• Journal of Pharmaceutical Investigation
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• v.32 no.2
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• pp.119-125
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• 2002

A rapid, selective and reproducible high-performance liquid chromatographic method has been developed for the determination of terazocin in human plasma. Terazocin plus the internal standard, prazocin hydrochloride, were extracted from alkalified plasma with tert-butylmethyl ether, back-extracted into 0.05% phosphoric acid. Fifty ${\mu}l-portions$ of extract were injected onto a octadecylsilane column and eluted with a mixture of acetonitrile, water and triethylamine (30 : 70 : 0.1 v/v, adjusted to pH 5.0 with dilute phosphoric acid) at a flow rate of 1.0 ml/min. The fluorescence intensity of column eluents was monitored at excitation wavelength of 250 nm and emission wavelength of 370 nm. No interference peaks were observed. The practical limit of quantitation was 5 ng/ml for terazocin. The average intraday and interday coefficients of variation were 4.15 and 3.54%, respectively. Also intraday and interday precisions over the range $5{\sim}60\;ng/ml$ were $0.49{\sim}2.92\;and\;0.38{\sim}5.12%$, respectively. The bioequivalence of two terazosin tablets, the $Hytrine^{\circledR}$ (Il Yang Pharmaceutical Co., Ltd.) and the $Teratonin^{\circledR}$ (Sam-A Pharmaceutical Co., Ltd.), was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). Sixteen healthy male volunteers $(24.6{\pm}2.0\;years\;old)$ were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 2 mg of terazosin was orally administered, blood was taken at predetermined time intervals and the concentration of terazosin in plasma was determined with a HPLC method using spectrofluorometric detector. AUC was calculated by the linear trapezoidal method. $C_{max}\;and\;T_{max}$ were compiled from the plasma drug concentration-time data. Analysis of variance (ANOVA) was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between the two preparations were 0.21 %, 5.53% and 8.82%, respectively. The powers $(1-{\beta})\;for\;AUC_t,\;C_{max}\;and\;T_{max}$ were >99%, 97.49%, and 33.26%, respectively. Minimum detectable differences $({\Delta},\;%)\;at\;{\alpha}=0.1\;and\;1-{\beta}=0.8$ and the 90% confidence intervals were all less than ${\pm}20%$ except for $T_{max}.\;AUC_t\;and\;C_{max}$ met the criteria of KDFA for bioequivalence, indicating that $Teratonin^{circledR}$ tablets are bioequivalent to $Hytrine^{circledR}$ tablets.

• Transactions of the Korean Society of Automotive Engineers
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• v.12 no.1
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• pp.17-24
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• 2004

As the environmental pollution becomes serious global problem, the regulation of emission exhausted from automobiles is strengthened. Therefore, it is very important to know how to reduce the NOx and PM simultaneously in diesel engines, which has lot of merits such as high thermal efficiency, low fuel consumption and durability. By this reason, the new concept called as Homogeneous Charge Compression Ignition(HCCI) engines are spotlighted because this concept reduced NOx and P.M. simultaneously. However, it is well known that HCCI engines increased HC and CO. Thus, the investigation of combustion characteristics which consists cool and hot flames for HCCI engines were needed to obtain the optimal combustion condition. In this study, combustion characteristics for direct injection type HCCI engine such as quantity of cool flame and hot flame, ignition timing and ignition delay were investigated to clarify the effects of these parameters on performance. The results revealed that diesel combustion showed the two-stage ignition of cool flame and hot flame, the rate of cool flame increase and hot flame decrease with increasing intake air temperature. On the other hand, the gasoline combustion is the single-stage ignition and ignition timing is near the TDC. In addition mixed fuel combustion showed different phenomenon, which depends on the ratio of gasoline component. Ignition timing of mixed fuel is retarded near the TDC and the ignition delay is increased according to ratio of gasoline.

• Journal of Electrochemical Science and Technology
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• v.10 no.3
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• pp.302-312
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• 2019

The voltage produced from the salinity gradient in reverse electrodialysis (RED) increases proportionally with the number of cell pairs of alternating cation and anion exchange membranes. Large-scale RED systems consisting of hundreds of cell pairs exhibit high voltage of more than 10 V, which is sufficient to utilize water electrolysis as the electrode reaction even though there is no specific strategy for minimizing the overpotential of water electrolysis. Moreover, hydrogen gas can be simultaneously obtained as surplus energy from the electrochemical reduction of water at the cathode if the RED system is equipped with proper venting and collecting facilities. Therefore, RED-driven water electrolysis system can be a promising solution not only for sustainable electric power but also for eco-friendly hydrogen production with high purity without $CO_2$ emission. The RED system in this study includes a high membrane voltage from more than 50 cells, neutral-pH water as the electrolyte, and an artificial NaCl solution as the feed water, which are more universal, economical, and eco-friendly conditions than previous studies on RED with hydrogen production. We measure the amount of hydrogen produced at maximum power of the RED system using a batch-type electrode chamber with a gas bag and evaluate the interrelation between the electric power and hydrogen energy with varied cell pairs. A hydrogen production rate of $1.1{\times}10^{-4}mol\;cm^{-2}h^{-1}$ is obtained, which is larger than previously reported values for RED system with simultaneous hydrogen production.

• Nuclear Engineering and Technology
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• v.54 no.3
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• pp.959-964
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• 2022

Lead is an important material, both for fusion or fission reactors. The cross sections of natural lead should be validated because lead is a main component of lithium-lead modules suggested for fusion power plants and it directly affects the crucial variable, tritium breeding ratio. The presented study discusses a validation of the lead transport libraries by dint of the activation of carefully selected activation samples. The high emission standard ²⁵²Cf neutron source was used as a neutron source for the presented validation experiment. In the irradiation setup, the samples were placed behind 5 and 10 cm of the lead material. Samples were measured using a gamma spectrometry to infer the reaction rate and compared with MCNP6 calculations using ENDF/B-VIII.0 lead cross sections. The experiment used validated IRDFF-II dosimetric reactions to validate lead cross sections, namely ¹⁹⁷Au(n, 2n)¹⁹⁶Au, ⁵⁸Ni(n,p)⁵⁸Co, ⁹³Nb(n, 2n)^92mNb, ¹¹⁵In(n,n')^115mIn, ¹¹⁵In(n,γ)^116mIn, ¹⁹⁷Au(n,γ)¹⁹⁸Au and ⁶³Cu(n,γ)⁶⁴Cu reactions. The threshold reactions agree reasonably with calculations; however, the experimental data suggests a higher thermal neutron flux behind lead bricks. The paper also suggests ²⁵²Cf isotropic source as a valuable tool for validation of some cross-sections important for fusion applications, i.e. reactions on structural materials, e.g. Cu, Pb, etc.

• Journal of Ecology and Environment
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• v.42 no.1
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• pp.20-29
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• 2018

Background: For various reasons such as agricultural and economical purposes, land-use changes are rapidly increasing not only in Korea but also in the world, leading to shifts in the characteristics of local carbon cycle. Therefore, in order to understand the large-scale ecosystem carbon cycle, it is necessary first to understand vegetation on this local scale. As a result, it is essential to comprehend change of the carbon balance attributed by the land-use changes. In this study, we attempt to understand accumulated soil carbon (ASC) and soil respiration (Rs) related to carbon cycle in two ecosystems, artificially turned forest into pastureland from forest and a native deciduous temperate forest, resulted from different land-use in the same area. Results: Rs were shown typical seasonal changes in the alpine pastureland (AP) and temperate deciduous forest (TDF). The annual average Rs was $160.5mg\;CO_2\;m^{-2}h^{-1}$ in the AP, but it was $405.1mg\;CO_2\;m^{-2}h^{-1}$ in the TDF, indicating that the Rs in the AP was lower about 54% than that in the TDF. Also, ASC in the AP was $124.49Mg\;C\;ha^{-1}$ from litter layer to 30-cm soil depth. The ASC was about $88.9Mg\;C\;ha^{-1}$, and it was 71.5% of that of the AP. The temperature factors in the AP was high about $4^{\circ}C$ on average compared to the TDF. In AP, it was observed high amount of sunlight entering near the soil surface which is related to high soil temperature is due to low canopy structure. This tendency is due to the smaller emission of organic carbon that is accumulated in the soil, which means a higher ASC in the AP compared to the TDF. Conclusions: The artificial transformation of natural ecosystems into different ecosystems is proceeding widely in the world as well as Korea. The change in land-use type is caused to make the different characteristics of carbon cycle and storage in same region. For evaluating and predicting the carbon cycle in the vegetation modified by the human activity, it is necessary to understand the carbon cycle and storage characteristics of natural ecosystems and converted ecosystems. In this study, we studied the characteristics of ecosystem carbon cycle using different forms in the same region. The land-use changes from a TDF to AP leads to changes in dominant vegetation. Removal of canopy increased light and temperature conditions and slightly decreased SMC during the growing season. Also, land-use change led to an increase of ASC and decrease of Rs in AP. In terms of ecosystem carbon sequestration, AP showed a greater amount of carbon stored in the soil due to sustained supply of above-ground liters and lower degradation rate (soil respiration) than TDF in the high mountains. This shows that TDF and AP do not have much difference in terms of storage and circulation of carbon because the amount of carbon in the forest biomass is stored in the soil in the AP.

• 한국연소학회:학술대회논문집
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• 2003.05a
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• pp.13-19
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• 2003

As the environmental pollution becomes serious global problem, the regulation of emission exhausted from automobiles is strengthen. Therefore, it is very important to know how to reduce the NOx and PM simultaneously in diesel engines, which has lot of merits such as high thermal efficiency, low fuel consumption and durability. By this reason, the new concept called as Homogeneous Charge Compression Ignition(HCCI) engines are spotlighted because this concept reduced NOx and P.M. simultaneously. However, it is well known that HCCI engines increased HC and CO. Thus, the investigation of combustion characteristics which consists cool and hot flames for HCCI engines were needed to obtain the optimal combustion condition. In this study, combustion characteristics for direct inject type HCCI engine such as quantity of cool flame and hot flame, ignition timing and ignition delay were investigated to clarify the effects of these parameters on performance. The results revealed that diesel combustion showed the two-stage ignition of cool flame and hot flame, the rate of cool flame increase and hot flame decrease with increasing intake air temperature. On the other hand, the gasoline combustion is the single-stage ignition and ignition timing is near the TDC. In addition mixed fuel combustion showed different phenomenon, which depends on the ratio of gasoline component. Ignition timing of mixed fuel is retarded near the TDC and the ignition delay is increased according to ratio of gasoline.

• Korean Journal of Soil Science and Fertilizer
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• v.39 no.2
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• pp.73-79
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• 2006

Aeration is the most important and indispensable operation unit for the treatment of swine manure using aerobic liquid-composting process. The composting of swine manure depends on biological treatment process, but the highly concentrated ammonia nitrogen is required a pretreatment to expect the appropriate efficiency of the biological treatment process. In this study, pilot experiments have been carried out to estimate of the fit condition about ammonia stripping process as a pretreatment to aerobic liquid- composting. pH adjustment with $Ca(OH)_2$ was economically superior to use of NaOH and optimum pH of ammonia stripping was 12.3, ammonia nitorgen was rapidly removed as pH were increased at $$35^{\circ}C$$. When air stripping is performed before aerobic liquid-stripping, a high initial pH is required for complete ammonia removal and is additional effects such as organic substances, phosphorus, turbidity, and color removal. Stripping process was very efficient in the pretreatment of highly concentrated ammonia nitrogen for composting of swine manure. Emission rate of gaseous ammonia was $0.5355mole\;s^{-1}$ at initial time and $0.0253mole\;s^{-1}$ at finitial time. The fit condition of ammonia stripping in this study were at the temperature of $$35^{\circ}C$$, and the pH of 12.3 during 48 hours.

• Korean Journal of Soil Science and Fertilizer
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• v.40 no.4
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• pp.292-297
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• 2007

Global warming and climate changes have been major issues for decades andvarious researches have reported their impact on our environment. According to recent researches, increased carbon dioxide ($CO_2$) concentration in the atmosphere is considered as a dominant contributor to global climate changes and thus numerous researches were conducted to control $CO_2$ concentration in the atmosphere. Soil management practices, such as reducing tillage intensity, returning plant residues, and enhancing cropping system have recommended for restoring organic carbon into the soils effectively. However, few studies on soil carbon sequestration have reported for Korean paddy soils. Therefore, evaluation of soil organic carbon (SOC) dynamics in the long-term single rice cropping system is essential in order to find out potential capacity of paddy field as a carbon sink source. The objective of this research was to evaluate SOC dynamics on the long-term single rice cropping system. Research was conducted in the research farm at National Institute of Agricultural Science and Technology, Rural Development Administration, Suwon. Long-term phosphorus and potassium fertilization and lime application didn't significantly affect on SOC compared to controls. We found that SOC contents were increased continually at the long-term composting plots with enhanced rate of carbon storage. In conclusion, continuous incorporation of plant residues (i.e., composting) is recommended to effectively sequester soil carbon for Korean paddy soils. This result implies that continuous composting in a paddy field may contributenot only for increasing SOC in the soils but also for mitigating global warming through reducing carbon dioxide emission into atmosphere. Therefore, we recommend that a strategy or policy measures to encourage farmers to return plant residues continuously for mitigation of global warming as well as soil fertility is being developed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.9
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• pp.526-535
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• 2018

Recently, in order to reduce the $CO_2$ emission in the island area, countermeasures to operate power system in a stable manner are being researched due to decrease of the operation rate in diesel generators and the increase of renewable energy sources. The phenomenon of energy sinking can be occurred if the output of renewable energy sources is larger than customer loads. Voltage of CVCF(constant voltage & constant frequency) battery could be increased rapidly according to the condition of SOC(state of charge) and blackout could be occurred due to shut-down of CVCF inverter, at carbon free island micro-grid based on the CVCF inverter. In order to overcome these problems, this paper proposes a transient operation algorithm in CVCF based micro-grid which in advance prevents shut-down of CVCF inverter during the energy sinking. And also this paper proposes the modeling of micro-grid including CVCF inverter, PV system, customer load using PSCAD/EMTDC S/W. From the results of micro-grid modeling based on the proposed algorithm, it is confirmed that CVCF based micro-grid can properly prevent shut-down of CVCF inverter according to SOC and battery voltage of CVCF inverter when energy sinking is occurred.

• Korean Journal of Construction Engineering and Management
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• v.14 no.4
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• pp.55-64
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• 2013

As GHG target management is introduced in Korea, designated establishment takes responsibilities to reduce more than 30% of expected GHG emission until 2020. Although decreasing GHG has been requested to universities which consume great amount of energy, there are difficulties to apply high cost countermeasures. Therefore, this research suggest a low cost, easily-applicable energy saving method, and derive potential GHG reduction amount in the case of SNU, Kwan-ak campus. First of all, 11 rooms of different use were chosen as the samples, and energy consumption in each room was measured. Standard models for each room were built through researching on the electric devices in each room. Moreover, energy consumption was computed for each devices through analyzing the pattern of electricity consumption. 32 GHG reduction technology and action program were chosen, and they were applied to the standard models for individual rooms. Through multiplying energy reduction rate of each program to energy consumption of each electric device, maximum energy reduction of each electric device is derived. Through that, Maximum GHG reduction for individual rooms and each month and the total GHG reduction capacity of Kwan-ak campus were computed. It was found out that approximately $5,311tCO_2$-eq can be reduced, when reduction technology and action program suggested by this research are applied. It appeared 24.48% of requested reduction amount to SNU can be reduced, till 2016.