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Analysis of Anti-Tumor Activity of Flammulina velutipes Extract on B16 cells  

Lee, Si-Rim (Departments of Food Science & Technology Kyungpook National University)
Nam, Dong-Yun (Departments of Food Science & Technology Kyungpook National University)
Lee, Hyun-Jin (Departments of Food Science & Technology Kyungpook National University)
Park, Chul-Hong (Departments of Food Science & Technology Kyungpook National University)
Heo, Jin-Chul (Departments of Food Science & Technology Kyungpook National University)
Kim, Jong-Guk (Departments of Food Science & Microbiology Kyungpook National University)
Lee, Jin-Man (Department of Food & Biotechnology, Hoseo University)
Lee, Chang-Yun (Green Peace Co., Ltd.)
Park, Hee-Ju (Green Peace Co., Ltd.)
Lee, Sang-Han (Departments of Food Science & Technology Kyungpook National University)
Publication Information
Food Science and Preservation / v.16, no.4, 2009 , pp. 599-603 More about this Journal
Abstract
To evaluate the anti-tumor activity of Flammulina velutipes extract, we used an in vitro wound-healing assay, and an in vivo approach using a mouse melanoma model. Wound-healing activity in B16 cells was affected by the extract in a dose-dependent manner, indicating that the extract had anti-metastatic activity. The extract also exhibited strong anti-tumor activity against lung cancer when B16 cells were injected into mouse veins together with B16 melanoma cells. The results indicatethat the Flammulina velutipes extract decreased B16 cancer cell growth by inhibition of cell migration both in vitro and in vivo.
Keywords
Flammulina velutipes extract; anti-tumor activity; B16 cells; in vitro; in vivo;
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1 Shomori, K., Yamamoto, M., Arifuku, I., Teramachi, K., Ito, H. (2009) Antitmnor effects of a water-soluble extract from Maitake (Grifola jrondosa) on human gastric cancer cell lines. Oncol Rep., 22, 615-620   PUBMED
2 Jedinak, A, Sliva, D. (2008) Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway. Int. J. Oncol. 33, 1307-1313   PUBMED
3 Gonzaga, M.L., Bezerra, D.P., Alves, A.P., de Alencar, N.M., Mesquita Rde, O., Lima, M.W., Soares Sde, A, Pessoa, C., de Moraes, M.O., Costa-Lotufo, L.V. (2009) In vivo growth-inhibition of Sarcoma 180 by an alpha-(1$\rightarrow\$4 )-glucan-beta-(1$\rightarrow\$6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill. Nat. Med. (Tokyo), 63, 32-40   DOI   ScienceOn
4 Heo, J.C., Park, J.Y., Lee, J.M., Kwon, T.K., Kim, S.U., Chung, S.K., Lee, S.H. (2005) Wisteria floribunda gall extract inhibits cell migration in mouse BI6Fl melanoma cells by regulating CD44 expression and GTP-RhoA activity. J. Ethnopharmacol., 102, 10-14   DOI   ScienceOn
5 Gu, Y., Fujimiya, Y., Itokawa, Y., Oshima, M., Choi, J.S., Miura, T, Ishida, T. (2008) Tumoricidal effects of beta-glucans: mechanisms include both antioxidant activity plus enhanced systemic and topical innnunity. Nutr. Cancer, 60, 685-691   DOI   PUBMED   ScienceOn
6 Borchers, A.T., Krishnamurthy, A, Keen, C.L., Meyers, F.J., Gershwin, M.E. (2008) The immunobiology of mushrooms. Exp. BioI. Med. 233, 259-276   DOI   ScienceOn
7 Wong, J.H., Wang, H,X., Ng, T.B. (2008) Mannorin, a new ribosome inactivating protein with antiproliferative and HIV-l reverse transcriptase inhibitory activities from the mushroom Hypsizigus marmoreus. Appl. Microbiol. Biotechnol., 81, 669-674   DOI   ScienceOn
8 Monro, J.A. (2003) Treatment of cancer with mushroom products. Arch. Environ. Health, 58, 533-537   DOI   ScienceOn
9 Okamura, T., Ogata, T., Minamimoto, N., Takeno, T., Noda, H., Fukuda, S., Ohsugi, M. (2001) Characteristics of wine produced by mushroom fermentation. Biosci. Biotechnol. Biochem., 65, 1596-1600   DOI   ScienceOn
10 Kaufmann, P. (2007) Mushroom poisonings: syndromie diagnosis and treatment. Wien. Med. Wochenschr. 157, 493-502   DOI   ScienceOn
11 Chang, S.T., Miles, P.G. (1989) Edible mushroom and their cultibation. CRC Press, New York, p27
12 Lee, J.S., Park, B.C., Ko, Y.J., Choi, M.K, Choi, H.G., Yong, C.S., Lee, J.S., Kim, J.A. (2008) Grifolajrondosa (maitake mushroom) water extract inhibits vascular endothelial growth factor-induced angiogenesis through inhibition of reactive oxygen species and extracellular signal-regulated kinase phosphorylation. J. Med. Food, 11, 643-651   DOI   ScienceOn
13 Du, G., Jin, L., Han, X., Song, Z., Zhang, H., Liang , W. (2009) Naringenin: a potential innnunomodulator for inhibiting lung fibrosis and metastasis. Cancer Res., 69, 3205-3212   DOI   ScienceOn
14 Jeurink, P.V., Noguera, C.L., Savelkoul, H.F., Wichers, H.J. (2008) Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells. Int. Immunopharmacol., 8, 1124-1133   PUBMED
15 Gasowska-Bajger, B., Wojtasek, H. (2008) fudirect oxidation of the antitumor agent procarbazine by tyrosinasepossible application in designing anti-melanoma prodrugs. Bioorg. Med. Chem. Lett., 18, 3296-3300   DOI   ScienceOn
16 Heo, J.C., Woo, S.U., Kweon, M.A, Park, J.Y., Lee, H.K., Son, M., Rho, J.R., Lee, S.H. (2008) Aqueous extract of the Helianthus annuus seed alleviates asthmatic symptoms in vivo. Int. J. Mol. Med., 21, 57-61   PUBMED
17 Guerra Dore, C.M., Azevedo, T.C., de Souza, M.C., Rego, L.A., de Dantas, J.C., Silva, F.R., Rocha, H.A., Baseia, I.G., Leite, E.L. (2007) Antiinflannnatory, antioxidant and cytotoxic actions of beta-glucan-rich extract from Geastrum saccatum mushroom. Int. Immunopharmacol., 7, 1160-1169   DOI   ScienceOn