• Journal of the Korean Society of Radiology
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• v.12 no.5
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• pp.623-630
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• 2018

Non-alcoholic fatty liver disease is the most common cause of chronic liver diseases. This study was to characterize early hepatic lipid changes in fatty liver rat model by in vivo short-echo time(TE) $^1H$-MRS(Proton - Magnetic Resonance Spectroscopy). Each the examinations were measured from liver parenchyma in rats at 0, 2, 4, 6, 8 weeks followed by high fat diet, respectively. Significant increase in lipid signals. 0.9, 1.3, 2.3, 2.8, and 5.3 ppm was found in animals with 2 weeks(p<0.01). Therefore, $^1H$-MRS is useful in detecting and characterizing various hepatic lipid alterations as early as 2 weeks for the start high fat diet.

• Journal of Korea Multimedia Society
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• v.16 no.3
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• pp.269-280
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• 2013

In this paper, we suggested the possibility of using an efficient classifier for the dependency analysis of retinal disease. First, we analyzed the classification performance and the prediction accuracy of GBN (General Bayesian Network), GBN with reduced features by Markov Blanket and TAN (Tree-Augmented Naive Bayesian Network) among the various bayesian networks. And then, for the first time, we applied TAN showing high performance to the dependency analysis of the clinical data of retinal disease. As a result of this analysis, it showed applicability in the diagnosis and the prediction of prognosis of retinal disease.

• Proceedings of the Korea Information Processing Society Conference
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• 2008.05a
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• pp.127-130
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• 2008

환경적, 식품적 본질의 변화로 인해 소아의 호흡기 계통에 대한 질환은 모든 부모들의 집중적 관심분야가 되고 있다. 또한 저출산 등의 사회적 문제가 심각해지면서 소아 때부터의 건강 관리 및 유지는 사회적 이슈가 되고 있는 실정이다. 따라서 본 논문에서는 소아 호흡기 계통의 질환에 대한 종류와 그에 대한 특징을 파악하여 조기에 진단할 수 있는 방법을 제안하고자 한다. 특히 소아 호흡기 계통 관련의 질환 중에서도 현대사회에서 가장 많이 발생되는 질환들을 알아보고 음성학적 분석 요소들과의 연관성을 추출하기 위한 것을 연구의 목적으로 하였다. 소아 호흡기 계통의 질환은 대체로 저항력이 약할 때 발병하며 치료에 많은 시간과 노력이 소모되므로 이에 대한 진단학적 방법을 제안함으로써 기초 예방을 할 수 있을 것으로 생각된다.

• RED RIBBON
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• s.63
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• pp.20-22
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• 2005

항문외과에서 에이즈 감염을 의심해야 할 경우는 항문 성교에 의한 물리적인 병변 및 성병의 형태로 나타나는 경우와 에이즈에 의해 면역이 저하됨에 따라 나타나는 여러 가지 기회 질환의 형태로 나타날 수 있다. HIV 감염자 및 AIDS환자의 항문, 직장 병변은 면역 저하와 관련된 여러 종류의 드문 감염질환과 종양의 형태로 나타날 수 있고 2가지 이상의 질병이 복합적으로 나타나는 경우가 흔하다. 많은 감염이 항문 성교를 받는 동성연애 남성에서 나타나지만 항문 성교의 과거력이 없는 이성 연애 남성 및 여성에게서도 생길 수 있다. 최근에는 이성간의 항문 성교가 HIV 감염의 중요한 원인 중 한가지로 강조되고 있다.

• The Journal of the Korea Contents Association
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• v.16 no.7
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• pp.309-318
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• 2016

This study aimed to provide basic data for the enhancement of health behaviors by examining relations among cardiocerebrovascular diseases knowledge, attitude, health behaviors among male workers in their 30, 40s, and then understanding factors having influence on health behaviors. Targeting male workers in their 30, 40s working for companies in J & S cities, a survey was conducted by using tools for the knowledge, attitude, and health behaviors. The data were analyzed with SPSS Win 21.0 program. In the results, Knowledge and attitude showed positive correlations with health behaviors. As factors having influence on targets' health behaviors, there were the knowledge of cardiovascular, department, marital status in the order while the overall explanatory power was 14.8%. Based on this study, the educational implications of health behaviors for the prevention of cardiocerebrovascular diseases, and suggestions for the follow up research were presented.

• Journal of Periodontal and Implant Science
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• v.36 no.1
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• pp.97-112
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• 2006

유리 라디칼과 활성 산소종, 산화방지제 간의 불균형이 염증성 구강내 질환의 발생과 진행에 있어 중요한 역할을 한다는 주장이 제기되었고 최근에는 만성 염증성 치주질환에서도 산화에 의한 소실이 관찰되었다. 다양한 내적인 항산화 방어 기전 중 superoxide dismutase 가 $O_2$를 $H_2O_2$로 효과적으로 전환시킴으로써 활성산소종에 대한 일차적인 방어를 맡고 있다. 현재까지 인간에서 발견된 superoxide dismutase 는 cytoplasmic copper-zinc SOD와 mitochondrial manganase SOD, extracellular SOD의 3가지 아형이다. 이번 연구는 만성 치주질환을 가전 환자의 치주조직에서 효소 항산화제인 SOD의 발현정도를 알아봄으로써 질환조직 내의 산화자극 정도를 평가해 보고자하였다. 전남대학교 치주과에 내원한 33명의 만성 치주질환자와 20명 의 임상적으로 건강한 대상으로부터 조직을 얻어 Cu/Zn-SOD와 Mn-SOD, EC-SOD를 이용한 면역조직화학 염색을 시행하였다. 임상적 소견과 조직학적 소견이 일치하지 않아 조직학적 소견을 기준으로 건강한 조직, 경도, 중등도, 중도 치주질환 조직으로 그룹을 나누고 완전한 상피와 결합조직을 가진 27개의 표본에 대한 분석을 시행하였다. 치주질환 조직에서 건강한 조직에 비해 Cu/Zn-SOD가 상피의 기저층과 상피에 근접한 결합조직에서 발현되고 Mn-SOD는 염증이 증가함에 따라 크게 상피의 과립증과 각화층, 그리고 상피에 근접한 결합조직에서 발현됨으로써 활성산소종이 치주조직 파괴에 관여한다는 것을 알 수 있었다. 세 아형 모두 혈관주위에서 발현되었고 특히 EC-SOD는 작은 모세혈관주위에서만 발현되었으나 염증에 의해 혈관벽이 두꺼워지고 혈관 수가 증가한 곳에서 뚜렷하게 염색되었다. 이번 연구는 염증성 치주조직내 증가된 SOD의 활성이 치주질환자의 산화자극 정도와 관련되어 있음을 시사하였다.

• Journal of Korean society of Dental Hygiene
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• v.21 no.5
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• pp.535-543
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• 2021

Objectives: This study investigated the relationship between the Korean healthy eating index (KHEI) and periodontal disease in the Korean adult population. Methods: The data used in the analyses were obtained from the seventh Korean National Health and Nutrition Examination Survey (2016-2018). Data were analyzed by chi-square tests and t-test. Multiple regression analysis was also performed to assess the association between KHEI and periodontal disease. Statistical significance was set at p<0.05. Results: Multiple logistic regression analysis adjusted for socioeconomic variables showed that medical and health behavior variables were significantly related to the KHEI 1 (<63.7, odds ratio [OR]: 1.23, 95% confidence interval [CI]: 1.03-1.46), KHEI 2 (63.7-79.9, OR: 1.14, 95% CI: 0.97-1.34), and risk for periodontal disease. Conclusions: The results showed a significant association between the KHEI and periodontal disease in the Korean adult population.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.8
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• pp.903-909
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• 2019

Periodontal disease is observed in many adult persons. However we has not clear know the molecular mechanism and how to treat the disease at the molecular levels. Here, we investigated the molecular differences between periodontal disease and normal controls using gene expression data. In particular, we checked whether the periodontal disease and normal tissues would be classified by machine learning algorithms using gene expression data. Moreover, we revealed the differentially expression genes and their function. As a result, we revealed that the periodontal disease and normal control samples were clearly clustered. In addition, by applying several classification algorithms, such as decision trees, random forests, support vector machines, the two samples were classified well with high accuracy, sensitivity and specificity, even though the dataset was imbalanced. Finally, we found that the genes which were related to inflammation and immune response, were usually have distinct patterns between the two classes.

• The Journal of the Korean bone and joint tumor society
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• v.12 no.2
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• pp.103-111
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• 2006

Purpose: Sternocostoclavicular hyperostosis (SCCH) is a disease of unknown etiology, which is characterized by periosteal reaction and endosteal hyperossification of the sternum, clavicles and upper ribs as well as ossification of the surrounding soft tissue. SCCH is a well recognized but uncommon condition which is important differential diagnosis to consider to avoid misdiagnosis and to differentiate the condition from malignant process. But few studies have reported long-term clinical result of SCCH. We report long-term clinical result of SCCH. Materials and Methods: From 1986 to 2000, 17 cases of SCCH were followed up over two to 14 years. We evaluated the radiologic, pathologic and clinical results. Results: Four men and thirteen women were studied. The age when first symptom appeared were raged from17 to 60(average-48.7) There are no specific bacteriological, serological or histological finding. Usually a permanent increase in the erythrocyte sedimentation rate is found. The radiological examination showed the signs of proliferate destructive arthritis in most case. The majority of patients respond to NSAIDs and antibiotics. Conclusion: Sternocostoclavicular hyperostosis is uncommon benign condition, but important condition in the differential diagnosis of inflammatory or malignant process of this joint.

• Journal of the Korean Society of Radiology
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• v.9 no.4
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• pp.227-234
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• 2015

In this paper, we studied possibility about application for CAD on diffuse liver disease through pixel texture analysis parameters(average gray level, skewness, entropy) which based statistical property brightness histogram and image analysis using brightness difference liver and kidney parenchyma. The experiment was set by ROI ($50{\times}50$ pixels) on liver ultrasound images.(non specific, fatty liver, liver cirrhosis) then, evaluated disease recognition rates using 4 types pixel texture analysis parameters and brightness gap liver and kidney parenchyma. As a results, disease recognition rates which contained average brightness, skewness, uniformity, entropy was scored 100%~96%, they were high. In brightness gap between liver and kidney parenchyma, non specific was $-1.129{\pm}12.410$ fatty liver was $33.182{\pm}11.826$, these were shown significantly difference, but liver cirrhosis was $-1.668{\pm}10.081$, that was somewhat small difference with non specific case. Consequently, pixel texture analysis parameter which scored high disease recognition rates and CAD which used brightness difference of parenchyma are very useful for detecting diffuse liver disease as well as these are possible to use clinical technique and minimize reading miss. Also, it helps to suggest correct diagnose and treatment.