• Journal of Environmental Science International
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• v.33 no.3
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• pp.227-234
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• 2024

We investigated the change in land-use alteration in a 45 km × 45 km area around the Upo wetlands in 1920s(before the Japanese occupation period), 1950s(immediately Korean independence) and the period 1970s to 2000s. These data can guide in understanding surface environmental changes in the lower Nakdong River from the early 20^th century to the present. The influence of the long-term decreasing trend of the wetland area at the Upo Swamp was evaluated using a high-resolution local circulation model. The cooling effect of the wetlands on surface air during the daytime in summer(e.g, early August) was approximately 2℃ greater in the 1920s than in the 2000s, which is attributed to wider water areas in the 1920s. Additionally, long-term changes in land use have caused changes in the convergence zone of local circulation wind.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7195-7200
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• 2014

Background: The aim of this study was to evaluate how CYP2C19 affects icotinib and metabolite' exposure, and to determine whether the exposure and EGFR genotype influences survival time, tumor metastasis and adverse drug reactions. Materials and Methods: 274 NSCLC patients who accepted 125mg icotinib/t.i.d. were chosen from a phase III study. Blood samples were obtained in $672^{nd}$ ($4^{th}$ week) and $1,680^{th}$ hours ($10^{th}$ week), and plasma was used to quantify the concentration of icotinib and blood cells were sampled to check the genotypes. Clinical data were also collected at the same time, including EGFR genotypes. Plasma concentrations were assessed by HPLC-MS/MS and genotype by sequencing. All data were analyzed through SPSS 17.0 and SAS 9.2. Results: CYP 2C19 genotypes affected bio-transformation from icotinib to M24 and M26, especially in poor-metabolisers. Higher icotinib concentrations (>1000 ng/mL) not only increased patient PFS and OS but also reduced tumor metastasis. Patients with mutant EGFR experienced a higher median PFS and OS (234 and 627 days), especially those with the 19del genotype demonstrating higher PR ratio. Patients who suffered grade II skin toxicity had a higher icotinib exposure than those with grade I skin toxicity or no adverse effects. Liver toxic reactions might occur in patients with greater M20 and M23 plasma concentrations. Conclusions: CYP2C19 polymorphisms significantly affect icotinib, M24 and M26 exposure. Patients with mutant EGFR genotype and higher icotinib concentration might have increased PFS and OS and lower tumor metastasis. Liver ADR events and serious skin effects might be respectively induced by greater M20, M23 and icotinib concentrations.

• The Journal of Korean Society of Virology
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• v.30 no.1
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• pp.71-81
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• 2000

We have determined and analyzed the full-length cDNA sequence of a coxsackievirus B3 (CVB3) Korean isolate (CVB3-Korea/97) which has been known as a general human pathogen. The whole genome contains 7,400 nucleotides and has a single large open reading frame with 6,555 nucleotides that encodes a potential polyprotein precursor of 2,185 amino acids. The genome also contains a 5' non-coding region (NCR) of 741 bases and a 3' NCR of 104 bases followed by poly(A) tail. Sequence homologies of nucleotides and deduced amino acids between the CVB3-Korea/97 strain and the prototype (Nancy strain) were 81.7% and 91.5%, respectively. The genes encoding the functional proteins including viral protease and RNA dependent RNA polymerase showed higher homology than those encoding the structural proteins. We have further analyzed the sequences of 5' NCR, VP1 and VP2 of CVB3-Korea/97, which are known as cardiovirulent determining factors at the nucleotide and amino acid levels. Although the CVB 3-Korea/97 strain was isolated from an aseptic meningitis patient without cardiomyopathy, its 234th nucleotide and 165th amino acid were uracil and Asn as same as those of other cardiovirulent strains one. However, the 155th amino acid of VP1, which closely associated with cardiovirulence, was replaced with $Arg^{155}$ by single nucleotide substitution from $A^{2916}$ to $T^{2916}$. Moreover, additional amino acid substitutions were observed in the flanking region of $Asp^{155}$. Taken together, amino acid(s) substitution in VP1 may playa critical role in determining cardiovirulence of the CVB3-Korea/97 strain rather than individual nucleotide replacements in the 5' NCR and/or an amino acid substitution in VP2.

• Clinical and Experimental Pediatrics
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• v.49 no.10
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• pp.1037-1041
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• 2006

Purpose : The prevalence of obesity and nonalcoholic steatohepatitis(NASH) was increased in adolescents. This study was performed to observe the prevalence of elevated aminotransferase levels in adolescents and to assess the correlations between aminotransferase levels and obesity related parameters(body mass index, waist circumference, hip circumference, waist to hip ratio and insulin level). Methods : We obtained weight, height, waist circumference and hip circumference from 2,417 male and 1,219 female adolescents. Mean age was $15.7{\pm}0.7$ years old. We measured fasting insulin, aspartate aminotransferase(AST) and alanine aminotransferase(ALT). Obese and overweight were defined as body mass indices(BMI) of more than the 95th, and 85th-94th percentiles, respectively, for age and sex. Results : The number of adolescents with obesity is 324(8.9 percent). 414(11.4 percent) subjects belonged to the overweight group. The average ALT level of obese, overweight and control groups were significantly different(obese : $32.1{\pm}34.3U/L$, overweight : $19.6{\pm}13.6U/L$, control : $12.7{\pm}6.7U/L$, P<0.001). The average AST level was also different according to group(obese : $27.8{\pm}16.5U/L$, overweight : $22.8{\pm}8.6U/L$, control : $20.8{\pm}8.5U/L$, P<0.001). AST and ALT were correlated with anthropometric parameters and insulin level. After multiple regression analysis, waist circumference was the significant predictive value for AST(r=0.234, P<0.001). Waist circumference, BMI and insulin levels were significant predictive values for ALT(r=0.435, P<0.001). Conclusion : The prevalence of abnormal aminotransferase was higher in the obese and overweight groups than control group. Waist circumference was useful to predict abnormal aminotransferase levels.

• Journal of The Korean Society of Grassland and Forage Science
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• v.32 no.3
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• pp.275-284
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• 2012

This study was carried out to determine the harvest management during autumn on the forage production, quality and regrowth of following year of Phragmites communis as native grass. Field experiments were conducted in Ansan and in Cheonan from 2010 to 2011. Forages were cut at 3 cm, 15 cm and 25 cm in height as compared to control (no harvest) in Ansan plots, and forages grown in Cheonan plots were cut at 10 cm and 20 cm in height with control (no harvest). The forages were harvested one time on Oct 7, 2011 in Ansan, and were harvested twice on July 7 and on October 7 in Cheonan. In Ansan, dry matter (DM) yield of control plot the following year were higher than those from harvested plots. In vitro digestible DM (IVDDM) yields, however, were the same: 1,236 kg/ha from control, 1,234 kg from 15 cm cut and 1,241 kg from 25 cm cut plots, except that lower IVDDM yield from 3 cm cut plot than these were observed. Forage quality of control plot was poorer than those of harvested ones. In vitro DM digestibility (IVDMD) and relative feed value (RFV) of control were 39.98% and 65.3, respectively as compared to harvested plots (42.36~46.40% IVDMD and 67.8~72.5 RFV). Yield and quality from Cheonan plots were similar to those from Ansan plots. Annual yield in DM and in CP from control plot were a little higher than those from harvested plots. However, there were no difference found in IVDDM yield between 20 cm cut (5,354 kg/ha) and control (5,178 kg). But IVDDM of 10 cm cut forages was less (4,531 kg). Forage quality scores were better from 20 cm cut, and 10 cm cut plot than control, in order (p<0.05). The quality grades were the 5th and 6th for forages from harvested plots and control plot, respectively. Regrown Phragmites communis from all Cheonan plots ranked the 4th in forage quality. More than 70% of annual yield was observed from the first grown forages. One time harvest per year was desirable for following regrowth and long time stable production of Phragmites communis. We recommended that Phragmites communis be harvested once for more forage yield with higher quality, and that optimum cutting height is 15~20 cm.

• Korean Journal of Poultry Science
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• v.15 no.3
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• pp.219-227
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• 1988

This experiment was carried out to evaluate biological availability of Ca and P in 4 different sources of tricalcium phosphate in young chicks. One hundred and twenty five-day-old male Single Comb White Leghorn chicks (10 treatments$\times$3replication$\times$4chicks) were used in trial 1 and 2, respectively, for 12 days of feeding period. Trial I was to evaluate the availability of phosphorus in the supplements, Standard purified diets were prepared to supply 0.07, 0.14 and 0.21％P using a mixture (1 : 1) of NaH$_2$PO$_4$ and KH$_2$PO$_4$ as the reference Phosphorus sources. Bone breaking strength of the tibia determeined by an Instron instrument appeared inadequate to be used as a criterion due to very high variations of the measurement within a treatment. Thus, tibia bone ash content was utilized as a criterion to evaluate th biological avilability of phosphorus in the supplements. The levels of the biological availability of the four different sources of dicalcium phoshate were 77.1, 91.0, 96.4 and 95.5％, respectively, and those of the three tricalcium phosphate sources were 94.1, 95.0 and 99.5％ , respectively. Trial 2 was to determeine the levels of Ca biologically available in the supplements. Standard purified diets were made to supply 0.2, 0.3 and 0.4％ Ca using CaCo$_3$ as the reference calcium source. When bone ash content was utilized as a criterion for the availability, the levels of calcium biologically available to the chicks were 78.3, 234.1, 87.6 and 244.5％, respectively, for the 4 different sources of dicalcium phosphate and 99.5, 84.0 and 101.5％ , respectively, for the 3 different sources of tricalcium phosphate. The observation that two calcium sources appeared to be utilized with an unusual efficiency can hardly be explained at this moment. When they were revaluated on the basis of body weight gain, the availabilities of the four sources of dicalcium phosphate were 89.2, 58.2, 104.1 and 103.1％ and of the three tricalcium phosphate were 112.6, 106.0 and 96.3％ , respectively.

• Journal of The Korean Association For Science Education
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• v.30 no.2
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• pp.234-248
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• 2010

This study was conducted among 52 elementary pre service teachers not majoring in the natural sciences, who were taking Earth Science as an elective course at the University of Education located in central Korea. These elementary pre service teachers participated in story writing on the subject of earth system cycles over eight occasions. Changes in their understanding of the Earth's cycles were verified by comparing mind mapping exercises performed before and after the story writing. Afterwards, 43 out of the 52 subjects volunteered for structured interviews, in which they performed story-telling exercises. This study presents examples of story analysis that uses a variation of the wheel-shaped story map, and proposes story mapping as a preferred method of analysis. Before and after creative story writing activities, pre service teachers' mind mapping is analyzed to study possible positive changes. This study identified a gap between the instructional contents of the Earth system unit included in the 7th and current revised school curriculums on the one hand, and the conceptions expressed by the pre service teachers who studied these contents on the other.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.4
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• pp.410-418
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• 2020

This study examined the correlations between investigating human rights sensitivity, interpersonal caring behavior, and biomedical ethics in nursing students who have clinical practice experience. The data were collected using structured questionnaires for 3rd and 4th grade nursing students who were attending three universities in Gyeonggi-do and Chungcheong-do. As a result of this study, nursing college students' human rights sensitivity, interpersonal caring behavior, and biomedical ethics were scored as 112.23, 3.95, and 2.03 points, respectively. There were significant differences in human rights sensitivity according to major satisfaction (t=3.320. p=.001), clinical practice satisfaction (t=2.557, p=.012), and clinical peer relationship (t=4.234, p<.001), interpersonal care behavior according to major satisfaction (t=3.423. p=.001), clinical practice satisfaction (t=4.364, p<.001), and clinical peer relationship (t=3.708, p=.001), and biomedical ethics according to major satisfaction (t=-2.404, p=.018). Human rights sensitivity showed positive correlations with biomedical ethics (r=.27, p<.01), and interpersonal caring behavior showed a positive correlation with biomedical ethics (r=.17, p<.05). Based on these findings, it is necessary to develop systematic nursing education programs to strengthen interpersonal caring behavior, biomedical ethics, and human rights sensitivity.

• Journal of Korean Home Economics Education Association
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• v.20 no.3
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• pp.49-64
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• 2008

The purpose of this study was to identify the relationships between the self-identity and career maturity of middle school students in Gyeongnam province. For this purpose following questions were formulated. First. Are there statistically significant differences in middle school students' self-identity by their background variables? Second, Are there statistically significant differences in middle school students' career maturity by their background variables? Third, How is the relationship between self-identity and career maturity? Fourth, How are the influences of background variables and self-identity on students' career maturity? Self-identity and career maturity were measured over 551 9th grade students(317 male and 234 female students) in Changwon, Jinju, Geoje, Hadong, Sancheong, and Tongreong areas. Frequency analysis, Cronbach'$\alpha$, t-test, one-way ANOVA, and multiple regression were used for statistical analysis. The results indicated that: 1. There were statistically significant differences in self-identity by mother's educational level, student's GPA, and economical background; 2. There were statistically significant differences in career maturity by student's gender, mother's educational level, and student's GPA; 3. There was 3. There were high static correlation between self-identity and career maturity and its subordinate items; 4. Sex and self-identity and its sub-items of students' independence, self-receptiveness, firm future goals, goal-orientation, intimacy have relative influences on career maturity.

• 재활복지
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• v.21 no.1
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• pp.97-119
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• 2017

The objective of this study is to understand the influence of discrimination experience on life satisfaction of the employed hearing-impaired, and also to verify the mediating effects of self-esteem on relations between discrimination experience and life satisfaction. To achieve this objective, the data of the 8th Panel Survey of Employment for the Disabled was used, and then the extracted data of 234 employed hearing-impaired persons was used for analysis. The results of this study are like below. First, discrimination experience showed negative(-) relations with self-esteem and life satisfaction while self-esteem showed positive(+) relations with life satisfaction. Second, when the perception of discrimination experience was low, the life satisfaction was high. Third, the mediating effects of self-esteem were verified on relations between discrimination experience and life satisfaction. Marital status, health, social-economical position has effected on life satisfaction. Based on such results of the study, suggestions were made to increase life satisfaction of the hearing-impaired.