• 한국환경보건학회지
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• 제34권4호
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• pp.279-284
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• 2008

This paper aims to provide basic data for work environment control, prevention of worker exposure to asbestos and improvement of air quality to protect workers ‘health after measuring the level of airborne asbestos and workers' exposure in a shipbuilding repair businesses. For this study, a total of 27 samples were collected from 27 workers who had been exposed to asbestos during engine, piping, boiler and other manufacturing processes in 'A' Shipbuilding Repair Company in Gyeongnam. This research was conducted from Oct. 1 to 30, 2007 and had the following results: The target group (27 workers) consisted of all men with an average age of 35.9 years and 6.6 years of work on average. Among them, fifteen 15 (55.6%) were smokers. In terms of their duties at work, there were 12 plumbing repair engineers (44.4%), 8 boiler repair engineers (29.6%) and 7 engine engineers (25.9%). The geometric mean concentration of airborne asbestos was 0.004 f/cc. A total of 4 samples exceeded the exposure limit. In particular, three exceeded the legal limit by more than double, which means that some workers have been highly exposed to asbestos. In terms of the concentration of asbestos fibres by work process, plumbing repair was the highest (0.0071 f/cc($0.001{\sim}0.57\;f/cc$)) while boiler was the lowest (0.0015 f/cc($0.001{\sim}0.007\;f/cc$)). Based on this study, proper action needs to be taken as soon as possible to protect workers from the threat of asbestos.

• 한국인쇄학회지
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• 제31권1호
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• pp.65-78
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• 2013

In gravure printing ink in printed flexible packaging considering the characteristics of the study more accurate color management options and results were as follows. When applying G7 calibration, P2P of the target GRACol G7 evaluate the delta $L^*$ and delta $F^*$, CMY and K-scale average of the results of delta $L^*$ and the highest tolerance G7 average of 1.5 and 3.0 are included in all the best. In addition, the average delta $F^*$ and super delta $F^*$, G7 tolerance by being included within the scope of color management, G7 calibration was possible. Target IT 8.7/4 CMYK, when applied to the calibration G7, Color gravure printing machine is applied to the average of the previous decreased from 12.4 to 3.6. In addition, if a digital proof is EPSON WT 7900 the average color applied to the previous reduction from 5.24 to 0.74 because of the gravure printing color proofing system was effective in the management. G7 calibration by applying the reference print profile of the Epson WT 7900-G-icc, the average was 0.74 coloration, and gravure-G-icc cases, the average color of the 3.60 per GRACol average of all the five colors below were included within the allowable range. Thus, the flexible packaging gravure printing color management of printed after applying the first G7 calibration, the results refer to the press by the profiling, and where best to take advantage of the profile creation was good.

• 유통과학연구
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• 제20권6호
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• pp.1-10
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• 2022

Purpose: This research proposes a new modified Recency-Frequency-Monetary (RFM) model by extending the model with spatial analysis for supporting decision-makers in discovering the promotional target market. Research design, data and methodology: This quantitative research utilizes data-mining techniques and the RFM model to cluster a university's provider schools. The RFM model was modified by adapting its variables to the university's marketing context and adding a district's potential (D) variable based on heatmap analysis using Geographic Information System (GIS) and K-means clustering. The K-prototype algorithm and the Elbow method were applied to find provider school clusters using the proposed RFM-D model. After profiling the clusters, the target segment was assigned. The model was validated using empirical data from an Indonesian university, and its performance was compared to the Customer Lifetime Value (CLV)-based RFM utilizing accuracy, precision, recall, and F1-score metrics. Results: This research identified five clusters. The target segment was chosen from the highest-value and high-value clusters that comprised 17.80% of provider schools but can contribute 75.77% of students. Conclusions: The proposed model recommended more targeted schools in higher-potential districts and predicted the target segment with 0.99 accuracies, outperforming the CLV-based model. The empirical findings help university management determine the promotion location and allocate resources for promotional information distribution and student recruitment.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2000년도 추계학술발표회 초록집
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• pp.12-12
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• 2000

This paper investigated the effect of the film deposition rate for $CrN_x$ microstructure and mechanical properties. For these purpose, pure Cr an stoichiometric CrN films were deposited with various target power density on Si hardened M2 tool steel. The variation of ni trogen concentration in $CrN_x$ f analyzed by AES and deposition rate was calculated by measuring of thickness using ${\alpha}-step$ profilometer. The microstructure was analyzed by X-Ray Diffract and Scanning Electron Microscopy(SEM), and mechanical properties were evalua residual stress, microhardness and adhesion tests. Deposition rate of Cr and CrN increased as an almost linear function of target power density from $0.25\mu\textrm{m}/min$ and $0.15\mu\textrm{m}/min$ to $0.43\mu\textrm{m}/min$. Residual stresses of Cr and CrN films were from tensi Ie to compressive stress with an increase of deposi tion rate a compressive stresses were increased as more augmentation of deposition r maximum hardness value of $2300kg/\textrm{mm}^2$ and the best adhesion strength correspond HF 1 were obtained for CrN film synthesized at the highest target densitY($13.2W/\textrm{mm}^2$) owing to high residual compressive stress and increasing mobility.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.141-141
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• 2017

The ubiquitin-proteasome pathway is the major regulatory mechanism in a number of cellular processes for selective degradation of proteins and involves three steps: (1) ATP dependent activation of ubiquitin by E1 enzyme, (2) transfer of activated ubiquitin to E2 and (3) transfer of ubiquitin to the protein to be degraded by E3 complex. F-box proteins are subunit of SCF complex and involved in specificity for a target substrate to be degraded. F-box proteins regulate many important biological processes such as embryogenesis, floral development, plant growth and development, biotic and abiotic stress, hormonal responses and senescence. However, little is known about the F-box genes in wheat. The draft genome sequence of wheat (IWGSC Reference Sequence v1.0 assembly) used to analysis a genome-wide survey of the F-box gene family in wheat. The Hidden Markov Model (HMM) profiles of F-box (PF00646), F-box-like (PF12937), F-box-like 2 (PF13013), FBA (PF04300), FBA_1 (PF07734), FBA_2 (PF07735), FBA_3 (PF08268) and FBD (PF08387) domains were downloaded from Pfam database were searched against IWGSC Reference Sequence v1.0 assembly. RNA-seq paired-end libraries from different stages of wheat, such as stages of seedling, tillering, booting, day after flowering (DAF) 1, DAF 10, DAF 20, and DAF 30 were conducted and sequenced by Illumina HiSeq2000 for expression analysis of F-box protein genes. Basic analysis including Hisat, HTseq, DEseq, gene ontology analysis and KEGG mapping were conducted for differentially expressed gene analysis and their annotation mappings of DEGs from various stages. About 950 F-box domain proteins identified by Pfam were mapped to wheat reference genome sequence by blastX (e-value < 0.05). Among them, more than 140 putative F-box protein genes were selected by fold changes cut-offs of > 2, significance p-value < 0.01, and FDR<0.01. Expression profiling of selected F-box protein genes were shown by heatmap analysis, and average linkage and squared Euclidean distance of putative 144 F-box protein genes by expression patterns were calculated for clustering analysis. This work may provide valuable and basic information for further investigation of protein degradation mechanism by ubiquitin proteasome system using F-box proteins during wheat development stages.

• 대한기계학회논문집A
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• 제41권4호
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• pp.321-327
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• 2017

본 연구에서는 수평 자세에서의 TIG 용접 시 반응표면법(RSM)을 이용하여, 최적의 이면비드 형상을 구하는 연구를 진행하였다. 입력변수로는 베이스 전류, 피크 전류, 용접속도를 선정하였고, 이면비드 폭을 용접품질에 관한 출력변수로 하여 목표값을 5.4 mm로 설정하였다. Box-Behnken 실험계획법에 따라 실험을 진행하였고, 비드 폭에 관한 2차 회귀모형을 구한 후, F-테스트를 이용하여 회귀모델을 검정하였다. 그리고 망목특성의 호감도 함수를 사용하여 이면비드 형상을 평가함으로써 최적화를 수행하였다. 이렇게 도출된 최적의 용접조건은 코드화된 값으로 베이스 전류; 0.9204, 피크 전류; 0.8676, 용접속도; 0.3776이었다. 검증실험 결과 목표값에 근접한 5.38 mm의 이면비드 폭을 얻을 수 있었다.

• Journal of the Korean Wood Science and Technology
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• 제45권2호
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• pp.223-231
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• 2017

This work was conducted to investigate on the effect of urea-formaldehyde (UF) resin viscosity on plywood adhesion. The viscosity of UF resin was controlled either by adjusting the condensation reaction during its synthesis to obtain different target viscosities (100, 200 and 300 mPa.s) at two levels of formaldehyde/urea (F/U) mole ratios (1.0 and 1.2) or by adding different amounts (10, 20 and 30%) of wheat flour into the resins for the manufacture of plywood. When the viscosity of UF resin increased by the condensation reaction, the adhesion strength of plywood bonded with UF resin of 1.2 F/U mole ratio consistently increased, while those bonded with the 1.0 F/U mole ratio resin slightly decreased, suggesting a difference in the adhesion in plywood. However, the adhesion strength of plywood decreased as the viscosity increased by adding wheat flour, regardless of F/U mole ratio. The manipulation of UF resin viscosity by adjusting the condensation reaction was much more efficient than by adding wheat flour in improving the adhesion performance of plywood. These results indicated that a way of controlling the viscosity of UF resin adhesives has a great influence to their adhesion in plywood.

• 약학회지
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• 제50권4호
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• pp.278-286
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• 2006

Classical dihydropyrrole[3,4-f]quinazoline antifolates 7,8 and 9, in which the tricyclic ring is structurally similar to the pteridine ring of $CH_2-THF(1)$, the cofactor of thymidylate synthase (TS), were synthesized, and their in vitro antitumor activity was evaluated by measuring the cell growth inhibitory activity against cancer cell lines. The target compounds were cytotoxic against CCRF-CEM, human T-cell acute lymphoblastic leukemia, with the cell growth inhibitory activity $(IC_{50})$ of $0.8{\sim}8.3\;{\mu}M$. Among the three compounds, 3-amino analog 7 was 10- and 3.5-fold more cytotoxic compared to the 3-methyl analogs 8 and 9, and its cytotoxicity was similar to that of the reference compound with the $IC_{50}$ value of $0.83\;{\mu}M$. This result was supposed as the consequence of the fact that dihydropyrroloquinazolinone ring with amino group was able to bind well in the active site of TS. In the case of 3-methyl analogs, analog 9, which has two-carbon bridge between the dihydropyrroloquinazolinone ring and benzoyl-L-glutamic acid, was 3-times more potent in cytotoxicity than analog 8 which has one-carbon bridge, and this result indicates that the distance and conformational orientation of the benzoyl-L-glutamic acid moiety with respect to the tricyclic ring may also be a crucial determinant of cell growth inhibitory activity.

• 음성과학
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• 제15권1호
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• pp.25-36
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• 2008

Language transfer means that the speaker's first language or previously acquired language influences on the production of the target language. This study aims at examining if there is native language influence on the production of English intonation by Korean speakers. The pitch accent patterns and the values of duration, F0, and intensity of the stressed vowel of the word with emphatic accent in the sentence produced by Korean speakers are compared to those of American English speakers. The results show that when the word receives emphatic accent in the sentence, American English speakers put H* accent on the stressed syllable of the word, but Korean speakers mostly assign high pitch on the last syllable of the word and have LH tonal pattern despite the fact that primary stress does not come on the last syllable within a word. In addition, comparison of the values of duration, F0, and intensity of the stressed vowel of the word with emphatic accent to those of the word with unmarked neutral accent shows that Korean speakers do not realize the intonation of the accented word appropriately because the values decrease even though the word has emphatic accent. This study finds out that there are differences in the production of English intonation of the word with emphatic accent between native speakers of English and Korean speakers, and that there is negative transfer of Korean intonation pattern to the production of English intonation by Korean speakers.

• 말소리와 음성과학
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• 제6권4호
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• pp.47-52
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• 2014

This study investigated how the degree of attention modulates English learners' perception of Korean stop contrasts. The contributions of VOT and F0 in perceiving Korean stops were examined while availability of attentional resources was manipulated using a dual-task paradigm. Results demonstrated the attentional modulation in the use of VOT, but not in F0: under less attention, the contribution of VOT to the perception of aspirated stops decreased, whereas that of lenis stops increased, which suggests more native-like performance. This implies that the role of attention in perceiving non-native contrasts might differ depending on how equivalent the acoustic and perceptual cues are between L1 and target L2 contrasts.