• Journal of Korean Society of Forest Science
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• v.96 no.2
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• pp.131-137
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• 2007

The first evidence has been provided about the variation within trnL-trnV and trnF-trnT spacer regions of cpDNAs in Korean fir and Manchurian fir, revealed by PCR-RFLP analysis. Four cpDNA haplotypes have accordingly been recognized by being analyzed using the trnL-trnV/Tru11 primer-enzyme combination and 3 haplotypes using the trnF-trnT/TagI combination, which exhibited inter and intraspecific variation. A total of 6 cpDNA haplotypes were recognized by pooling the PCR-RFLP variants observed in both combinations. Haplotypes 2 and 3 were common for both species investigated, whereas haplotypes 1, 4, and 5 were detected only in Korean fir and haplotype 6 was detected only in Manchurian fir. Although haplotypes 2 and 3 were common in both species, haplotype 2 was major haplotype for Korean fir and haplotype 3 was one of the 2 major haplotypes for Manchurian fir. Restricted occurrence of haplotype 4 in Mt. Halla and haplotype 5 in Mt. Jiri of the Korean fir may represent the existence of geographic isolation by the sea between them. Diagnostic potential of individual haplotypes in discriminating between the two species as well as between their populations is discussed.

• Preventive Nutrition and Food Science
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• v.19 no.4
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• pp.333-342
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• 2014

Limited epidemiologic data is available regarding the cardiovascular effects of mercury exposure. The purpose of this study was to determine the relationship between mercury exposure from fish consumption and cardiovascular disease in a nationally representative sample of Korean adults using the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV 2008~2009). Survey logistic regression models accounting for the complex sampling were used to estimate the odds ratios (OR) adjusted for fish consumption frequency, age, education, individual annual income, household annual income, body mass index (BMI), waist circumference (WC), alcohol consumption status, and smoking status. The mean blood mercury level in the population was $5.44{\mu}g/L$. Trends toward increased blood mercury levels were seen for increased education level (P=0.0011), BMI (P<0.0001), WC (P<0.0001), and fish (i.e., anchovy) consumption frequency (P=0.0007). The unadjusted OR for hypertension in the highest blood mercury quartile was 1.450 [95% confidential interval (CI): 1.106~1.901] times higher than that of the lowest quartile. The fish consumption-adjusted OR for hypertension in the highest blood mercury quartile was 1.550 (95% CI: 1.131~2.123) times higher than that of the lowest quartile, and the OR for myocardial infarction or angina in the highest blood mercury quartile was 3.334 (95% CI: 1.338~8.308) times higher than that of the lowest quartile. No associations were observed between blood mercury levels and stroke. These findings suggest that mercury in the blood may be associated with an increased risk of hypertension and myocardial infarction or angina in the general Korean population.

• Transactions of the Korean Society of Automotive Engineers
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• v.6 no.6
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• pp.113-131
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• 1998

The objective of the present study is to investigate the characteristics of the dividing flow in the laminar flow region. Using glycerine water solution(wt43%) for Newtonian fluid and the polymer of viscoelastic fluid(500wppm) for non-Newtonian fluid, this research investigates the flow state of the dividing tube in steady laminar flow region of the two dimensional dividing tube by measuring the effect of Reynolds number, dividing angle, and the flow rate ratio on the loss coefficient. In T- and Y-type tubes, the loss coefficients of the Newtonian fluid decreases in constant rate when the Reynolds number is below 100. The effect of the flow rate ratio on the loss coefficients is negligible. But when the Reynolds number is over 100, the loss coefficient with various flow rate ratios approach an asymptotic value. The loss coefficient of the non-Newtonian fluid for different the Reynolds number shows the similar tendency of the Newtonian fluid. And when the Reynolds number is over 300, the loss coefficient is approximately 1.03 regardless of flow rate ratio or the dividing angle. The aspect ratio does hardly influence the reattachment length and the loss coefficient of both Newtonian and non Newtonian fluid. The loss coefficient decreases as the Reynolds number increases. The loss coefficient of Newtonian fluid is larger than that of non-Newtonian fluid.

• The Korean Journal of Nuclear Medicine
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• v.21 no.2
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• pp.151-154
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• 1987

Total 114 patients were studied prospectively with radioiodine uptake (RAIU) and $^{99m}TcO_4^-$ thyroid scan to design a very simple, rapid and inexpensive method measuring the thyroid uptake on thyroid scan. After the RAIU was obtained at 24 hours after P.O. of $^{131}I$, Thyroid scan was performed at 20 minutes after LV. of $^{99m}TcO_4^-$ and the bilateral salivary glands were included in the scan field. Pinhole collimated and computer assisted gamma camera was used. Three regions of interest were set on each salivary gland and on the thyroid by automatic edge detection method. Mean counts per pixel were calculated for each ROI and the salivary-thyroid ratio (STR) was defined as; $$STR(%)=\frac{Mean\;counts\;per\;pixel\;of\;salivary\;glands\;(KC)}{Mean\;counts\;per\;pixel\;of\;thyroid\;gland\;(KC)}\times100$$ 114 cases consisted of 41 normal, 55 hyperthyroid and 18 hypothyroid patients and correlation between the STR and the RAID were evaluated in total and each group. The STR and the RAID showed reverse linear regression in 114 cases (r= -0.8, P=0) and closer correlation was shown in hyperthyroid group (r= -0_9, p=0). Mean STR in normal group was 47.6%. In predicting the RAID by STR, sensitivity and specificity were 88.3% and 64.9% in 114 cases and 95.3% and 83.3% in hyperthyroid group. It is recommended that the STR be used in place of the RAID giving same information at saving time, money and radiation exposure.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.6
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• pp.2805-2810
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• 2016

Background: Differentiated thyroid cancer is the most common endocrine malignancy with a generally good prognosis. Knowing long-term outcomes of each patient helps management planning. The study was conducted to develop and validate a clinical prognostic score for predicting disease remission in patients with differentiated thyroid cancer based on patient, tumor and treatment factors. Materials and Methods: A retrospective cohort study of 1,217 differentiated thyroid cancer patients from two tertiary-care hospitals in the Northeast of Thailand was performed. Associations between potential clinical prognostic factors and remission were tested by Cox proportional-hazards analysis in 852 patients (development cohort). The prediction score was created by summation of score points weighted from regression coefficients of independent prognostic factors. Risks of disease remission were estimated and the derived score was then validated in the remaining 365 patients (validation cohort). Results: During the median follow-up time of 58 months, 648 (76.1%) patients in the development cohort had disease remission. Five independent prognostic factors were identified with corresponding score points: duration from thyroid surgery to $^{131}I$ treatment (0.721), distant metastasis at initial diagnosis (0.801), postoperative serum thyroglobulin level (0.535), anti-thyroglobulin antibodies positivity (0.546), and adequacy of serum TSH suppression (0.293). The total risk score for each patient was calculated and three categories of remission probability were proposed: ${\leq}1.628$ points (low risk, 83% remission), 1.629-1.816 points (intermediate risk, 87% remission), and ${\geq}1.817$ points (high risk, 93% remission). The concordance (C-index) was 0.761 (95% CI 0.754-0.767). Conclusions: The clinical prognostic scoring model developed to quantify the probability of disease remission can serve as a useful tool in personalized decision making regarding treatment in differentiated thyroid cancer patients.

• Journal of Yeungnam Medical Science
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• v.31 no.2
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• pp.148-151
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• 2014

Radioactive iodine (RAI) therapy is widely used for the treatment of Graves disease. After RAI therapy, 44% become hypothyroid and up to 28% remain hyperthyroid. The development of thyrotoxicosis after RAI therapy is believed to be mediated by 2 different mechanisms: a transient increased release of thyroid hormone due to radiation thyroiditis and the rare development of Graves disease due to the formation of antibodies to the thyroid-associated antigens released from the damaged follicular cells. A 55-year-old woman was hospitalized with severe headache, weight loss, and palpitation. She received a dose of 7 mCi of RAI (I-131) about 6 weeks earlier. Thyroid function test showed 7.98 ng/dL free T4, >8 ng/mL T3, < $0.08{\mu}IU/L$ thyroid stimulating hormone, and high titer thyroid stimulating immunoglobulin (TSI) (85.8 IU/L). She improved with propylthiouracil, propranolol, and steroid treatment. The TSI, however, was persistently elevated for 11 months.

• Journal of Radiation Industry
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• v.7 no.2_3
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• pp.221-224
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• 2013

RI-Biomics is a new compound word of radiation technology and Biomics related to the study of life. RI-Biomics is high radiation fusion technology by combining evaluation of pharmacokinetics in vivo (RI-ADME) of new drugs and medical materials using radioisotope and molecular imaging technology using nuclear medicine equipments. RI-Biomics fields are emerging with the increasing usage of radioisotopes (RI). In this paper, we investigated the latest trends of radioisotope using in RI-Biomics fields. The representative radioisotopes are $^{14}C$, $^3H$ and $^{32}P$ for the optimization and the selection of candidates in the development process of new drugs among the RI-Biomics fields. As shown in the status of accumulated income of radioisotopes, using amounts of radioisotopes are showing a tendency to increase every year. $^{14}C$ is 61.6% increase of accumulated income growth rate and $^3H$ increased by 58.8% and $^{32}P$ increased by 33.9% in 2012 compared to 2007. These isotopes are used in a variety of fields as using of $^{14}C$ for microdosing test, development of [$^3H$]cholesterol absorption inhibitors, study of [$^{131}I$]pyronaridine tetraphosphate for malaria therapy. These are going on in vivo test sucessfully. So, clinical research step is expected to begin soon. Therefore, usages of radioisotopes are necessary and need for the evaluation of pharmacokinetics, optimization and the selection of new drug candidates in the development process of new drugs among the RI-Biomics fields. So, using of radioisotopes is predict to increase continuously except for primarily used $^{14}C$, $^3H$.

• Korea journal of population studies
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• v.35 no.2
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• pp.103-131
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• 2012

As divorce and singlehood have been on the rise over the last decades, marital statuses are more diverse than the past for middle-aged men and women in South Korea. While marital status is crucial for health behaviors and statuses, but few studies examine the associations between health differentials and marital status for the middle-aged in South Korea. Using the 2010 Social Survey collected by the Statistics Korea, this study analyzes how health behaviors and statuses vary by the marital status. In particular, this paper examines whether marital statuses and gender interact to influence health behaviors and statuses. I find that married middle-aged people are healthier than divorced, single, and widowed middle-aged people. But this the negative influence of the non-married status are much greater for men than women. Some female non-married groups do not differ from married middle-aged people in some indicators of health behaviors. Single female middle-aged people are better in general satisfaction levels than married middle-aged people.

• Journal of Korean society of Dental Hygiene
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• v.18 no.6
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• pp.1003-1012
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• 2018

Objectives: The purpose of this study was to contribute to the provision of a safe practice environment and practical sexual harassment prevention education for dental hygiene students who practice clinically. Methods: A total of 260 students with experience in clinical practice at dental hygiene colleges and universities in Gwangju and Jeonnam was included in this study. From May 1, 2018 to June 30, 2018, subjects were surveyed about sexual harassment experience, sexual harassment related information, self-esteem, and self-assertiveness. Statistical analysis was performed by frequency analysis, independent t-test, Mann-Whitney test, one way ANOVA, Pearson's correlation analysis, and multiple regression analysis. Results: In the sexual harassment survey revealed that 64.3% of offenders were patients and 50.0% of the offenders were in their 40s. A total of 78.6% of the offenders reported harassment in hospital type "dental clinics." Most respondents disclosed that "I did not do anything" (60.7%). Psychologically, 75.0% felt "shame and insult." Self-esteem was high in the fourth grade (3.68). Self-esteem and self-assertiveness were higher among those with no sexual harassment experiences (131.77 and 132.81, respectively; p<0.05). Correlation analysis indicated that self-esteem and self-assertiveness were correlated (r=0.509, p<0.01). Factors influencing the perception of sexual harassment include: three to four months of clinical practice (${\beta}=0.361$), experience of sexual harassment (${\beta}=-0.551$), and self-esteem (${\beta}=0.503$). Conclusions: It is necessary to provide systematic and diverse information to address sexual harassment. A proper perception of what constitute sexual harassment in clinical practice is also relevant. Furthermore, practical sexual harassment prevention education program should be developed and implemented.

• The korean journal of orthodontics
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• v.51 no.2
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• pp.126-134
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• 2021

Objective: This study aimed to evaluate the following null hypothesis: there are no differences in the morphology of the temporomandibular joint (TMJ) structures in relation to vertical and sagittal cephalometric patterns. Methods: This retrospective study was performed with 131 participants showing no TMJ symptoms. The participants were divided into Class I, II, and III groups on the basis of their sagittal cephalometric relationships and into hyperdivergent, normodivergent, and hypodivergent groups on the basis of their vertical cephalometric relationships. The following measurements were performed using cone-beam computed tomography images and compared among the groups: condylar volume, condylar size (width, length, and height), fossa size (length and height), and condyle-to-fossa joint spaces at the anterior, superior, and posterior condylar poles. Results: The null hypothesis was rejected. The Class III group showed larger values for condylar width, condylar height, and fossa height than the Class II group (p < 0.05). Condylar volume and superior joint space in the hyperdivergent group were significantly smaller than those in the other two vertical groups (p < 0.001), whereas fossa length and height were significantly larger in the hyperdivergent group than in the other groups (p < 0.01). The hypodivergent group showed a greater condylar width than the hyperdivergent group (p < 0.01). The sagittal and vertical cephalometric patterns showed statistically significant interactions for fossa length and height. Conclusions: TMJ morphology differed across diverse skeletal cephalometric patterns. The fossa length and height were affected by the interactions of the vertical and sagittal skeletal patterns.