• Korean Journal of Radiology
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• v.22 no.10
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• pp.1719-1729
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• 2021

Objective: Emphysema and small-airway disease are the two major components of chronic obstructive pulmonary disease (COPD). We propose a novel method of quantitative computed tomography (CT) emphysema air-trapping composite (EAtC) mapping to assess each COPD component. We analyzed the potential use of this method for assessing lung function in patients with COPD. Materials and Methods: A total of 584 patients with COPD underwent inspiration and expiration CTs. Using pairwise analysis of inspiration and expiration CTs with non-rigid registration, EAtC mapping classified lung parenchyma into three areas: Normal, functional air trapping (fAT), and emphysema (Emph). We defined fAT as the area with a density change of less than 60 Hounsfield units (HU) between inspiration and expiration CTs among areas with a density less than -856 HU on inspiration CT. The volume fraction of each area was compared with clinical parameters and pulmonary function tests (PFTs). The results were compared with those of parametric response mapping (PRM) analysis. Results: The relative volumes of the EAtC classes differed according to the Global Initiative for Chronic Obstructive Lung Disease stages (p < 0.001). Each class showed moderate correlations with forced expiratory volume in 1 second (FEV₁) and FEV₁/forced vital capacity (FVC) (r = -0.659-0.674, p < 0.001). Both fAT and Emph were significant predictors of FEV₁ and FEV₁/FVC (R² = 0.352 and 0.488, respectively; p < 0.001). fAT was a significant predictor of mean forced expiratory flow between 25% and 75% and residual volume/total vital capacity (R² = 0.264 and 0.233, respectively; p < 0.001), while Emph and age were significant predictors of carbon monoxide diffusing capacity (R² = 0.303; p < 0.001). fAT showed better correlations with PFTs than with small-airway disease on PRM. Conclusion: The proposed quantitative CT EAtC mapping provides comprehensive lung functional information on each disease component of COPD, which may serve as an imaging biomarker of lung function.

• Journal of Plant Biotechnology
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• v.37 no.1
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• pp.89-95
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• 2010

Dihydroflavonol 4-reductase (DFR) is a key enzyme of the flavonoid biosynthesis pathway which catalyses the NADPH-dependent reduction of 2R,3R-trans-dihydroflavonols to leucoanthocyanidins. In this study we describe cloning and expression of the genes encoding the flavonoid-biosynthetic enzyme DFR in Gypsophila paniculata L. Inspection of the 1279 bp long sequence revealed an open reading frame 1063 bp, including a 36 bp 5' leader region and 181 bp 3' untranslated region. Comparison of the coding region of this DFR cDNA sequence including the sequences of Arabidopsis thaliana, Citrus sinensis, Dianthus caryophyllus, Ipomoea batatas, Matthiola incana, Nierembergia sp, Petunia hybrida, Solanum tuberosum, Vitis vinifera reveals an identity higher than 69% at the nucleotide level. The function of this nucleotide sequences was verified by comparison with amino acid sequences of the amino-terminus and tryptic peptides from purified plant enzyme, by northern blotting with mRNA from wild type and mutant plants, by in vitro expression yielding and enzymatically active reductase, as indicated by the small leucopelargonidin peak. Genomic southern blot analysis showed the presence of only one gene for DFR in Gypsophila paniculata.

• Journal of the Korean Society of Food Culture
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• v.34 no.4
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• pp.389-400
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• 2019

In this study we compared the cognitive function (Mini-Mental State Examination for Dementia Screening: MMSE-DS) and nutrient intake of elderly women with dementia in a long-term care facility (EW-LCF) and a day-time care facility (EW-DCF). This survey was conducted from July 2015 to May 2017 on 73 elderly women with dementia (47 women in LCF and 26 women in DCF) in the city of Incheon. The data obtained from interviews with the subjects and caregivers were analyzed using the SPSS 20.0. The total score of the MMSE-DS and intakes of most nutrients in the EW-LCF were significantly lower compared to the EW-DCF (p<0.05). The nutrient adequacy ratios (NAR) of protein, vitamin A, C, $B_6$, $B_{12}$, thiamin, riboflavin, niacin, folic acid, calcium and phosphorus in the EW-LCF were significantly lower compared to the EW-DCF (p<0.05). However, the indexes of nutritional quality (INQ) of vitamin C, $B_6$, thiamine, niacin, calcium, magnesium, and iron in the EW-LCF were significantly higher compared to the EW-DCF (p<0.05). As a result, the subjects showed an unbalanced and insufficient nutrition intake status regardless of the type of care facility. Most nutrient intakes of the EW-LCF with lower cognitive function were very significantly lower compared to the EW-DCF (p<0.001). Therefore, it is necessary to assess the cognitive function and nutritional status regularly at care facilities for the elderly women suffering with dementia and to provide specialized individual nutritional management.

• Journal of the Korean Ceramic Society
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• v.37 no.5
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• pp.425-431
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• 2000

Cobalt ferrite thin films on Corming glass substrate were fabricated by a sol-gel method. Cobalt ferrite thin films with the grain size of 20-35 nm and thickness of 50nm were obtained. Rapid thermal annealing (RTA) and Annealing processes were adopted for comparison of characteristics of the films. Coercivity values were changed with thermal condition and magnetization values were increased as a function of soaking time. With prolonged soaking time, however, it was decreased because of the diffusion of cations from the glass substrate. The RTA process in preparation of cobalt ferrite thin film was the effective way to prevent and to form a single spinel phase in reduced soaking time. The film heated at 600$^{\circ}C$ for 30 minutes by RTA had coercivity of 2,600 Oe, saturation magnetization 460 emu/㎤, and Mr$.$$\delta$ of 1.43 memu/$\textrm{cm}^2$.

• Journal of computational fluids engineering
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• v.13 no.2
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• pp.62-67
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• 2008

This study aims to investigate numerically the static stiffness characteristics of porous air bearing and to estimate appropriate permeability values of porous medium. In particular, a new roughness model is proposed and implemented into the commercial CFD code (FLUENT Ver. 6.2) by using C language based user subroutine. The predicted results are extensively compared with experimental data. The roughness model is also validated through comparison with the results from open literature. It is found that the predictions for static stiffness are in good agreement with experimental data. Therefore, the suggested model based on the roughness Reynolds number can be used in studying the stiffness characteristics of porous air bearing effectively. In addition, numerical simulations of various diameter size and conditions are conducted. According the results, it is expected that the static stiffness of porous air bearing has the non-linear characteristics.

• Journal of computational fluids engineering
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• v.13 no.1
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• pp.28-34
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• 2008

A particle method recognized as one of the gridless methods has been developed to investigate the nonlinear free-surface motions interacting to the structures. The method is more feasible and effective than convectional grid methods for solving the non-linear free-surface motion with complicated boundary shapes. The right-handed side of the governing equations for incompressible fluid, which includes gradient, viscous and external force terms, can be replaced by the particle interaction models. In the present study, the developed method is applied to the dam-broken problem on dried- and wet-floor and its adequacy will be discussed by the comparison with the experimental results.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.05
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• pp.402-405
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• 1997

The analysis of heart sounds is a noninvasive diagnostic method useful to diagnose heart valve function. In this paper we compared the ability of spectral analysis method for prosthetic heart valve sounds. Phonocardiograms of prosthetic heart valve were analyzed in order to derive frequency domain feature suitable for the classification of the valve state. The FFT-based methods did not provide sufficient frequency resolution to completely characterize the spectrum of prosthetic heart valve sounds. A high resolution parametric methods were shown to give superior frequency resolution. In parametric methods, all methods provide a 1st & 2nd & 3rd frequency component. But Shank method provided a most dominant frequency peak.

• Bulletin of the Society of Naval Architects of Korea
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• v.24 no.3
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• pp.35-42
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• 1987

For the analysis of natural vibrations of a rectangular stiffened plate with inner cutouts, an application of the Rayleigh-Ritz method is investigated. In construction of the trial function for the Rayleigh quotient, only the outer boundary conditions are satisfied with combination of Euler beam functions. As to the modeling of stiffened plates for the energy calculations, a lumping stiffener-effects method and the orthotropic plate analogy are considered for the purpose of comparison. Some numerical results obtained by the Rayleigh-Ritz method are compared with results by experiments and the finite element method. The following are major conclusions; (1) With the lumping stiffener-effects modeling the Rayleigh-Ritz method gives good results of both natural frequencies and mode shapes. The orthotropic plate analogy in cases of regularly stiffened plates is of restrictive use i.e. acceptable for a small cutout. (2) The natural frequency of a stiffened plate with inner cutouts between stiffeners is higher than that of without cutouts and increase as the hole area ratio increases as long as there are no discontinuous stiffeners due to the cutout.

• 한국전산유체공학회:학술대회논문집
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• 2007.10a
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• pp.258-263
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• 2007

A particle method recognized as one of the gridless methods has been developed to investigate the nonlinear free-surface motions interacting to the structures. The method is more feasible and effective than convectional grid methods for solving the non-linear free-surface motion with complicated boundary shapes. The right-handed side of the governing equations for incompressible fluid, which includes gradient, viscous and external force terms, can be replaced by the particle interaction models. In the present study, the developed method is applied to the dam-broken problem on dried- and wet-floor and its adequacy will be discussed by the comparison with the experimental results.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.1
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• pp.54.1-54.1
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• 2018

For space weather forecast, it is important to determine three-dimensional parameters of coronal mass ejections (CMEs). To estimate three-dimensional parameters of CMEs, we have developed a full ice-cream cone model which is a combination of a symmetrical flat cone and a hemisphere. By applying this model to 12 SOHO/LASCO halo CMEs, we find that three-dimensional parameters from our method are similar to those from other stereoscopic methods. For several geoeffective CME events, we determine CME mass by applying the Solarsoft procedure (e.g., cme_mass.pro) to SOHO/LASCO C3 images. CME volumes are estimated from the full ice-cream cone structure. We derive CME mean density as a function of CME height for these CMEs, which are approximately fitted to power-law functions. We find that the ICME mean densities extrapolated from the power law functions, are correlated with their corresponding ICME ones in logarithmic scales.