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http://dx.doi.org/10.3746/jkfn.2010.39.3.363

Effects of Artemisia princeps Extract on Bone Metabolism  

Lee, Seung-Min (Korea Medical Science Institute)
Kim, Myung-Gyou (Korea Medical Science Institute)
Lee, Seung-Youn (Korea Medical Science Institute)
Kang, Tae-Hoon (Korea Medical Science Institute)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.39, no.3, 2010 , pp. 363-368 More about this Journal
Abstract
Artemisia princeps has been utilized as a traditional medicine for a variety of diseases in Korea. In this study, we investigated the effects of Artemisia princeps extract (APE) on bone metabolism both in vitro using primary mouse bone marrow-derived macrophage and in vivo using ovariectomized rats. APE decreased the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells and TRAP activity. Also, APE inhibited bone resorptive activity of differentiated osteoclasts. In ovariectomized rats, APE alleviated the decrease in the trabecular bone mineral density. These results showed that APE might be useful for the prevention of postmenopausal bone loss.
Keywords
Artemisia princeps; osteoclast; tartrate-resistant acid phosphatase activity; bone resorptive activity; bone mineral density;
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