• 생물정신의학
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• 제5권2호
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• pp.227-234
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• 1998

Objective : Many evidences suggest that patients with bipolar disorder have functional abnormalities in their postreceptor signal transduction pathways, and mood stabilizing effect of lithium is exerted by modulating this dysfunctioning system. Carbamazepine, an antiepileptic agent, is also known to be effective in the treatment and prevention of bipolar disorder. But the precise mechanism of action of the drug is still poorly understood. This study was performed to elucidate the possible therapeutic mechanism of carbamazepine. Method : The effects of chronic carbamazepine administration on protein kinase A and protein kinase C activities in frontal cortex of rat brain after 2 weeks of drug administration were measured and compared with those of control subjects. Results : Mean(${\pm}SE$) value of activity(phosphate transfer ${\mu}mol/mg$ of $protein{\cdot}min$) of protein kinase A in control and test group was $0.249563{\pm}0.036$ and $0.539853{\pm}0.078$, and that of protein kinase C was $0.654817{\pm}0.053$ and $1.146205{\pm}0.052$ respectively, being increased in test group. And differences between the two groups were statistically significant for both enzymes(protein kinase A ; p<0.01, protein kinase C ; p<0.001). Conclusion : These results show that chronic carbamazepine administration increases protein kinase A and C activities, and concerning the possible mode of therapeutic action in bipolar disorder it is suggested that enhanced enzymes phosphorylate receptor-G-protein-effector complexes to dampen hyperfunctioning neuronal activity and thus stabilize the system.

• 한국의류학회지
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• 제7권2호
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• pp.45-52
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• 1983

The purpose of this study was to investigate between locus of control, body cathexis and four aspects of clothing behavior. Locus of control was measured by Rotter's The Internal-External Scale and body cathexis by Secord and Jourard's Body Cathexis Scale. Two aspects of clothing behavior were assessed with Lee's questionnaires dealing with status symbol and clothing satisfaction. Clothing Acceptance I was determined with questionnaires designed to measure the acceptance of color and casual wear and Clothing Acceptance II by line drawings of clothing representing formal type, informal type, and new mode type designed to measure the acceptance of business suits. The questionnaires in this study were administered to a sample of men (between 20 to more than 60 years of age) in Seoul. The data from 303 respondents were analyzed. The results were: 1) Locus of control was not related to Clothing Acceptance I(acceptance of color and casual wear), but positively related to Clothing Acceptance II(acceptance of business suit), that is, the persons having wider latitudes of acceptance in business suits were internally controlled in locus of control. 2) Locus of control was negatively related to status symbol, that is, the persons having higher concepts in status symbol were externally controlled in locus of control. 3) Body cathexis was positively related to clothing satisfaction, that is, the persons having higher satisfaction toward their clothing were more satisfied with their body.

• 한국진공학회:학술대회논문집
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• 한국진공학회 1998년도 제14회 학술발표회 논문개요집
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• pp.133-133
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• 1998

In the thin film alloy formation of the transition metals ion-beam-mixing technique forms a metastable structure which cannot be found in the arc-melted metal alloys. Sppecifically it is well known that the studies about the electronic structure of ion-beam-mixed alloys pprovide the useful information in understanding the metastable structures in the metal alloy. We studied the electronic change in the ion-beam-mixed ppt-Ct alloys by XppS and XANES. These analysis tools pprovide us information about the charge transfer in the valence band of intermetallic bonding. The multi-layered films were depposited on the SiO2 substrate by the sequential electron beam evapporation at a ppressure of less than 5$\times$10-7 Torr. These compprise of 4 ppairs of ppt and Cu layers where thicknesses of each layer were varied in order to change the alloy compposition. Ion-beam-mixing pprocess was carried out with 80 keV Ae+ ions with a dose of $1.5\times$ 1016 Ar+/cm2 at room tempperature. The core and valence level energy shift in these system were investigated by x-ray pphotoelectron sppectroscoppy(XppS) pphotoelectrons were excited by monochromatized Al K ａ(1486.6 eV) The ppass energy of the hemisppherical analyzer was 23.5 eV. Core-level binding energies were calibrated with the Fermi level edge. ppt L3-edge and Cu K-edge XANES sppectra were measured with the flourescence mode detector at the 3C1 beam line of the ppLS (ppohang light source). By using the change of White line(WL) area of the each metal sites and the core level shift we can obtain the information about the electrons pparticippating in the intermetallic bonding of the ion-beam-mixed alloys.

• 대한수의학회지
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• 제44권2호
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• pp.303-310
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• 2004

To establish a prediction table of parturition day real-time B-mode ultrasonographic examinations were performed in 12 pregnant Shih-tzu bitches. Measurement of inner chorionic cavity diameter and fetal head diameter was performed from 15 days of gestation to parturition. These were converted retrospectively based on the day of parturition (Day 0). The data of inner chorionic cavity diameter obtained from Day -44 to Day -25 and fetal head diameter obtained from Day -25 to Day -1 were used to compile a prediction table of parturition day. The 22 pregnant Shih-tzu with unknown mating time were examined to assess an accuracy of the table established in this study. And these results were applied to the prediction of parturition day and compared to actual parturition day. Parturition day prediction based on the inner chorionic cavity diameter and fetal head diameter was 100% accurate within ${\pm}2$ days. In addition, the accuracy for parturition day within 0, ${\pm}1$, and ${\pm}2$ days interval using the prediction table of parturition day were 68, 82, and 100%, respectively. Therefore, the prediction table of parturition day seems to be a useful tool for the prediction of parturition day in practice.

• 대한지구과학교육학회지
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• 제6권2호
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• pp.124-135
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• 2013

The purpose of this study was to find the relationship between elementary school teachers' beliefs of inquiry and science performance assessment. To collect data for analyzing elementary school teachers' beliefs of inquiry and their practice of science performance assessment, the researcher was surveyed with elementary school teachers by open-ended questionnaires and interview. The findings of this study were as follows; First, Most of elementary school teachers beliefs of inquiry was shown as constructivist tendency. This view of inquiry involves watching and doing experiments, and the skills of thinking processes, in which learners make their own interpretations rather than merely acquiring preexisting knowledge structures. Second, for content knowledge, participants' preception about the target of science performance assessment involved assessing application of science knowledge rather than basic level of substantive knowledge. For inquiry process, participants' preception about the target of science performance assessment involved assessing the lower level of inquiry rather than the higher level of inquiry. Most of participants was measured using a paper and pencil test for the actual evaluation methods due to the ease and objectivity of the assessment, the lack of understanding how to perform the performance evaluation process and method. Especially, participants who recognize that the higher level of inquiry was used performance and informal mode of assessing.

• The Korean Journal of Physiology and Pharmacology
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• 제7권1호
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• pp.25-28
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• 2003

Ion channel inhibitors are widely used for pharmacological discrimination between the different channel types as well as for determination of their functional role. In the present study, we tested the hypothesis that 4-aminopyridine (4-AP) could affect the large conductance $Ca^{2+}$-activated $K^+$ channel ($BK_{Ca}$) currents using perforated-patch or cell-attached configuration of patch-clamp technique in the rabbit pulmonary arterial smooth muscle. Application of 4-AP reversibly inhibited the spontaneous transient outward currents (STOCs). The reversal potential and the sensitivity to charybdotoxin indicated that the STOCs were due to the activation of $BK_{Ca}$. The $BK_{Ca}$ currents were recorded in single channel resolution under the cell-attached mode of patch-clamp technique for minimal perturbation of intracellular environment. Application of 4-AP also inhibited the single $BK_{Ca}$ currents reversibly and dose-dependently. The membrane potential of rabbit pulmonary arterial smooth muscle cells showed spontaneous transient hyperpolarizations (STHPs), presumably due to the STOC activities, which was also inhibited by 4-AP. These results suggest that 4-AP can inhibit $BK_{Ca}$ currentsin the intact rabbit vascular smooth muscle. The use of 4-AP as a selective voltage-dependent $K^+$ (KV) channel blocker in vascular smooth muscle, therefore, must be reevaluated.

• 한국환경성돌연변이발암원학회지
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• 제25권4호
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• pp.157-160
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• 2005

Biofilm 내부의 항생제 내성 박테리아의 성장형태는 만성감염과 질병을 발생한다. 인위적 형성한 biofilm의 체외실험 모델 시스템 통한 항생제 침투 실험을 수행하였다. 항생제 내성 균주 (E. coli, S. aureus)는 항생제 내성균주 은행으로부터 획득하였다 Ca-alginate bead를 인위적 biofilm으로 사용하였고, 세포 생존률을 향상시키기 위해 공기 압축을 이용한 세포 포획 실험도 측정되었다. biofilm의 항생제 감수성은 항생제의 농도 따라 최저 저해 농도 (MIC)를 이용하여 측정되었다. bead생성에 따른 안정성은 bead를 형성하지 않은 세포와 비교하여 감소하였다. 항생제에 민감한 E. coli의 경우 시간이 지남에 따라 균체수도 감소하였으나, 항생제 내성 E. coli는 일정한 균체수를 유지하였다. bead형성 후 항생제 투여 효과는 항생제 내성이 있고, 낮은 농도의 항생제를 처리할수록 더 높은 생존률을 보였다.

• 비파괴검사학회지
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• 제21권1호
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• pp.39-45
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• 2001

신호처리법으로 현재 많이 사용되고 있는 푸리에 변환은 신호의 주파수 성분이 시간에 따라 어떻게 변화하는지를 표현하지 못한다. 따라서 최근 이와 같은 푸리에 변환의 단점을 보완하여, 신호의 시간과 주파수에 대한 정보를 동시에 표현할 수 있는 시간-주파수 해석법들이 개발되었다. 본 연구에서는 음향방출을 이용하여 복합재료의 주요 발생원으로 알려져 있는 기지균열, 섬유분리, 섬유파괴 덴 층간분리 등과 같은 파괴기구를 해석하였다. 각각의 파괴특성이 나타나도록 시험편을 제작하여 인장시험 시 검출된 음향방출신호의 시간-주파수 해석을 통해 전체 파괴기구의 특징을 분석하였다.

• 한국ITS학회 논문지
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• 제14권1호
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• pp.94-102
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• 2015

고속도로 하이패스 이용률은 59.4%(2013년말 기준)로서 지속적으로 증가하고 있는 추세이다. 본 연구에서는 고속도로 영업소를 이용하는 승용차의 연료소모량을 측정하기 위해서 4개 차종을 대상으로 차대 동력계를 이용한 탄소균형법을 적용하였고, 일반 영업소와 하이패스 영업소의 주행 모드 18개를 설정하여 실험하였다. 그 결과 폐쇄식 구간의 경우 차종에 따라 21.0~56.4ml/veh, 개방식 구간의 경우 10.5~28.1ml/veh의 연료소모 절감효과가 있는 것으로 분석되었다. 또한, 하이패스 이용률에 따른 연간 연료비용 절감효과는 이용률 70%일 경우 282~573억원, 80%일 경우 322~655억원, 90%일 경우 362~737억원, 100%일 경우 403~819억원으로 산정되었다.

• 약학회지
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• 제52권3호
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• pp.172-175
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• 2008

Stable isotope ratio of carbon and nitrogen ($\delta^{13}C$ & $\delta^{15}N$), and $\Delta^{9}$-tetrahydrocannabinol (THC) contents were measured on 37 Korean cannabis and 10 commercial grade marijuana seized in Korea. Factors influencing on the measured values and their variations were investigated. $\delta^{13}C$ value of cannabis is specified mainly by water availability. Korean cannabis showed relatively low $\delta^{13}C$ values ranging -33.29$\sim$-27.01% (mean=-31.01%), which reflect geographic conditions of Korea where is rainy, especially during summer. $\delta^{15}N$ values, which reflect individual planting conditions, were relatively high up to -0.5$\sim$18.0% (mean=6.44%). It reflects characteristics of Korean cannabis growing wild in forest or cultivated in fertile soil. Tetrahydrocannabinol is the major hallucinogenic compound of cannabis. Ethanol extracts of cannabis leaves were derivatized by N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), and the derivatives were analyzed by GC-MS in selected ion monitoring (SIM) mode. THC contents of Korean cannabis ranged 0.11$\sim$4.34% (mean=1.47%), which were relatively low compared with commercial grade marijuana.