysical methods. In the GPR section, fault and intrusion observed on the outcrop are revealed not to extend to the building site. With respect to weathering degree, the outcrop characterized by low resistivity and velocity corresponds to the grade of 'completely weathered' from the geotechnical investigations.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.2
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• pp.149-154
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• 2007

An antibacterial substance to the Streptococcus mutans, a causative bacterium for decayed teeth, was isolated from the dried sea mustard, Undaria pinnatifida, and identified by GC and GC/MS. Acetone extract from the sea mustard (10.4 kg), was evaporated and partitioned to 4 fractions such as hexane, chloroform, butanol and water. The most active chloroform fraction were further purified through basic alumina, silicic acid and ODS column, successively, and finally, 3 antibacterial substances were isolated on the HPLC attached ODS column by using 95% MeOH and guided with UV detector (254 nm). Antibacterial substances (total 160mg, yield $1.5\times10^{-3}$%) had the same Rf value (0.42) on the TLC developed hexane diethyl ether acetic acid (80:30:1) and those methyl esters moved to 0.95. They were identified as the same unsaturated fatty acid, $C_{18:4,\;n-3}$ (3,6,9,12-octadecatetraenoic acid, stearidonic acid) compared relative retention times (15.5 min) with authentic fatty acid on the GC chromatogram. It was further confirmed unambiguously on the GC/MS giving molecular ion peak at m/z 290 which coincided with its methyl ester.

• Food Engineering Progress
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• v.21 no.3
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• pp.267-272
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• 2017

To improve dispersibility of cereal powder without additives, granulation of cereal powder was conducted using fluidized-bed granulator. Operation condition was sample 300 g, internal temperature $40^{\circ}C$, ventilation speed $30-90m^3/h$, inlet temperature $90^{\circ}C$ and spray pressure 2.5 bar. The amount of distilled water (20-45%) as binder, granulation time (10-15 min) and drying time (3-10 min) were controlled. Mean diameter over volume (Brouckere mean, $D_{4,3}$) was increased from $123{\mu}m$ to $263{\mu}m$ and dispersibility was improved from 73% to 92.25% at experiment conditions. Wettability (wetting time) was drastically decreased from 5,000 second to 7 second. Granulation of cereal powder did not affect sinkability and mean diameter over volume as wet analysis was about the same between raw and granulated cereals. Such phenomenon means that granulation with only water as binder enables cereal powder to disperse in water or milk without rapid sedimentation.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.9 no.1
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• pp.55-59
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• 1999

The Rapid Expansion of Supercritical fluid Solutions (RESS) process was applied to particles coating. Microcapsules prepared by spray drying were used as the core particles, and two kinds of paraffin were used as the coating materials. Supercritical $CO_{2}$ solutions of paraffin were expanded through the short nozzle into the bed that was fluidized by air. Extraction temperature and pressure were varied at $50~120^{\circ}C$, $150~200\;kg/\textrm{cm}^2$, respectively. The thickness of theoritical coating layer ws measured, and precipitate coating layer on surface was analyzed by using SEM, FT-IR. The release behaviors of $Mg^{2+}$ ions were inspected by atomic absorbance spectrophtometer.

• Applied Microscopy
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• v.33 no.3
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• pp.215-222
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• 2003

The ultrastructure of damaged hair shaft from blow-drying at typical temperature $40{\sim}170^{\circ}C$ for daily beautiful face have been investigated by using transmission electron microscope and scanning electron microscope. When we used to hair dryer for a long time in our everyday life, the following morphological alternations were found in hair. First, the partial of scales in outer cuticle were detached simultaneously with separation of intercellular membrane complex of cuticle cells. Then hair broke cuticle off and exposed to cortex. Secondly, the cortical cell in the cortex was fissured into its macrofibril. The melanin granules were scattered between macrofibrils. As a result, I confirmed that blow-drying removed the hair's bonded water and made hard on hair which lost elasticity. After all, hair showed irregular, rough surface and vanished its luster.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2010.04a
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• pp.227-227
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• 2010

기존 도공지 생산 공정에서 널리 사용되던 블레이드 도공방식을 대체할 수 있을 것으로 기대되는 커튼코팅 방식은 스크래치, 스트릭, 미스팅, 블레이드의 마모등을 발생시키지 않고 고고형분 도공이 가능하며 우수한 커버리지를 갖는 도공층을 형성시킬 수 있다는 장점을 갖고 있다. 뿐만 아니라 하나의 코팅 유닛에서 여러개의 도공층을 한번에 형성시킬 수 있어 설비투자비용 및 건조에너지, 공간활용도 절감 측면에서도 한층 유리하다. 커튼 코팅 방식에서 도공액의 유동은 도공액이 필름 형태로 사출되는 sheet forming zone, 도공액 커튼이 낙하하는 curtain flow zone, 도공액 커튼이 원지와 접촉하는 impingement zone으로 나뉜다. 커튼 코팅이 이루어지기 위해서는 sheet forming zone과 curtain flow zone에서 도공액이 얇은 막 상태를 안정적으로 유지하고 impingement zone에서는 고속으로 이송되는 도공원지에 의한 급격한 신장 조건에서 도공액 필름이 끊어지지 않고 유지되어야 한다. 이를 위해 유화제를 통해 동적 표면 장력을 낮초고 rheology modifier를 통해 점도 및 신장점도를 조절해 도공액의 커튼 안정성을 부여하는 연구가 보고된 바 있다. 도공액 제조시 바인더로 널리 사용되는 S/B 라텍스는 입도, 유리전이온도, 표면전하 등 그 특성을 달리하여 제조할 수 있으며 이러한 특성에 따라 도공액의 점도와 같은 유변특성이 변화하여 도공액의 커튼 안정성에 영향할 것으로 예상된다. 따라서 본 연구에서는 입자경과 유리전이온도, 카르복실화 정도 등을 달리한 다양한 S/B 라텍스를 사용하여 유변특성을 달리한 도공액을 제조하고 커튼 안정성의 변화를 살펴보고자 하였다.

• Journal of Conservation Science
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• v.12 no.1 s.15
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• pp.26-30
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• 2003

We examined the species of charcoals excavated at the late paleotithic site of Suyanggae. Suyanggae is located on the riverbed of Han river near Banyans, central Korea. The charcoals belong to the post-glacial period (radiocarbon dates: $18,630\~16,400\;BP$). Only two species were identified. Most of samples (139 among 142) examined were Pinus spp. (diploxylon). The other 3 samples were Picea spp. The results suggest the upper layer at $235\~245\;cm$ below the ground level was formed during dry and warm post glacial period, predominated by two needle pines and lower layer at 270 cm below the ground layer during the last glacial maximum period, predominated by spruces.