• Journal of Acupuncture Research
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• 제18권6호
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• pp.240-249
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• 2001

Obejective : Based on ${\ll}$sixty-ninth Nan${\gg}$ (${\ll}$難經${\cdot}$六十九難${\gg}$) the interpromoting of the five element's balance method to discuss following 'when deficiency than should strengthen mother and when excessive than eliminate son' theories. Method : This strengthening and eliminating method is based on Jang-bu organ's balance method when 'east is excessive (liver excessive (肝實 )) and west is deficiency (lung deficiency (肺虛))' then 'eliminate the south and strengthen the north's method. Results : The seventy-fifth Nan (${\ll}$難經${\cdot}$七十五難${\gg}$) explains' son effects mother's excessive and mother effects son's deficiency' theory where it balance method of the inter-overacting five elements controlling Jang-bu organ's differentiations. The eighty-first Nan (${\ll}$難經${\cdot}$八十一難${\gg}$) explains strengthening-eliminating method of 'lung excessive and liver deficiency.' Since there are two different perspective of seventy-fifth and eighty-first Nan, we must compare and discuss to make right point of view. Conclusion : the treatment method in ${\ll}$Nan kyoung sixty ninth nan${\gg}$ could be understood as a view of five element constitutional theory (五行體質理論), the treatment method in ${\ll}$Nan kyoung seventyty-fifth nan${\gg}$ of eleminating fire and strengthning water in case of liver excess and lung defficiency and the treatment method in ${\ll}$Nan kyoung eighty-first nan${\gg}$ of strengthning liver and eleminating lung in case of lung excess and liver defficiency could be understood as a view of the yin-yan constitutional theory (陰陽體質理論).

• Journal of Acupuncture Research
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• 제18권6호
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• pp.250-263
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• 2001

Objective : I refered to oriental medical records to study on the use Ohaeng-acupuncture through compared ${\ll}$Classic on Difficulty${\gg}$ with . Methods : The original text about ${\ll}$Classic on Difficulty${\gg}$ was used ${\ll}$Nan Jing Ben YI${\gg}$, annotations were excerpted and record that were necessary for this study. The structural formula was composed together to compare ${\ll}$Classic on Difficulty${\gg}$ with . Results : ${\ll}$Classic on Difficulty${\gg}$ deals with fundamental medical theories and gives differentiation of syndromes of some diseases in the form of questions and answers. ${\ll}$The Sixty nineth Difficulty, Classic on Difficulty${\gg}$ 'Xu Ze Bu Qi Mu(虛者補其母), Shi Ze Xie Qi Zi (實者瀉其子)' that united ${\ll}$Ling Shu(靈樞) - Jing Mai(經脈篇)${\gg}$ 'Sheng Ze Xie Zhi(盛則瀉之) Xu Ze Bu Zhi(虛則補之)' with Ohaeng-xiangsheng theory is the base of the 'Bu Xie (補瀉)'. ${\ll}$The seventy fifth Difficulty, Classic on Difficulty${\gg}$ 'Xie Nan Huo (瀉南方火) Bu Bei Shui (補北方火)' that based Ohaeng-xiangke theory and the 'Qu Xue(取穴)' takes the form of the 'Bu Mu Xie Zi (補母瀉子)' in standard of internal organs which are etiologic al cause named 'Shi(實)'.

• Journal of Acupuncture Research
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• 제19권5호
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• pp.1-9
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• 2002

Objective : The study of relations between twelve meridians and pulse diagnosis Method : The possiblity of pulse diagnosis on the pulse points(脈動處) of each meridian through the scription of $\ll$Maek beop(脈法)$\gg$ $\ll$Nae kyeong(內經)$\gg$ and $\ll$Nan kyeong(難經$\gg$ Result : The comparative pulse diagnosis method(比較脈診法) in the scription of $\ll$Mack beop$\gg$ progressed to the five Jang bu maek(五臟脈) in the scription of $\ll$Young chu : Sa gi jang bu byeong hyeong(靈樞 邪氣臟腑病形)$\gg$ in accordance with the progress of pulse diagnosis and the theory of medicine. Conclusions : The comparative pulse diagnosis method in the scription of $\ll$Mack beop)$\gg$ progressed to the five Jang bu maek(五臟脈) in the scription of $\ll$Young chu : Sa gi jang bu byeong hyeong$\gg$ and the moxibustion and Pyum bup(貶法) in the scription of $\ll$Mack beop$\gg$ altered to acupuncture therapy on the five shu points(五輸穴)

• Journal of Acupuncture Research
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• 제19권4호
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• pp.124-131
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• 2002

Objective : The purpose of this study is to research for the formation of Ohaeng-acupuncture. Methods : I refered to ${\ll}$Classic on Difficulty${\gg}$ (難經), ${\ll}$Ling Shu${\gg}$ (靈樞), ${\ll}$Zhen Jiu Ju Ying${\gg}$ (針灸聚英), ${\ll}$Yi Xue Ru Men${\gg}$ (醫學入門) and annotations were excerpted and record that notied the Ohaeng-acupuncture. Results : The results obtained as follows. 1. ${\ll}$Ling Shu${\gg}$ "Sheng Ze Xie Zhi, Xu Ze Bu Zhi"(盛則瀉之, 虛則補之) united with "Ying Sui Bu Xie"(迎隨補瀉), developed the principle of "Qu Xue" in ${\ll}$Classic on Difficulty${\gg}$. 2. ${\ll}$Classic on Difficulty${\gg}$ explained the interdependent relations, interrestraining relations, the relations of subjugation and reverse restriction in illness condition between the five viscera according to the theory of generation, restriction, subjugation and reverse restriction in five elements. ${\ll}$Classic on Difficulty${\gg}$ united five shu points (五兪穴) with five elements. 3. Zi jing Bu xie according to Xiang Sheng theory is develped from ${\ll}$Classic on Difficulty${\gg}$ "Xu Ze Bu Qu Mu, Shi Ze Xie Qi Zi"(虛則補其母 實則瀉其子) to ${\ll}$Classic on Difficulty${\gg}$ , ${\ll}$Zhen Jiu Ju Ying${\gg}$. 4. Ta jing Bu xie according to Xiang Sheng theory is develped from ${\ll}$Tu Zhu Nan Jing${\gg}$ to ${\ll}$Yi Xue Ru Men${\gg}$. 5. The principle of treatment according to Zi-Ta jing Bu xie based Xiang Ke is develped from ${\ll}$The seventy fifth Difficulty Classic on Difficulty${\gg}$ to Sa Am Do In(舍岩道人).

• Journal of Acupuncture Research
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• 제21권1호
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• pp.1-20
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• 2004

Pulse-feeling took its origin from making a diagnosis along meridians in the course of discovering and forming meridians and for a long time its meaning was mixed with meridians in the course of recognizing "The Pulse" then was separated from meridians in the early days of Western Han Dynasty. Ancient pulse-feeling methods are pulse-feeling method by the twelve regular meridians, pulse-feeling method by three regions and nine modes, pulse-feeling method by Inyeong(人迎) and Chon-gu(寸口), etc. Pulse-feeling was changed in proportion to diagnostic purpose and method of treating and if method and region of pulse-feeling is arranged, we will infer correlation between meridians and pulse-feeling and will infer transitional system of past pulse-feeling and will forecast transition of future pulse-feeling. As the result that I study the transition of the above three pulse-feeling methods of meridians diagnosis: 1. Three pulse-feeling methods of meridians diagnosis flowed into diagnostic method by taking pulse of setting six region for Chon(寸), Gwan(關) and Cheok(尺), i.e. the Chon[寸] spot pulse of $\ll$Nan-gyeong$\gg$ and were changed into diagnostic method being fit for use of five Su points, The Front-Mo points and Back-Su points that grasp the pathology of mutual internal organs and treat the disease. 2. Today it is suggesting the transition of another pulse-feeling method that do not apply diagnostic method by taking pulse of setting six region for Chon(寸), Gwan(關) and Cheok(尺), i.e. the Chon[寸] spot pulse of $\ll$Nan-gyeong$\gg$ to 19C Sasang(四象) Constitutional Medicine or 20C Eight Constitutional Medicine.

• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9295-9300
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• 2014

Interleukin-17A (IL-17A) is a multifunctional cytokine which plays a crucial role in the initiation and progression of cancer. To date, several studies have investigated associations between IL-17A -197G>A (rs2275913) polymorphism and digestive cancer risk, but the results remain conflicting. We here aimed to confirm the role of this single nucleotide polymorphism (SNP) in susceptibility to digestive cancer through a systemic review and meta-analysis. Ten eligible case-control studies were identified by searching electronic databases, involving 3,087 cases and 3,815 controls. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to estimate the strength of the association. The results of overall analyses indicated that the variant A allele was associated with an increased risk of digestive cancer (AA vs GG: OR=1.51, 95%CI=1.18-1.93; AA vs GG+GA: OR=1.45, 95%CI=1.12-1.87; A vs G: OR=1.21, 95%CI=1.05-1.39). In subgroup analysis stratified by specific cancer type, elevated risk among studies of gastric cancer was found (AA vs GG: OR=1.68, 95%CI=1.24-2.28; AA vs GG+GA: OR=1.62, 95%CI=1.16-2.26; A vs G: OR=1.23, 95%CI=1.04-1.46). According to ethnicity, there was evidence in the Asian populations for an association between this polymorphism and cancer risk (GA vs GG: OR=1.19, 95%CI=1.05-1.36; AA vs GG: OR=1.56, 95%CI=1.15-2.12; AA+GA vs GG: OR=1.28, 95%CI=1.13-1.44; AA vs GG+GA: OR=1.42, 95%CI=1.01-2.00; A vs G: OR=1.24, 95%CI=1.08-1.44), while in the Caucasian populations an association was found in the recessive model (AA vs GG+GA: OR=1.62, 95%CI=1.17-2.24). In conclusion, the results of this meta-analysis suggest that the IL-17A -197G>A polymorphism contributes to an increased risk of human digestive cancer, both in the Asian and Caucasian populations and especially for gastric cancer.

• Journal of Acupuncture Research
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• 제20권6호
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• pp.103-119
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• 2003

Below are the reports arranged from the research of ${\ll}$XiFangZiMingTangJiuJing(西方子明堂灸經)${\gg}$, which appears in the research of the main issue. ${\ll}$XiFangZiMingTangJiuJing${\gg}$ was written during the Nan-song period, approximately between 1142~1194, and was probably completed between 1142~1148. This book is the very first book specific on the moxibustion theory which exists these days and also thoroughly contains the moxibustion theory. So it contains many documents of the moxibustion theory which are missing these days. Also it's possible that the illustration presented in this book followed ${\ll}$MingTangJing(明堂經)${\gg}$ of SunSiMiao(孫思邈). The way of arranging the GuiJing(歸經) of YuZue(兪穴) and deciding the location of acupuncturing(穴位) differs from reports given by other documents. As seen above, ${\ll}$XiFangZiMingTangJiuJing${\gg}$ has a consulting value on the moxibustion theroy(灸法), both in clinic and the research of documents. So we are looking forward that there would be a more profound research continuing in the future.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6685-6690
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• 2015

Background: Genetic studies have shown a possible relationship between the rs16969968 polymorphism in CHRNA5 and the risk of lung cancer. However, the results have been conflicting. Thus we rigorously conducted a meta-analysis to clarify any association. Materials and Methods: A total of 10 case-control studies involving 17,962 lung cancer cases and 77,216 control subjects were analysed. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to measure the strength of the association. Results: We found the CHRNA5 rs16969968 polymorphism to be associated with the risk of lung cancer (AA vs GG: OR=1.60, 95%CI=1.51-1.71). On stratified analysis by smoking status, a statistically significant increased risk was observed in the smoking group (AA vs GG: OR=1.80, 95%CI=1.61-2.01). However, this polymorphism was not associated with lung cancer risk in Asians (AA vs GG: OR=0.95, 95%CI=0.35-2.59), whereas it was linked to increased risk of lung cancer among Caucasians (AA vs GG: OR=1.65, 95%CI=1.55-1.76). Conclusions: Our meta-analysis provided statistical evidence for a strong association between rs16969968 polymorphism and the risk of lung cancer, especially in smokers and Caucasians. Application of this relationship may contribute to identification of individuals at high risk of lung cancer and indicate a chemoprevention target.

• Journal of Acupuncture Research
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• 제20권1호
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• pp.1-12
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• 2003

Objectives : The purpose of this study is to compare Xingjian(LR2) Shaofu(HT8) with Dadun(LR1) Shaofu(HT8) on Blood Pressure in Hypertensive RAT induced by Two Kidney One Clip(2KIC). Methods : This experiments was to investigate the effects of LR2 HT8(originated from ${\ll}$Classic on Difficulty${\gg}$ Shi Ze Xie Qi Zi), LR1 HT8(originated from ${\ll}$Ling Shu${\gg}$ Sheng Ze Xie Zhi) acupuncture on the blood pressure, cardiomegalic index, and plasma levels of atrial natriuretic peptide in hypertensive rat induced by 2K1C. Results: 1. Blood pressure was decreased significantly after third acupuncture of LR2 HT8. 2. Blood pressure was decreased significantly after acupuncture of LR2 HT8, but was increased after LR2 HT8. 3. Cardiomegalic index was not changed after acupuncture of LR2-HT8 and LR1-HT8 4. Plasma levels of atrial natriuretic peptide was increased significantly after acupuncture of LR2 HT8 but LR1 HT8 was not changed.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7515-7520
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• 2014

Many studies have indicated possible associations between a polymorphism of adiponectin receptor 1 (ADIPOR1) rs1342387 and risk of cancer, but contradictory results have been reported. The main aim of this study was to draw a reliable conclusion about the relationship between the rs1342387 polymorphism and cancer incidence, by conducting a literature search of Pubmed, Embase, Wanfang and Cochrane libraries. Eleven studies including 3, 738 cases and 4, 748 controls were identified in this meta-analysis. The ADIPOR1 rs1342387 polymorphism was associated with risk of colorectal cancer for all genetic comparison models (GG vs AA, OR: 1.44, 95%CI: 1.21-1.70; G carriers vs A carriers, OR: 1.23, 95%CI: 1.11-1.36; dominant model, OR: 1.28, 95%CI: 1.10-1.49 and recessive model, OR: 1.31, 95%CI: 1.12-1.55). Stratified by ethnicity, the rs1342387 polymorphism was significantly associated with risk of colorectal cancer in Asian ancestry for all genetic comparison models (GG vs AA, OR: 1.56, 95%CI: 1.26-1.92; G carriers vs. A carriers OR: 1.30, 95%CI: 1.18-1.43; dominant model OR: 1.31, 95%CI: 1.08-1.60 and recessive model OR: 1.44, 95%CI: 1.26-1.64), but not in Caucasian or mixed (Caucasian mainly) groups. In summary, the ADIPOR1 rs1342387 polymorphism is significantly associated with risk of colorectal cancer among individuals of Asian ancestry.