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Involvement of Nitric Oxide and Prostanoid on Photorelaxation in Pig Renal Artery  

Kim, Joo-Heon (College of Veterinary Medicine, Gyeongsang National University and Institute of Animal Medicine)
Shim, Cheol-Soo (College of Veterinary Medicine, Gyeongsang National University and Institute of Animal Medicine)
Jeon, Seok-Cheol (Cardiac center, Mason Samsung General Hospital Masan)
Publication Information
Korean Journal of Veterinary Research / v.42, no.3, 2002 , pp. 321-326 More about this Journal
Abstract
The effect of nitric oxide synthase(NOS) inhibita, $N^G$-nitro-L-arginine-methyl ester(L-NAME) and prostanoid synthesis inhibiter, indomethacin on the photorelaxation, when was exposed to the long-wave length UV-light, was examined on the precontraction by the phenylephrine in the isolated pig renal artery. 1. UV-light relaxed both with-endothelium and without-endothelium in the pig renal arterial ring contracted by the phenylephrine. The magnitude of photorelaxation was dependent on the exposure time for UV-light. 2. UV-Iight induced relaxation was inhibited by L-NAME and indomethacin on the precontraction by the phenylephrine in the isolated pig renal artery. 3. UV-Iight induced relaxation was inhibited by methylene blue on the precontraction by the phenylephrine in the isolated pig renal artery. These results suggest that UV-light induced photorelaxation may be due to cGMP involved both nitric oxide and prostanoid on the precontraction by the phenylephrine in the isolated pig renal artery.
Keywords
Photorelaxation; L-NAME; indomethacin; methylene blue; renal artery;
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