• Korean Journal of Food Science and Technology
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• v.45 no.2
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• pp.241-247
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• 2013

AOAC Mouse Bioassay Analysis (MBA) has been the gold standard for the analysis of paralytic shellfish poisoning toxin (PSP toxin) for more than 50 years. However, this method has inaccurate limit of quantification and cannot be used to determine toxic profiles. An HPLC method (PCOX) was optimized for Korean shellfish to establish an alternative or supplementary method for PSP analysis and was intended to be used for the official monitoring and regulation of food. The recovery rate of the PCOX method was 83.5-112.1% and the limit of quantification for total toxin was about $8.6{\mu}g$/100 g. A long-term comparison study showed a good correlation of the PCOX results with the AOAC MBA results: the correlation factors were 0.9534 and 0.9109 for oyster and mussel matrices, respectively. The PCOX method may be used as an alternative or supplementary method for AOAC MBA to monitor the occurrence of PSP and to analyze PSP toxin profile in oysters and mussels.

• Journal of the Korean Society for Precision Engineering
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• v.31 no.7
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• pp.627-634
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• 2014

Machine tool vibration is well known for reducing machining accuracy. Because vibration response of a linear structure generally depends on its transfer function if the magnitude of excitation were kept constant, this study introduces a RET(Random Excitation Test) based on FRF method to evaluate stiffness of a prototype HDMTL(Heavy-Duty Multi-Tasking Lathe) for large crankshaft of marine engine. Firstly, two force loops of the lathe and corresponding structural loops were identified:1) workpiece - spindle - head stock - main bed, 2) workpiece - tool post - carriage bed. Secondly, compliances of each structural loop were measured respectively using RET with a hydraulic exciter and then converted into stiffness. Finally, the measured stiffness was compared with that obtained previously by FEM analysis. As the result, both measured and computed stiffness were closely in agreement with each other. And the prototype HDMTL has evidently sufficient rigidity above ordinary heavy-duty lathes.

• Journal of the Korean Society of Marine Environment & Safety
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• v.19 no.1
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• pp.78-84
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• 2013

The primary objective of the current work is to develop efficient numerical code to assess the resistance performance of the twin hull form. Resistance performance for the two different twin hull forms with asymmetric and symmetric mono hull using developed code are evaluated. Numerical calculations and model tests have been compared to validate a developed code used in the current work. Comparison were carried out through sinkages of the bow and stern, trim angle and wave-making resistance. Comparative analysis regarding hydrodynamic characteristic of different twin hull forms is worthy of application in the hull form development stage.

• Journal of the Earthquake Engineering Society of Korea
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• v.9 no.5 s.45
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• pp.21-28
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• 2005

This paper proposes a shaking table test considering the dynamic soil strcuture interaction (SSI) by using the accelerations measured from superstructure and shaking table. The proposed method based on the substructure method is that only superstructure is used as an experimental model and dynamic soil stiffness is reflected on the controller of shaking table for soil model. At the moment, an experimental superstructure is excited by a shaking table with the motion required to emulate the dynamic behavior of total SSI system. First, the validity of the proposed method is verified by the verification model of numerical simulation, which is derived from the equation of motion of SSI system under consideration. Also, the applicability of the proposed method to shaking table test is numerically verified from the simulation model incorporating the transfer function of shaking table.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.3C
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• pp.157-170
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• 2006

Downhole method is considered as giving a little unreliable Vs profile when the signal to noise ratio(S/N) is low and the travel time information is erroneous although it is economical and ease of operation. Direct method has been applied for obtaining adequate result in this case. But it is difficult to determine optimum result by using direct method which is subjective and considering straight ray path. Therefore, in this paper, Mean Refracted Ray Path Method(MRM) was proposed, which is automated and considering refracted ray path. Artificial travel time data adding some travel time error was generated by forward modeling based on Snell's Law and travel time data was also obtained from numerical signal traces using FEM modelling. Using these travel time data, reliability of MRM was verified in the manner of comparing the results determined by MRM with the model. Finally, proposed method was applied to the real field data and it was considered as improved method for obtaining the optimum result in downhole seismic method.

• The Korean Journal of Applied Statistics
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• v.33 no.2
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• pp.137-145
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• 2020

Phase I clinical trials (Dose Finding Studies) are the first step in administering new drugs developed through animal experiments or in vitro experiments to humans. An important area of interest in designing Phase I clinical trials is determining the dose that provides the greatest efficacy and acceptable safe dose to the patient. In this paper, we propose a method to determine the maximum tolerated dose considering efficacy and safety using Biased coin design and stopping rule. The proposed method is compared with existing methods through simulation.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.10a
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• pp.311-314
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• 2003

This paper describes a virtual instrument system with faulty sensor reconstruction mechanism based on personal computer. This system consists of sensor control board using 16bit RISC machine, error signal reconstruction algorithm based on principal component analysis and auto tunned GUI interface according to the attached sensors. USB module is used for fast communication between PC and sensor controller. To show the veridity of the proposed system, the proposed system was applied to the developed sun tracker with 8 solar sensors.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.4
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• pp.489-496
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• 2019

This paper is a study on the evaluation of loss factor of damping treatment materials to reduce the noise and vibration for panels of railway vehicles and automobiles. In order to determine the modal parameters of damping materials, beam excitation tests were carried out using different type PVC coated aluminum and steel base beam specimens. The specimens were excited from 10 Hz to 1000 Hz frequency range using sinusoidal force, and transfer mobility data were measured by using an accelerometer. The loss factors were determined by using integrated program, based on theories of Half Power Method, Minimum Tangent Error Method, Minimum Angle Error Method and Phase Change Method, which enable to evaluate the parameters using modal circle fit and least squares error method. In the case of lower loss factor and data of linear characteristics, any method could be applied for evaluation of parameters, however the case of higher loss factor or data including non-linear characteristics, the minimum angle error method could reduce the loss factor evaluation. The obtained dynamic properties of the coating material could be used for application of Finite Element Method analyzing the noise control effects of complex structures such as carbody or under-floor boxes of rolling stock. The damping material will be very useful to control the structural noise, because the obtained modal loss factors of each mode show very good effect on over $2^{nd}$ mode frequency range.

• Journal of the Korean Geosynthetics Society
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• v.14 no.2
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• pp.89-94
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• 2015

In this study, the mixed soil with an optimum mixed ratio was suggested in order to recycle the powdered sludge of basalt in Jeju Island as the impermeable liner materials. As the results of soil laboratory tests, the grain size of the powdered sludge of basalt is less than 0.1mm and the powdered sludge was classified into ML or CL category in accordance with the Unified Soil Classification System (USCS). Also, the grain size of natural soils is ranged from 0.1 mm to 10 mm and the soils were classified into SW category in USCS. To select the optimum mixed ratio of powdered sludge, the variable permeability test was performed to various mixed soils with different powdered sludge amount under both optimum compaction and field conditions. As the results of permeability tests, the coefficient of permeability of mixed soils was decreased with increasing the mixed ratio of powdered sludge, and the mixed soil with mixed ratio of 60% has the minimum coefficient of permeability. Therefore, the optimum mixed ratio of powdered sludge is 60% for recycling the powdered sludge of basalt as the impermeable liner materials.

• The Korean Journal of Pesticide Science
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• v.8 no.1
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• pp.22-29
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• 2004

To evaluate mutagenicity of Phosphinotricin Acetyltransferase(PAT) which is expressed by the glufosinate-resistance gene pat, in vitro reverse mutation test using Salmonella typhimurium, chromosome aberration test using chinese hamster lung(CHL) cells and in vivo micronucleus test of mice were performed. In the reverse mutation, the PAT did not induce mutagenicity in Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537 with and without metabolic activation at $5000{\mu}g/plate$. In the chromosome aberration test, the results showed no incidence of increased structural and numerical chromosome aberrations at any doses tested(100, 10, $1{\mu}g/mL$). In micronucleus test, the ratio of micronuclei was measured in polychromatic erythrocytes of bone marrow of male ICR mice intraperitoneally administrated with PAT(1250, 625, and 313 mg/kg), the results showed no incidence of increased micronucleated polychromatic erythrocytes (MNPCE). These results indicate that PAT might not have mutagenic potential in vitro and vivo systems.