• 제목/요약/키워드: $^{125}I$-Labeled hyaluronic acid

검색결과 1건 처리시간 0.015초

방사성 히알루론산 합성 (Synthesis of 125I-Labeled Hyaluronic Acid)

  • 마소영;이동은;박상현
    • 방사선산업학회지
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    • 제8권2호
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    • pp.77-81
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    • 2014
  • Hyaluronic acid is a disaccharide polymer that consists of glucuronic acid and N-acetylglucosamine, and is a glycosaminoglycan. It is widely distributed in animal connective tissue, coexisting with chondroitin sulfate. It forms viscous secretions or gel by bonding to protein in the body, and thus maintains and lubricates tissue structures. In addition, its antibiotic properties are applied to cosmetics and pharmaceuticals. Therefore, it has recently been an object of great interest at cosmetic and pharmaceutical companies. $^{125}I$ has a longer half-life (59.4 days) than many other radioisotopes, and is therefore useful to long-term studies. In this study, a facile and efficient procedure for the synthesis of $^{125}I$-labeled hyaluronic acid has been designed for in vivo imaging and pharmacokinetic studies of hyaluronic acid, which are required for the development of new drugs.