• 한국가스학회지
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• 제18권4호
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• pp.1-7
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• 2014

화학물질로부터 근로자의 건강보호를 위해 사용량이 많으나 작업환경 및 유해성 평가 자료가 부족한 gasoline에 대해 유해성(hazards)을 조사하고 국내 취급실태 및 일부 취급 사업장의 작업환경 측정을 통해 위해성(risk assessment)을 평가하였다. 연구결과 gasoline은 생식독성 추정 및 생식세포 변이원성 물질인 1B, 그리고 IARC Group 2B, ACGIH A3 물질이었다. 작업환경 측정결과는 TLV-TWA 기준 $900mg/m^3$미만이었으며, 유해성 평가결과 발암 $RfC_{(Worker)}$는 $0.3mg/m^3$, 만성흡입독성 $RfC_{(Worker)}$는 $2.7mg/m^3$, 발달독성 $RfC_{(Worker)}$는 $2.7mg/m^3$이었다. 그리고 위험도 평가에서 발암성은 459, 만성흡입독성은 51, 발달독성은 51이었으며, 이를 토대로 한 gasoline의 위험도는 1을 초과하는 물질로 평가되었다.

• 한국산업보건학회지
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• 제28권1호
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• pp.80-90
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• 2018

Objectives: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker($RfC_{worker}$) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for HCFC-123, which caused an acute hepatotoxicity incident. Methods: An acute hepatotoxicity incident due to the fire extinguishing agent HCFC-123 was investigated. Toxicological hazard and health hazard classifications were examined and a non-carcinogenicity $RfC_{worker}$ value was calculated for HCFC-123. An OEL and the necessity of legal management were recommended as well. Results and Conclusions: An OEL for HCFC-123 of 10 ppm($62.5mg/m^3$), which considered the $RfC_{worker}$ value, 5.56 ppm, produced in dose-response assessment and the exposure level of 19.1-20.9 ppm measured as an eight-hour TWA(time-weighted average) in the incident place, is recommended. HCFC-123 is urged to be included as a chemical requiring legal management in the Occupational Safety and Health Regulations. In addition, it is recommended that a peak exposure of ACGIH be adopted in the Notice of the Ministry of Employment and Labor.

• 한국산업보건학회지
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• 제29권1호
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• pp.13-20
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• 2019

Objective: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker($RfC_{worker}$) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for PHMG-Phosphate(CAS No. 89697-78-9), It is a humidifier disinfectant that generated many lung injuries. Methods: We have investigated the recommendation or guidelines of foreign OEL for PHMG-Phosphate and the actual state of legal management in Korea. To examine the procedures and methods for recommendation OEL. Toxicological hazard and health hazard classifications were examined and a non-carcinogenicity $RfC_{worker}$ value was calculated for PHMG-Phosphate. An OEL and the necessity of legal management were recommended as well. Results and Conclusions: The OEL for PHMG-Phosphate is recommended to be $0.01mg/m^3$. The recommended OEL is close to 10 times the RfCworker value of $0.000833mg/m^3$ calculated from the chemical dose-response hazard assessment, which is a 2017 study. The CMIT/MIT(3:1) mixture, which was a social issue as a humidifier disinfectant substance, was also exposed to the same ratio in March 2018, establish the OEL. It is recommended to establish OEL for PHMG-Phosphate to prevent worker health hazards and for chemical safety management.