• Title/Summary/Keyword: ${\beta}$-HAA

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Preparation and Properties of $N^1,N^1,N^4,N^4$-Tetrakis(hydroxyethyl)cyclohexanetrans-1,4-dicarboxamide as a Crosslinker of Polyester Powder Coatings (폴리에스터계 분체도료용 경화제 $N^1,N^1,N^4,N^4$-Tetrakis(hydroxethyl) cyclohexane-trans-1,4-dicarboxamide의 제조 및 특성)

  • Jung, Hong-Ryun;Heo, Joon;Lee, Wan-Jin;Kim, Hyung Jin;Lim, Hyung Soo
    • Applied Chemistry for Engineering
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    • v.20 no.2
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    • pp.195-200
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    • 2009

  • To develop a crosslinker for the polyester powder coatings, $N^1,N^1,N^4,N^4$-tetrakis(hydroxyethyl)cyclohexane-1,4-dicarboxamide (Cy-${\beta}-HAA$), incorporated with a cyclohexane ring within the main chain of commercial ${\beta}-hydroxyalkylamide$ (${\beta}-HAA$), was prepared from the amidation of dimethyl trans-1,4-cyclohexanedicarboxylate and diethanolamine in the presence of $NaOCH_3$, The structure of $Cy-{\beta}-HAA$ was confirmed by its NMR, FT-IR and ESI-MS spectra. $Cy-{\beta}-HAA$ was thermally more stable than ${\beta}-HAA$. When $Cy-{\beta}-HAA$ was used as a crosslinker for the polyester powder coatings, it provided the smooth coating surface and reduced the formation of pinholes in the coating surface with comparison with ${\beta}-HAA$.

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Study on the Effect of KamiTongJonHaaATang Extracts on Thrombosis, Brain Ischemia and Brain damage (가미통전화어탕(加味通栓化瘀湯)이 혈전증(血栓症)과 뇌허혈증(腦虛血症) 및 뇌손상(腦損傷)에 미치는 영향(影響)에 대한 실험적(實驗的) 연구(硏究))

  • Ahn, Taek Won;Kim, Byeong Tak
    • Journal of Haehwa Medicine
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    • v.8 no.1
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    • pp.379-401
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    • 1999

  • The effect of KamiTongJonHaaATang extracts on hypercholesterolemia, platelet aggregation, pulm onary thrombosis, KCN-induced coma, forcal brain ischemia, cytotoxicity of PC12 cells induced by amyloid ${\beta}$ protein(25-35), and NO production in RAW cells stimulated lipopolysaccharide were investigated, respectively. The results were summarized as follows; 1. KTJHAT extracts showed a significant decrease of serum total cholesterol, triglyceride, phospholipid, LDL-cholesterol, and VLDL-cholesterol in hypercholesterolemia induced by 2% cholesterol diet in NZW rabbit. 2. KTJHAT extracts induced a significant inhibition of human platelet aggregation induced by thrombin and ADP but did not affect human platelet aggregation induced by collagen. 3. KTJHAT extracts showed a protective effect on pulmonary thrombosis induced by collagen and epinephrine. 4. KTJHAT extracts prolonged the duration of KCN-induced coma. 5. KTJHAT extracts showed a significant decrease of brain ischemic area and edema in MCA occlusion. Also, KTJHAT extracts showed a decrease of neurologic grade in hind limb but did not affect neurologic grade in fore limb. 6. KTJHAT extracts showed a protective effect on cytotoxicity of PC 12 cells induced by amyloid ${\beta}$ protein(25-35) in a dose dependent manner. 7. KTJHAT extracts showed a significant decrease of NO production in RAW cells induced by lipopolysaccharide. These results suggested that KTJHAT extracts might be usefully applied for prevention and treatement of thrombosis and brain damage.

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