• Title/Summary/Keyword: $RfC_{worker}$

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Working Environment and Risk Assessment of Gasoline in Workplace (Gasoline 취급 사업장의 작업환경 측정 및 위해성 평가)

  • Kim, Hyeon-Yeong
    • Journal of the Korean Institute of Gas
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    • v.18 no.4
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    • pp.1-7
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    • 2014
  • To protect the workers' health, we evaluated the hazards of gasoline which the large amounts of use and lack of information, and perform the risk assessment through the measurement of working environment. It is estimated the reproductive toxicity, and has germ cell mutagenicity class 1B, also IARC 2B, ACGIH A3 with carcinogenicity. With working environment, it is measured as below the TLV-TWA $900mg/m^3$. It is also calculated $0.3mg/m^3$ as carcinogenicity RfC (worker), $2.7mg/m^3$ as chronic inhalation toxicity RfC (worker), $2.7mg/m^3$ as developmental toxicity RfC (worker). From all of these results, it is calculated that the risks are 459, 51 and 51 as carcinogenicity, chronic inhalation toxicity and developmental toxicity, respectively. It is concluded that the risk of gasoline is evaluated over 1.

Recommendation of an Occupational Exposure Limit and Legal Control Following an Acute Hepatotoxicity Incident from HCFC-123 (HCFC-123의 급성 독성간질환 발생 사례에 따른 노출기준 및 법 관리 필요성 권고)

  • Lee, Kwon Seob;Jo, Ji hoon;Choi, Bo Kyung;Lee, Hye Lim;Byeon, Sang Hoon
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.28 no.1
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    • pp.80-90
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    • 2018
  • Objectives: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker($RfC_{worker}$) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for HCFC-123, which caused an acute hepatotoxicity incident. Methods: An acute hepatotoxicity incident due to the fire extinguishing agent HCFC-123 was investigated. Toxicological hazard and health hazard classifications were examined and a non-carcinogenicity $RfC_{worker}$ value was calculated for HCFC-123. An OEL and the necessity of legal management were recommended as well. Results and Conclusions: An OEL for HCFC-123 of 10 ppm($62.5mg/m^3$), which considered the $RfC_{worker}$ value, 5.56 ppm, produced in dose-response assessment and the exposure level of 19.1-20.9 ppm measured as an eight-hour TWA(time-weighted average) in the incident place, is recommended. HCFC-123 is urged to be included as a chemical requiring legal management in the Occupational Safety and Health Regulations. In addition, it is recommended that a peak exposure of ACGIH be adopted in the Notice of the Ministry of Employment and Labor.

Recommendation of Occupational Exposure Limit through occupational hazard assessment of PHMG-Phosphate (PHMG-Phosphate의 직업적 유해성평가를 통한 노출기준 제안 연구)

  • Lee, Hye Lim;Byeon, Sang Hoon;Lee, Kwon Seob
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.29 no.1
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    • pp.13-20
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    • 2019
  • Objective: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker($RfC_{worker}$) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for PHMG-Phosphate(CAS No. 89697-78-9), It is a humidifier disinfectant that generated many lung injuries. Methods: We have investigated the recommendation or guidelines of foreign OEL for PHMG-Phosphate and the actual state of legal management in Korea. To examine the procedures and methods for recommendation OEL. Toxicological hazard and health hazard classifications were examined and a non-carcinogenicity $RfC_{worker}$ value was calculated for PHMG-Phosphate. An OEL and the necessity of legal management were recommended as well. Results and Conclusions: The OEL for PHMG-Phosphate is recommended to be $0.01mg/m^3$. The recommended OEL is close to 10 times the RfCworker value of $0.000833mg/m^3$ calculated from the chemical dose-response hazard assessment, which is a 2017 study. The CMIT/MIT(3:1) mixture, which was a social issue as a humidifier disinfectant substance, was also exposed to the same ratio in March 2018, establish the OEL. It is recommended to establish OEL for PHMG-Phosphate to prevent worker health hazards and for chemical safety management.