• Journal of Life Science
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• v.33 no.7
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• pp.538-548
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• 2023

The research has been conducted on the isolation of antimicrobial compounds from plant natural extracts and their potential application in oral health care products. This study aimed to investigate the antimicrobial mechanism by analyzing the changes in gene expression of Streptococcus mutans, a major oral pathogen, in response to complex compounds extracted from Aralia continentalis and Arctii Semen using organic solvents. Transcriptome analysis (RNA-seq) revealed that both natural extracts commonly upregulated or downregulated the expression of various genes associated with different metabolic and physiological activities. Three genes (SMU_1584c, SMU_2133c, SMU_921), particularly SMU_921 (rcrR), known as a transcription activator of two sugar phosphotransferase systems (PTS) involved in sugar transport and biofilm formation, exhibited consistent high expression levels. Additionally, component analysis of the A. continentalis extract was performed to compare its effects on gene expression changes with the A. Semen extract, and two active compounds were identified through gas chromatography-mass spectrometry (GC-MS) analysis of the active fraction. The n-hexane fraction (ACEH) from the A. continentalis extract exhibited antibacterial specificity against S. mutans, leading to a significant reduction in the viable cell counts of Streptococcus sanguinis and Streptococcus gordonii among the tested multi-species bacterial communities. These findings suggest the broad-spectrum antibacterial activity of the A. continentalis extract and provide essential foundational data for the development of customized antimicrobial materials by elucidating the antibacterial mechanism of the identified active compounds.

• 한국노년학
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• v.31 no.4
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• pp.1209-1228
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• 2011

The study is set out to examine the degree of on the life satisfaction and policy effects of the job creation project for the participating elderly The Subject of the study were 950 elderly people patrici parted In the job·creation project for the elderly in the aged welfare agency in the Seoul. For data analysis, SPSS15.0 for window program was utilized. The primary findings from the research can be summarized as follows. It was found that as for the participating reasons for the creation project most have responded to coding the living expenses; followed by the a sense of fulfillment by work, maintain health, not wanting to burden their children, society participating. After examining the difference in the personal effects felt by the elderly after participating in the job creation project by participation type, it revealed that the elderly who has participated in the job creation project has responded to the improved mental health, followed by the mental steadily and the alleviation of Ioneliness, in the order given for the personal effects. but the analysis on the social effects of the job creation project for the elderly by the participation type showed that the most elderly participating in the thought the promotion of social participating as the social effects of the job crenation project. The analysis on the degree of on the life satisfaction for the job creation project were effects policy. It is safe to say in order to raise the degree of satisfaction and vitalize the job creation project for the elderly, more realistic job creation project which reflects the characteristics of each type and various demands of the elderly would be essential.

• 한국노년학
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• v.29 no.2
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• pp.683-699
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• 2009

Family caregiving to the elderly is one of the most important social issues in recent Korea. Among various kinds of family caregivers, spouse caregivers particularly constitute a special group, generally characterized by continuous intimate association with the care recipients at many levels and by special commitments and responsibilities associated with the marriage bond. And the number of spouse caregiver is expected to increase in the future. Moreover, since a conjugal relation is consisted of husband and wife, their caregiving experiences and caregiving burden may vary by gender. Thus, the present study was to examine the effect of caregiving experience, especially caregiving motivation and social support focusing on the gender differences. We analysed 「2001 Survey of Care-giving Status and welfare Needs of Older Persons in Korea」 data by performing descriptive statistics, t-test and logistic regression. As a result, we found that the husband was likely to feel more burden when he started caregiving because of few alternatives. For wife caregivers, the less awareness of social support they had, the more possibility of economic burden they felt. With these results, we suggest the necessity of having gender-sensitive perspective in research and policy making for caregivers.

• 한국노년학
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• v.29 no.3
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• pp.953-970
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• 2009

The successful aging paradigm suggests that the elderly keep their social ties and actively participate in various activities in later life. Many Korean studies on aging, however, have overlooked the importance of various social activities and relationships beyond kinship. This article aims to investigate the perceived social activities among Korean elders to comprehend the subjectivity of successful aging. 613 respondents, over 50 years old, are selected from a national survey data which was collected by face-to-face interview based on the structured questionnaire. The respondents are classified into pre old (50-64), young old (65-74), old old (over 75). Major findings are as follows. The social activities are grouped into two sub-categories: 'relational activity' and 'productive activity'. The activity types are different by the age cohorts. Various activities are considered in terms of one's needs or motivations, and properly chosen based on the subjective evaluation during life course. Both demographic variables such as sex, area and social context variables such as marital status, living-together show influence on the activity type choices. Plans for later life and work ethics are important as well. Policies regarding social participation emphasizing productivity should positively consider relational motives, as perceived by the Korean elderly.

• 한국노년학
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• v.39 no.1
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• pp.145-167
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• 2019

The purpose of this study is to examine the solidarity types between parents-children and to verify whether the types of solidarity relationships are directly related to life satisfaction of older adults. To achieve this, 2,072 Korean elderlies from proportional stratified sample were participated, and the data was divided into urban and rural area where respondents live in. The Latent Profile Analysis(LPA), multiple regression analysis were mainly used for data analysis. The results of the study were as follows: The major findings are following. Patterns of parental bond among urban and rural elderly were classified into three(urban) and two(rural) patterns. For the effect of each parental bonding pattern on life satisfaction, positive effect of parental bond was found only in urban dwellers. In other words, for older people in rural areas, parental bond did not significantly affected on life satisfaction. However, elderly in rural area showed non-familial factor based relationship, such as social capital(community trust, social cohesion, and social support), was influenced their life satisfaction rather than relationship with children. Finding from the study highlight political and practical implications for improving life satisfaction for the elderly.

• Korean Journal of Social Welfare Studies
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• v.42 no.3
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• pp.233-265
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• 2011

Material hardship measures have been used to supplement the traditional income-based poverty measures. Recently poverty researchers have increasingly used measure of material hardship to examine the well-being of low income families. Measuring the material hardship might be useful to a better understanding of the multi-dimensions of the poverty in Korea. Using the data of the Korea Welfare Panel Study(the fourth wave), I examine incidences of material hardship across quintiles of the income distributions and the factors that might affect the experience of material hardship among the poor families. Major findings are as follows. Descriptive results show that nearly one-fifth of all families had experienced at least one of the five material hardships in the year. Those in the bottom quintiles and the poor families are more likely to experience material hardship than the other quintiles and non-poor families. But, incidences of the material hardship in the middle income quintiles and low income families are not a few(18 percent and 37 percent). Logistic regression results show that family-consumption related variables, income other economic resources(asset and public assistance), and household's employment status affect the experience of material hardship among the poor families. But, material hardship among the poor families is not significantly related with family income. These results indicate that material hardship measures are the useful indicators to understanding the multi-dimensions of the poverty in Korea. And they suggest that an extensive reform of the public assistance policy is necessary to relieve the material hardships of the poor in Korea.

• Health Policy and Management
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• v.33 no.3
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• pp.311-324
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• 2023

Background: Long-term care insurance for the elderly has been stably established along with the quantitative expansion of long-term care facilities. Indeed, the need for a paradigm about human rights-based service approach is being raised throughout society from a service perspective. Therefore, this study aimed to analyze the association between elderly human rights awareness and quality of service by considering human rights education as a moderate variable. Methods: This study conducted surveys with 138 caregivers working in long-term care facilities located in Seoul and Gangwon. General characteristics, awareness of human rights, and the level of service quality were examined using descriptive statistics, frequency analysis, and correlation analysis. And multi-variable linear regression with a hierarchical framework was employed. These analyses were performed using IBM SPSS ver. 25.0. Results: Of the 138 caregivers, 97.1% were female, 87.7% were more than 50 years old, and most of their education level was high-school graduates. Their length of employment ranged from more than 5 years to less than 10 years. The level of awareness regarding elderly human rights of the elderly was below normal (mean=2.21), but the quality of service was high (mean=4.21), and the need for human rights education was also high (mean=4.28). Among the general characteristics, the length of employment was significantly associated with awareness of elderly human rights. Moreover, political rights awareness, included as sub-domains of human rights, was positively associated with quality of service. However, the moderating variable, human rights education, was not significantly associated with the quality of service. Conclusion: In this study, human rights education, as a moderating variable, did not have a statistically significant effect on caregivers' human rights awareness in relation to service quality. This finding is inconsistent with previous research results. These results can be explained by the fact that the frequency of education in long-term care facilities was a significant factor in the practice of protecting the human rights of the elderly. Therefore ongoing encouragement for the frequency of current human rights education and improvements in the educational approach appear to be necessary. In addition, these findings reveal the need for strength of education policies and effective in-depth research about human rights and quality of service to respect the human rights of the elderly.

• Journal of Korea Port Economic Association
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• v.39 no.3
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• pp.47-60
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• 2023

A thorough inventory of ship emissions, particularly ship's emission of in-port area is necessary to identify significant sources of exhaust gases such as NOx, SOx, PM, and CO₂ and trends in emission levels over time, and reduce their serious effects on the environment and human health. Therefore, the goal of this study is to assess the volume of emissions from ships in Mokpo port, which serves as a gateway to the southwest coast of Korea, using a bottom-up methodology and data from the automatic identification system (AIS) and the Korean Port Management Information System (Port-MIS). In this work, an analysis of ship movement utilizing AIS data and an actual set of data on ship specification were gathered. By examining ship movement using AIS data, We also proposed a new approach for identifying cruising/maneuvering mode. Finally, the results were classified by ship operating mode, by exhaust gas, by ship type, and by berth, which provides a thorough and in-depth analysis of the air pollution caused by ships in Mokpo port.

• Journal of Nutrition and Health
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• v.56 no.6
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• pp.615-628
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• 2023

Purpose: Increasing levels of domestic fine dust (DFD) have emerged as a serious problem that threatens public health by causing chronic respiratory diseases and skin aging. The present study was performed to investigate the inhibitory effects of Gryllus bimaculatus (the two-spotted cricket), which has recently attracted attention as an edible insect in South Korea, on DFD-induced aging and inflammation. Methods: To verify that DFD causes skin aging and investigate the anti-aging effect of an aqueous ethanolic-Gryllus bimaculatus extract (AE-GBE), human diploid fibroblasts (HDF) were treated with 100 ㎍/mL of European reference material (ERM)-CZ100 dust for 24 hrs in the presence or absence of 100 ㎍/ml AE-GBE. Aging and cellular toxicities were assessed by measuring reactive oxygen species (ROS) levels, DNA fragmentation, and β-galactosidase activity. The protein levels of cyclooxygenase (COX) 2, matrix metalloproteinase (MMP)-1, and collagen were measured by western blot, and the mRNA expressions of inflammation-related genes were assayed by quantitative reverse transcriptase polymerase chain reaction. Results: Treatment with ERM-CZ100 induced an aged phenotype in HDF cells, as evidenced by increased ROS levels, DNA fragmentation, and senescence-associated β-galactosidase activity, but cotreatment with AE-GBE significantly reduced these inductions. The mRNA expressions of pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, induced by ERM-CZ100 were also reduced by AE-GBE cotreatment, which also reduced COX2 expression. Moreover, ERM-CZ100-induced MMP-1 expression and reduced collagen type I expression were recovered by AE-GBE treatment. Conclusion: These results suggest that AE-GBE is a potential treatment for domestic fine dust-induced skin inflammation and inflammaging.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2023.04a
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• pp.49-49
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• 2023

본 실험은 콤부차의 발효시 에너지원으로 첨가되는 당(sucrose) 대신 꾸지뽕(Cudrania tricuspidata Bureau; silkworm thorn) 과일 발효액을 첨가하여 꾸지뽕-콤부차의 기능성을 구명하고자 하였다. 대조구인 콤부차는 끓여서 식힌 물 900mL에 홍차 2.4g을 넣어 한시간 동안 추출한 후 초기당도가 10°Bx가 되도록 sucrose를 첨가하였고, 처리구는 sucrose대신 꾸지뽕 과일 무게 대 sucrose의 비율을 1 대 0.9의 비율로 조제하여 발효시킨 꾸지뽕 발효액(당도 50°Bx)을 10°Bx가 되도록 희석하여 첨가하였다. 여기에 발효균인 SCOBY를 첨가한 후 실온에 3주간 보관하면서 1주일 간격으로 시료를 채취하여 총폴리페놀성 화합물 및 카테킨류 함량, 항산화 활성 및 인체 정상 폐세포주인 MRC-5와 폐암세포주인 A549의 세포 증식에 미치는 영향을 구명하였다. 발효 3주 동안 채취한 꾸지뽕-콤부차를 MRC-5 세포에 처리하였을 때 발효 2주까지는 꾸지뽕-콤부차가 대조구에 비해 약 10~30% 세포 증식효과를 보였고 발표 3주째에는 유사한 증식효과를 보였다. 폐암세포주 A549에 처리시에는 발효 2주째 대조구에 비해 낮은 증식율을 보였으나 그 차이는 크지 않았다. 이 결과는 꾸지뽕-콤부차가 인체 폐세포 증식을 촉진하나 폐암세포의 증식을 크게 억제하지는 않음을 의미한다. 총폴리페놀성화합물 함량은 대조구의 경우 발효기간이 경과함에 따라 증가하는 반면 꾸지뽕-콤부차는 조제직후 대조구에 비해 유의적으로 높은 함량을 보이다 서서히 감소하였는데 발효 2주째 대조구와 유사한 수준에 도달하였으며 3주째에는 대조구에 비해 낮은 함량을 보였다. 카테킨류(Epigallocatechin, Epigallocatechin gallate, 그리고 Epicatechin gallate, epicatechin)는 총 페놀성화합물과는 반대의 경향을 보였는데, 발표 2주까지는 꾸지뽕-콤부차의 함량이 유의적으로 높았다가 발표 3주째 크게 낮아졌다. 활성산소 제거능은 발효 2주째까지는 대조구에 비해 낮았으나 3주째 유의적으로 높아져 꾸지뽕-콤부차의 항산화활성은 카테킨류 함량에 비례함을 알 수 있었다. 기능성분 함량과 MRC-5 증식에 관한 상관분석시 총풀리페놀함량이 세포증식에 정의 상관관계를 나타내었다.