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http://dx.doi.org/10.3746/jkfn.2007.36.1.008

Effect of Mycelia Extracts from Lentinus edodes Mushroom-Cultured Astragalus membranaceus Bunge on Anti-cancer and Anti-allergy Activities  

Bae, Man-Jong (Dept. of Herbal Foodceutical Science, Daegu Haany University)
Kim, Kwang-Joong (Dept. of Oriental Medicine, Daegu Haany University)
Kim, Soo-Jung (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Haany University, Kyungbuk Technopark)
Ye, Eun-Ju (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Haany University, Kyungbuk Technopark)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.36, no.1, 2007 , pp. 8-13 More about this Journal
Abstract
This study was conducted to investigate the effect of mycelia of Lentinus edoes mushroom-cultured Astragalus membranaceus Bunge (LAM) on proliferation of cancer cell lines (Hep3B, MCF-7 and HeLa), sarcoma 180 (S-180), and anti-allergy. In an anti-cancer test using Hep3B (hepatic cancer cell), MCF-7 (breast cancer cell) and HeLa (uterine cancer cell), LAM extract showed higher antiproliferating effect than that of Astragalus membranaceus Bunge (AM) extract. In an anti-cancer testing using Hep3B cells and MCF-7 cells, LAM extract showed growth-inhibitory effect of 65.23% at 3 mg/mL and 69.23% at 5 mg/mL, respectively. In an anti-cancer testing using HeLa cells, LAM extract showed growth-inhibitory effect of 42.01% at 5 mg/mL. In addition, LAM showed the tumor suppressive effect in mice injected with S-180 cells. The growth-inhibitory rates against tumor cells were 47% for LAM and 37% for AM. LAM inhibited histamine release from rat peritoneal mast cells activated by compound 48/80. These results suggest that Lentinus edodes mushroom-cultured herb has an antiproliferating effect against cancer cell lines (Hep3B, MCF-7 and HeLa), S-180 tumor and will be beneficial in the treatment of allergic reaction.
Keywords
Astragaius membranaceus Bunge; anticancer activity; mycelium; sarcoma-180; antiallergy;
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Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By SCOPUS : 3
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1 Kitagawa I, Wang HK, Saito M, Yoshikawa H. 1983. saponin and sapogenol. X X X VI. Chemical constituents of Astragali Radix, the root of Astragalus membranaceus Bunge. 3. Astragalosidees III, V and VI. Chem Pharm Bull 31: 716-722   DOI
2 Kim JH, Park JS, Chae BS, Kang TW, Park CB, Ahn YK. 1996. Immunobiological studies on doses of methanol extract of Astragali Radix. Yakhak Hoeji 40: 326-334   과학기술학회마을
3 Park EM, Ye EJ, Kim SJ, Kim SA, Bae MJ. 2005. Effect of beverage using herbs on the antimicrobial, anticancer and antiallergy activities. J Korean Soc Food Sci Nutr 34: 953-958   과학기술학회마을   DOI   ScienceOn
4 Hikino H, Kanno C, Mirin Y, Hayashi T. 1985. Isolation and hypoglycemic acitivity of Ganoderans A and B, glycans of Ganoderman lucidum fruit bodies. Planta Med 51: 339-340   DOI   ScienceOn
5 Kim YS, Park KH. 1995. Screening method for antihepatotoxic activity using $CCI_4$-induced cytotoxicity in primary cultured rat hepatocytes. Kor J Pharmacogn 26: 51-56   과학기술학회마을
6 Fang SD, Chen Y, Xu XY, Ye CQ, Zhai SK, Shen ML. 1982. Studies of active principles of Astralalus mongholicus Bunge. I. Isolaton, characterization and biological effect of its polysaccharides. Org Chem 30: 26-32
7 Zhou QJ. 1985. Chinese medicinal herbs in the treatment of viral hepatitis. In Advances in Chinese Medicinal Materials Research. Chang HM, Yeung HW, Tso WW, Koo A, eds. World Scientific, Singapore. p 215-224
8 Cui B, Inoue J, Takeshita T, Kinjo J, Nohara T. 1982. Triterpene glycosides from the seeds of Astragalus sinicus L. Chem Pharm Bull 40: 3330-3339
9 Chen MH, Liu FS. 1988. Studies on chemical constituents of Astragalus complanatus R. Brown II. Acta Pharm Sin 23: 20-218
10 Park MH, Oh KY, Lee BW. 1998. Anti-cancer activity of Letinus edodes and Pleurotus astreatus. Korean J Food Sci Technol 30: 702-708   과학기술학회마을
11 Bae MJ, Yee ST, Chae SY, Shin SH, Kweon SH, Park MH, Song MK, Hwang SJ. 2004. The effects of arabinoxylane and the polysaccharide peptide (PSP) on the antiallergy, anticancer. J Korean Soc Food Sci Nutr 33: 469-474   과학기술학회마을   DOI   ScienceOn
12 Tsunoda A. 1969. A mushroom extract as an interferon inducer. Ann N Y Acad Sci 173: 719-725   DOI
13 Hamuro J, Chihara G. 1984. Lentinan, a T-cell oriented immunopotentiator. In Modulation Agents and Their Mechanisms. Fenichel RL, ed. Marcel dekker, New York and Basel. Vol 19, p 409-436
14 Takehara M, Mori K, Kuida K, Hanawa MA. 1981. Antitumor effect of virus-like particles from Lentinus edodes (Shiitake) on Ehrlich ascites carcinoma in mice. Arch Virol 68: 297-301   DOI
15 Takehara M, Kuida K, Mori K. 1979. Antiviral activity of virus-like particles from Lentinus edodes (Shitake). Arch Virol 59: 269-274   DOI
16 Fujii T, Maeda H, Suzuki F, Ishida N. 1978. Isolation and characterization of a new antitumor polysaccharide, KS-2, extracted from culture mycelia of Lentinus edodes L.. Antibiotics 31: 1079-1085   DOI
17 Suzuki S, Oshima S. 1976. Influence of shiitake (Lentinus edodes) on human serum cholesterol. Mushroom Sci 9: 463-467
18 Tu GS. 1988. Pharmacopoeia of the People's Republic of China. People's Medical Publishing House, Beijing. p 109-112
19 Zhang YD, Wang YL, Shen JP, Li DX. 1984. Hypotensive and antiinflammatory effects of Astragalus saponin I. Acta Pharm Sin 19: 333-340
20 Park KH, Kim YS, Kyung JS. 1996. Screening for inhibitiory effect of solvent fractions prepared from herbal drugs on $CCI_4$-induced cytotoxicity in primary cultured rat hepatocytes and evaluation of antihepatotoxicity in vivo. Yakhak Hoeji 40: 52-58
21 Purmova J, Opletal L. 1995. Phytotherapeutic aspects of diseases of the cardiovascular system. V. Saponins and possibilities of their use in prevention and therapy. Ceska Slov Farm (B2Q) 44: 246-251
22 Zhao KS, Mancini C, Doria G. 1990. Enhancement of the immune response in mice by Astragalus membranaceus extracts. Immunopharmacology 20: 225-233   DOI   ScienceOn
23 Park EM, Kim SJ, Ye EJ, Bae MJ, Jo KC. 2005. Effect of mycelia extracts of mushroom-cultured ginseng by-product on proliferation in cancer cell lines. J Korean Soc Food Sci Nutr 34: 323-329   과학기술학회마을   DOI   ScienceOn
24 Jo SG. 1995. Experimental studies on the change of cytotoxic and antitumor effects according to the prebrewed method of Semen Tiglii and Rhizoma Coptidis. J Kor Oriental Oncology 1: 191-211   과학기술학회마을
25 Lee JW, Chung CH, Jeong HJ, Lee KH. 1990. Anticomplementary and antitumor activities IY-105. Kor J Appl Microbiol Biotechnol 18: 571-577   과학기술학회마을
26 Sun T, Chang YH, Uy JQ. 1981. Effect of Fu-Zheng therapy in the management of diseases. Chin Med J 61: 97-101