• Journal of Radiation Protection and Research
• /
• v.36 no.3
• /
• pp.160-167
• /
• 2011

This study conducts cross-comparison through verification of treatment planning of using beam spoiler and bolus, according to the dose variation of different tumor bed and metastatic lymph node cancers, against ionization and optically stimulated luminescence detectors(OSLDs), in head and neck radiotherapy. Verification of treatment planning examined the feasibility of inserting detectors through simulated solid dry water slabs under identical irradiated conditions from treatment planning system to measure beam spoiler and 0.5, 1 cm bolus. In addition, two detectors were cross-compared for verification of treatment planning accuracy and reliability within ${\pm}$2%. The study found that, given a beam spoiler thickness of 0.5 cm and beam spoiler-to-skin distance of 10 cm subjected to optimal dose distribution given for metastatic lymph node cancers, the bolus low-level skin dose was less, and the tumor bed dose reduced slightly. Additionally, two detectors were cross-compared for accuracy within ${\pm}$1%. Accordingly, The use of beam spoiler was determined that reduces skin side effects and can deliver an optimal dose distribution for tumor, and to apply to future clinical studies should be performed.

• Radiation Oncology Journal
• /
• v.12 no.1
• /
• pp.27-31
• /
• 1994

There are a number of reports suggesting that there may be a correlation between the clinical response to radiotherapy in various tumors and the clonogenic survival of cell lines derived from these tumors following exposure to 2 Gy(SF2). Authors conducted this study to determine SF2 for cells in primary culture from surgical specimens. The tumor tissues with squamous cell carcinoma of uterine cervix and head and neck were obtained. The tumor tissues were disaggregated to single cells by incubating with collagenase type w for 2 hours with constant stirring. Single cell suspensions were inoculated in four 24-well plates precoated with cell adhesive matrix. After 24 hours of incubation at 37$ ^{\circ}C $, rows of four wells were then irradiated, consisting of control set and five other sets each receiving doses of 1,2,3,4, and 6 Gy. After incubation for a total of 13 days, the cultures were stained with crystal violet and survival at each dose was determined by quantitative image analysis system, To determine whether cell growth was of epithelial origin, immunocytochemical staining with a mixture of cytokeratin and epithelial monoclonal antibodies were performed on cell cultures. During the period of this study, we received 5 squamous cell carcinoma specimens of head and neck and 20 of uterine cervical carcinoma. Of these, 15 yielded enough cells for radiosensitivity testing. This resulted an overall success rate of 60$ \% $. The mean SF2 value for 15 tumours was 0.55$\pm$0.17 ranging from 0.20 to 0.79. These results indicate that there is a broad range of sensitivities to radiation in same histologic type. So with a large patient population, we plan to determine whether a different SF2 value is associated with tumours that are controlled with radiotherapy than those that are not.

• Journal of the Korean Society of Radiology
• /
• v.82 no.5
• /
• pp.1196-1206
• /
• 2021

Purpose To construct a standard dataset of contrast-enhanced CT images of liver tumors to test the performance and safety of artificial intelligence (AI)-based algorithms for clinical decision support systems (CDSSs). Materials and Methods A consensus group of medical experts in gastrointestinal radiology from four national tertiary institutions discussed the conditions to be included in a standard dataset. Seventy-five cases of hepatocellular carcinoma, 75 cases of metastasis, and 30-50 cases of benign lesions were retrieved from each institution, and the final dataset consisted of 300 cases of hepatocellular carcinoma, 300 cases of metastasis, and 183 cases of benign lesions. Only pathologically confirmed cases of hepatocellular carcinomas and metastases were enrolled. The medical experts retrieved the medical records of the patients and manually labeled the CT images. The CT images were saved as Digital Imaging and Communications in Medicine (DICOM) files. Results The medical experts in gastrointestinal radiology constructed the standard dataset of contrast-enhanced CT images for 783 cases of liver tumors. The performance and safety of the AI algorithm can be evaluated by calculating the sensitivity and specificity for detecting and characterizing the lesions. Conclusion The constructed standard dataset can be utilized for evaluating the machine-learning-based AI algorithm for CDSS.

• Journal of Chest Surgery
• /
• v.37 no.3
• /
• pp.275-278
• /
• 2004

A 9-month-old male infant was admitted for evaluation of incidentally noticed cardiac mass. The patient had no symptoms and there was no hemodynamic abnormality. Echocardiographic finding showed a huge left ventricular free wall mural mass, which did not obstruct the left ventricular outflow tract. Maximal excision of the left ventricular free wall mass was performed. The pathologic finding revealed cardiac fibroma. During the 7-month of follow-up after surgery, there was no evidence of arrhythmia or tumor recurrence.

• The Journal of the Korean bone and joint tumor society
• /
• v.11 no.2
• /
• pp.204-207
• /
• 2005

Osteosarcoma is mainly developing around the knee joint. But osteosarcoma of the calcaneus is rare. A 20 year old male patient visited our clinic due to persistent pain around the calcaneus. We diagnosed it to osteosarcoma of the calcaneus and treated with below knee amputation and adjuvant chemotherapy. We experienced a case of osteosarcoma of the calcaneus and would like to report it with review of literatures.

• Proceedings of the Korea Contents Association Conference
• /
• 2015.05a
• /
• pp.173-174
• /
• 2015

간에서 발생하는 악성종양과 양성종양의 대표적 질환 으로는 간세포암(Hepatocelluar carci- noma, HCC)과 간혈관종(Hepatic hemangioma, HH)이다. CT검사를 이용한 진단에 있어서 두 질환은 시간변화에 따른 조영증강양상 차이가 나타난다. Liver 3-phase computed tomography검사를 시행하여 시간별 조영증강 양상을 알아보았다. 본 연구는 조영제 주입전, 동맥기(35sec), 문맥기(70sec), 지연기(180sec)에 대한 Enhan -cement Pattern 변화와 HU(Hounsfield unit)값 변화, pixel값 변화의 관찰로서 검증하였다. 실험결과 HU를 사용한 방법에서 의미있게 구분되었고 임상적용 시 판독에 도움을 줄 것으로 생각한다.

• Proceedings of the KSMRM Conference
• /
• 2003.10a
• /
• pp.36-36
• /
• 2003

목적： 고형성 종양에 특이적으로 발현하는 MR 분자영상용 조영제의 후보물질을 분자생물학적 방법 및 in vitro 분자영상기법을 이용하여 탐색하고자 하였다. 대상 및 방법： 암이 진행됨에 따라 유전자가 과발현되는 세포표면 단백질인 CD44 와 세포막에 존재하는 단백질분해효소의 일종인 MTI-MMP를 일차 선정하여 유전자 수준 및 단백질 수준에서 분자생물학적 방법으로 종양특이성에 대해 검증하였고, 특히 각종 암세포에서 발현양이 증가하는 CD44의 변형인 CD44v6 항체를 이용하여 생세포에서의 표적화에 대한 광학적 검증을 위해 초상자성 나노입자 대신 형광입자(FITC)를 결합하여 confocal microscopy로 실시간 표적화에 대한 분자영상을 획득하였다.

• Korean Journal of Head & Neck Oncology
• /
• v.29 no.2
• /
• pp.93-96
• /
• 2013

원격 전이된 비인두암 환자에서 주요한 치료 방법은 고식적 항암화학치료에 국한되어왔다. 그러나 적극적인 항암화학치료로 비인두암 환자 중 많은 환자에서 치료 반응을 보이며, 치료 반응을 보인 환자군에서는 국소 제어가 중요한 문제가 된다. 본 저자들은 원격 전이 된 환자 1예를 보고하고자 한다. 환자는 큰 크기의 다발성 전이가 있었으나 항암화학요법으로 관해 상태를 보였다. 이후 공고화 항암화학방사선요법을 추가하였고 현재 30개월 간 무병상태이다. 원격전이된 비인두암에서 공고화 항암화학방사선 요법의 역할에 대하여 문헌 고찰을 통해 논의하고자 한다.

• Proceedings of the KOR-BRONCHOESO Conference
• /
• 1991.06a
• /
• pp.44-44
• /
• 1991

선친성 경부 종양은 표재성, 무통성 종물로 임상적으로는 이차적 감염후 발견되는 경우가 많다. 이학적 검사 및 경부초음파 검사로 임상적 진단은 용이하나 확진을 위해서는 수술후 조직병리검사가 필수적이다. 저자들은 최근 2년간에 서울중앙병원에서 경부 종물을 주소로 내원하여 수술후 조직병리검사로 확진된 47례에 대해 후향적 조사를 실시하여 다음과 같은 결론을 얻었기에 문헌적 고찰과 함께 보고하는 바이다. 1)총 47례중 갑상설 낭종이 가장 많은 빈도를 차지하였고(31, 9%) 새성낭종(25.5%), 낭포성 히그로마(21.3%), 유표피낭포(14.9%), 혈관종(6.4% )순이었다. 2)성별 분포는 남녀간의 큰 차이 없었다. (남46.8%, 여 53.2%) 3)연령별 분포는 20대 이하에서 가장 많은 빈도를 보였다. (63.9%) 4)위치별 분포는 경부중앙(42.6%), 우측경부(38.3%), 좌측경부(19.1%)를 보였다. 5)주된 증상은 경부종물을 주소로 내원한 경우가 대부분이었으며, 증상의 기간은 1년 미만이(53.2%) 가장 많았다.

• Korean Journal of Head & Neck Oncology
• /
• v.22 no.2
• /
• pp.142-146
• /
• 2006

Background and Objectives : This study reports our clinicopathological experiences of major salivary gland tumors. Materials and Methods : This study included 302 patients with major salivary gland tumors who had got the diagnosis from January 1995 through December 2004. Medical records were reviewed retrospectively. Results : We found 244 benign and 58 malignant major salivary gland tumors. Among 267 parotid tumors, the most common benign parotid tumor was pleomorphic adenoma. Mucoepidermoid carcinoma, adenoid cystic carcinoma, and acinic cell carcinoma were three most common parotid malignancies. Among 33 submandibular gland tumors, 20 cases were benign and 13 were malignant. There were one benign and one malignant sublingual gland tumors. The duration of symptom of submandibular gland tumors was longer than that of parotid tumors. Most patients presented with asymptomatic mass. Seventy-one percent of salivary gland malignancies underwent postoperative radiation therapy. Five-year disease free survival rate of parotid malignant tumors seemed to be higher than that of submandibular one, although there was no statistical significance. Conclusion : Malignancy rate of each salivary gland followed old axiom that it is inversely related with the size of gland. Submandibular gland tumor tends to be delayed to reach diagnosis. Clinicians must be alert about this finding because submandibular gland tumors are known to have poorer prognosis than parotid tumors.