• The Korean Journal of Applied Statistics
• /
• v.34 no.2
• /
• pp.153-166
• /
• 2021

A main goal of pharmacogenomics studies is to predict individual's drug responsiveness based on high dimensional genetic variables. Due to a large number of variables, feature selection is required in order to reduce the number of variables. The selected features are used to construct a predictive model using machine learning algorithms. In the present study, we applied several hybrid feature selection methods such as combinations of logistic regression, ReliefF, TurF, random forest, and LASSO to a next generation sequencing data set of 400 epilepsy patients. We then applied the selected features to machine learning methods including random forest, gradient boosting, and support vector machine as well as a stacking ensemble method. Our results showed that the stacking model with a hybrid feature selection of random forest and ReliefF performs better than with other combinations of approaches. Based on a 5-fold cross validation partition, the mean test accuracy value of the best model was 0.727 and the mean test AUC value of the best model was 0.761. It also appeared that the stacking models outperform than single machine learning predictive models when using the same selected features.

• International Journal of Industrial Entomology and Biomaterials
• /
• v.13 no.2
• /
• pp.113-117
• /
• 2006

Heterosis was studied involving two multivoltine silkworm breeds viz, APM1 and SLKSPM through rearing and isozyme analysis. A positive significant heterotic effect was observed in fecundity, hatching % and survivability. The heterobeltiosis was observed only in fecundity and hatching %. Isozyme analysis of ${\alpha}-esterase$ showed variation in loci and allelic expression. The allele with heterozygosity $(Est-2^{12})$ was observed at the Est-2 locus in $F_1$ progeny. Est-3 was observed in $F_1$ progeny, whereas it was completely absent in both parental lines. The present study suggests that the markers ($Est-2^{12}$ and Est-3) targeted for introgression may be useful for the improvement of fecundity and survivability as the phenomenon of heterosis was observed only in $F_1$ progeny.

• Journal of Korean Society on Water Environment
• /
• v.23 no.2
• /
• pp.193-200
• /
• 2007

The AOPs research defined by creating a sufficient amount of OH radicals from the dissolution of organic materials through photoxidation and research for a complete elimination of residual organic materials by membrane are actively ongoing. This research focuses on the hybrid processing of AOPs and M/F membrane to dissolve and eliminate organic chemicals in drinking water which are suspected of carcinogens. For this purpose, underground water was used as a source of drinking water for the hybrid processing of AOPs oxidation and M/F membrane, and a pilot plant test device was installed indoor. Carcinogenic chemicals of VOCs and pesticide were artificially mixed with the drinking water, which was then diluted close to natural water in order to examine treatment efficiency and draw optimal operation conditions. The samples used for this experiment include four chemicals phenol, chloroform, in VOCs and parathion, carbaryl in pesticide. As a result of the experiments conducted with simple, and compound solutions, the conditions to sufficiently dissolve and eliminate carcinogenic chemicals from the hybrid processing of where carcinogens were artificially added are : (hydrogen peroxide) prescribed solution 100 mg/L under pH 5.5~6.0, and the temperature $12{\sim}16^{\circ}C$, at the normal temperature and pressure. $d-O_3$ volume of 5.0 ppm and above and 30-40 minutes of reaction time are most appropriate and using MF/UF for membrane was ideal.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.38 no.5
• /
• pp.466-476
• /
• 1993

Field experiment was carried out to study the new and old leaf development and photosynthesis of sorghum-sudangrass hybrid 855F, pearl millet Suwon No.6 and barnyard millet in cutting and non-cutting plots from the 2nd cutting day(September, 17th). Leaf regrowth of sorghum-sudangrass hybrid and pearl millet begun after the 2nd cutting day, except barnyard millet. Photosynthetic rate of new leaf blades in cutting plots reached to higher level than old leaf at 12th to 20th day after cutting(DAC). Stomatal density of leaf blade of each crop in non-cutting plot was observed higher pearl millet and sorghum-sudangrass hybrid than barnyard millet. New leaf blade of each crop in cutting plot was showed complete development in stomata size, form and vascular bundles in 12th DAC. Non-structural carbohydrates(NSC) contents of stembase in sorghum-sudan hybrid which had 17 %, the highest among three forages decreased daily into 8th DAC and begun to increase from 20th DAC. But, those of pearl millet and barnyard millet in cutting plots were about 10 % at cutting day and inclined to decrease continuously into the 20th DAC and reached about 3～4% in 32nd DAC. These results showed that regrowth energy of sorghum-sudangrass hybrid was mainly dependent on non-structural carbohydrates of stembase until 12th DAC, but pearl millet had active lower leaves supported its regrowth by concurrent photosynthesis. As barnyard millet which did not reserve enough NSC, its regrowth fail to survive under low temperature. Also, late regrowth of rest two forage crops was delayed with decreasing daily temperature after mid-September.

• Journal of Welding and Joining
• /
• v.22 no.2
• /
• pp.13-18
• /
• 2004

레이저 빔과 아크를 하나의 용접 프로세스로 병합하는 기술에 관해서는 이미 70년대부터 알려져 왔으나 별다른 개발로 이어지지 못하다가 최근에서야 다시 눈을 돌리게 되었다. 이 기술의 핵심 과제는 아크의 장점과 레이저의 장점을 어떻게 단일 혼합 프로세스로 조합하느냐 하는 것이다.(중략)

• International Journal of Industrial Entomology and Biomaterials
• /
• v.5 no.2
• /
• pp.153-162
• /
• 2002

Earlier breeding experiments undertaken at Central Sericultural Research and Training Institute, Mysore, India since a decade had resulted in the development of many productive and qualitatively superior bivoltine hybrids. However, the hot climatic conditions of tropics prevailing particularly in summer are not conducive to rear these high yielding bivoltine hybrids. This has necessitated breeding of compatible bivoltine hybrids for year-round rearing. Accordingly, the Japanese hybrid, B2Ol ${\times}$ BCS12 which was found to be tolerant to high temperature was used as breeding resource material. Following hybridization and selection rearing of silkworms was taken up in SERICATRON (Environmental chamber with precise and automatic control facilities for uniform maintenance of temperature and humidity) at high temperature of $36{\times}1^{\circ}C$ and 85${\times}$5% RH in fifth instar and the control batches at $25{\times}1^{\circ}C$ and 65{\times}$5% RH. Directional selection was resorted to the batches reared at 36$\pm$1$^{\circ}C$ till F$_{5}$ keeping pupation rate as important selection criteria. From $F_{2}% onwards the experiment was modified in such a way as to conduct normal rearing every alternate generation to regain the lost vitality due to continuous exposure to high temperature and high humidity stress. At $F_{2}$ , Oval and dumb-bell cocoons were separated out and designated as CSR18 and CSR19, respectively. By utilizing these lines at $F_{12}$, the hybrid CSR18$\times$CSR19 was prepared and studied for the thermotolerance by subjecting to stress condition at high temperature of 36$\pm$1$^{\circ}C$ and 85$\pm$5% RH in fifth instar and the control batches at $25{\times}1^{\circ}C$ and 65${\times}$5% RH. The better performance of CSR18${\times}$CSR19 (survival > 88%) at $36{\times}1^{\circ}C$ clearly indicates the general superiority of CSR18${\times}$CSR19 with regard to high temperature tolerance over the productive hybrids and CSR18$\times$CSR19 can perform well in varied agro-climatic conditions of the tropics with optimum qualitative and quantitative characteristics.s.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.36 no.2
• /
• pp.175-185
• /
• 2023

A hybrid supercapacitor is a promising energy storage device in view of its excellent capacitive performance. Commercial three-dimensional foam nickel (Ni) can be used as an ideal framework due to an interconnected network structure. However, its application as an electrode material for supercapacitors is limited due to its low specific capacity. Herein, we report a successful growth of MnO₂ on the surface of graphene by a one-step hydrothermal method; thus, forming a three-dimensional MnO₂-graphene-Ni hybrid foam. Our results show that the mixed structure of MnO₂ with nanoflowers and nanorods grown on the graphene/Ni foam as a hybrid electrode delivers the maximum specific capacitance of 193 F·g^-1 at a current density 0.1 A·g^-1. More importantly, the hybrid electrode retains 104% of its initial capacitance after 1,000 charge-discharge cycles at 1 A·g^-1; thus, showing the potential application as a stable supercapacitor electrode.

• Proceedings of the Korean Vacuum Society Conference
• /
• 1999.07a
• /
• pp.155-155
• /
• 1999

반도체 소자의 초고집적화와 고속화에 따라 최소 선폭이 급격히 줄어듬에 따라 현재 사용되고 있는 다층금속배선의 층간절연막 0.18$\mu\textrm{m}$ 급 이상의 소자에 적용할 경우 기생정전용량이 증가하여 신호의 지연 및 금속배선간에 상호간섭현상으로 반도체 소자의 동작에 심각한 문제가 대두되고 있다. 이러한 물제를 해결하기 위하여 nonoporous silica, fluorinated amorphous carbon, polyimides, poly(arylene)ether, parylene, AF4, poly(tetrafluoroethylene), divinyl siloxane bisbenzocyclobutene, Silk, 그리고 유무기 hybrid nanofoam 등이 저유전물질로 각광을 받고 있으며, 여기에 대한 연구가 우리나라를 비롯하여 미국, 일본 등에서 많은 연구가 이루어지고 있다. 따라서 본 연구에서는 2003년에 개발될 0.13$\mu\textrm{m}$급 이상의 차세대 반도체 소자에 적용될 수 있는 저유전물질 개발현황과 이들 물질 중 4GDRAM 급이상의 소자에 적용가능성이 가장 높은 유무기 hybrid nanofoam, a-C:F와 C:F-SiO2 박막에 대한 특성에 대하여 소개하고자 한다.

• JSTS:Journal of Semiconductor Technology and Science
• /
• v.8 no.2
• /
• pp.143-149
• /
• 2008

A novel compact model for a five-port transformer balun is proposed for the efficient circuit design of hybrid balun. Compared to the conventional model, the proposed model provides much faster computation time and more reasonable values for the extracted parameters. The hybrid balun, realized in $0.18\;{\mu}m$ CMOS, achieves 2.8 dB higher gain and 1.9 dB lower noise figure than its passive counterpart only at a current consumption of 0.67 mA from 1.2 V supply. By employing the hybrid balun, a differential zero-IF receiver is designed in $0.18\;{\mu}m$ CMOS for IEEE 802.15.4 ZigBee applications. It is composed of a differential cascode LNA, passive mixers, and active RC filters. Comparative investigations on the three receiver designs, each employing the hybrid balun, a simple transformer balun, and an ideal balun, clearly demonstrate the advantages of the hybrid balun in fully differential CMOS RF receivers. The simulated results of the receiver with the hybrid balun show 33 dB of conversion gain, 4.2 dB of noise figure with 20 kHz of 1/f noise corner frequency, and -17.5 dBm of IIP3 at a current consumption of 5 mA from 1.8 V supply.

• Plant Resources
• /
• v.5 no.1
• /
• pp.1-6
• /
• 2002

Genetic improvement of the cultivated soybean [Glycine max (L.) Merr] may be possible through hybridization with its wild progenitor, G. soja Sieb. & Zucc. Interspecific cross between G. max (Hwangkeumkong) and G. soja (IT.182932) was made in the summer of 1997. In F$_2$ the percentage of plant height, nodes per plant, and pods per plant were high but gradually reduced from F$_2$ to F$_4$. In contrast pod length, seeds per pod, and 100-seeds weight were increased gradually through generations advanced. Wild variation as evident in F$_2$ in plant height, number of branches, pods per plant, and 100-seeds weight. Twenty six percent of the F$_2$, 44 % of the F$_3$ and 60% of the F$_4$ segregants showed more G. max traits. The combination of useful traits from both species is possible through interspecific hybridization. The characters that could be transferred from wild species to cultivated species are more pod number, better capacity, and resistance to disease and insects. The interspecific derivatives offer scope for selection for high grain yield. Therefore, introducing genes from G. soja to G. max could be contribute to greater genetic diversity of future cultivars. And semicultivated soybean had some desired characteristics including tolerance to adverse environments and multi-seed characters. It means the infusing of semicultivated germplasm to the cultivated soybean could increase number of seeds and pods per plant significantly, and consequently could enhance selecting potential on yield.