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Effect of Lactobacillus brevis HY7401 Intake on the Serum Ethanol Concentration in Rats  

Ahn, Young-Tae (Research and Development Center, Korea Yakult Co., LTD.)
Kim, Yong-Hee (Research and Development Center, Korea Yakult Co., LTD.)
Bae, Jin-Seong (Research and Development Center, Korea Yakult Co., LTD.)
Lim, Kwang-Sei (Research and Development Center, Korea Yakult Co., LTD.)
Huh, Chul-Sung (Research and Development Center, Korea Yakult Co., LTD.)
Yang, Woo-Young (Culture System, Inc.)
Kim, Hyung-Su (Culture System, Inc.)
Baek, Young-Jin (Research and Development Center, Korea Yakult Co., LTD.)
Publication Information
Korean Journal of Food Science and Technology / v.36, no.4, 2004 , pp. 604-608 More about this Journal
Abstract
Possibility of Lactobacillus strains able to metabolize ethanol and acetaldehyde in vitro and in vitro was studied. Lactobacillus brevis strains showed higher alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activities than those of other lactic acid bacteria strains. L. brevis HY7401 exhibited the highest ADH and ALDH activities and decreased considerable amounts of ethanol and acetaldehyde in vitro. L. brevis HY7401 cell intake significantly decreased serum ethanol levels in rats fed ethanol (4g/kg BW) compared to control groups. Ethanol level in small intestines of rats fed L. brevis HY7401 was about 50%, and their acetic acid concentration was twofold higher than control. Results reveal L. brevis HY7401, isolated from human, metabolizes ethanol and acetaldehyde in vitro and in vivo.
Keywords
ADH; ALDH; ethanol; Lactobacillus brevis HY7401;
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