• Genomics & Informatics
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• v.13 no.1
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• pp.15-24
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• 2015

Fatty acid synthase (FASN, EC 2.3.1.85), is a multi-enzyme dimer complex that plays a critical role in lipogenesis. This lipogenic enzyme has gained importance beyond its physiological role due to its implications in several clinical conditions-cancers, obesity, and diabetes. This has made FASN an attractive pharmacological target. Here, we have attempted to predict the theoretical models for the human enoyl reductase (ER) and ${\beta}$-ketoacyl reductase (KR) domains based on the porcine FASN crystal structure, which was the structurally closest template available at the time of this study. Comparative modeling methods were used for studying the structure-function relationships. Different validation studies revealed the predicted structures to be highly plausible. The respective substrates of ER and KR domains-namely, trans-butenoyl and ${\beta}$-ketobutyryl-were computationally docked into active sites using Glide in order to understand the probable binding mode. The molecular dynamics simulations of the apo and holo states of ER and KR showed stable backbone root mean square deviation trajectories with minimal deviation. Ramachandran plot analysis showed 96.0% of residues in the most favorable region for ER and 90.3% for the KR domain, respectively. Thus, the predicted models yielded significant insights into the substrate binding modes of the ER and KR catalytic domains and will aid in identifying novel chemical inhibitors of human FASN that target these domains.

• Proceedings of the Korean Nuclear Society Conference
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• 2004.10a
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• pp.881-882
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• 2004

• 프린팅코리아
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• v.13 no.2
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• pp.84-85
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• 2014

(주)리코코리아(대표이사 사카이 하루히사 www.ricoh-korea.co.kr)는 지난 1월 23일 오피스솔루션(OS) 비즈니스 전국 런칭을 맞아 '2014 리코코리아 킥오프 이벤트'를 JW메리어트호텔 그랜드볼룸에서 약 150여명의 대리점 담당자들이 참석한 가운데 성황리에 개최했다.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2004.06a
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• pp.316-317
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• 2004

사용후핵연료를 이용한 건식 핵연료 원격 제조 공정중 OREOX공정으로부터 핵분열기체 방출특성 평가를 위한 실험을 수행하였다. 사용후핵연료 분말화 공정인 1차 산화 및 OREOX공정에서 방출되는 핵분열기체를 실시간으로 측정할 수 있는 장치를 제작$\cdot$설치하였으며, 측정 대상 핵분열기체는 Kr-85를 포함하여 C-14$^{14}CO_2$ 형태), I-129, 기체상 트리튬 등이다. 그림 1은 방출되는 핵분열기체를 포집 또는 연속측정하기 위한 개념도이며, 그림 2는 핫셀구역에 설치된 장치 사진이다.(중략)

• Proceedings of the Korean Nuclear Society Conference
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• 2004.10a
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• pp.772-773
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• 2004

• Electronics and Telecommunications Trends
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• v.16 no.5 s.71
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• pp.85-93
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• 2001

본 고에서는 최근 IETF를 중심으로 새롭게 제안되고 있는 Xcast(Explicit Multicast) 기술에 관해 소개한다. Xcast 멀티캐스트 방식은 IBM의 SGM(Small Group Multicast), Alcatel의 CLM(Connectionless Multicast), Fujitsu의 MDO6(Multiple Destination Option for IPv6) 제안을 수정, Xcast로 통합한 것으로 기존 IP 멀티캐스트 방식과는 달리, IP 패킷 내에 수신자 목록을 명시적으로 포함하여 전송함으로써 소규모 그룹 통신을 위해 적합한 새로운 멀티캐스트 통신 방식이다. 본 고에서는 Xcast 기본 프로토콜 규격을 중심으로 최근 기술동향 및 국내 Xcast-KR 연구동향 등을 소개한다.

• 프린팅코리아
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• v.8 no.3
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• pp.84-85
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• 2009

IT기술과 인쇄기계가 결합되는 사례가 적지 않은 요즘이지만 패키지나 번들 수준을 벗어나서 1:1 맞춤형으로 제공되는 사례나 아예 전적으로 집중하는 사례는 그리 흔하지 않은 것이 사실이다. 지난 1987년 출범한 대신정보통신(대표 이재원, www.dsic.co.kr)은 IT기술을 기반으로 하는 전형적인 정보통신분야의 회사이지만 IT기술과 시스템프린터를 융합한 고객맞춤형 디지털프린팅사업을 하는 POD사업본부(본부장 김종배이사)는 많은 고객을 확보, 활발한 사업을 전개하고 있다. POD사업본부는 특화 및 차별화된 상품 및 서비스 개발에 역점을 기울여 왔으며 오세코리아, 다이니폰스 크린코리아, 리코 등 유력한 프린터 제조사들과 협력관계를 맺고 다양하고 생산성 높은 작업을 지원하는 시스템 프린터와 토탈 Out_put 솔루션을 제공해 왔다.

• Korean Journal of Family Medicine
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• v.39 no.6
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• pp.333-339
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• 2018

Background: There is a distinction in alcohol consumption behavior between adults and college students. This study aims to verify the usability and the optimal cutoff point of Alcohol Use Disorders Identification Test-Korean revised version (AUDIT-KR) for screening alcohol use disorder in college students when the diagnostic and statistical manual of mental disorders (DSM), 5th edition diagnostic criteria is applied. Methods: A total of 922 college students living in Daejeon were enrolled and divided into two groups based on how many items they corresponded to among DSM-5 alcohol use disorder diagnostic criteria: those who corresponded to ${\geq}2$ of the 11 items were classified into the patient group (107 males, 89 females) while the others into the control group (311 males, 415 females). The participants were evaluated using AUDIT-KR to find the optimal cutoff point for screening alcohol use disorder, sensitivity, and specificity. Results: The mean${\pm}$standard deviation scores in the AUDIT-KR were $12.76{\pm}7.27$, $10.72{\pm}4.62$ for males and females, respectively, in the patient group. In contrast, in the control group the scores were $6.26{\pm}5.23$ and $3.95{\pm}3.59$ in males and females, respectively. The area under the receiver operating characteristic curve (95% confidence interval) regarding alcohol use disorder screening by AUDIT-KR was 0.768 (0.715-0.821) and 0.883 (0.848-0.919) for males and females, respectively. The optimal cutoff point of alcohol use disorder for males was >9, sensitivity 64.49%, and specificity 76.85%. The optimal cutoff point for females was >6, sensitivity 82.02%, and specificity 80.48%. Conclusion: This study suggested that AUDIT-KR can be used as a screening tool for alcohol use disorder in groups of college students when DSM-5 diagnosis criteria are applied.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.10
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• pp.1498-1507
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• 2003

A SMPS(scanning mobility particle sizer) system measures the number size distribution of particles using electrical mobility detection technique. An aerosol charge neutralizer, which is a component of the SMPS, is a bipolar charger using a radioactive source to apply an equilibrium charge distribution to aerosols of unknown charge distribution. However, the performance of aerosol charge neutralizers is not well known, especially for highly charged particles. In this study, the effect of the particle charging characteristics of two aerosol charge neutralizers on the measurement using a SMPS system was experimentally investigated for highly charged polydisperse particles. One has radioactive source of $^{85}$ Kr (beta source, 2 mCi) and the other has $^{210}$ Po (alpha source, 0.5 mCi). The air flow rate passing through each aerosol charge neutralizer was changed from 0.3 to 3.0 L/min. The results show that the non-equilibrium character in particle charge distribution appears as the air flow rate increases although the particle number concentration is relatively low in the range of 1.5∼2x10$^{6}$ particles/㎤. The low neutralizing efficiency of the $^{85}$ Kr aerosol charge neutralizer for highly charged particles can cause to bring an artifact in the measurement using a SMPS system. However, the performance of the $^{210}$ Po aerosol charge neutralizer is insensitive to the air flow rate.

• Journal of the Korean Society of Marine Environment & Safety
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• v.23 no.6
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• pp.731-738
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• 2017

Twin-hulls frequently incur structural damage at connecting members between the hull and deck induced by pitching motions during voyages. so, reasonable reinforcement is necessary around vulnerable spots such as corner knuckle, the chine bottom and inner hull. Since guidelines for structural design are not clear, engineers often respond by reinforcing plate thickness, changing stiffener sizes and reducing frame spacing, etc. These members constitute about 85 % of the longitudinal dimensions of the ship, so it is necessary to locally reinforce certain points to minimize weight stress, and also solve construction cost problems while securing the freeboard margin. Therefore, we developed a new program by analyzing the structural design procedures for the twin car-ferries based on Korean Register of Shipping (KR) High Speed Craft Rules, identifying items that need to be added. In order to ensure the reliability of buckling estimations for procedures and design programs, we conducted a comparative study with other standards and confirmed that differences were minimal.