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Hashimoto T, Hayashi A, Amano Y, Kohno J, Iwanari S, Yamada Y (1991) Hyoscyamine 6f3-hydroxylase, an enzyme involved in tropane alkaloid biosynthesis, is localized at the pericyde of the root. J Biol Chem 266:4648-4653
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Hashimoto T, Nakajima K, Ongena G, Yamada Y (1992) Two tropinone reductases with distinct stereospecificities from cultured roots of Hyoscyamus niger. Plant Physiol. 100:836-845
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Nakajima K, Yamada Y, Akama H, Nakatsu T, Kato H, Hashimoto T, Oda JI, Yamada Y (1998) Crystal structures of two tropinone reductases: Different reaction stereospecificities in the same protein fold. Proc Natl Acad Sci USA 95:4876-4881
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Hashimoto T, Kohno J, Yamada Y (1989) 6 -hydroxyhyoscyamine epoxidase from cultured roots of Hyoscyamus niger. Phytochemistry 28: 1077-1082
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Hashimoto T, Yamada, Y (1989) Biosynthesis of scopolamine from [7_ H] 6f3-hydroxyhyoscyamine in Duboisia shoot cultures. Agric Bioi Chern 53:863-864
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Hashimoto T, Yamada Y (1994) Alkaloid biogenesis: Molecular aspects. Annu Rev Plant Physiol Plant Mol Biol 45:257-85
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Hashimoto T, Yukimune Y, Yamada Y (1986) Tropane alkaloid production in Hyoscyamus root cultures. J Plant Physiol 124:6175
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Hashimoto T, Mitani A, Yamada Y (1990) Diamine oxidase from cultured roots of Hyoscyamus niger. Its function in tropane alkaloid biosynthesis. Plant PhysioI 93:216-221
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Hashimoto T, Matsuda J., Yamada Y (1993) Two-step epoxidation of hyoscyamine to scopolamine is catalyzed by bifunctional hyoscyamine 6f3-hydroxylase, FEBS Lett 329:35-39
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Hibi N, Fujita T, Hatano M, Hashimoto T, Yamada, Y (1992) Putrescine f'i-methytransferase in cultured roots of Hyoscyamus albus. Plant Physiol. 100:826-835
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Hibi N, Higashiguchi S, Hashimito T, Yamada Y (1994) Gene expression in tobacco low-nicotine mutants. Plant cell 6:723-735
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Nakajima K, Hashimoto T, Yamada Y (1994) Opposite stereospecificity of two tropinone reductases is conferred by the substratebinding sites. J. Biol.Chem. 269:11695-11698
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Matsuda J, Okabe S, Hashimoto T, Yamada Y (1991) Molecular cloning of hyoscyamine 6 -hydroxylase, a 2-oxoglutaratedependent dioxygenase, from cultured roots of Hyoscyamus niger. J Bioi Chern 266:9460-9464
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Nakajima K, Hashimoto T (1999) Two tropinone reductases, that catalyze opposite sterespecific reductions in tropane alkaloid biosynthesis, are localized in plant root with different cell-specific patterns. Plant cell Physiol 40: 1099-1107
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Nakajima, K, Hashimoto T, Yamada Y (1993) Two tropinone reductases with different stereospecificties are short-chain dehydrogenases evolved from a common ancestor. Proc Natl Mad Sci USA 90:9591-9595
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Nakajima K, Kato H, Oda JI, Yamada Y, Hashimoto T (1999) Sitedirected mutagenesis of putative substrate-binding residues reveals a mechanism controling the different stereospecificities of two tropinone reductases.Proc Natl Acad Sci USA 274:16563-16568
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Shoji T, Nakajima K, Hashimoto T (2000) Ethylene suppresses jasmonate-induced gene expression in nicotine biosynthesis. Plant Cell Physiol 41:1072-1076
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Suzuki KI, Yamada Y, Hashimoto T (1999) Expression of Atropa belladonna putrescine N-methytransferaes gene in root pericycle. Plant Cell Physiol 40:289-297
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Yamada Y, Hashimoto T (1989) Substrate specificity of hyoscyamine 6 -hydroxylase from cultured root of Hyoscyamus niger. Proc Jpn Acad Sci Ser B 65: 156-159
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Yamada Y, Okabe Y, Hashimoto T (1990) Homogeneous hyoscyamine 6 -hydroxylase from cultured root of Hyoscyamus niger. Proc Jpn Acad Sci Ser B 66:73-76
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Yun DJ, Hashimoto T, Yamada Y (1992) Metabolic engineering of medicinal plants: Transgenic Atropa belladonna with an improved alkaloid composition. Proc Natl Acad Sci USA 89: 11799-11803
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Yun DJ, Hashimoto T, Yamada Y(1993) Transgenic tobacco plants with tow consecutive oxidation reactions catalyzed by hyoscyamine 6 -hydroxylase. Biosci Biotech Biochem 57:502-503
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