• Asian-Australasian Journal of Animal Sciences
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• 제20권1호
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• pp.119-123
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• 2007

The objectives of this study were to characterize the changes occurring in the levels of insulin-like growth factors (IGF-I and IGF-II) in bovine milk during a one-year lactation period, and to determine the parameters affecting IGF content in bovine milk. Milk was collected individually from lactating Holstein cows (n=70), and IGF-I and -II levels were determined via radioimmunoassay, using 125I after acid-ethanol treatment. The proximate compositions of the milk samples were determined using a near-infrared milk analyzer. The data were analyzed by the GLM and CORR procedures using SAS software to determine significant differences (p<0.05) occurring within groups (dairy farms, lactation periods, season, and parity). We noted an approximately six-fold reduction in the IGF-I concentration (from 2,462.7 to 353.0 ng/ml) and a three-fold drop in the IGF-II concentration (from 929.1 to 365.7 ng/ml) in the bovine colostrum, between 6 h after parturition and 18 h after parturition. IGF-I and -II content, measured at the early, middle, and late stages of lactation did not change significantly throughout the entirety of the lactation period. Interestingly, parity did not significantly affect IGF-I content, but did significantly affect IGF-II content between the primiparous and multiparous cows. We also found there were no significant relationships between IGF-I and total protein content or somatic cell counts (p<0.05).

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6673-6678
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• 2014

Background: To investigate the prognostic value of serum PIVKA-II (prothrombin induced by the absence of vitamin K or antagonist-II) in BCLC (Barcelona Clinic Liver Cancer) 0-A hepatocellular carcinoma (HCC) patients after curative resection. Materials and Methods: Preoperative sera were collected from 140 patients with BCLC 0-A HCCs undergoing curative resection during 2011-2012 in Zhongshan Hospital. Follow-up ended on November 2013. ELISA was used to detect the serum concentrations of preoperative PIVKA-II. The prognostic value of PIVKA-II and other clinicopathological factors was analyzed by the Kaplan-Meier method and the multivariate Cox proportional hazards model. Results: During follow-up, 39 of 140 patients suffered recurrence and the 1-year recurrence rate was 27.9%. The high-PIVKA-II expression group had lower 1-year time to progression (TTP) compared with the low-expression group (54.8% vs 20.2%, p<0.001). Patients with high preoperative PIVKA-II expression showed a relatively higher risk of developing postoperative recurrence than those with low expression in the low-recurrence-risk subgroups, including ${\alpha}$-fetoprotein ${\leq}400ng/mL$ (45.4% vs 16.7%; p=0.006), tumor size ${\leq}5cm$ (54.2% vs 18.1%; p<0.001), single tumor (56.0% vs 19.1%; p<0.001), absence of satellite lesions (53.3% vs 19.8%; p=0.001), absence of vascular invasion (52.6% vs 14.9%; p=0.002), and Edmondson stage I/II (60.9% vs 20.3%; p<0.001). PIVKA-II was the strongest independent prognostic factor for TTP (hazard ratio, 2.877; 95% CI 1.524-5.429; p=0.001). Conclusions: Elevated PIVKA-II is associated with early recurrence of BCLC 0-A HCC after curative resection and can be considered a novel prognostic predictor.

• 대한소아치과학회지
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• 제48권1호
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• pp.1-11
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• 2021

이 연구의 목적은 골격성 2급 부정교합 소아·청소년의 상기도 공간을 분석하고, 이에 영향을 미치는 요인을 알아보고자 함이다. 총 67명의 골격성 2급 소아·청소년의 CBCT영상으로 연구를 진행하였다. 상기도 부피와 최소 단면적은 3차원 CBCT 영상을 통해 평가하였으며, 악안면 형태와 골 성숙도는 2차원 두부방사선사진을 통해 평가하였다. 상기도 부피 및 최소 단면적과 다양한 변수들간의 연관성이 분석되었다. 상기도 공간은 최대 성장기 이전의 환자에서 가장 작았으며, 연령과 양의 상관관계를 보였다. 상기도 부피는 전안면 고경 및 연령과, 최소 단면적은 하악 폭경 및 연령과 가장 높은 상관관계를 나타냈다. 골격성 2급 소아·청소년의 상기도 공간은 연령, 골 성숙도, 세 평면에서의 악안면 형태와 유의한 연관성을 가졌다.

• Toxicological Research
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• 제7권1호
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• pp.93-112
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• 1991

This study was carried out to investigate the various factors on induction of experimental hepatocarcinogenesis in Sprauge-Dawley rats. The experimental animals were divided into three Experiment. Experiment I, II and III were began rats with initial age of 6, 16 and 55 weeks, respectively. All Experiment were injected intrapertioneal with diethylnitrosamine (DENA` 200 mg/kg) as an intiator and group 3, 4 of Experiment I, II and III were fed on diet containing 0.02% 2-acetylaminofluorene (2-AFF) as a promoter for 6 weeks. Three weeks after two-thirds partial hepatectomy was performed in group 2, 4 of Experiment I & II and group 3 of Experiment III.

• 임상간호연구
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• 제19권2호
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• pp.265-274
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• 2013

Purpose: The aim of this study was to determine the risk factors contributed to unplanned readmission to intensive care unit (ICU) and to investigate the prediction model of unplanned readmission. Methods: We retrospectively reviewed the electronic medical records which included the data of 3,903 patients who had discharged from ICUs in a university hospital in Seoul from January 2011 to April 2012. Results: The unplanned readmission rate was 4.8% (n=186). The nine variables were significantly different between the unplanned readmission and no readmission groups: age, clinical department, length of stay at 1st ICU, operation, use of ventilator during 24 hours a day, APACHE II score at ICU admission and discharge, direct nursing care hours and Glasgow coma scale total score at 1st ICU discharge. The clinical department, length of stay at 1st ICU, operation and APACHE II score at ICU admission were the significant predictors of unplanned ICU readmission. The predictive model's area under the curve was .802 (p<.001). Conclusion: We identified the risk factors and the prediction model associated with unplanned ICU readmission. Better patient assessment tools and knowledge about risk factors could contribute to reduce unplanned ICU readmission rate and mortality.

• 대한수학회논문집
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• 제13권1호
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• pp.29-36
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• 1998

We show that if M is a $II_1$-factor and a countable discrete group G acts outerly on M then Jones' index $[M:M^G]$ of a pair of $II_1^-factors is equal to the order $\mid$G$\mid$ of G. It is also shown that for a subgroup H of G Jones' index $[M^H:M^G]$ is equal to the group index [G:H] under certain conditions.

• 한국조경학회지
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• 제29권1호
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• pp.1-10
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• 2001

The purpose of this thesis is to classify landscape-type of golf course, and t provide a better understanding of landscape of existing golf courses, seek a developed method for landscape, and other useful knowledge. In order to classify landscape type of the golf course, and analyze the preference for the determinants, we have selected 4 golf courses in Yongin, Kyonggi Province. The analysis in this study shows that a variable, 'familiarity' is the most potent influence of visual preference, (Sig 0.01), and it can be divided into five classes of landscape-type in golf course. More specifically, we conducted the analysis of the image of views and visual preference to bring out major factors which could decide visual preference in golf courses. The results between visual preference and physical variable are as follows; 1. It implies that a factor for a image of the view in golf course is analyzed by 4 districts from factor 1 to factor 4. An ability explaining those factors in the whole of variable quantity is 51.742%, implying factors for the image of the scene in golf courses are appeared as familiarity, changeableness, spaciousness, and naturalness. Among those factors, since familiarity(C.V.; 26.783%) and changeableness(C.V.; 112.200%) took high rank, this represents the fact that familiarity or changeableness highly affects the forming of image. 2. Defending on degree of image ability in golf course, we could classify as five types such as Type I, Type II, Type II, Type IV, and Type V. 3. As a result of calculating type of factor score, Type I had the lowest ranking in naturalness, and rather lower than others such as organization and spaciousness. The II is a top-ranked one in familiarity and naturalness, while it has the lowest ranking in spaciousness. Type III has the highest ranking in organization and preference. Type IV is the lowest-ranked one in familiarity and preference. Type IV is the lowest-ranked one is familiarity and preference. Type V has the highest ranking in spaciousness, but the lowest ranking in organization. 4. As a result of preference, Type III, Type II, Type V, Type I, and Type IV come out in order. That water-seen place type charges the highest rank shows the importance of changeable materials. 5. These factors-familiarity, organization, spaciousness and naturalness- are the major materials of the scene of view in golf courses. The possibility of how to use those for designing and making enhanced golf courses should be reinvestigated through these factors. Especially, it is acknowledged that the duction of changeableness, which is not mentioned in the study of informational approach, is much stimulating for the designing use. A further research on this theme should be made in the future, not limiting to the golf courses in Yongin.

• 환경정책연구
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• 제14권2호
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• pp.3-25
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• 2015

도심재생하천 내부의 수리적 특성이 열환경 변화에 미치는 영향을 알아보고자 하천의 물리적 구조와 수리적 특성, 기상요소, 온열환경을 분석하였다. 연구 대상지는 복원된 도시하천으로서 큰 의의를 가지는 청계천을 선정하였다. 유형은 물리적 구조별 녹피율의 차이에 따라 유형 I(0.0%)과 유형 II(20.2%)로 구분하였다. 여울이 끝나는 Ba지점에서 수온은 $0.2^{\circ}C$ 감소, 유속은 0.7~0.9m/s 증가, 용존산소량은 0.5~0.6mg/L 증가하였으며, 기온은 평균 $1.1{\sim}1.4^{\circ}C$ 감소, 상대습도는 평균 6.6~8.7% 증가, 풍속은 불규칙한 변화를 보였다. 습구흑구온도지수 분석결과, 유형에 따른 상류부의 하천 내부와 수면 외부의 값의 차이는 미비하였으나, 유형 I의 하류부에서 감소폭은 $0.3{\sim}0.6^{\circ}C$, 유형 II는 $0.8^{\circ}C$ 등이었다. 기온저감의 효과는 수직높이로 유형 I의 경우 120cm, 유형 II는 140cm까지 영향이 있었으며, 거리별 기온저감의 효과는 유형 I의 경우 여울이 끝나는 Ba지점 이후로 증가하였고, 유형 II의 경우 지속해서 감소하였다.

• 한방안이비인후피부과학회지
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• 제19권3호통권31호
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• pp.1-12
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• 2006

Objective : Angiogenesis is an essential process for metastasis of solid tumors and Psoriasis. Lots of Researches for anti-angiogenic effect to angiogenic factors have been carried out in the world. So this experiment was carried out for whether Lacca Sinica Exsiccata(LSE) extracts have an anti-angiogenic effect for angiogenic factors. Methods: To investigate the roles of the LSE extracts, we performed MIS assay, western blots using HaCaT cells and HepG2 cells. And then, HaCaT cells were treated with 10, 50, 100, 250, $500{\mu}g/ml$ LSE extracts. After 4hrs, HaCaT cells were theated with IGF-II protein for 1hr. HepG2 cells were treated with 1, 10, 25, 50, 100, 200 ${\mu}g/ml$ LSE extracts. After 4hrs, HepG2 cells were theated with $CoCl_2$ for 24hrs Results: 1. In $50{\mu}g/ml$ and $100{\mu}g/ml$ density we confirmed the inhibition effect of LSE extracts to $HIF-1{\alpha}$ activation which was induced by IGF-II in HaCaT cells. 2. In $50{\mu}g/ml$ density we confirmed the inhibition effect of LSE extracts to $HIF-1{\alpha}$ activation which was induced by $CoCl_2$ in HepG2 cells. 3. In $25{\mu}g/ml$ density we confirmed the inhibition effect of LSE extracts to VEGF activation which was induced by $CoCl_2$ in HepG2 cells. Conclusion: The above-mentioned results proved that LSE extracts reduced $HIF-1{\alpha}$ protein level in the HaCaT cells and HepG2 cells. These results suggest that inhibition of HaCaT cell and HepG2 cell proliferation by LSE extracts contributes to the anti-angiogenic activities on the keratinocytes and hepatocellular carcinoma.

• 약학회지
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• 제37권6호
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• pp.605-614
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• 1993

To investigate the endothelial dependence of angiotensin II(A II)-induced responses in the systemic and pulmonary arterial system of acute renal hypertensive rats of 2-kidney, 1-ligation type (RHRs), A II-induced vasocontractile and pressor effects were evaluated in isolated arteries and in vivo, respectively. A II dose-dependently contracted intact thoracic aorta and pulmonary artery (E$_{max}$:40% at 10$^{-7}$M and 80% at 3$\times$10 $^{-8}$M, respectively) from normotensive rats(NRs), which was significantly increased by removal of endothelial cells or pretreatment with EDRF inhibitors. In NRs, A II increased mean systemic and pulmonary arterial pressure(33 and 5.6mmHg at 0.1 $\mu\textrm{g}$/kg, respectively), the effect being significantly increased (P<0.01) by L-NAME(30mg/kg, i.v.). However, A II-induced contraction of intact thoracic aorta and pulmonary artery(E$_{max}$: 33% at 10$^{-7}$M and 93% at 3$\times$10$^{-8}$M, respectively) from RHRs were not changed after endothelial function was disrupted as above; similarly, pressor effects of A II on the systemic and pulmonary arterial pressure in RHRs did not altered by L-NAME. A II tachyphylactic responses for intact thoracic aorta from NRs and RHRs(65 and 87% at 10$^{-8}$M, respectively) were greater than those for pulmonary artery(19 and 19% at 10$^{-8}$M, respectively). Distruption of endothelial function significantly (P<0.01) depressed A II tachyphylaxis for thoracic aorta, but not for pulmonary artery. These results suggest that vascular reactivity to A II is not altered in RHRs, and it is greater for pulmonary arterial system than for systemic arterial system. A II reactivity is EDRF-dependent in both arterial systems of NRs, but EDRF-independent for RHRs. Finally, EDRF is one of the major factors underlying A II tachyphylaxis for thoracic aorta, but not for pulmonary artery.