• Journal of The Korean Ophthalmological Society
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• v.59 no.11
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• pp.1071-1076
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• 2018

Purpose: To report a case of immunoglobulin G4 (IgG4)-related ophthalmic disease associated with adult xanthogranulomatous disease. Case summary: A 38-year-old male with a history of cholecystectomy visited our clinic for bilateral periorbital swelling. Histopathology of the orbital biopsy showed diffuse infiltration of foamy histiocytes with Touton giant cells and lymphoid follicles, with a diagnosis of adult-onset xanthogranuloma. After excisional biopsy, he was treated with azathioprine and prednisolone. Four years after treatment, he again visited the clinic due to bilateral, yellowish eyelid masses. Serological examinations were all nonspecific findings, except for elevation of IgG and IgG4 levels. Magnetic resonance imaging showed bilateral symmetric soft tissue enlargement with slightly heterogeneous T1/T2 isosignal intensity, with contrast enhancement at the superolateral aspect of extraconal spaces. Excisional biopsy and blepharoplasty were performed. Immunohistochemical sections showed that the IgG4+/IgG plasma cell ratio was 10-20% and the IgG4 plasma cell count was 22/high power field (HPF). His past sections of 2013 from the pathology department were again stained and showed that the IgG4+/IgG plasma cell ratio was 40-50% and the IgG4 plasma cell count was 59/HPF. Thus, he was definitely diagnosed with IgG4-related ophthalmic disease. Conclusions: If there is recurrent eyelid swelling, IgG4-related ophthalmic disease should be considered as a differential diagnosis. And the patient with adult xanthogranulomatous disease can be diagnosed with IgG4-related ophthalmic disease.

• Korean Journal of Remote Sensing
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• v.15 no.1
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• pp.1-8
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• 1999

The estimation technique of surface water temperature by satellite remote sensing has been applied to ocean and large lakes using AVHRR. However, the spatial resolution AVHBR is not abquate for coastal region and small lakes. Landsat 5 TM has 120 m spatial resolution, which suits better. We carried out analysis of surface water temperature in Lake Sihwa and near coastal area using Landsat 5 TM. To relate digital number to the brightness temperature, we applied Empirical, NASA, RESTEC, Quadratic methods. Comparing calculated and observed value, we obtained as follows; NASA method, $R^2=0.9343$, RMSE(Root Mean Square Error)=3.5876$^{\circ}C$; RESTEC method, $R^2=0.8937$, RMSE=3.76$^{\circ}C$; Quadratic method, $R^2=0.8967$, RMSE=2.949$^{\circ}C$. Because Landsat TM has only one band for extracting surface temperature, it was difficult to correct for the atmospheric errors. For improving the accuracy of surface temperature detection using Landsat TM, there is a need for a method to decrease the effect of atmospheric contents.

• The Journal of the Convergence on Culture Technology
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• v.5 no.4
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• pp.79-85
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• 2019

'Experiments in Art and Technology' Group was established in the mid-20th century, and then developed the larger interdisciplinary experiments into the range of art world and its outside field. The motive power of group's activities was the collaboration between artists and engineers traversing the boundary between old different disciplinary conventions. E.A.T was officially launched in 1967 by the engineers Billy $Kl{\ddot{u}}ver$ and Fred Waldhauer and the artists Robert Raushenberg and Robert Whitman. They performed various possibility of material, technology, and engineering available to contemporary art. By reflecting the function of art and technology in society, eventually they developed the methodology of new aesthetics which had organic relationship with contemporary world. In this sense, this research have its academic significance. This paper firstly examined the socio-cultural context of emerging the E.A.T. group as a representative model for convergent practice, and verified the fact that the collaboration between artists and engineers had produced the expansion of artistic expression as well as new relationship among art, engineering, and society by considering E.A.T's various projects. Therefore, I will refer the E.A.T. group as an exemplary model for concrete method of collaboration that contemporary discourses about convergence need.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.85-85
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• 2017

효율적 물관리란 거대한 물순환 과정에서 인간이 편안한 삶을 사는데 필요한 물의 이용효율을 극대화하는 것이다. 과거의 물관리는 이원화된 수량과 수질관리, 수량중심에서는 용수공급과 홍수조절이 주요한 관심사였다. 현재는 과거의 물관리에 친수와 환경을 더한 복잡한 분야로 확대되고 있다. 통합물관리란 물을 최적으로 관리하기 위해 물관리 이해당사자간의 소통과 물 기술의 고도화를 기반으로 기존에 분산된 물관리 구성요소들(시설 정보, 수량 수질 등)을 권역적으로 관리하는 것을 말한다. 본 연구에서는 대청댐 방류에 따른 금강 하류부의 홍수추적을 위해 수행한 댐하류 소유역별 강우량 빈도분석 과정, 용담댐 방류를 고려한 대청댐 홍수도달시간 검토, Poincare Section과 신경망기법을 이용한 수문자료 예측, 추계학적 다변량 해석과 다변량 신경망해석에 의한 대청댐 유입량 산정과정, 보조여수로 건설에 따른 주여수로와 보조여수로간의 연계운영방안, 단계(관심, 주의, 경계, 심각)를 고려한 대청댐 확보수위 산정, 저수지 중장기 운영계획 수립과 댐 운영 기준수위를 결정하기 위해 누가차분방식으로 적용되는 갈수기 유입량 빈도분석에 대한 실무적용 사례를 소개하고자 한다. 강우량 빈도분석 과정은 L-모멘트방법(Hosking과 Wallis, 1993)을 적용하였고, 홍수도달시간 검토는 평균유속, 하류 수위상승 기점 영향검토, 수리학적 모형(FLDWAV, Progressive lag method 등)을 활용하였다. 카오스 이론을 도입하여 대청댐 수문자료의 상관성 검토 및 추계학적 모형을 이용한 모의발생을 유도하여 수문자료 예측을 시행하였다. 추계학적 모형과 신경망모형 연구의 대상은 대청댐으로, 시계열 자료는 댐의 월강우량, 월유입량, 최고기온, 평균기온, 최소기온, 습도, 증발량 등의 자료를 기반으로 하였다. 적용기간은 1981~2009년의 자료를 이용하여 2010년 1월부터 12월까지 12개월 동안의 월유입량을 예측하였다. 수문자료 해석의 기본이 되는 약 30년간의 자료를 이용하여 분석을 실시하였다. 대청댐의 유입량 예측을 위해 적용된 모형으로는 추계학적 모형인 ARMA모형, TF모형, TFN 모형 등이 적용되었고, 또한 신경망 모형의 종류인 다층 퍼셉트론, PCA모형 등을 활용하여 실측치와 가장 가깝게 근사화시키는 방법론을 찾고자 하였다. 또한, 기존여수로와 보조여수로 연계운영을 위해 3차원 수치해석을 통한 댐하류 안정성 검토 및 확보수위 산정을 통해 단계(관심, 주의, 경계, 심각)별로 대처가 가능한 수위를 산정하였다.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.359-359
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• 2018

이상치는 표본자료에서 크게 어긋나 다른 자료들로부터 떨어져 표시되는 자료로써, 실제로 발생할 확률이 매우 낮은 자료로 정의되고 있다. 설계홍수량을 산정하기 위하여 적용하고 있는 극치계열의 연최대치 강우자료에는 기계오작동 및 엔지니어의 표독오류가 발생하고 있으며, 기후변화에 따른 거대태풍 및 국지적인 집중호우 발생 등으로 인한 극치값 등에서 이상치가 관측되고 있다. 통상 이상치들은 통계분석시 자료 본연의 특성을 왜곡시켜 편향된 결과를 산정할 수 있으므로 빈도해석시 이상치해석 절차를 수행하여 자료의 적정성을 확인하여야 한다. 현재 실무에서는 설계홍수량 산정요령과 하천설계기준 해설 등에서 관련 내용을 기술하고 있지만, 국내 강우자료의 기록연수의 부족으로 인하여 빈도해석시 이상치 해석이 미수행되고 있어 이상치에 따른 자료편의가 발생하면 결과물인 확률강우량이 왜곡되게 산정될 수 있다. 따라서, 본 연구에서는 국내 주요 도시의 강우자료를 이용하여 이상치검정을 수행하였다. 대상지점으로는 서울, 부산, 대전, 대구, 인천, 광주, 울산 등의 비교적 긴 관측년수를 보유하고 있는 광역시를 선정하였으며, 지속기간은 10분, 1~24시간의 25개 강우자료를 적용하였다. 이상치검정 방법으로는 타 방법에 비하여 이상치 검정력이 뛰어난 것으로 알려진 2가지 방법을 채택하였으며, 표본자료의 평균과 표준편차로 표준화된 z값을 이용하여 상 하 한계선를 초과하는 값을 확인하는 z-Score 방법중 향상된 중위수 절대편차(MAD)에 의한 수정 z-Score 방법(Hoaglin, 1993)과 Box-Plot 방법(Tukey, 1969)을 적용하였다. Box-Plot 방법(Tukey, 1969)은 전체 자료를 25%씩 사분위로 구분하는 방법으로 정렬된 자료계열을 중앙값, 박스, 수염(whiskers), 이상치로 구분한다. 정렬된 25~75% 값들을 박스로 포함하여 외곽의 수염값들을 이상치로 분류하며, 특히 사분위수의 도식화로 데이터의 분포를 파악하기 좋으며, 이상치들의 위치와 자료의 비대칭 여부를 쉽게 파악할 수 있다. 본 연구의 수행으로 수정 z-Score 방법의 경우에는 서울과 대구지점에는 이상치가 없으며, 부산지점에는 13개, 대전지점 7개, 인천지점 5개, 광주지점 32개, 울산지점 26개가 나타났다. Box-Plot 방법으로는 서울지점 35개, 부산지점 39개, 대전지점 32개, 대구지점 38개, 인천지점 51개, 광주지점 61개, 울산지점 65개의 이상치가 분석되었다. 연구를 수행한 결과, 수정 z-Score 방법에 비하여 Box-Plot 방법에 의한 이상치가 더 많이 발생하였으며, 각각의 방법으로 지속기간 및 연도별 이상치 발생자료를 확인하였다. 방법별 이상치 발생현황 등을 분석하여 지점별 발생횟수를 분석하였으며, 추후 지점 및 자료의 보완이 수행되면 활용성을 증대시킬 수 있을 것으로 판단된다.

• Journal of the Korean Society of Marine Environment & Safety
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• v.23 no.6
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• pp.613-619
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• 2017

Recently, the size of container ships has been progressively increasing, and much attention is required for safe navigation in shallow areas such as coastal waters and ports due to increases in draft. It is necessary to understand the characteristics of ship motion not only in still waters but also with waves. Especially in shallow regions, squat due to the vertical movement of the ship can be an important evaluation factor for the safe navigation, and wave drift force acting in the horizontal direction can have a great influence on the maneuverability of a ship. In this study, a numerical simulation using computational fluid dynamics has been performed for the wave exciting force acting in the vertical direction and the wave drift force acting in the horizontal direction for a very large container vessel sailing in shallow zone. As a result, it was found that total resistance in still waters greatly increased in shallow water. Wave drift force was shown to decrease given longer wavelengths regardless of water depth. It was observed that the wave exciting force in shallow water was considerably larger than at other water depths. As wave height against the central part of the ship lowered, the aft side rose.

• Journal of the Korean Magnetics Society
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• v.8 no.6
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• pp.362-368
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• 1998

The magnetic properties, thermal stability and anti-corrosion properties of $Cr_86Al_14$ spin valves multilayers were studied. It was found that the magnetic properties of $Cr_86Al_14$ spin valves depend on the thickness of antiferromagnetic, ferromagnetic and non-ferromagnetic layers. Exchange coupled field ($H_{ex}$) and magnetoresistance ratio (%) showed the largest value of 20 Oe, 2 % in $glass/Cr_{86}Al_{14}(600 $\AA$)/Ni_{81}Fe_{19}(50$\AA$)/Cu(40 $\AA$)/Ni_{81}Fe_{19}(40 $\AA$)$ spin valves. The $H_{ex}$ MR ratios (%) of CrAl and FeMn spin valves were decreased with increasing annealing temperatures and were lost at 150 $^{\circ}C$, 250 $^{\circ}C$ respectively. Based on these result, it was elucidated that CrAl is more thermally stable than FeMn. It was also shown that there was no change of $H_{ex}$ MR ratios in CrAl, while FeMn was changed and lost 15 days later in corrosion resistance test under 35 $^{\circ}C$, 90 % humidity condition. FeMn was found to be pitted and peeled off 15 days later by SEM micrographic analysis.

• Journal of the Korea Society of Computer and Information
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• v.25 no.6
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• pp.109-117
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• 2020

An edutainment system aims to help learners to recognize problems effectively, grasp and classify important information needed to solve the problems and convey the contents of what they have learned. Edutainment contents can be usefully applied to education and training in the both scientific and industrial areas. Our present work proposes an edutainment system that can be applied to a drug discovery process including virtual screening by using intuitive multi-modal interfaces. In this system, a stereoscopic monitor is used to make three-dimensional (3D) macro-molecular images, with supporting multi-modal interfaces to manipulate 3D models of molecular structures effectively. In this paper, our system can easily solve a docking simulation function, which is one of important virtual drug screening methods, by applying gaming factors. The level-up concept is implemented to realize a bio-game approach, in which the gaming factor depends on number of objects and users. The quality of the proposed system is evaluated with performance comparison in terms of a finishing time of a drug docking process to screen new inhibitors against target proteins of human immunodeficiency virus (HIV) in an e-drug discovery process.

• Geophysics and Geophysical Exploration
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• v.8 no.1
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• pp.1-6
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• 2005

Analogue physical modelling using granular materials (i.e., sandbox experiments) has been applied with great success to a number of geological problems at various scales. Such physical experiments can also be simulated numerically with the Discrete Element Method (DEM). In this study, we apply the DEM simulation to the collision between the Indian subcontinent and the Eurasian Plate, one of the most significant current tectonic processes in the Earth. DEM simulation has been applied to various kinds of dynamic modelling, not only in structural geology but also in soil mechanics, rock mechanics, and the like. As the target of the investigation is assumed to be an assembly of many tiny particles, DEM simulation makes it possible to treat an object with large and discontinuous deformations. However, in DEM simulations, we often encounter difficulties when we examine the validity of the input parameters, since little is known about the relationship between the input parameters for each particle and the properties of the whole assembly. Therefore, in our previous studies (Yamada et al.,2002a,2002b,2002c), we were obliged to tune the input parameters by trial and error. To overcome these difficulties, we introduce a numerical biaxial test with the DEM simulation. Using the results of this numerical test, we examine the validity of the input parameters used in the collision model. The resulting collision model is quite similar to the real deformation observed in eastern Asia, and compares well with GPS data and in-situ stress data in eastern Asia.

• Journal of Applied Biological Chemistry
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• v.64 no.3
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• pp.291-298
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• 2021

In this study, we investigated whether the combined administration of berberine (BBR) and silibinin (SBN) was effective in improving hyperlipidemia and anti-obesity efficacy using a high-fat diet (HFD)-fed obese mouse model. HFD-induced obese mice were supplemented with the BBR and SBN combination (BBR-SBN) along with the HFD administration for 8 weeks. During the experiment, body weight, food intake, and levels of total cholesterol, triglyceride and high-density lipoprotein (HDL)-cholesterol were analyzed. Consumption of HFD in the mice caused rapid increases in body weight and the levels of total cholesterol and triglycerides compared to the normal control (NC) group. However, supplementation of BBR-SBN in these obese mice significantly reduced body weight gain and suppressed the levels of total cholesterol and triglyceride with the increment of HDL cholesterol level. In the HFD-fed group, abdominal fat weight was significantly increased and the adipocytes within the epididymal adipose tissue were found to have expanded sizes compared to the NC group. However, in the BBR-SBN group, the sizes of the adipocytes were comparable to those of the NC group and abdominal fat weight was significantly reduced. Moreover, the deposition of giant vesicular fat cells in liver tissues seen in the HFD-fed group was considerably reduced in the BBR-SBN group. These results suggest that the BBR-SBN combination tends to have synergic potential as an anti-obesity agent by significantly reducing body weight gain as well as lowering serum lipid levels and thus improving anti-obesity efficacy in HFD-induced obese mice.