• Journal of Convergence for Information Technology
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• v.10 no.12
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• pp.146-155
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• 2020

This study was to evaluate the usefulness of gamma glutamyl transferase (GGT) as a surrogate marker predicting metabolic syndrome. 7,155 non obese men over the age of 20 were studied as subjects. The criteria for diagnosing MetS were the National Cholesterol Education Program - Third Adult Treatment Panel (NCEP-ATP III). The risk of developing MetS according to GGT was conducted logistic regression analysis, and the ROC (receiver operating characteristic) curve was obtained to confirm GGT ability to predict the risk of MetS. Regardless of age and body mass index, MetS had a 7.09 times higher risk of onset in the fourth quartile than in the first quartile of GGT (p<0.001). The AUC (area under the curve) of GGT for the diagnosis of MetS was 0.715, and the cutoff value of GGT was 40.0 U/L, the sensitivity was 65.0%, and the specificity was 70.2%. Therefore, GGT is considered to be a useful diagnostic index for diagnosing MetS.

• Korean Journal of Biological Psychiatry
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• v.24 no.4
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• pp.219-224
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• 2017

Objectives This study sought to investigate the relationship between age, sex and alterations in levels of % carbohydrate-deficient transferrin (%CDT) and gamma-glutamyl transferase (GGT) in patients admitted with alcohol dependence. Methods The study retrospectively enrolled 187 patients who were diagnosed with alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (DSM-IV) and were admitted into a closed ward in Hallym University Hangang Sacred Heart Hospital from 2009 to 2012 and Hallym University Kangnam Sacred Heart Hospital from 2012 to 2017. Demographic factors (age, sex) and biochemical markers [%CDT, GGT, mean corpuscular volume (MCV), aspartate transferase (AST), alanine transferase (ALT)] were collected by reviewing medical records. Alterations in the levels of %CDT and GGT in different groups for each demographic factor were compared after correcting for confounding variables (age, initial %CDT, GGT, MCV, AST, ALT). Results Decreased %CDT and GGT were observed during the period of abstinence after admission. The normalization period for %CDT increased with age, while the normalization period for GGT was longer in female patients. Conclusions These results suggest that alcohol-dependent patients that vary in age have different alterations in %CDT, while different sexes have different alterations in GGT. Age and sex can be potential indicators of treatment response after abstinence in patients with alcohol dependence. Further studies are needed to evaluate the relationship between these factors with regards to physiological and hematological changes in alcohol dependence.

• Journal of the Korea Society of Computer and Information
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• v.27 no.3
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• pp.119-126
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• 2022

The reported risk factors for gallstone disease (GD) are old age, female sex, obesity, metabolic syndrome and migrants. Many younger adults tend to live in Jeju City, where transportations are convenient and commercial activities are active. Whereas, older people tend to live in Seogwipo City, because they engaged in fisheries and agriculture. Rates of migrants and old age could affect the prevalence of GD among residents in two regions. Therefore, the purpose of this study was to compare the GD prevalence and analyze risk factors affecting GD including residencies. A total of 13,050 subjects who visited a single health medical check-up center on Jeju Island between 2012 and 2019 were included. We performed univariate and multivariate analysis to identify risk factors for GD. The prevalence of GD among residents were 5.7% in Jeju City and 5.8% in Seogwipo City, respectively. Multivariate analysis revealed that age (P=0.008), body mass index (P=0.044), high-density lipoprotein cholesterol (P=0.006) and gamma-glutamyl transferase (P=0.013) were independent factors affecting GD. The old age, mean higher body mass index, gamma-glutamyl transferase and mean lower high-density lipoprotein cholesterol were independent risk factors affecting GD. However, residencies did not affect the prevalence of GD.

• Proceedings of the Korean Society of Computer Information Conference
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• 2022.01a
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• pp.155-157
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• 2022

담낭용종은 담낭암의 원인일 수 있다. 담낭용종의 잘 알려진 위험요소는 대사증후군, 젊은 나이, 이상지질혈증 등이다. 제주도는 한반도에서 약 80km 떨어져 있으며 한라산을 중심으로 두 개의 행정구역(제주시와 서귀포시)으로 나뉘어 있다. 국제공항과 국제항구는 유일하게 제주시에만 위치해 있다. 또한 제주시에는 서귀포시보다 기업체와 학교의 수가 더 많다. 식이 및 알코올 소비는 두 지역 간에 다르며 이러한 요인이 담낭용종 유병률에 영향을 미칠 것이다. 따라서 이 연구의 목적은 두 지역 거주민들의 담낭용종 유병률을 조사하고 담낭용종과 관련된 다양한 요인들을 비교해보고자 하였다. 본 연구는 2009년 1월부터 2019년 12월까지 제주대학교병원 단일 건강검진센터를 방문한 21,734명을 대상으로 하였다. 담낭용종 유병률과 관련된 요인을 제주시 거주민과 서귀포시 거주민 두 집단으로 나누어 조사하였다. 담낭용종 유병률은 제주시가 10.1%, 서귀포시가 9.2% (P = 0.039)였다. 평균 연령과 고위험 음주자의 비율은 서귀포시에서 더 높았다. 평균 체질량지수와 공복혈당, 총콜레스테롤, 저밀도지질단백질-콜레스테롤, 아스파르테이트아미노전이효소, 감마-글루타밀전이효소, 알칼리인산분해효소 수치는 제주시에서 낮게 나타났다. 이 연구에서 담낭용종 유병률은 제주도의 두 지역 간에 유의한 차이가 있었다. 연령과 알코올 소비는 이러한 차이에 기여하는 주요 요인이 될 수 있다.

• Journal of the Korean Data and Information Science Society
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• v.21 no.2
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• pp.201-209
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• 2010

Due to the dramatic increase of mortality from ischemic heart disease (IHD) during the last decade, it is highly warranted to present the effective prevention strategy. Therefore this study identified the major risk factors of IHD over 10 years of follow-up among 2,268,018 participants of National Health Insurance Exam in 1996 with Cox proportional hazard model. In men, BMI, blood pressure, smoking were significantly associated with IHD, whereas hypertension, perceived health status and ${\gamma}$-GTP were related with IHD in women.

• Korean Journal of Occupational Health Nursing
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• v.22 no.4
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• pp.324-333
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• 2013

Purpose: This study was conducted to compare the changes in the levels of liver enzymes after providing health education to workers. Methods: Among 909 electronics-manufacturing workers, 96 (10.6%) workers had abnormal liver functions. Of these, male workers were randomly assigned into either the health education experimental group (48 [52.2%]) or the control group (44 [47.8%]). Depending on the level of participation in the health education, workers in the experimental group were classified into the participation (32 [34.8%]) and non-participation groups (16 [17.4%]). Changes in the levels of liver enzymes were compared among three groups. Results: The changes in the levels of gamma-glutamyltransferase (r-GTP) in the participation, non-participation, and control groups were $-25.3{\pm}54.5$ IU/L, $-4.4{\pm}24.1$ IU/L, and $-5.3{\pm}38.8$ IU/L, respectively (p=.036). Aspartate transaminase, alanine transaminase, waist circumference, body mass index, daily alcohol consumption, weekly exercise, and changes in smoking habits in the 3 groups did not differ significantly. In the multiple linear regression analysis, the variable of education participation revealed a significant regression coefficient of -25.10 when the change in r-GTP levels was the dependent variable. Conclusion: A brief health education targeted towards the management of liver disease among workers improved r-GTP levels.

• Proceedings of the Korean Society of Computer Information Conference
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• 2022.01a
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• pp.159-162
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• 2022

담낭용종의 잘 알려진 위험요소는 대사증후군, 연령, 이상지질혈증 등이다. 제주도는 한반도에서 가장 큰 섬으로 한국의 본토에서 약 80km 떨어져 있으며 행정구역상 제주시와 서귀포시로 나뉘어 있지만 기업들과 편의시설들, 학교들 때문에 자연스럽게 시내와 시외로 더 나누어진다. 많은 이주민들과 젊은 성인들은 상업 활동이 활발한 시내 지역에 사는 경향이 있다. 고령 성인들은 어업이나 농업에 종사하기 때문에 시외 지역에 사는 경향이 있다. 고령의 성인들은 전통적인 식이를 유지하고 있고, 그들 중 다수는 힘든 노동으로 인해서 고위험 알코올 음주자의 비율이 높다. 이러한 요인들로 인해 두 지역간의 담낭용종 유병률에도 차이가 있을 것이다. 따라서 이 연구의 목적은 제주도 두 지역간에 담낭용종의 유병률을 알아보고 그 유병률과 관련된 다양한 요인들을 비교해 보고자 하는 것이다. 이 연구는 2009년 1월부터 2019년 12월까지 제주대학교병원 단일 건강검진센터에서 건강검진을 시행한 21,734명을 대상으로 하였다. 시내 지역과 시외 지역 거주민들의 담낭용종 유병률은 각각 10.1%와 8,7% (P = 0.006)로 의미있게 차이가 있었다. 평균 총콜레스테롤 수치가 시내 지역 거주민들에서 시외 지역 거주민들보다 높았고, 음주와 관련된 평균 알카라인 인산분해효소와 감마-글루타밀전이효소 수치들과 평균연령은 시외 지역 거주민들이 시내 지역 거주민들보다 더 높았다. 나이, 알코올 섭취와 평균 콜레스테롤 수치가 이러한 두 지역 간에 담낭용종 유병률의 차이를 만들었을 것이다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.12
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• pp.395-400
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• 2020

Pigs have been used widely in biomedical research owing to their physiologic and anatomic similarities to humans. Analysis of the hematologic and biochemical values in pigs is an important basis for biomedical research and veterinary clinical diagnosis, but research on transgenic pigs has been sparse. This study was conducted to obtain basic data on transgenic pigs and to describe and compare the reference values for hematologic and biochemical parameters in human tissue plasminogen activator (htPA) transgenic pigs vs normal pigs. Blood samples were obtained from 7 normal LY (Landrace-Yorkshire crossbred) pigs and 8 transgenic pigs and 16 hematologic and 15 serum biochemical parameters were tested. Among the hematologic parameters tested, significant differences were observed in the red blood cells (RBC), mean red blood cell hemoglobin (MCH), and lymphocytes (LYM), between the non-transgenic and transgenic pigs. Among the biochemical parameters tested, the blood urea nitrogen (BUN), total protein (TP), cholesterol (CHOL), alanine aminotransferase (ALT), creatinine (CREA), gamma glutamyl transpeptidase (GGT), globin (GOB), and amylase (AMYL) showed significant differences between the two groups. Thus, the values determined in this study can be used as basic reference values for transgenic pigs and will contribute to their use in biomedical research.

• Journal of the Korea Society of Computer and Information
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• v.27 no.2
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• pp.195-201
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• 2022

There was a report that the prevalence of gallbladder polyps (GBPs) and some clinical variables were different between the urban and rural area, which was performed in a mainland. Thus the previous report could have some confounding factors. Therefore, the purpose of this study was to compare the prevalence of GBPs and clinical variables on the isolated island to exclude extrinsic confounding factors. We compared the prevalence of GBPs and clinical variables among 21,734 residents who visited a single medical check-up center in Jeju National University Hospital from January 2010 to December 2019 according to their residences on Jeju Island. The prevalence of GBPs were 10.1% in the urban area 8.7%, respectively (P = 0.006). Among clinical variables, the rate of central obesity, the mean levels of fasting blood glucose, low density lipoprotein-cholesterol, alkaline phosphate and gamma-glutamyltransferase and the mean age among residents in the rural area was statically higher in the urban area; however, the mean total cholesterol level among residents in the urban area significantly higher than in the rural area. This study showed that the prevalence of GBPs and some clinical variables among residents were statistically different between the urban area on Jeju Island.

• The Journal of the Korea Contents Association
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• v.10 no.7
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• pp.268-275
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• 2010

Coronary artery calcium scores(CACS) has been used as surrogate marker for coronary atherosclerosis. We evaluated 1042 patients who visited the Department of Health Promotion Center in Chonnam National University Hospital and had a test of the CACS from January 2006, to December 2008. This study was performed to evaluate the relation of the CACS with Cadiovascular disease(CVD) risk factors and FRS. CACS and FRS was a significant difference between the group whose calcium score was 0 and the group whose calcium scores were 1 in case of men 2.38(95% CI, 1.83-3.11), women 2.12(95% CI, 1.03-4.35). The age-and sex-adjusted odds ratios for predictor of CVD risk factors to women with age was 1.10(95% CI, 1.06-1.15), HDL-cholesterol was 2.38(95% CI, 1.04-5.44), Fasting plasma glucose was 2.89(95% CI, 1.16-7.21), to men with age was 1.11(95% CI, 1.08-1.14), LDL-cholesterol was 2.12(95% CI, 1.28-3.50), gamma-GTP was 1.73(95% CI, 1.17-2.55), Diabetes mellitus medication was 3.92(95% CI, 1.73-8.89). The CACS seems to be a siginificant factor to evaluate the CVD risk factors.