• Journal of Veterinary Clinics
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• v.27 no.6
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• pp.751-754
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• 2010

A 6-year-old spayed female Persian cat presented with a 3-month history of recurrent ulcerative keratitis with noticeable opacification and vascularization of the right cornea. The lesion was nonresponsive to topical antibiotics and to nonsteroidal anti-inflammatory drugs. Ophthalmic examination showed signs of ocular discomfort, such as epiphora and blepharospasm, in the right eye. Biomicroscopic examination revealed an irregular, edematous, vascularized mass with pink to white tissue on the entire cornea and mild conjunctivitis. A tentative diagnosis of feline proliferative eosinophilic keratitis (FPEK) was made on the basis of clinical appearance. Cytologic examination of the cornea showed a mixture of numerous eosinophils and mast cells, which confirmed the original diagnosis of FPEK. The cat was treated with a topical antibiotic-corticosteroid combination, cyclosporine ointment, trifluridine eye drops, and oral Llysine. The clinical signs improved remarkably 18 days after the cat was first examined. The short-term use of corticosteroids and long-term use of cyclosporine and an anti-viral agent resolved the lesion without recurrence of the disease for 1 year.

• 월간산업보건
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• s.295
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• pp.11-14
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• 2012

Phenothiazine의 직업적 노출기준(TLV-TWA)은 $5mg/m^3$으로 권고되었다. TLV-TWA의 수준은 피부자극과 변색, 각막염 그리고 태양광에 직접 노출되었을 때 나타나는 광감작반응의 가능성을 최소화하기 위해 설정되었다. 고용량의 phenothiazine을 경구 투여하면 간과 신장이 손상되며 용혈성의 빈혈이 발생한다. Phenothiazine의 피부흡수에 의한 전신 독성이 증명되어 피부흡수 "Skin" 경고주석을 권고하였다. 감작제(SEN)와 발암성 경고주석 그리고 TLV-STEL을 설정하기에는 유용한 자료가 부족하다.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.3
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• pp.403-406
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• 2014

Purpose: In this study, we studied ocular disease by age in Ulsan. Methods: We checked medical record of 300 patients who visited eye clinic in Ulsan. Results: The main ocular disease on the age of 10 was keratitis, that of 20 was dry eye syndrome & keratitis, that of 30 was chalazion & conjunctivitis, that of 40~50 was conjunctivitis, that of 60 was conjunctivitis & cataract. Conclusions: The main cause of ocular disease of 10~20's are unsuitable wear of contact lenses & long-time use of smart phone as well as computer. That of 30~50's are allergic conjunctivitis and chemical material reaction as well as other several factors. Especially, attack rate of conjunctivitis of 30~50's is higher than city because of industrial area (Ulsan). The main cause of ocular disease in 50~60's is a kind of senility. Therefore, based on the results of this study, it could be used the basic data of education on ocular disease prevention in Ulsan.

• Parasites, Hosts and Diseases
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• v.36 no.1
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• pp.7-14
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• 1998

In order to understand the action mechanism of polyhexamethylene biguanide (PHMB) to the cyst of Accnthcnloebc on the morphological basis, the cysts of four corneal isolates of Acanthanoebc were treated with minimal cysticidal concentration (MCC) of PHMB and their ultrastructural changes were examined by transmission electron microscopy. The most striking change of cysts treated with PHMB compared with normal cysts was the shrinkage of intracystic amoebae, which resulted in the separation of the plasma membrane of intracystic amoeba from endocystic wall. Subplasmalemmal lipid droplets became irregularly shaped . In severely damaged cysts, cytoplasm was aggregated and organelles were severely deformed. Cytoplasmic materials were leaked out through the damaged plasma membrane. Most cysts showed aggregation of nuclear chromatin material. Number of mitochondrial cristae was also reduced. Ecto- and endo-cystic walls were relatively well tolerated. Findings in the present study revealed that PHMB affected mainly on plasma membrane, but lesser on organellar membrane of intracystic amoeba. It seemed likely that PHMB might kill cystic forms of Accnthamoebc by similar mechanism in which this environmental biocide can damage the cell wall of Escherichia coli by binding with acidic phospholipids.

• Journal of Korean Ophthalmic Optics Society
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• v.9 no.2
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• pp.233-239
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• 2004

This study investigated the status of soft contact lens wear in college students. The results were as follows: 1. The most prevalent age of initial contact lens wear was 19 years or 20 years, with an age distribution in females from as early as 10 years to 20 years. 2. For almost all subjects, the test clinic for the contact lens wear assessment and purchase of the contact lenses was an optical shop. 3. The main advantage for most male subjects was use for sports, whereas most female subjects used contact lenses for cosmetic reasons. 4. The most common side-effects experienced due to contact lens wear were red eye, foreign body sensation, and eye pain. 5. The most frequently reported eye disease caused by contact lens wear was conjunctivitis, with only few subjects experiencing keratitis. 6. Following treatment for the side effects of contact lens wear, most subjects hoped to re-use the previous contact lenses, some subjects wanted to change to new contact lenses, and others subjects refused further contact lens wear.

• The Korean Journal of Mycology
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• v.36 no.2
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• pp.178-182
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• 2008

Although the number of patients with Acanthamoeba keratitis has increased dramatically since the widespread use of contact lens, it is still very hard to cure the disease. The proteases from the Acanthamoeba were reported to play important role in the pathogenesis of keratitis. In this study, the inhibitors for extracellular serine proteases of A. castellanii were screened from the extracts of 230 mushroom samples collected from various regions of Korea. The mushrooms were extracted with methanol and water ($65^{\circ}C$). Filtered and concentrated extracts (0.3 mg/ml) were preincubated with proteases before addition of peptide substrate N-succinyl-ala-ala-pro-phe p-anilide. The selected extracts showing strong inhibitory effects were characterized. Although inhibition with single extract was not so high enough, the complete inhibition was achieved with combination of two extracts. The selected extract showed little effect on other serine proteases such as thrombin (human and bovine) and on general protease such as protease K.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1981.05a
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• pp.40.3-41
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• 1981

The ichthyosiform dermatosis is consisted of a heterogenous group of hereditary disorders. Authors report a case of 26 year old female patient who has congenital ichthyosiform dermatosis associated with sensorineural hearing loss, neovascularization of cornea, partial alopecia and abnormalities of nails and teeth. The audiological findings of this patient were as follows: 1. Bilateral severe sensorineural hearing loss. 2. SISI scores: 100% at 1, 000 Hz and 4, 000 Hz on both ear. 3. Tone decay test: 25 dB decay at 1, 000 Hz and 4, 000 Hz respectively on both ear. 4. SRTs : 85 dB on both ear. 5. Speech discrimination scores : 80% at 95 dB hearing level(MCL) on both ear. With above results, cochlear lesion is suspected in this syndrome.

• Journal of Veterinary Clinics
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• v.12 no.1
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• pp.849-852
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• 1995

데마슘과 사상균의 일종인 Curvularia lunata가 식물파편으로 오염된 흙에 의해 눈에 외상을 입은 젊은 수토끼(Orytolaggus cunuculis)에서 각막궤양을 일으킨 것으로 밝혀졌다. 이 토끼는 직경 1.5 mm의 각막궤양, 각막부종, 전방축농, 눈물 등을 나타내었다. 각막 소파시료의 KOH 표본과 진균배지에서의 분리를 통해 진균이 확인되었다. 눈의 외상은 진균성각막염의 발생소인이었다. 토끼장의 흙은 Curvularia lunata의 집락을 많이 형성하였으며, 이것이 감염원으로 추정되었다. 이것은 애완용 토끼에서 Curvularia lunata에 의한 안진균증의 최초의 보고인 것으로 판단된다. 외상의 병력이 있는 동물임상의 다양한 상황에서 Curvularia lunata의 병인론적 역할이 연구되어야 함을 강조하였다.

• Korean Journal of Microbiology
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• v.46 no.2
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• pp.152-156
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• 2010

Disposable contact lenses, which are one type of soft contact lenses, provide convenience in use, but also cause various ocular infectious diseases. Microorganisms that cause eye diseases include Acanthamoeba, bacteria, Fungi, and so on. It is impossible to prevent microorganism contamination completely due to the use of hands as wearing contact lenses. The contamination by various microorganisms leads to infectious keratitis, but it is not well known for the exact microorganisms that affect the disease. For this reason, to identify the microorganisms, two groups that are commonly used for disinfection of lenses were divided: normal saline solution and multiple purpose solution. Using these solutions the degree of microorganism contamination was observed according to the days of 1, 3, 5, 10, and 15. Twenty students by two groups from Ophthalmic Optics department at D college in Daegu Metropolitan city participated in the experiment after their ocular health conditions were checked. During they wore one-day disposable lenses for 1, 3, 5, 10, and 15 days, bacteria were cultured in media. The results, which were Gram stained by selecting the cultured colonies, show as followings: Gram positive cocci 33%, Gram-negative cocci 2%, Gram positive bacilli 34%, and the Gram negative bacilli 31%, respectively. As for the identification of potential pathogens, VITEK system and API kit methods were used. Keratitis caused by bacteria known as Staphylococcus aureus, Pseudomonas aeruginosa were detected as a result of wearing contact lenses. This study examined the distribution of bacteria as wearing one-day disposable contact lenses and pathogenic bacteria according to the duration of wearing them. In conclusion, the importance of hygiene when using contact lenses is suggested.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.1
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• pp.11-20
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• 2006

Objective : This experimental study was performed to investigate the effect of herbal eye drops, Sean-tang and Coptidis rhizoma on Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa keratitis. Methods : After administering herbal eye drops (Sean-tang, Coptidis rhizoma) on Staphylococcus ausreus, Staphylococcus. epidermidis and Pseudomonas aeruginosa, I measured MIC and the size of inhibition zone. MIC was measured by dropping to $50{\mu}{\ell}$ according to density(l00%, 10%, 1%, 0.1%). Anti-bacterial potency was measured by the size of inhibition zone with change of volume. Result : On Staphylococcus aureus, Staphylococcus epidermidis, Coptidis rhizoma showed the highest anti-bacterial potency and on Pseudomonas aeruginosa, Sean-tang, Coptidis rhizoma was nor anti-bacterial potency. Conclusions : The present author think that the herbal eye drops, Sean-tang and Coptidis rhizoma can be used to cure Staphylococcus aureus, Staphyloccus epidermidis keratitis and if further study is performed, the use of the herbal eye drops will be valuable and beneficial in the clinical medicines.