• 대한화학회지
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• 제30권2호
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• pp.188-194
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• 1986

에탄올-물 혼합용매내에서 p-클로로 염화벤질의 가용매분해반응에 대한 속도상수를 압력 1~1,600bar, 온도를 30${\circ}$, 40${\circ}$C 에서 측정하였다. 반응속도들은 온도와 압력이 증가함에 따라 증가하고, 에탄올 몰 분율이 증가함에 따라 감소하였다. ln k대 압력의 플로트는 압력에 따라 이차함수꼴로 변함을 알았고, 이 플로트로부터 ${\Delta}V^{\neq}$와 ${\Delta}{\beta}^{\neq}$의 값을 얻었다. 그 결과 ${\Delta}V^{\neq}$와 ${\Delta}{\beta}^{\neq}$의 값은 약 0.20몰 분율에서 Extremum behavior가 나타남을 알았다. 이 현상을 용매구조 변화로 논의하였다. ln k대 용매파라미터, q 및 ln $C_w$의 플로트사이의 관계로부터 본 연구의 반응은 $S_N1(2)$메카니즘으로 진행됨을 추정할 수 있었다.

• KSBB Journal
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• 제13권1호
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• pp.77-82
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• 1998

미생물 효소에 의해 생산된 생산모액 내의 글루타치온(L-${\gamma}$-glutamyl-L-cysteinylglycine, GSH)을 액체크로마토그래피를 이용하여 분리하였다. GSH와 결합하는 수지를 선택하기 위해 여러 수지와 GSH 수용액을 사용하여 회분식 흡착실험을 한 결과, pH 8.0에서 음이온 교환수지인 Q-sepharose와 QAE- sephadex에 GSH가 결합하였으나, QAE-sephadex는 수지와 결합된 GSH를 이탈시키기 위해 사용된 salt에 의해 부피가 줄어들어 부적합하였다. GSH 분리를 위한 기초실험을 위하여 GSH, cysteine, glutamate, glycine, $\gamma$-glutamylcysteine, ATP, glucose의 혼합액에서 GSH와 $\gamma$-glutamylcysteine를 다른 물질로부터 1차 분리할 수 있었다. NaCl의 농도를 조절하여 두 물질이 중첩되는 현상을 제거하여 분리하고자 하였으며, GSH의 tailing현상을 줄이도록 노력하였다. NaCl(35mM)을 용해시킨 Tris buffer를 사용함으로써 두 물질의 분리가 가능하였고, 생산모액을 사용하여 실험한 결과, 혼합 시료와 유사한 분리결과를 얻을 수 있었다. Standard solution에서의 GSH 분리결과 72.6%의 회수율을 보였으며, 생산 모액에서는 84.4%의 회수율을 각각 보였다.

• 한국환경농학회지
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• 제24권1호
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• pp.17-23
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• 2005

한정된 수질자료를 이용 오염부하 산정시 집중적으로 많은 샘플을 채취한 경우에 비해 어느 정도 차이를 갖는지를 규명하는 것은 모니터링에 따른 오염부하량 산정결과의 신뢰범위 파악뿐만 아니라 경제적인 수질 샘플 채수빈도 수립에 곡 필요할 것으로 사료된다. 그 결과를 요약하면 다음과 같다. 논에서의 강-은유출시 채수 빈도가 오염부하 산정에 미치는 영향을 파악하기 위해 9개의 강우사상에 대해 2시간 간격으로 연속 수질샘플을 실시하여 분석한 결과 전체적으로 강우-유출과정 중 T-N, T-P, SS 농도는 시간별로 증 감변동을 하였으나 유량과의 상관성은 나타나지 않았다. 수질샘플 횟수에 의한 영향은 강우-유출과정 중 5회 정도 샘플을 실시하면 많은 수의 샘플을 채수한 경우에 비해 T-N ${\pm}15.2%$, T-P는 $-20.0{\sim}26.2%$, SS는 $-28.6{\sim}35.7%$ 범위안에서 오염부하를 추정할 수 있는 것으로 나타났으며, 차이범위가 ${\pm}10%$ 내에 들어가기 위한 샘플수는 일주기 조사시 T-N, T-P의 경우는 6회, SS의 경우는 단기유출시는 4회 정도 실시하면 되고, 장기 유출시에는 11회 정도 실시하면 되는 것으로 조사되었다. 유량-유하부하량 관계식에서 ${\pm}10%$내의 차이를 보일 샘플횟수는 T-N의 경우는 6회 이상, T-P와 SS는 9회 이상 정도 실시하면 되는 것으로 조사되었다.

• 수산해양기술연구
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• 제28권2호
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• pp.184-190
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• 1992

The combustion characteristics, ignition delay, p-t, dp/dt, Q-t of diesel oil and fish oil blended diesel oils was investigated according to pressure and temperature in a constant volume combustion bomb. The results are as follows: 1) The influence of temperature and pressure on the ignition delay was almost constant in high temperature, regardless of the blending rates, and the ignition delay was shortest in the 60% blend. 2) The maximum pressure was high in order of with pure diesel oil, with the 20% blend and the 60% blend. 3) The rate of pressure rise was high in order of with pure diesel oil, with the 20% blend and the 60% blend. The rate of maximum pressure rise was significantly higher with pure diesel oil than with two blends. 4) The amount of accumulative heat release was large in order of with pure diesel oil, with the 20% blend and the 60% blend.

• Journal of Power Electronics
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• 제18권6호
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• pp.1751-1759
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• 2018

This paper presents parallel-connected inverters to achieve accurate proportional power sharing. Due to line impedance mismatch, reactive power cannot be distributed proportionally when using the conventional $P-{\omega}$ and $\mathcal{Q}-E$ droop. In order to realize reactive proportional power sharing, the ratio of the droop coefficients should be inversely proportional to their power-sharing ratios. Meanwhile, the ratio of the line impedance should be inversely proportional to the desired power-sharing ratio, which is very difficult to be met in practice. In order to deal with this issue, a practical control strategy is presented. By measuring the PCC voltage and using the virtual impedance, the output impedance of individual inverters is reconstructed to counteract the line impedance effect. In order to guarantee system stability, a low pass filter is designed to suppress the bandwidth of the line compensation. Finally, the simulation and experimental results are given to verify the effectiveness of the proposed control strategy.

• 대한수학회보
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• 제57권4호
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• pp.1061-1073
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• 2020

In this paper, the expressions of meromorphic solutions of the following nonlinear complex differential equation of the form $$f^n+Qd(z,f)=\sum\limits_{i=1}^{3}pi(z)e^{{\alpha}_i(z)}$$ are studied by using Nevanlinna theory, where n ≥ 5 is an integer, Q_d(z, f) is a differential polynomial in f of degree d ≤ n - 4 with rational functions as its coefficients, p₁(z), p₂(z), p₃(z) are non-vanishing rational functions, and α₁(z), α₂(z), α₃(z) are nonconstant polynomials such that α'₁(z), α'₂(z), α'₃(z) are distinct each other. Moreover, examples are given to illustrate the accuracy of the condition.

• 한국전기전자재료학회논문지
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• 제19권12호
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• pp.1118-1122
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• 2006

In this study, in order to develop the low temperature sintering multilayer piezoelectric actuator, PMN-PNN-PZT system ceramics were manufactured and their microstructure, ferroelectric and piezoelectric properties were investigated. By increasing sintering temperature, remanent polarization$(P_r)$ was increased due to the increase of sinterability and grain size. However, coercive $field(E_c)$ showed an opposite tendency to remanent polarization owing to the feasibility of domain wall motion. At the sintering temperature of $900^{\circ}C$, dielectric $constant({\varepsilon}_r)$, electromechanical coupling $factor(k_p)$, piezoelectric $constant(d_{33})$ and mechanical quality $factor(Q_m)$ showed the optimal value of 1095, 0.60, 363 and 1055, respectively, for multilayer piezoelectric actuator application.

• 한국농공학회지
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• 제43권6호
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• pp.163-173
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• 2001

This study describes the characteristics of concentrations of pollutants such as total nitrogen(T-N), total phosphorous(T-P), and chemical oxygen demand(COD) at paddy areas during 2-year irrigation periods. The most common order in average concentrations of T-P and COD is podded water > irrigation(or drainage) water > percolated water. Most of pollutants concentrations in drainage water are lower than those in irrigation water after early July due to large uptake of pollutants by rice crop and denitrification. The exponential L (load)-Q(discharge) equations for classified irrigation periods are significant at 0.001 level for irrigation and drainage waters. For drainage water, the concentrations of T-N and COD slightly decrease with discharge, while the T-P concentrations slightly increase with discharge.

• 한국수산과학회지
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• 제22권1호
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• pp.41-47
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• 1989

Using computer simulated irregular waves, variations of ocean wave statistics according to sea state are analyzed, and the reasonable conditions that transform the energy spectrum to individual wave statistics are discussed. Ocean wave statistics varying with sea state are found to respond linearly to the spectral peakedness parameter $Q_p$ and spectrum moments $m_n$ (n = 0, 1, 2${\cdots}{\cdots}\;\infty$ ). It is clarified that the 2nd-order spectrum moment is a reasonable parameter which represents the wave statistics including wave periods, and that the spectrum analysis should be carried out under the conditions of minimum data length of 10 times of peak period $T_p$ with time lag of $7T_p$ to satisfy the stable condition of wave statistics.

• 한국임상약학회지
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• 제26권4호
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• pp.312-317
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• 2016

Objective: Midazolam is mainly metabolized by cytochrome P450 (CYP) 3A. Inhibition or induction of CYP3A can affect the pharmacological activity of midazolam. The aims of this study were to develop a population pharmacokinetic (PK) model and evaluate the effect of CYP3A-mediated interactions among ketoconazole, rifampicin, and midazolam. Methods: Three-treatment, three-period, crossover study was conducted in 24 healthy male subjects. Each subject received 1 mg midazolam (control), 1 mg midazolam after pretreatment with 400 mg ketoconazole once daily for 4 days (CYP3A inhibition phase), and 2.5 mg midazolam after pretreatment with 600 mg rifampicin once daily for 10 days (CYP3A induction phase). The population PK analysis was performed using a nonlinear mixed effect model ($NONMEM^{(R)}$ 7.2) based on plasma midazolam concentrations. The PK model was developed, and the first-order conditional estimation with interaction was applied for the model run. A three-compartment model with first-order elimination described the PK. The influence of ketoconazole and rifampicin, CYP3A5 genotype, and demographic characteristics on PK parameters was examined. Goodness-of-fit (GOF) diagnostics and visual predictive checks, as well as bootstrap were used to evaluate the adequacy of the model fit and predictions. Results: Twenty-four subjects contributed to 900 midazolam concentrations. The final parameter estimates (% relative standard error, RSE) were as follows; clearance (CL), 31.8 L/h (6.0%); inter-compartmental clearance (Q) 2, 36.4 L/h (9.7%); Q3, 7.37 L/h (12.0%), volume of distribution (V) 1, 70.7 L (3.6%), V2, 32.9 L (8.8%); and V3, 44.4 L (6.7%). The midazolam CL decreased and increased to 32.5 and 199.9% in the inhibition and induction phases, respectively, compared to that in control phase. Conclusion: A PK model for midazolam co-treatment with ketoconazole and rifampicin was developed using data of healthy volunteers, and the subject's CYP3A status influenced the midazolam PK parameters. Therefore, a population PK model with enzyme-mediated drug interactions may be useful for quantitatively predicting PK alterations.