• The Korean Journal of Nuclear Medicine Technology
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• v.16 no.2
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• pp.57-61
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• 2012

Purpose : The whole body bone scan on nuclear medicine is a widely accepted examination and procedure. However, unusual nonosseous uptake can be observed, which reflects a rare interaction between the radiopharmacceutical and the patient. This study aimed to evaluate the influence of MRI(Magnetic Resonance Imaging) contrast and $^{99m}Tc$-DPD(Dicarboxpropane diphosphonate) on whole body bone scan. Materials and Methods : We analyzed the 982 patients who were examined by $^{99m}Tc$-DPD on whole body bone scan in nuclear medicine department of pusan national university hospital from january to december 2010. All these 982 patients had MRI contrast administration prior to whole body bone scan. We analyzed laboratory test. Results : 46 patients(men 39, women 7) showed diffuse hepatic uptake on whole body bone scan. These uptakes were disappeared on the follow-up whole body bone scan. There were no significant difference of CBC test, liver function tests and renal function tests. Conclusion : The study might be an indirect evidence that diffuse hepatic and splenic uptake of 99mTc-DPD on whole body bone scan after intravenous administration of Gadolinium(Gd) MRI contrast. To perform a precise examination, Gd-contrast agent should be removed from the body before performing a whole body bone scan.

• Pediatric Infection and Vaccine
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• v.9 no.2
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• pp.175-181
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• 2002

Purpose : Scrub typhus(tsutsugamushi disease) is a febrile disease characterized by fever, rash, eschar, lymphadenopathy. Therapy with tetracycline(doxycycline) or chloramphenicol is currently recommended for the treatment for scrub typhus. But there are limitations in usage a tetracycline(doxycycline) for scrub typhus in the children. Recently, there was a report that azithromycin, a macrolide antibiotic was used for scrub typhus in pregnant woman successfully. So we evaluated the effectiveness of the Clarithromycin, other a macrolide antibiotic, for scrub typhus. Methods : Seven patients with scrub typhus at department of internal medicine and three patients with scrub typhus at department of pediatrics Masan Fatima Hospital were involved for this study. A serologic diagnosis for scrub typhus were performed by use of passive hemagglutination test. Clarithromycin(Abbott Laboratories, North Chicago, IL, USA) was administrated orally in a daily dose of 500 mg for adult patients and 15 mg/kg/bid/day for pediatric patients. Results : There were 7 cases of adult patients, varying from 28 to 76 years of age and 3 cases of pediatirc patients, varying from 4 to 7 years of age with scrub typhus. All of cases had fever, myalgia, headache, rash, eschar. Seven cases had positive passive hemagglutination test and eight cases had abnormal liver function. Mean duration for the removal of fever after medication was 1.3 day(1~2 days) and all cases were recovered without complications. Conclusion : Our results suggest that Clarithromycin therapy may be effective for scrub typhus.

• Neonatal Medicine
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• v.16 no.2
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• pp.197-204
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• 2009

Purpose: The objective of this study was to describe the frequency of hepatobiliary dysfunction (HD) at our hospital and determine the possible risk factors and complications associated with the development of HD in very low birth weight infants (VLBWI) treated with parenteral nutrition (PN). Methods: A retrospective study of VLBWI (n=92) that required PN between 2004 and 2008 in the NICU at the Bucheon St. Marys Hospital of Catholic University was performed. HD was defined by a direct bilirubin (DB) >2 mg and a transaminase of 60 IU/L defined cholestasis and liver injury. Groups I, II, and III were limited to cases of cholestasis, liver injury without cholestasis, and no abnormalities, respectively. The VLBWI were compared to each other. Results: Thirty-six subjects (39.1%) had cholestasis and 51 (55.4%) had liver injury. In addition, 36 (39.1%), 19 (20.7%), and 37 (40.2%) subjects were classified as groups I, II, and III, respectively. The three groups showed significant differences in gestational age, 1- and 5-minute Apgar scores, use of surfactant, duration of parenteral nutrition, frequency of RBC transfusions, bronchopulmonary dysplasia (BPD), and patent ductus arteriosus (PDA) (P<0.05). The multiple regression analysis with cholestasis as the dependent variable, showed a significant correlation with gestational age, use of surfactant, frequency of RBC transfusions, and PDA. Conclusion: Various factors, such as birth weight, gestational age, 1- and 5-minute Apgar scores, use of surfactant for respiratory distress syndrome (RDS), frequency of RBC transfusions, BPD, and PDA may be related to hepatobiliary dysfunction in VLBWI treated with PN.

• 대한예방의학회:학술대회논문집
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• 1995.10a
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• pp.325-326
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• 1995

• 대한핵의학회:학술대회논문집
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• 1969.12a
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• pp.8.3-9
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• 1969

• Journal of Yeungnam Medical Science
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• v.6 no.2
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• pp.257-263
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• 1989

Rotor syndrome is a rare disease of hereditary hyperbilirubinemia transmitted with autosomal recessive trait. In general, Rotor syndrome shows direct hyperbilirubinemia and there has been several reports since Sons's report in 1966, in Korea. A 34-year-old female with admitted with the chief complaint of intermittent icteric sclera for 24 years. There was no family history of jaundice. Rotor syndrome was diagnosed by oral cholecystogram, BSP retention test, $^{99m}Tc$-DISIDA scan, liver biopsy and electromiuoscopy study of liver biopsy specimen. We report this case with brief review of the literature.

• Journal of radiological science and technology
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• v.37 no.4
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• pp.287-294
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• 2014

Gallstone is the most common disease of the biliary system. Korean has experienced an increase in the percentage of cholesterol gallstones. The major risk factors associated with cholesterol gallstones are age, gender as well as obesity. This study was designed to determine the prevalence of gallstones in the last three years and evaluate the associated risk factors in the population who underwent health screening. The study population consisted of 2,484 males and 2,212 females who visited the health promotion center in Dalseogu, Daegu in Korea from January 2011 to December 2013. Each participant in the study had their biliary system gallbladder examined using ultrasonography. Classified as underweight, normal weight or overweight using the population of obese according to the body mass index, and classified according to mood diagnosis of diabetes presented by the American Diabetes Association. Fasting blood glucose and number of liver function, the divided the control group by referring to the normal liver function values used herein. The geological map, I was classified as NCEP APT III. A showed of total 148 people were found to have gallstones. The prevalence of sex among 148 patients (3.15%) 84 men (1.79%) and 64 women 1.36%) which shows significantly there is little difference. 1.84% 40 years and below, 3.38% 40's showed age prevalence was 4.66% in 50's and above. In addition, Total-cholesterol was at the most in 52 people, LDL-cholesterol in 398 people, Triglyceride in 36 people, HDL-cholesterol in 19 people. The abnormal group, was created from the total-cholesterol categories from a physical examination of a subject that has been found to be gallstones in the gallbladder. A result of conducting the univariate analysis shows the prevalence of gallstones, a correlation that is meaningful. The logistic regression analysis of multiple ages was chosen to show risk factors age independent cholelithiasis. In spite of the conclusion, gallstones are not displayed in relation to the metabolic syndrome but in order to clarify this, not only the subject of a health examination is needed but, a further study of the general public when possible.

• Journal of agricultural medicine and community health
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• v.13 no.1
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• pp.88-96
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• 1988

농촌주민(農村住民) 400명(名) 도시주민(都市住民) 600명(名)에 대한 혈액(血液) 및 혈청학적검사(血淸學的檢査)를 통하여 그 건강상태(健康狀態)를 조사(調査)한바 다음과 같은 성적을 얻었다. 지역별(地域別) 각종검사(各種檢査)의 평균치(平均値)는 농촌남자(農村男子)에서 적혈구수(赤血球數), 혈색소량(血色素量), 적혈구용적치(赤血球容積値)들은 도시주민(都市住民)이 농촌주민(農村住民)에 비(比)하여 높았고 백혈구수(白血球數)는 농촌주민(農村住民)에서 높았다. 신기능검사(腎機能檢査)에서 혈중요소질소치(血中尿素窒素値) 및 creatinine치(値)는 도시주민(都市住民)에서 높았고 간기능검사(肝機能檢査)에서는 총단백질량(總蛋白質量), bilirubin 및 alkaline phosphatase치(値)는 도시주민(都市住民)에서 albumin, SGOT는 농촌주민(農村住民)에서 높았다. 기타(其他)범주에서는 혈중(血中) calcium은 도시주민(都市住民)에서 인(燐), 혈당(血糖) 및 cholesterol(値)는 농촌주민(農村住民)에서 높았다. 평균치(平均値)는 성별차이(性別差異)에서는 농촌(農村), 도시(都市) 모두 남자(男子)의 평균치(平均値)가 총단백질치(總蛋白質値) 및 인치(燐値)를 제(除)하고는 모두 남자(男子)에서 높았다. 다음으로 각검사치(各檢査値)의 정상범위(正常範圍)에 대한 이상치율(異常値率)을 보면 농촌남자(農村男子)에서 적혈구용적치(赤血球容積値)에서 정상범위(正常範圍)가 하치율(下値率)이 도시남자(都市男子)에 비하여 높았으나 백혈구수치(白血球數値)는 농촌주민(農村住民)에서 정상범위이상치(正常範圍以上値)가 높았다. 혈중요소실요치(血中尿素窒素値)는 정상범위이상(正常範圍以上), 이하치간(以下値間)이나 도농주민간(都農住民間)에 별차이(別差異)가 없었고 creatinine은 도시주민(都市住民)에서 이상치율(異常値率)이 높았다. 간기능검사(肝機能檢査)에서는 총단백(總蛋白), alkaline phosphatase는 도시주민(都市住民)에서 정상범위이상치(正常範圍以上値)가 고율(高率)인데 반(反)하여 albumine SGOT 및 SGPT는 농촌주민(農村住民)에서 이상치율(以上値率)이 높았다. 기타(其他)범주에서는 calcium은 도시주민(都市住民)에서 인(燐) 및 혈당치(血糖値)는 농촌주민(農村住民)에서 정상범위이상치율(正常範圍以上値率)이 높았고 cholesterol치는 정상범위이하(正常範圍以下) 및 이상치(以上値) 모두 도시주민(都市住民)에서 고율(高率)이었다. 여자(女子)에서는 혈액상(血液相)에서는 남자(男子)에 비(比)하여 정상범위이상치(正常範圍以上値)의 빈도(頻度)가 더욱 심하였으나 기타치(其他値)에서는 남자(男子)에 비(比)하여 도농간(都農間)의 차이(差異)가 적은점(點)을 제외(除外)하고는 거의 같은 경향(傾向)을 나타내었다.

• KSBB Journal
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• v.17 no.4
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• pp.403-408
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• 2002

For stimulating the in vivo secretion of IGF-1 (insulin-like growth factor-1) which is well known to promote the various physiological actions in human body, the natural herbal extract, YGF251 (young growth factor 251), was developed and evaluated for its effect as IGF-1 secretagogue in this study. The clinical study was peformed as double blind test, and 31 adult female and male volunteers between the age of 40 and 70 were investigated for their changes of concentration of IGF-1 , insulin level, weight, blood pressure, and liver and kidney functions. As the result of paired sample test on the change of the concentration of IGF-1, in YGF251 treated group, it was 245.6 ng/mL before dosing. The concentration of IGF-1 was increased to 269.3 ng/mL after a month and to 275.6 ng/mL after two months, and both were statistically significant (p〈0.05). While in control group, the concentration of IGF-1 was 280.0 ng/mL before dosing, but decreased to 239.2 ng/mL after a month and to 230.2 ng/mL after two months, and both were also statistically significant (p〈0.05). In YGF251 treated group, the concentration of insulin in blood increased about 2 times after a month dosing as an average level, but in control group, it showed a decrease of 36% compared with before dosing. And there were little changes regarding to the measured weight and blood pressure. Various measured data in order to observe the alteration in liver and kidney functions by the administration of YGF251 showed a little change within measuring error range.

• Journal of the Korean Society of Food Science and Nutrition
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• v.20 no.5
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• pp.426-432
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• 1991

To investigate the effect of the unsaturated plant oil on the normal liver and lipid metabalism rats were fed the daily dose of 1.57ml/kg body weight of perilla oil (Iodine value 190~207), corn oil (Iodine value 115~130) and olive oil (Iodine value 80~85) respectively for 28 days. The results were as follows. For the 14 days the test groups showed normal weight gain with 7.86~20.89% increase rate. In the period of the 3rd and the 4th week the increase rate of the perilla oil group was decreased significantly under 17.53~13.8% of control level, but the remainders(corn oil, olive oil) keep normal. The feeding of corn and olive oil for 28 days did show any harmful effect on normal GOT, GPT activity, ALK-P, serum cholesterol and serum triglyceride value of rat. The perilla oil feeding for 21~28 days slightly increased the GOT, GPT activity as 174.87, 93.46u but decreased the cholesterol and triglycerids value as 54.6~0.36mg/dl compared to control. In the pathological finding of test group liver some rats in 28 days feeding group showed reactive vesicula nuclei in corn oil group and mild fatty metamorphosis in olive oil group. But most subjects did not show any characterized sign of acute or subacute liver damage.