• 제목/요약/키워드: $GI_{50}$

검색결과 1,944건 처리시간 0.029초

Evaluation of Anticancer Activity of Curcumin Analogues Bearing a Heterocyclic Nucleus

  • Ahsan, Mohamed Jawed
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권4호
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    • pp.1739-1744
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    • 2016

  • We report herein an in vitro anticancer evaluation of a series of seven curcumin analogues (3a-g). The National Cancer Institute (NCI US) Protocol was followed and all the compounds were evaluated for their anticancer activity on nine different panels (leukemia, non small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer) represented by 60 NCI human cancer cell lines. All the compounds showed significant anticancer activity in one dose assay (drug concentration $10{\mu}M$) and hence were evaluated further in five dose assays (0.01, 0.1, 1, 10 and $100{\mu}M$) and three dose related parameters $GI_{50}$, TGI and $LC_{50}$ were calculated for each (3a-g) in micro molar drug concentrations (${\mu}M$). The compound 3d (NSC 757927) showed maximum mean percent growth inhibition (PGI) of 112.2%, while compound 3g (NSC 763374) showed less mean PGI of 40.1% in the one dose assay. The maximum anticancer activity was observed with the SR (leukemia) cell line with a $GI_{50}$ of $0.03{\mu}M$. The calculated average sensitivity of all cell lines of a particular subpanel toward the test agent showed that all the curcumin analogues showed maximum activity on leukemia cell lines with $GI_{50}$ values between 0.23 and $2.67{\mu}M$.

  • https://doi.org/10.7314/APJCP.2016.17.4.1739 인용 PDF KSCI

변성 고아미 쌀전분을 이용한 쿠키의 소화율과 물리적 및 관능적 특성 (Digestive, Physical and Sensory Properties of Cookies Made of Dry-Heated OSA-High Amylose Rice Starch)

  • 한정아
    • 한국식품과학회지
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    • 제41권6호
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    • pp.668-672
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    • 2009

  • 고아미쌀에서 분리해낸 전분에 octenyl succinic anhydride기를 도입하여 에스테르화한 후 $130^{\circ}C$에서 2시간 열처리하여 변성전분을 제조하고 이를 밀가루와 50:50으로 섞어 제조한 쿠키는 밀가루만을 사용한 쿠키와 비교해볼 때 혈당상승을 지연시키는 효과가 컸으나 쿠키의 단단함과 바삭거림은 많이 떨어졌다. 쿠키의 선호도는 색이나 고소한 냄새보다는 경도와 바삭거림과 같은 조직감 특성에 많이 좌우되므로 조직감 향상을 위해 밀가루와 변성전분을 50:50으로 섞은 후 총 가루함량의 0.5%에 해당하는 xanthan 검을 첨가하여 반죽을 만들고 쿠키를 제조하면 검류와 전분의 상호작용으로 인해 단단함과 바삭거림 등 조직감의 향상과 함께 당지수를 효과적으로 낮춰 당뇨환자들의 간식으로 소비될 수 있을 것으로 기대된다. 본 실험에 사용된 변성전분은 당지수를 충분히 감소시킬 수 있으므로 쿠키뿐 아니라 혈당조절이 필요한 식품에 밀가루를 대체할 식품소재로 사용될 수 있을 것이며, 동시에 고아미 쌀의 소비도 증가시킬 수 있을 것으로 생각된다.

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A chaperone surveillance system in plant circadian rhythms

  • Cha, Joon-Yung;Khaleda, Laila;Park, Hee Jin;Kim, Woe-Yeon
    • BMB Reports
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    • 제50권5호
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    • pp.235-236
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    • 2017

  • The circadian clock is an internal system that is synchronized by external stimuli, such as light and temperature, and influences various physiological and developmental processes in living organisms. In the model plant Arabidopsis, transcriptional, translational and post-translational processes are interlocked by feedback loops among morning- and evening-phased genes. In a post-translational loop, plant-specific single-gene encoded GIGANTEA (GI) stabilize the F-box protein ZEITLUPE (ZTL), driving the targeted-proteasomal degradation of TIMING OF CAB EXPRESSION 1 (TOC1) and PSEUDO-RESPONSE REGULATOR 5 (PRR5). Inherent to this, we demonstrate the novel biochemical function of GI as a chaperone and/or co-chaperone of Heat-Shock Protein 90 (HSP90). GI prevents ZTL degradation as a chaperone and facilitates ZTL maturation together with HSP90/HSP70, enhancing ZTL activity in vitro and in planta. GI is known to be involved in a wide range of physiology and development as well as abiotic stress responses in plants, but it could also interact with diverse client proteins to increase protein maturation. Our results provide evidence that GI helps proteostasis of ZTL by acting as a chaperone and a co-chaperone of HSP90 for proper functioning of the Arabidopsis circadian clock.

  • https://doi.org/10.5483/BMBRep.2017.50.5.064 인용 PDF KSCI

치핵근치술 후 휘담식 수기요법을 병행한 한방관리 증례 1 (After Hemorrhoidectomy Korean Medicine Treatment with Whidam's SuGi Therapy: A Case Report)

  • 최형일;김나영;안훈모
    • 대한의료기공학회지
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    • 제22권1호
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    • pp.72-82
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    • 2023

  • Objective : The purpose of this study is to report about a 50's female patient after Hemorrhoidectomy, whose symptoms were relieved after Korean medicine treatment with Whidam's SuGi Therapy. Methods : The patient in this study received Korean medicine treatment such as herbal medication, acupuncture treatment, cupping therapy and specially Whidam's SuGi therapy. Results : After the treatment, the symptoms of pains were relieved. Vas fell from 9 to 2 and overall, the body condition has improved. Conclusions : This study showed that Whidam's SuGi therapy added with Korean Medicine treatment can be an effective choice for after Hemorrhoidectomy.

  • https://doi.org/10.22942/mg.2023.22.1.072 인용 PDF