• 전력전자학회지
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• 제2권2호
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• pp.26-29
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• 1997

• 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
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• 한국정보과학회언어공학연구회 2020년도 제32회 한글 및 한국어 정보처리 학술대회
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• pp.317-320
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• 2020

연설문은 구어체와 문어체 두 가지 특성을 모두 갖고 있는 복합적인 데이터 형태이다. 발화자의 문장 표현, 배열, 그리고 결합에 따라 그 구조가 다르기 때문에, 화자 별 갖는 문체적 특성 또한 모두 다르다. 국정을 다루는 정치인들의 연설문은 국정 현황을 포함한 다양한 주요 문제점을 다룬다. 그러면 발화자의 문서 내 문체적 특성을 고려할 경우, 해당 문서가 어느 정치인의 연설문인지 파악 할 수 있는가? 본 연구에서는 대한민국 정책 브리핑 사이트로부터 한국어 기반 사전 학습된 언어 모델을 활용하여 연설문에 대한 미세조정을 진행함으로써 발화자 예측 분류 모델을 생성하고, 그 가능성을 입증하고자 한다. 본 연구는 5-cross validation으로 모델 성능을 평가하였고 KoBERT, KoGPT2 모델에서 각각 90.22%, 84.41% 정확도를 보였다.

• IMMUNE NETWORK
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• 제8권3호
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• pp.90-97
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• 2008

Background: Hypersensitivity pneumonitis (HP) comprises a group of lung diseases resulting from repeated inhalation of various antigens such as Saccharopolyspora rectivirgula (SR). HP is categorized as a Th1 disease. Therefore, it has been suggested that IL-4, Th2 type cytokine, plays a protective role in the development of HP. However, the functional role of IL-4 in HP has not been extensively investigated in vivo. Therefore, we investigated the functional role of IL-4 in HP using IL-4 knockout (KO) mice. Methods: HP was induced by repeated exposure to SR in C57BL/6 (B6) and IL-4 KO (C57BL/6 background) mice. Results: IL-4 KO mice aggravated HP in terms of histological alteration, SR-specific immune responses, and inflammatory cell infiltration in the lungs compared with B6 mice. IL-4 KO mice produced high levels of IFN-${\gamma}$, TGF-${\beta}$ and TNF-${\alpha}$ in the lungs, whereas B6 mice showed the enhanced production of IL-4. Moreover, chemokines such as MIP-1${\alpha}$, MCP-1, and RANTES were highly expressed in IL-4 KO mice. IFN-${\gamma}$-secreting CD4, CD8 T cells, and neutrophils were enhanced in the bronchoalveolar lavage fluid (BALF) of IL-4 KO mice than those of B6 mice. The administration of recombinant(r) IL-4 restored these immunologic parameters in IL-4 KO mice. Conclusion: These results indicate that IL-4 plays a suppressive role in SR-induced HP by attenuating Th1-dominant immune responses.

• IMMUNE NETWORK
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• 제11권6호
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• pp.358-363
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• 2011

Background: Traditionally, interferon-${\gamma}$ (IFN-${\gamma}$) was regarded as a pro-inflammatory cytokine, however, recent reports suggested role of IFN-${\gamma}$ in immune tolerance. In our previous report, we could induce tolerance to male antigen (HY) just by male islet transplantation in wild type C57BL/6 mice without any immunological intervention. We tried to investigate the influence of IFN-${\gamma}$ deficiency on tolerance induction by male islet transplantation. Methods: To examine the immunogenicity of male tissue in the absence of IFN-${\gamma}$, we transplanted male IFN-${\gamma}$ knock-out (KO) skin to female IFN-${\gamma}$ KO mice. Next, we analyzed male IFN-${\gamma}$ KO islet to streptozotocin-induced diabetic female IFN-${\gamma}$ KO mice. And, we checked the functionality of grafted islet by graft removal and insulin staining. Results: As our previous results in wild type C57BL/6 mice, female IFN-${\gamma}$ KO mice rejected male IFN-${\gamma}$ KO skin within 29 days, and did not reject male IFN-${\gamma}$ KO islet. The maintenance of normal blood glucose level was dependent on the presence of grafted male islet. And the male islet recipient did not reject 2nd challenge of male islet graft also. Conclusion: Deficiency of IFN-${\gamma}$ does not have influence on the result of male skin graft and male islet transplantation. Conclusively, male islet transplantation induced T cell tolerance is not dependent on the presence of IFN-${\gamma}$.

• Molecules and Cells
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• 제42권8호
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• pp.589-596
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• 2019

${\beta}Pix$ is a guanine nucleotide exchange factor for the Rho family small GTPases, Rac1 and Cdc42. It is known to regulate focal adhesion dynamics and cell migration. However, the in vivo role of ${\beta}Pix$ is currently not well understood. Here, we report the production and characterization of ${\beta}Pix$-KO mice. Loss of ${\beta}Pix$ results in embryonic lethality accompanied by abnormal developmental features, such as incomplete neural tube closure, impaired axial rotation, and failure of allantois-chorion fusion. We also generated ${\beta}Pix$-KO mouse embryonic fibroblasts (MEFs) to examine ${\beta}Pix$ function in mouse fibroblasts. ${\beta}Pix$-KO MEFs exhibit decreased Rac1 activity, and defects in cell spreading and platelet-derived growth factor (PDGF)-induced ruffle formation and chemotaxis. The average size of focal adhesions is increased in ${\beta}Pix$-KO MEFs. Interestingly, ${\beta}Pix$-KO MEFs showed increased motility in random migration and rapid wound healing with elevated levels of MLC2 phosphorylation. Taken together, our data demonstrate that ${\beta}Pix$ plays essential roles in early embryonic development, cell spreading, and cell migration in fibroblasts.

• 한국인터넷방송통신학회논문지
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• 제22권4호
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• pp.23-28
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• 2022

최근 스마트폰 또는 타블렛 PC와 같은 스마트기기가 정보의 창구 역할을 하게 되면서 다수의 사용자가 웹포털을 통해 웹 뉴스를 소비하는 것이 더욱 중요해졌다. 하지만 인터넷 상에 생성되는 뉴스의 양을 사용자들이 따라가기 힘들며 중복되고 반복되는 폭발하는 뉴스 기사에 오히려 혼란을 야기 시킬 수도 있다. 본 논문에서는 뉴스 포털에서 사용자의 질의로부터 검색된 뉴스후보들 중 KoBART 기반의 문서요약 기술을 활용한 뉴스 추천 시스템을 제안한다. 실험을 통해서 새롭게 수집된 뉴스 데이터를 기반으로 학습한 KoBART의 성능이 사전훈련보다 더욱 우수한 결과를 보여주었으며 KoBART로부터 생성된 요약문을 환용하여 사용자에게 효과적으로 뉴스를 추천하였다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2006년도 학술발표회 논문집
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• pp.992-996
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• 2006

2005년부터 홍수기 유입된 탁수를 조기방류함에 있어서 안동댐과의 연계운영을 통한 탁도저감 대책이 수립되었으며, 이와 더불어 하류하천의 탁도관리 시스템 구축이 요구되는 실정이다. 본 연구에서는 이러한 하류하천의 탁도관리를 지원하는 모형을 구축함으로써 안동 및 임하댐의 연계운영을 통한 하류하천 탁도관리방안을 수립하고자 한다. 기본적으로 시간적인 변동이 심한 댐 방류시나리오를 입력자료로 구성하여 탁도자료와 함께 하류하천의 영향거리를 분석하고 자연흐름에 의한 탁도저감을 평가하고자 함이 연구의 골자가 된다. 본 연구에서는 임하 및 안동댐의 호내 탁도분포를 조사하고 하류하천의 지점별 탁도를 측정함과 동시에 동적수질모형인 KoRiv1-win 모형을 사용하여 하류단 탁도를 계산할 수 있도록 구성하였으며 댐직하류 구간에 대해서는 2차원 유한요소 흐름해석 모형인 SMS모형을 사용해서 모의를 수행하였다. 2차원 및 1차원 수리해석 및 수질해석결과를 바탕으로 탁수전파 거리 및 탁도도달 시간을 산정함하고 하류단 탁도저감을 위한 저수지 연계운영에 활용할 수 있도록 하였다.

• Mycobiology
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• 제45권2호
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• pp.57-63
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• 2017

The species of the genus Chlorociboria Seaver are very common on the forest floor, and can be easily distinguished by small and numerous blue-green fruitbody, especially the blue substrate dyed with xylindein produced by this group. This genus has rather high species diversity in the Southern Hemisphere, while a little attention was paid to this group in East Asia area. During a field survey in South Korea, several Chlorociboria specimens were collected. Based on morphological and phylogenetic analyses, three species of Chlorociboria were reported, including one new record in South Korea and one new record in Jeju Island. The key to the species of Chlorociboria from South Korea is provided.

• International Journal of Advanced Culture Technology
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• 제8권2호
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• pp.277-282
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• 2020

The first zoea of Microcassiope orientalis is described and illustrated from laboratory hatched materials. Comparisons with previous studies of the first zoeal stages in the Xanthidae from Korean waters, revealed that some former studies were incorrected. The first zoea of M. orientalis described by Ko was identical to the first zoea of Macromedaeus distinguendus described by Terada. In addition, zoeal stages of Nanocassiope granullipes described by Ko & Clark was revealed the zoeal stages of M. cassiopes. So, the first zoea of M. orientalis is redescribed and illustrated in detailed with color photo herein, and compare its morphological characteristics with previous described zoea of N. granulipes by Ko & Clark.

• 한국환경보건학회지
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• 제48권2호
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• pp.96-105
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• 2022

Background: Pyrethroid insecticides account for more than 30% of the global insecticide market and are frequently used in agricultural settings and residential and public pest control among the general population. While several animal studies have suggested that exposure to pyrethroids can alter glucose homeostasis, there is only limited evidence of the association between environmental pyrethroid exposure and diabetes in humans. Objectives: This study aimed to report environmental 3-phenoxybenzoic acid (3-PBA) concentrations in urine and evaluate its association with the risk of diabetes in Korean adults. Methods: We analyzed data from the Korean National Environmental Health Survey (KoNEHS) Cycle 2 (2012~2014) and Cycle 3 (2015~2017). A total of 10,123 participants aged ≥19 years were included. Multiple logistic regressions were used to calculate the odds ratios (ORs) for diabetes according to log-transformed urinary 3-PBA levels. We also evaluated age, sex, education, monthly income, marital status, alcohol drinking, physical activity, urinary cotinine, body mass index, and sampling season as potential effect modifiers of these associations. Results: After adjusting for all the covariates, we found significant dose-response relationships between urinary 3-PBA as quartile and the prevalence of diabetes in pooled data of KoNEHS Cycles 2 and 3. In subgroup analyses, the adverse effects of pyrethroid exposure on diabetes were significantly stronger among those aged 19~39 years (p-interaction<0.001) and those who consumed high levels of cotinine (p-interaction=0.020). Conclusions: Our findings highlight the potential diabetes risk of environmental exposure to pyrethroids and should be confirmed in large prospective studies in different populations in the future.