• 지질공학
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• 제21권3호
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• pp.213-219
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• 2011

간척지를 대상으로 시간영역 전자 탐사를 수행하였다. 간척에 사용한 준설 토양은 인접 바다에서 채취한 해양 퇴적물 점토로서, 현재 준설층은 상부의 일부분만 고결된 상태이고, 그 하부는 점토와 해수가 혼재된 미고결 상태이다. 해양기원 퇴적 점토는 일반적으로 0.3 S/m 이상의 매우 높은 전기전도도를 갖는다. 연구지역은 암반 상부에 전도성 표토층이 두껍게 존재하는 환경으로서, TEM 탐사를 실시하여 전도성 표토층 하부에 존재하는 기반암의 공간적 분포를 파악하였다. TEM 탐사에서 사용된 송수신 배열은 $30m{\times}30$ m 동위치 송수신 배열이고, SIROTEM MK3의 이른 지연 시간대(0.050~20.575 ms)에서 TEM 반응을 측정하였다. TEM 자료에 대한 역산 결과를 시추 자료와 비교한 결과, 해성 점토로 구성된 준설층과 원지반 퇴적층의 전기비저항 값은 약 2 ${\Omega}$-m 이하로 해석된다. 퇴적층 하부에 존재하는 풍화암은 약 $10{\sim}20\;{\Omega}-m$ 범위의 전기비저항 값을 보이며, 연암은 약 70 ${\Omega}$-m 이상의 값을 갖는다. 지표로부터 풍화암까지의 심도는 26~58 m 범위이며, 풍화암의 하부에 분포한 연암의 심도는 지표로부터 46~75 m 범위를 보였다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제28권2호
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• pp.154-165
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• 2006

Objectives : It is difficult to place implants at a severely atrophied edentulous mandible because of vertical and horizontal alveolar defect. The autogenous and allogenic bone graft and guided bone regeneration are useful, but there are some limitations such as the resorption and infection of the grafted bone, and insufficiency of soft tissue. Distraction osteogenesis has recently evolved a challenging technique to overcome major draws of conventional augmentation procedures, we, therefore, report the four applications of implant placement after vertical alveolar distraction osteogenesis. Patients and Methods : Four patients(all female, mean age: $60{\pm}6$ years) with severe alveolar ridge deficiencies at their anterior mandible were treated with vertical alveolar distraction osteogenesis by intraoral device(Track 1.5, 15 mm model, KLS Martin, Tuttlingen, Germany) and placement of implants (Branemark MK III, TiUnite). After the latency periods of 5, 7, 8 days, distraction rhythm and rate were $0.5\;mm{\times}2\;times/day$ in the case of good bone quality, and $0.25\;mm{\times}3\;times/day$ in the case of poor bone quality. After consolidation periods of mean fifteen weeks, five implants for each patients were placed at the interforaminal area. Results : On average, a vertical gain of $11.38{\pm}1.38\;mm$ was obtained by distraction. And all distraction zone showed complete ossification by panoramic radiography. There were no postoperative complications other than numbness of lower lip in one case. Total twenty implants in four patients were placed and their outcomes were satisfactory. Conclusion : It is a useful method to place five implants after vertical distraction osteogenesis of the severely atrophied mandible for the implant-supported fixed prosthesis.

• 한국토양비료학회지
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• 제38권3호
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• pp.119-126
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• 2005

강원도 홍천군에 위치한 내린천 상류의 자운리는 석비레 성토지에서 대다수 영농활동을 하고 있어 강우에 의한 토양유실이 심각하게 발생하고 있다. 자운 2리와 4리의 농경지에 대해 필지별로 지료를 구축한 후 토양유실량을 RUSLE를 기준으로 평가하였으며, 허용토양유실량을 $11MT\;ha^{-1}\;yr^{-1}$로 보고, 그 이하로 낮추기 위한 최적영농관리방안을 살펴보았다. 조사결과, 토양관리가 불량하여 40% 이상의 경작지에 토양보전을 위한 적정관리가 필요한 것으로 나타났다. 관리방안의 적용이 없을 경우 발생하는 토양유실량은 자운 2리에서 평균 $15.6MT\;ha^{-1}\;yr^{-1}$, 자운 4리에서 평균 $9.0MT\;ha^{-1}\;yr^{-1}$ 이었으며, 석비레 성토지는 대부분 토양유실허용 수준을 초과하였다. 이 지역에 필요한 적정관리방안은 완충식생대, 등고선 및 부초, 승수로 및 배수로, 초생수로, 승수로, 우회수로, 사면정비, 그러고 피복작물 등이 제시되었으며, 이 지역에서 토양유실량을 허용수준 이하로 낮추기 위해 필지별로 필요한 영농관리방안의 필요량은 완충식생대 7,680 m, 등고선 및 부초 123 ha (35%), 승수로 및 배수로 201 ha (58%), 초생수로 13,880 m, 우회수로 3,860 m, 사변정비 8,365 m, 그리고 피복작물 3,492 ha (100%)인 것으로 평가되었다. 경사지 농경지의 적정관리방안의 도입은 우리나라와 같이 수계에 직접 연결된 밭이 많고 상류권에 위치하여 상수원에 영향이 우려되는 지역에서 특히 시급한 과제로 최적영농관리방안에 대한 깊은 연구와 작용이 이루어져야 하며 이러한 프로그램을 교육하고 지속적으로 감시하며 더 나은 관리방안을 찾아서 보완해 나가는 연구가 요구된다.

• Tuberculosis and Respiratory Diseases
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• 제45권5호
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• pp.1073-1081
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• 1998

원발성 폐 림프종은 매우 드문 질환으로서 대부분이 BALT기원의 저등급 B-세포 림프종으로 알려져 있다. 국내에서는 원발성 폐 림프종에 대한 연구가 미비하여 보고예가 많지는 않으나 대부분이 T-세포형 림프종이었다. 임상적인 측면에서, T-세포 림프종이 진단당시 진행된 형태로 발견되어 예후가 극히 불량한 것과는 대조적으로 저등급 B-세포 림프종은 비교적 예후가 좋은 것으로 보고되어 있다. 저자 등은 진단후 1년간의 추적 관찰기간 동안 무통성의 만성적인 임상경과를 보이는 비교적 예후가 좋은 저등급 B-세포 원발생 폐 림프종 1 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제23권4호
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• pp.324-331
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• 2001

The present study was aimed to investigate the effects of latency period on alveolar ridge distraction using the intraoral distraction device. Nine adult mongrel dogs of either sex, weighing about 15kg, were used. They were divided into 3-day, 5-day, and 7-day groups according to the latency period. The left upper and lower premolars and first molars were extracted. Twelve weeks after the extraction, an osteotomy was performed and the distraction device was applied. After the latency period, the distraction was applied at a rate of 1.2mm for 8 days. The distraction device was left in place for 2 weeks to allow consolidation and was then removed. The animals were sacrified at 8 weeks after completion of distraction and were examined macroscopically, radiographically, and histologically. After completion of the distraction, the alveolar crest protruded prominently, showing the vertical augmentation of the alveolar bone. Soft tissues were broken down after the 6th day of distraction in 3-day latency group, and premature union occurred on the 7th day of distraction in the 7-day latency group. The average distance was $9.40{\pm}0.3mm$ in 3-day latency group, $9.35{\pm}0.1mm$ in 5-day latency group, and $8.85{\pm}0.1mm$ in 7-day latency group. In the radiograph taken at 8 weeks after distraction, there was slight bone resorption around the medial and distal edges of the alveolar bone segment, and a new bone deposition was observed in the neighboring alveolar crest area in all groups. Fibrous tissues were present in a part of the buccal cortical bone area of the distraction gap, and the woven and lamellar bones were observed in the distracted gap. There were bony bridges in the distraction gap in all animals examined. These results suggest that optimal time of latency period on alveolar ridge distraction using the intraoral distraction device is about 5 days in dogs, and about 7days in human beings.

• 한국학교ㆍ지역보건교육학회지
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• 제15권1호
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• pp.105-119
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• 2014

Objectives: This study investigates the factors influencing values on life-respect among middle school students. Methods: The participants in this study were 126 students from S middle school and Y middle school, both located in Gyeongnam province. The experimental group consisted of 40 students from S middle school, Control group-Iconsisted of 39 students from S middle school, and Control group-II consisted of 47 students from Y middle school. The experimental group was provided with 12 incidences of the life-respect education program from April 1st to June 29th. One period took 45 minutes and proceeded according to a structure of introduction, development, and consolidation. The experimental group received a life-respect education program, Control group-I received health teaching, but Control group-II didn't receive any special education except what was regularly part of their curriculum. The content of the life-respect education program included the following topics: value of life-respect, respect for human life and ethics, life-respect campaign, having a healthy mind, suicide prevention, dealing with crisis, prevention of school violence, abortion and life-respect, social weak minority consideration, death, brain death, euthanasia, life cycle and task, and forest activities. Questionnaires were administered as pre and post-tests which consisted of questions regarding death anxiety, suicide risk, and values on life-respect. The pre and post-tests were analyzed with t-tests, paired t-tests, ANOVAs, and factor analyses using SPSS 18.0. Results: 1. There was a statistically significant increase in the experimental group(p<.0001) and control group-I(p<0.05) in value and attitude about life-respect. On the other hand, it was shown that there was no difference between pre and post-test in control group-II. 2. The result of examining the differences between pre and post-tests after education on values and attitudes toward life-respect using ANCOVA showed, there was a statistically significant difference (p<0.001) among the three groups. Conclusion: the life-respect education program which was conducted over 12 meeting with middle school students had an positive effect, which can be used as basic data for fostering values on life-respect. These findings indicate that the life-respect education program this study used is effective for fostering value of life-respect and decreasing suicide risk.

• Radiation Oncology Journal
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• 제19권3호
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• pp.237-244
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• 2001

목적 : 침윤성 방광암 환자를 대상으로 TURBT (Transurethral Resection of Bladder Tumor)과 유도 항암화학요법(neoadjuvant MCV chemotherapy) 후 방사선 항암화학 병용요법(cisplatin chemotherapy and radiotherapy)을 받은 환자에서 치료의 적응도, 국소 반응율, 방광 보존율과 생존율을 알아보고자 하였다. 대상 및 방법 : 1990년 10월부터 1998년 6월까지 TURBT 시행 후 병리 조직검사 상 침윤성 방광 이행상피암으로 진단 받은 병기 T2-T4, Grade II 환자 21명을 대상으로 하였다. 치료과정은 TURBT 후 4주 간격으로 2회의 유도 MCV(methotrexate, cisplatin, vinblastine) 복합 항암화학요법을 시행하고 그 후 cisplatin과 방사선 동시 병용요법을 시행하였다. 방사선치료는 $6\~15$ MV X-ray를 사용하여 하루 1.8 Gy씩 $39.6\~45\;Gy$를 전 골반에 $4\~5$주간에 걸쳐 조사하였다. 치료 종료 후 방광내시경을 통해 관해율을 판정하여 완전 관해인 경우 $1\~2$주 후 보강 방사선조사를 cisplatin과 병용하여 19.8 Gy를 시행하였다. 부분 관해인 경우 근치적 방광 절제술을 예정하였고 수술이 불가능한 경우에는 항암제 병용 강화 방사선치료를 받도록 하였다. 환자의 추적관찰기간은 $34\~67$개월로 중앙값이 49.5개월이었다. 결과 : 총 26명의 환자가 유도 항암화학요법을 위해 등록되었으며 유도 항암화학요법과 방사선 항암화학 병용요법을 완료한 환자는 21명$(81\%)$이었다. 유도 항암화학요법과 방사선 항암화학 병용요법 후 방광내시경을 통해 완전 관해 판정을 받은 환자는 21명 중 7명$(33\%)$이었고 부분 관해 환자는 14명$(67\%)$이었다. 완전 관해 환자 중 강화 항암제 병용 방사선 19.8 Gy를 받은 환자는 7명 중 6명$(85\%)$이었고, 이들 중 5명$(14\%)$은 재발 없이 방광을 보존하였다. 부분관해 환자중 1명이 근치적 방광적출술을 받았으며 3명이 TURBT와 2회의 MCV 항암요법을, 10명이 추가의 항암화학 방사선 병용요법을 받았다. 근치적 방광적출술을 받은 1명은 수술 소견상 방광 내 종양이 존재했으나 수술 후 재발이 없었다. 전체 21명의 환자중 12명$(58\%)$이 방광을 보존하면서 생존하고 있고 8명이 방광암으로 사망하였으며 1명이 다른 질병으로 사망하였다. 전체 환자의 중앙 생존기간은 27개월이며, 5년 생존율은 $55\%$ 였다. 유도 항암화학요법과 항암제 방사선치료 후 완전 관해 환자의 경우 5년 생존율은 $80\%$, 부분 관해 환자 $14\%$로 의미 있는 차이를 보였다(p=0.001). 유도 항암화학요법과 항암제 병용 방사선치료를 받은 환자에서 grade 3 이상의 혈액학적 부작용의 빈도는 각각 백혈구 감소증 6명$(29\%)$, 혈소판 감소증 1명$(4\%)$이었으며 이로 인한 화학요법의 지연은 1명$(4\%)$에서 관찰되었다. 결론 : 침윤성 방광암 환자에서 유도 항암화학요법 및 항암제 병용 방사선치료를 적용하여 방광 보존을 및 5년 생존율에 있어 만족할 만한 결과를 얻었다. 완전한 TURBT와 유도 MCV 항암요법과 cisplatin 방사선 병용요법에서 완전관해 여부가 방광보존가능성과 생존율에 영향을 미치는 요소로 생각되고 만약 완전관해를 이루지 못하면 근치적 방광적출술을 시행하는 것이 바람직할 것이다.

• The Korean Journal of Ecology
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• 제27권3호
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• pp.165-171
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• 2004

상수리나무 뿌리의 분해율과 분해과정에 따른 영양염류의 변화를 조사하였다. 33개월경과 후 뿌리의 분해율은 직경 0.2㎝ 미만(R₁), 0.5∼1㎝(R₂), 1∼2㎝(R₃), 2∼4㎝(R₄)가 각각 49.6%, 47.5% 66.4%, 66.1%, 분해상수 k는 각각 0.249/yr, 0.234/yr, 0.397/yr, 0.393/yr로 직경이 큰 것의 분해율이 높았다. 상수리나무 뿌리는 유사한 직경의 상수리나무 가지에 비해 분해가 빠른 것으로 나타났다. 분해 과정에 따른 뿌리의 질소 함량은 모든 직경급에서 증가하는 경향을 보였다. 33개월경과 후 뿌리의 질소 잔존률은 R₁, R₂, R₃ 그리고 R₄ 각각 66.5%, 86.7%, 84.4%, 44.4%이었다. 분해중인 뿌리의 인 함량은 분해 초기에 감소하다 후반부에는 증가하는 경향을 보였으며, 33개월 후 인의 잔존률은 R₁, R₂, R₃ 그리고 R₄ 각각 64.7%, 62.4%, 93.1% 30.7%이었다. 분해중인 뿌리의 칼륨 함량은 분해가 진행됨에 따라 초기 값보다 현저하게 감소하였으며, 33개월경과 후 칼륨의 잔존률은 R₁, R₂, R₃그리고 R₄에서 각각 11.6%, 10.6%, 5.9%, 7.7%이었다. 분해과정 중 칼슘 함량의 변화는 직경급에 따라 달랐으며, 33개월경과 후 칼슘의 잔존률은 R₁, R₂, R₃ 그리고 R₄에서 각각 66.2%, 51.0%, 39.1%, 48.3%이었다. 뿌리의 마그네슘 함량은 직경이 작을수록 초기 함량이 높았으며, 분해가 진행됨에 따라 R₄에서는 초기 값에 비해 함량이 증가하였으나 Rl₁ R₂, R₃에서는 초기 값보다 감소하였다. 33개월경과 후 마그네슘 잔존률은 R₁, R₂, R₃ 그리고 R₄에서 각각 15.3%, 29.9%, 24.6%, 69.4%로 칼슘과는 달리 직경이 큰 뿌리에서 잔존률이 높았다.on of hub-and-spoke system, integration of logistics bases, introduction of (automatic) parking building, diversification of transportation mode, and etc. At the same time, we constructed three practically executable scenarios based on those ideas. The first is "Center Hub" scenario, the second is "Metropolitan Hub" scenario. The third and last scenario is "Regional Consolidation of Warehouses (distribution centers)".f worldly desire' and 'cordiality' that one could be deserved his diligency becoming a part of the harmonious idealistic living place. Fourthly, on the character of story teller. Originally he is a incomer of "Gang-Ho" from real world. so that reason, he is showing dualism not to deny the loyalty oath to his king, while he intends to satisfy with the life in "Gang- Ho" separating himself from real world. As a gentry, at that time, the loyalty oath is inevitable one and that is found from

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1431-1434
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• 2015

Background: Breast cancer is one of the most common cancers among women worldwide and the HER2 receptor plays an important role in its development and progression. This systematic review aimed to summarize the role of HER2 in brain metastasis in patients with breast cancer. Materials and Methods: We conducted a literature search by advanced search in title field using the Scopus, Pubmed, and Google scholar databases until the end of June 2014. With metastasis, metastatic, HER2, brain, and breast cancer, as terms of search we selected 31 articles, which were reviewed by two independent and blinded expert reviewers. The studies were first selected according to their titles and abstracts. Quality of the studies were then assessed using the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) protocol for observational studies and CONSORT(Consolidation of Standards for Reporting Trials) protocol for clinical trials. For statistical analyses, we used STATA, version 11.0 software. Forest and funnel diagrams were drawn and for heterogeneity, index was also considered. Also we used meta regression analysis. Results: Finally, we reviewed 10 studies. The prevalence of brain metastasis in HER2-positive breast cancer patients was 24.9%. There was publication bias in the reviewed studies. Meta regression analysis showed that follow up time had no significant effect (p=0.396) on the prevalence of brain metastasis. Conclusions: The results showed a high prevalence of brain metastasis in HER2 positive breast cancer patients.

• 한국토양비료학회지
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• 제48권3호
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• pp.194-204
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• 2015

Six study sites in Gumi, Goryeong in Gyeongbuk province and Naju in Jeonnam province were selected to investigate soil properties of poorly drained horizons in paddy soils. The horizons were re-established layers which were parent material layers originated from fluvial deposits. Topsoil layers were differentiated from piled parent materials while soil structure of the topsoil layer was massive with striated microstructure. Compaction at soil re-establishment and a lack of structure and aggregate development in these soils may cause the limitation of vertical water movement and result in poorly drained horizons. Soil samples were taken from paddy fields with top soils of sandy loam, silt loam and silty clay loam and re-established soils of coarse and fine texture. The samples were taken from each horizon for the analyses of soil chemical and mineral properties. Soils with re-established soils of coarse texture had greater amounts of sands from top soil texture distributions, while soils with fine texture had greater amounts of silts. Chemical properties of top soils were analyzed from rice cultivated soils at the time of re-establishments and one year after the re-establishments. The coarse texture of the re-established horizons decreased in EC values from 0.23 to $0.11(dS\;m^{-1})$, available phosphate values from 112 to $54(mg\;kg^{-1})$, and exchangeable Ca values from 6.6 to $4.9(cmol_c\;kg^{-1})$. On the other hand, soils with fine texture showed decrease only in pH and exchangeable Ca values. Especially, organic matter and available phosphate contents showed heterogeneous distributions from each horizon. This result may be caused by mixture of plough layer and subsurface layer during and consolidation. Hydraulic conductivity values were low at the boundaries of top soil and parent material layers except SL/coarse soil. Soil microstructure was massive structure without soil clods or pores and showed striated structure. Therefore, re-established paddy fields with fluvial deposits as parent material layers showed limited vertical movements of soil water because of occurrence of compacted layers and less-development of soil clods and aggregates.