• Journal of Pharmaceutical Investigation
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• 제15권3호
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• pp.130-139
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• 1985

Inclusion compounds of suprofen with ${\alpha}-$ and, ${\beta}-cyclodextrins\;({\alpha}-CyD,\;{\beta}-CyD)$ were studied in comparison with suprofen alone and commercial suprofen capsules. Inclusion compound formations of suprofen with ${\alpha}-$, and ${\beta}-CyDs$ in aqueous solution and in solid state were confirmed by UV absorption, circular dichroism spectroscopies, IR spectroscopy, differential scanning calorimetry and X-ray diffraction measurements. Solid inclusion complexes were prepared by freeze-drying method, and their molar ratios were found to be 1 : 1. The dissolution rate of inclusion complexes of suprofen with CyDs was notably higher than that of suprofen alone.

• 한국입자에어로졸학회지
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• 제19권1호
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• pp.13-20
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• 2023

The Asian dust observation network operates β-ray attenuation samplers to measure PM₁₀ concentrations. In addition, equivalence evaluation and accuracy inspection(Precision Tests) are conducted every year for the reliability of data. β-ray attenuation samplers(16 units) were comparatively observed from May to June 2020 and from July to December 2021. During the observation period, the average daily temperature was the lowest at 6.4℃ in December and the highest at 27.3℃ in August. The average daily humidity ranged from 60% to 100%, but the average daily humidity was over 75% from July to September. The minimum value of the PM₁₀ Gravimetric method was 5.0 ㎍/m³, the maximum value was 53.4 ㎍/m³, and the average value was 17.8 ㎍/m³. The equivalence evaluation results of the PM₁₀ Gravimetric method and β-ray attenuation samplers satisfied the criteria (slope: 1±0.1, intercept: 0±0.5). A relative error analysis between the PM₁₀ Gravimetric method and β-ray attenuation samplers equipment showed that the relative error increased when the concentration was low and the temperature and humidity were high. In addition, in the β-ray attenuation samplers 5-minute interval observation data in May 2020, a relatively large Standard devication was shown as an average maximum ±23.4 ㎍/m³ and a minimum ±15.2 ㎍/m³. At standard deviations of 10% and 90%, equipment with high variability (deviation) was measured at 6 ㎍/m³and 61 ㎍/m³, and equipment with low variability was measured at 12 ㎍/m³ and 47 ㎍/m³. It was confirmed that concentration differences occurred due to differences in variability for each equipment.

• 한국수소및신에너지학회논문집
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• 제12권4호
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• pp.247-255
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• 2001

The relation between the deformation and the geometrical shape, and the effect of cold work on the hydrogen absorption behavior in palladium were investigated. The Pd specimens used were plates and wires as cold worked and annealed states. The palladium plates and wires were loaded with hydrogen by electrochemical method. Experimental analyses were carried out through X -ray diffraction, micrometer measurement and decimal balance measurement. As the results, it is found that the effect of cold work on hydrogen absorption capacity was relatively small. The deformation of the palladium plates in thickness direction is larger than in other lateral directions whereas the palladium wires showed the same deformation ratio in all radius directions because of the circular distribution of coexisting $\alpha$ and $\beta$ phases. The products of plastic deformation such as slip lines and voids etc. were observed abundantly in all specimens although the specimens had undergone only once of a hydrogen absorption and desorption.

• Bulletin of the Korean Chemical Society
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• 제33권11호
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• pp.3755-3760
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• 2012

Single crystals of lithium potassium phthalate (LiKP) were successfully grown from aqueous solution by solvent evaporation technique. The grown crystals were characterized by single crystal X-ray diffraction. The lithium potassium phthalate $C_{16}\;H_{12}\;K\;Li_3\;O_{11}$ belongs to triclinic system with the following unit-cell dimensions at 298(2) K;$a=7.405(5){\AA}$;$b=9.878(5){\AA}$;$c=13.396(5){\AA}$;${\alpha}=71.778(5)^{\circ}$;${\beta}=87.300(5)^{\circ}$;${\gamma}=85.405(5)^{\circ}$; having a space group P1. Mass spectrometric analysis provides the molecular weight of the compound and possible ways of fragmentations occurs in the compound. Thermal stability of the crystal was also studied by both simultaneous TGA/DTA analyses. The UV-Vis-NIR spectrum shows a good transparency in the whole of Visible and as well as in the near IR range. Third order nonlinear optical studies have also been studied by Z-scan technique. Nonlinear absorption and nonlinear refractive index were found out and the third order bulk susceptibility of compound was also estimated. The results have been discussed in detail.

• 한국화재소방학회논문지
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• 제32권3호
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• pp.134-139
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• 2018

최근 초미세먼지는 사회적 재난으로 간주될만큼 국민건강에 심각하게 영향을 미쳐 사회문제가 되고 있다. 기존의 미세먼지 측정 방식은 베타선 흡수방식을 사용하여 실시간 측정 및 소형화가 어려운 단점이 존재한다. 본 논문에서는 광산란 방식을 사용하여 소형화 및 저비용의 센싱 장치를 개발하였다. 광산란 방식을 적용한 센서는 내부에 반도체 레이저 다이오드를 사용하여 구성하였으며, 전압레벨의 신호를 주파수레벨로 변환하여 기존 방식의 한계를 극복하고 미세먼지 입자 크기별 분리가 가능하도록 구현하였다. 또한 개발 시스템은 블루투스 통신으로 스마트폰과 연결하여 미세먼를 모니터링하고, 장치를 제어할 수 있다.

• Journal of Pharmaceutical Investigation
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• 제35권4호
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• pp.279-285
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• 2005

Ground CS-891 (N-[1-(4-methoxyphenyl)-1-methylethyl]-3-oxo-4-aza-5a-androst-1-ene-$17{\beta}$-carboxamide) of poorly water soluble drug was obtained using a Heiko Seisakusho model TI-100 vibration mill, and samples with different crystallinity were prepared at mixture ratios of 10:0, 7:3, 5:5, 3:7 and 0:10 (intact;ground CS-891). Physicochemical characterizations were obtained using qualitative and quantitative X-ray diffractometry, different scanning calorimetry (DSC), scanning electron microscopy (SEM), Quantasorb surface area analyzer, and controlled atmosphere microbalance. With increase of amorphous CS-891 in mixture ratios, the intensities of X-ray diffraction peaks of crystalline CS-891 were decreased, whereas surface area, water absorption, and exothermic peaks in DSC were increased. The apparent solubility of ground CS-891 was $4.4\;{\mu}g/ml$ and the solubility of intact CS-891 was $3.1\;{\mu}g/ml$ at $37{\pm}1^{\circ}C$. The apparent precipitation rates of CS-891 in a supersaturated solution during the solubility test were increased with an increase of amorphous CS-891, and a crystalline form of CS-891 transformed from amorphous CS-891 after the solubility test was found by X-ray diffraction analysis, DSC and SEM. The dissolution profiles of CS-891 with different crystallinity at $37{\pm}1^{\circ}C$ by the USP paddle method were investigated, and the apparent dissolution rate constant of ground CS-891 was about 5.9-fold higher than that of intact CS-891. A linear relationships between the crystallinity of CS-891 and the apparent dissolution rate constant (r>0.96) were obtained.

• 한국결정성장학회지
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• 제21권3호
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• pp.99-104
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• 2011

단결정 성장을 위한 $MgGa_2Se_4$ 다결정은 수평 전기로에서 합성하였으며, 결정구조는 rhombohedral이고 격자상수 $a_0$는 3.953 ${\AA}$, $c_0$는 38.890 ${\AA}$였다. $MgGa_2Se_4$ 단결정박막은 HWE(Hot Wall Epitaxy) 방법으로 반절연성 GaAs(100)기판에 성장시켰다. 단결정박막의 성장 조건은 증발원의 온도 $610^{\circ}C$, 기판의 온도 $400^{\circ}C$에서 진행되었으며 성장 속도는 0.5 ${\mu}m/h$였다. 단결정박막의 결정성은 이중 결정 x-선 회절곡선의 반폭치와 X-선 회절무늬의 ${\omega}-2{\theta}$로부터 구하여 최적 성장 조건을 알 수 있었다. Hall 효과는 van der Pauw 방법에 의해 측정되었으며, 온도에 의존하는 운반자 농도와 이동도는 293 K에서 각각 $6.21{\times}10^{18}/cm^3$, 248 $cm^2/v{\cdot}s$였다. $MgGa_2Se_4$/SI(Semi-Insulated) GaAs(100) 단결정 박막의 광흡수 스펙트럼을 10 K에서 293 K까지 측정하였다. 광흡수 스펙트럼으로부터 구한 에너지 갭 $E_g(T)$는 varshni 공식 $E_g(T)=E_g(0)=({\alpha}T^2/T+{\beta})$을 잘 만족함을 알 수 있었다. 여기서 $E_g(0)=2.34\;eV$, ${\alpha}=8.81{\times}10^{-4}\;eV/K$, ${\beta}=251\;K$였다.

• 방사성폐기물학회지
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• 제3권3호
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• pp.159-165
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• 2005

원자력 시설의 해체 시 발생되는 다양한 종류의 폐기물 중에서 배관류를 재활용하거나 처분하기 위해서는 배관 내부의 정확한 방사선학적인 오염 특성의 평가가 선행되어야 한다. 그러나 기존의 측정법인 survey-meter를 이용한 오염도의 직접 측정은 배관 내부와 같은 국소지역의 오염 특성을 정확하게 평가할 수 없으며, 간접법을 이용한 표면오염도 측정의 경우도 시료채취의 어려움뿐만 아니라 시료채취 시 작업자의 오염 가능성이 있기 때문에 적용성에 많은 문제점이 있다. 본 연구에서는 Monte Carlo 모사기법을 이용해 직경이 작은 배관 내부의 베타선 오염도를 측정하기 위하여 플라스틱 섬광체를 모사하였으며, 모사 결과에서 베타선 에너지를 효율적으로 측정할 수 있는 최적의 플라스틱 섬광체 두께 및 형상을 도출할 수 있었다. 이 전사모사 결과를 바탕으로 섬광체의 가공 및 배관 내부에서의 검출기 이송 문제를 고려해 검출기를 제작하였으며 그 특성을 평가하였다. 그 결과 배관 내부의 오염도 측정에 적합한 검출기 성능을 확인하였고, 파이프 내부처럼 국소 지역의 방사선학적 오염 특성 평가를 위한 검출기 개발 가능성을 확인하였다.

• 한국구조물진단유지관리공학회 논문집
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• 제27권4호
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• pp.70-77
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• 2023

미세먼지는 생태학적으로 심각한 문제를 발생시키는 원인이고, 건설현장에서 발생되는 비산먼지는 국내 미세먼지의 주요 발생 원인이다. 그러나 콘크리트 제조업 현장을 포함한 건설 현장에서는 비산먼지 발생단계에서 측정은 거의 이루어지지 않고 있으며, 수동적인 제거방안들이 대부분인 실정이다. 따라서, 본 연구에서는 콘크리트 제조업에서 골재 하역시 발생하는 비산먼지를 발생단계에서 관리하기 적합한 비산먼지 측정 방법을 선정하고, 자동 비산먼지 저감시스템을 골재 하역장에 적용하여 저감시스템 작동 여부에 따른 비산먼지 저감량을 분석하는 것을 목적으로 하였다. 결과적으로, 베타선흡수법과 광산란법의 비교측정을 통하여 광산란법의 신뢰성을 확보하였고, 광산란법 보정계수를 산출하여 콘크리트 제조업 현장 비산먼지 질량농도 측정값에 적용하였다. 또한, 자동 비산먼지 저감시스템 작동 여부에 따른 비산먼지 저감률을 도출하였다.