Browse > Article
http://dx.doi.org/10.11002/kjfp.2012.19.5.792

Inhibitory Effect of Angelica keiskei Extract in an Atopic Dermatitis Animal Model  

Kim, Min-A (Department of Food Science & Biotechnology, Kyungpook National University)
Son, Hyeong-U (Department of Food Science & Biotechnology, Kyungpook National University)
Nam, Dong-Yoon (Department of Food Science & Biotechnology, Kyungpook National University)
Cha, Yong-Su (Department of Food Science & Biotechnology, Kyungpook National University)
Shin, Yong-Kyu (Bion Co, Ltd.)
Choi, Yong-Hee (Department of Food Science & Biotechnology, Kyungpook National University)
Lee, Sang-Han (Department of Food Science & Biotechnology, Kyungpook National University)
Publication Information
Food Science and Preservation / v.19, no.5, 2012 , pp. 792-798 More about this Journal
Abstract
The purpose of this study was to evaluate the anti-atopic-dermatitis effect of Angelica keiskei extract using a DNFB-induced animal model of atopic-dermatitis symptoms. A. keiskei was prepared via extraction with DW, 50% ethanol, and 100% ethanol in addition to fresh juice. All the extracts reduced the thickness levels of the ears and ear epidermis against swelling by DNFB inducement, especially in the aqueous-extract-treated group. The mRNA expressions of matrix metalloproteinases (MMPs), however, were not observed, which may indicate that Angelica keiskei extract alleviates the atopic-dermatitis symptoms in an MMP-independent manner. Finally, the level of the inflammatory cytokine IL-4 was inhibited only in the juice-treated group, although the IL-13 level was inhibited in the juice-, 50%-ethanol-extract-, and 100%-ethanol-extract-treated groups in a dose-dependent manner, and was not inhibited in the aqueous-extract-treated group. Taken together, these results suggest that Angelica keiskei extract has an inhibitory effect on atopic dermatitis, and may be a useful biomaterial for the development of cosmeceuticals.
Keywords
Angelica keiskei; atopic dermatitis; DNFB-induced animal model;
Citations & Related Records
Times Cited By KSCI : 11  (Citation Analysis)
연도 인용수 순위
1 Kim SJ, Cho JY, Wee JH, Jang MY, Rim YS, Kim C, Shin SC, Moon JH, Park KH (2005) Isolation and identification of two psoralen derivatives as antioxidative compounds from the aerial parts of Angelica keiskei. Korean J Food Sci Technol, 37, 656-659   과학기술학회마을
2 Kim OK, Lee MW, Park WB, Ham SS, Kung SS (1992) The nutritional components of aerial whole plant and juice of Angelica keiskei Koidz. Kor J Food Sci Technol, 24, 592-596   과학기술학회마을
3 Jo HW, Park JC (2008) Phenolic compounds isolated from the leaves of Angelica keiskei showing DPPH radical scavenging effect. Kor J Pharmacogn, 39, 146-149   과학기술학회마을
4 Son HU, Nam DY, Kim MA, Cha YS, Kim JM, Shin YK, Lee SH (2011) Inhibitory effect of Angelica keiskei extracts on melanogenesis. Korean J Food Preserv, 18, 998-1001   과학기술학회마을   DOI
5 Heo JC, Nam DY, Seo MS, Lee SH (2011) Alleviation of atopic dermatitis-related symptoms by Perilla frutescens Britton. Int J Mol Med, 28, 733-737
6 Nagase H, Woessner JF Jr (1999) Matrix metalloproteinases. J Biol Chem, 274, 21491-21494   DOI
7 Blumenthal MN, Zhong W, Miller M, Wendt C, Connett JE, Pei D (2010) Serum metalloproteinase leukolysin (MMP-25/MT-6): a potential metabolic marker for atopy-associated inflammation. Clin Exp Allergy, 40, 859-866   DOI   ScienceOn
8 Mori S, Pawankar R, Ozu C, Nonaka M, Yagi T, Okubo K (2012) Expression and roles of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in allergic nasal mucosa. Allergy Asthma Immunol Res, 4, 231-239   DOI
9 Zhang M, Dai C, Zhu H, Chen S, Wu Y, Li Q, Zeng X, Wang W, Zuo J, Zhou M, Xia Z, Ji G, Saiyin H, Qin L, Yu L (2011) Cyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9. Mol Cell Biochem, 357, 387-395   DOI
10 Harper JI, Godwin H, Green A, Wilkes LE, Holden NJ, Moffatt M, Cookson WO, Layton G, Chandler S (2010) A study of matrix metalloproteinase expression and activity in atopic dermatitis using a novel skin wash sampling assay for functional biomarker analysis. Br J Dermatol, 162, 397-403   DOI   ScienceOn
11 Li C, Lasse S, Lee P, Nakasaki M, Chen SW, Yamasaki K, Gallo RL, Jamora C (2010) Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8. Proc Natl Acad Sci USA, 107, 22249-22254   DOI   ScienceOn
12 Jang SN, Kim KR, Yun MY, Kang SM (2009) The effect of $\gamma$-PGA on NC/Nga mice a mouse model for mite antigen-induced atopic dermatitis. Kor J Microbiol Biotechnol, 37, 53-63   과학기술학회마을
13 Escoubet-Lozach L, Glass CK, Wasserman SI (2002) The role of transcription factors in allergic inflammation. J Allergy Clin Immunol, 110, 553-564   DOI   ScienceOn
14 Park YM (2006) Advanced in the pathophysiology of atopic dermatitis. Pediatr Allergy Respir Dis, 16, 189-196
15 Lee SH (2010) Analysis of anti-allergic activities by chaff vinegar liquor. J Life Sic, 20, 960-963   과학기술학회마을   DOI
16 Park YL, Park J (2007) Pathogenesis of atopic dermatitis. Korean J Invest Dermatol, 14, 67-72
17 Lee GS, Jung HM, Oh SK, Cheong JH, Kang TJ (2012) Effects of herbal complex on atopic dermatitis in BALB/c Mice. Kor J Pharmacogn, 43, 59-65   과학기술학회마을
18 Kim HA, Yun MY, Song HH, Cheong KJ, Yoo HS (2010) Effects of lavender, lemon and eucalyptus essential oil on Th2 related factors of DNCB-induced atopy dermatitis in NC/Nga mice model. J Pharmacopuncture, 13, 53-61   과학기술학회마을   DOI   ScienceOn
19 Leung DY, Soter NA (2001) Cellular and immunologic mechanisms in atopic dermatitis. J Am Acad Dermatol, 44, S1-S12   DOI   ScienceOn
20 Yawalkar N, Schmid S, Braathen LR, Pichler WJ (2001) Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis. Br J Dermatol, 144, 1133-1139   DOI   ScienceOn
21 Yang HJ, Park KW, Kim HS, Cho SM, Park KM (2010) Effect of anti-atopic allergic reaction in response to oriental herb extracts. Korean J Food Sci Technol, 42, 109-114   과학기술학회마을
22 Jung HK. Park PS, Huh NC, Kim SO, Kim KS, Lee MY (1998) Inhibitory effect of Angelica keiskei Koidz green juice on the liver damage in CCL4-treated rats. J Korean Soc Food Sci Nutr, 27, 531-536   과학기술학회마을
23 Tatsuji E, Hiromu O, Kinuko N, Yoko K, Katsumi S, Masashige T, Eiji K, Hiroaki S, Ikunoshin K (2007) Antidiabetic activities of chalcones isolated from a Japanese herbm Angelica keiskei. J Agric Food Chem, 55, 6013-6017   DOI   ScienceOn
24 Jeoung YJ, Kang KJ (2011) Effect of Angelica keiskei Extract on Apoptosis of MDA-MB-231 Human Breast Cancer Cells. J Korean Soc Food Sci Nutr, 40, 1654-1661   과학기술학회마을   DOI   ScienceOn
25 Park JY, Jeong HJ, Kim YM, Park SJ, Rho MC, Park KH, Ryu YB, Lee WS (2011) Characteristic of alkylated chalcones from Angelica keiskei on influenza virus neuraminidase inhibition. Bioorg Med Chem Lett, 21, 5602-5604   DOI   ScienceOn