• Bulletin of the Korean Chemical Society
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• 제34권9호
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• pp.2663-2670
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• 2013

The purpose of stability testing is to provide evidence about how the quality of a drug varies with time under the influence of a variety of environmental factors. In this study, erythropoietin (EPO) was analyzed under different pH (pH 3 and pH 9) and temperature ($25^{\circ}C$ and $40^{\circ}C$) conditions according to current Good Manufacturing Practice (cGMP) and International Conference on Harmonisation (ICH) guidelines. The molecular weight difference between intact EPO and deglycosylated EPO was determined by SDS-PAGE, and aggregated forms of EPO under thermal stress and high-pH conditions were investigated by size exclusion chromatography. High pH and high temperature induced increases in dimer and high molecular weight aggregate forms of EPO. UPLC-ESI-TOF-MS was applied to analyze the changed modification sites on EPO. Further, normal-phase high-performance liquid chromatography was performed to identify proposed glycan structures and high pH anion exchange chromatography was carried out to investigate any change in carbohydrate composition. The results demonstrated that there were no changes in modification sites or the glycan structure under severe conditions; however, the number of dimers and aggregates increased at $40^{\circ}C$ and pH 9, respectively.

• 한국환경생태학회지
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• 제12권4호
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• pp.331-344
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• 1999

한려해상국립공원 거제도지구 산림의 군집구조 및 천이계열을 연구하기 위하여 56개 조사구(10m$\times$10m)를 설치하고 식생조사를 하였다. 56개 조사구는 TWINSPAN분석에 의하여 굴참나무-느티나무군집(I), 굴참나무-생달나무-참식나무군집(II), 곰솔-생달나무-참식나무군집(III), 곰솔-소나무군집(IV)으로 분리되었다. 거제도지역 대부분의 산림은 인위적 교란을 받은 후 형성된 맹아림과 조림식생으로 4개 군집의 평균 수령은 35~40여년이었고 $600\m^2$당 출현종수는 32~44종이었다. 또한 낙엽활엽수(굴참나무, 느티나무 등)림은 참식나무, 생달나무를 중심으로 한 상록활엽수림으로, 상록침엽수(곰솔, 소나무 등)림은 참식나무, 생달나무, 육박나무 등 상록활엽수림으로 생태적 천이가 진행되고 있었다.

• 한국농공학회지
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• 제19권2호
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• pp.4377-4384
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• 1977

The curvilinear hydrograph can be replaced by an equivalent triangular hydrograph which is more easily constructed and, for routing through reservoirs or stream channels, gives results about as accurate as those obtained using the curvilinear hydrograph. A synthetic hydrograph is prepared using the data from a number of watersheds to develop a dimensionless unit hydrograph applicable to ungauged watersheds. The dimensionless unit hydrograph for the NakDong River Basin was prepared from the unit hydrographs of a variety of nine subwatersheds. The equation for the peak rate of flow (unit volume of runoff in 1.0mm) was derived as {{{{ { q}_{p } = { 0.21AR} over { {T }_{p } } }}}} The results summarized in this study are as follows: 1) It found that the watershed lag time (Lg, hrs) could be expressed by Lg=0.253(L.Lca)0.4171 The product L.Lca is a measure of the size and shape of the watershed. Correlation coefficient for Lg was 0.97 which defined with high significance. 2) The base length of the unitgraph, in hours, was adopted as Tb=17.51+2.073Lg with high significant correlation coefficient, 0.92. 3) Time in hour from start of rise to peak rate (TP) generally occured at the position of 0.289 Tb with some indication of higher values for larger watershed. 4) Triangular hydrograph is a dimensionless unitgraph prepared from the 40 unitgraphs. The equation is shown as {{{{ { q}_{p } = { K.A.R} over { { T}_{p } } }}}}. The constant K=0.21 is defined to NakDong River basin. 5) In the light of the results analyzed in this study, average errors in the peak discharge of the Trjangular unitgraph was estimated as 5.34 percent to the peak of observed average unitgraph. Each ordinate of the Triangular unitgraph was approached closely to the observed one.

• Safety and Health at Work
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• 제14권4호
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• pp.476-482
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• 2023

Introduction: There is a growing global interest in the issue of precarious employment. We aimed to analyze the characteristics and socio-demographic distribution of precarious employment using a summative score approach. Methods: To operationalize precarious employment, we utilized data from the Korean Working Conditions Survey and focused on three distinct dimensions: employment insecurity, income inadequacy, and a lack of rights and protections. By constructing a summative scale ranging from -16 to 2, with lower scores indicating higher precariousness, we measured employment precariousness among Korean wage workers. To compare employment precariousness according to survey participant characteristics, we employed the Wilcoxon Rank Sum Test. Results: We analyzed a weighted number of 38,432 workers. The overall sample showed a median (Q1, Q3) summative scale score of -3 (-6, -1). The median summative score was lower for women compared to men (men: -2; women: -5; p < 0.001), as well as for young or older workers compared to middle-aged workers (young: -4; middle-aged: -2; older: -5; p < 0.001). Similarly, workers with lower educational levels (middle school or below: -8; high school: -5; college or above: -2; p < 0.001) and non-white collar workers (blue collar: -5; service/sales worker: -6; white collar: -2; p < 0.001) experienced higher levels of employment precariousness. Conclusion: Our findings indicate that certain vulnerable groups, such as women, young or older adults, workers with low educational attainment, and caregiving or low-skilled elementary workers, are disproportionately exposed to high employment precariousness. Active policy interventions are needed to improve the employment quality of vulnerable groups.

• 한국의류학회지
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• 제20권1호
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• pp.98-112
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• 1996

Tho purpose of this study was to investigate hygienic and comfortable properties of socks. Materials are nine summer socks either frequently being worn or new products recently introduced to market. Three female and three male adults participated in this study. Through wearing experiment, the numbers of microbes on foot and sock were counted and subjective sensation was measured. The microbes were isolated and identified based on growth physiological characteristics. Nine different socks had smaller number of bacteria of sock than that of foot. The number of bacteria of sock was significantly related with that of foot in cotton socks, in piled cotton socks, in mesh cotton socks, in cotton+ nylon+ linen blended socks, in nylon socks. Total number of bacteria of tv cut finished socks was most small and total number of bacteria was increased in the order of ultra fresh finished socks, untreated cotton socks, nylon socks, cotton + nylon+ linen blended socks, mesh cotton socks, polyester+ nylcn+ linen blended socks, piled cotton socks, cotton socks. Total number of bacteria of cotton socks and piled cotton socks were significantly different from that of uv cut finished socks. Finished socks and .jocks has high air permeability had significantly small number of bacteria. Comfortable sensation in nylon socks and polyester+nylon+linen socks was significantly uncomfortable. The way socks finished and air permeability of .jocks affected theirs hygienic property, while fiber type of them affected comfortablene, is. Bacteria identified were Staphylo coccus aureus, S. au rice larir, S. cahn ii, S. ep ids midis, S. haemo Iyticus, S. h am in 2's. S.fapraphyticus, S. warnery, 1 cinetobater calcoaceticus bio. anitratus, p.reudomonas mendocina, p. paucimobilis, Flavimonas Q ryzihabitans (CDC Group VE-2), and Xanthomanas maltophina. Fungi isolated were Spicaria sp., Thrichoderma sp., Fusarium sp., Aspergillus sp., Epicoccum sp., Cladosporium sp., and Penicillium sp..

• Toxicological Research
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• 제11권2호
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• pp.329-335
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• 1995

Incubation of aflatoxin $B_1$ $(AFB_1)$ with microsomes isolated from human liver number 110 yielded two metabolite peaks which were aflatoxin $Q_1$ $(AFQ_1)$ and $(AFB_1)$-exo-8, 9-epoxide (exo-epoxide) in high performance liquid chromatography. Production ratio of $AFQ_1$ to exo-epoxide was 2.43$\pm $0.04. Metabolism of $(AFB_1)$ to $(AFQ_1)$ and exo-epoxide was inhibited by troleandomycin in a same degree although troleandomycin was not activated as a mechanism-based inhibitor. The inhibitory effect was dependent upon either the incubation time with $(AFB_1)$ or the preincubation time before the addition of $(AFB_1)$. Incubation of troleandomycin and NADPH by the microsomes resulted in the formation of a cytochrome P 450 (P450)-metabollc intermediate (MI) complex and the level was approximately 80% of total P450 3A4 in the microsomes. This figure was similar to that of the inhibitory effect of troleandomycin on $AFB_1$ metabolism. Glutathione which was reported that it prevented the formation of MI complex in rat liver microsomes did not inhibit the formation of MI complex in human liver microsomes. These results suggested that the inhibitory effect of troleandomycin on $AFB_1$ metabolism is due to the formation of MI complex with P450 3A4. And the reaction mechanism of troleandomycin by human liver microsomes might be dlfferent from that one by rat liver microsomes.

• 한국응급구조학회지
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• 제21권1호
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• pp.17-44
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• 2017

Purpose: This study aimed to identify the effects of cardiopulmonary resuscitation (CPR) training using a meta-analysis by effect size. Methods: The effect sizes for each variable and the overall effect size for the collected data were identified. The homogeneity verification of the effect size and the difference among the average effect sizes for each mediation variable were determined. Results: The overall average effect size for CPR training was 1.747. Homogeneity verification of the overall effect size was a Q-value of 3716.962, which was statistically significant (p=.000) when${\alpha}=.05$. CPR training showed statistically significant differences depending on age (p=.002), sex (p=.006), number of trainees (p=.000), research design (p=.000), training method (p=.027), and practical training tools (p=.000). Conclusion: CPR training can effectively improve knowledge, skills, and attitudes about CPR. The results of this meta-analysis contribute to the development of more effective educational guidelines for future CPR training and the advancement of the CPR education field.

• 전기학회논문지P
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• 제52권4호
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• pp.172-178
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• 2003

This paper examines the application of high voltage static var compensator(SVC) with cascade multilevel inverter which employs H-bridge inverter(HBI). This method has the primary advantage that the number of voltage levels can be increased for a given number of semiconductor devices when compared to the conventional control methods. The SVC system is modeled using the d-q transform which calculates the instantaneous reactive power. This model is used to design a controller and analyze the SVC system. From the mathematical model of the system, the design procedures of the circuit parameters L and C are presented in this thesis. To meet the specific total harmonic distortion(THD) and ripple factor of the capacitor voltage, the circuit parameters L and C are designed. Simulated and experimental results are also presented and discussed to validate the proposed schemes.

• 대한지역사회작업치료학회지
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• 제2권1호
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• pp.85-96
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• 2012

목적 : 본 연구는 배회가 있는 치매 노인에게 신체 그룹 작업치료 참여가 인지기능, 심리행동증상 및 사회적 행동기능에 어떠한 영향을 미치는지 알아보고자 하였다. 연구방법 : 본 연구는 대전 ${\bigcirc}{\bigcirc}$요양원에 거주하고 있는 노인 중 고도의 치매(MMSE-K 9점 이하)를 가지고 있는 노인 13명을 대상으로, 2010년 7월부터 2010년 9월까지 주 1회 총 9회 실시하였다. 평가도구는 배회유형과 정도를 알아보기 위해 Algase Wandering Scale-V2를 사용하였고, 인지기능을 알아보기 위해서 인지기능 척도를 사용하였고, 심리정신행동을 알아보기 위해서 Neuropsychiatric Inventory-Questionnaire (NPI-Q)를 사용하였으며, 사회행동기능을 알아보기 위해 사회행동 척도를 사용하였다. 결과 : 대응표본 t-test를 이용하여 신체그룹 작업치료를 시행하기 전과 후를 살펴본 결과 인지도 기능손상정도와 심리행동증상은 감소되었으나, 유의한 결과(p>0.05)를 얻지는 못하였고, 사회적 행동기능, 심리행동증상의 심각정도, 배회의 정도는 유의하게 감소(p<0.05)된 것을 보여주었다. 결론 : 신체 그룹 작업치료를 한 결과 고도의 치매노인도 향상되었으며, 특히 사회적 행동기능, 심리행동증상의 정도, 배회의 정도가 향상되었음을 볼 수 있었다. 치매를 가지고 있는 노인에게도 꾸준한 치료가 필요하며, 앞으로 충분한 대상자와 대조군 그리고 치매노인의 다양한 변수를 고려한 지속적인 프로그램 개발이 필요하다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.947-952
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• 2015

The aim of this study was to evaluate the effects of grape juice on colon carcinogenesis induced by azoxymethane (AOM) and expression of NF-kB, iNOS and TNF-${\alpha}$. Methods: Forty male Wistar rats were divided into 7 groups: G1, control; G2, 15 mg/kg AOM; G3, 1% grape juice 2 weeks before AOM; G4, 2% grape juice 2 weeks before AOM; G5, 1% grape juice 4 weeks after AOM; G6, 2% grape juice 4 weeks after AOM; G7, 2% grape juice without AOM. Histological changes and aberrant crypt foci (ACF) were studied, while RNA expression of NF-kB, TNF- and iNOS was evaluated by qPCR. Results: The number of ACF was higher in G2, and G4 presented a smaller number of crypts per focus than G5 (p=0.009) and G6. Small ACF (1-3) were more frequent in G4 compared to G2, G5 and G6 (p=0.009, p=0.009 and p=0.041, respectively). RNA expression of NF-kB was lower in G3 and G4 compared to G2 (p=0.004 and p=0.002, respectively). A positive correlation was observed between TNF-${\alpha}$ and NF-kB gene expression (p=0.002). In conclusion, the administration of 2% grape juice before AOM reduced the crypt multiplicity, attenuating carcinogenesis. Lower expression of NF-kB was observed in animals exposed to grape juice for a longer period of time, regardless of concentration.