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http://dx.doi.org/10.5352/JLS.2022.32.3.196

Beneficial Effects of Fermented Cricket Powder as a Hair Growth Promoting Agent in a Mice Model  

Hwang, Jihye (Department of Biology Education, Teachers College and Institute for Phylogenomics and Evolution, Kyungpook National University)
Hwang, Ui Wook (Department of Biology Education, Teachers College and Institute for Phylogenomics and Evolution, Kyungpook National University)
Publication Information
Journal of Life Science / v.32, no.3, 2022 , pp. 196-201 More about this Journal
Abstract
Insects have been proposed as new protein sources for human nutrition, and protein availability is affected by insect characteristics. Fermentation can be used to obtain a variety of insect-based ingredients and products with unique properties, but its effect on protein availability is unknown. Fermented cricket (Gryllus bimaculatus) powder consists mainly of protein, and its oral administration has been reported to improve hair growth in androgenetic alopecia. The purpose of this study was to evaluate the hair-promoting activity of fermented cricket powder in an animal model using male C57BL/6 mice (25-30 g). The abdominal hair of the mouse (2x2.5 cm) was gently removed, and the groups fed as follows: Intact controls (no cricket powder); cricket powder only; and fermented cricket powder only. Food was applied daily for 11 weeks. Observational and physical examinations were performed and the results of the different groups compared. The application of fermented cricket powder significantly (p<0.01) promoted hair growth compared to the intact controls. The C57BL/6 results confirmed increased growth after seven weeks when the proportion of anagen follicles had increased by about 125% and 120% in the control and cricket powder groups, respectively. In conclusion, fermented cricket powder can be seen as a promising alternative alopecia treatment because it promotes hair growth, and, given the powder's composition, trace elements such as amino acids may have contributed to these effects.
Keywords
Alopecia; cricket powder; fermented cricket powder; G. bimaculatus; hair growth;
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1 Qian, Y., Li, G. J., Wang, R., Zhou, Y. L., Sun, P. and Zhao, X. 2014. In vitro anticancer effects of insect tea in TCA8113 cells. J. Cancer Res. Ther. 10, 1045-1051.   DOI
2 Shen, Q. X., Li, C. L., Shen, H., Liu, H. H., Xiang, C. Q. and Ding, X. C. 1996. Expression of cDNA of human chorionic gonadotropin beta-subunit (beta-hCG) cDNA in insect cells and effect of expressed product on mouse lymphocytes in vitro. Shi. Yan. Sheng. Wu. Xue. Bao. 29, 95-100.
3 Orkusz, A. 2021. Edible insects versus meat-nutritional comparison: Knowledge of their composition is the key to good health. Nutrients 13, 1207.   DOI
4 Sherriff, J., Griffiths, D. and Daube, M. 2010. Cricket: notching up runs for food and alcohol companies? Aust. N. Z. J. Public Health 34, 19-23.   DOI
5 Ligoxygakis, P. 2017. Immunity: Insect immune memory goes viral. Curr. Biol. 27, R1218-R1220.   DOI
6 Wang, X., Marr, A. K., Breitkopf, T., Leung, G., Hao, J., Wang, E., Kwong, N., Akhoundsadegh, N., Chen, L., Mui, A., Carr, N., Warnock, G. L., Shapiro, J. and McElwee, J. K. 2014. Hair follicle mesenchyme-associated PD-L1 regulates T-cell activation induced apoptosis: a potential mechanism of immune privilege. J. Invest. Dermatol. 134, 736-745.   DOI
7 Demirturk, N., Aykin, N., Demirdal, T. and Cevik, F. 2006. Alopecia universalis: a rare side effect seen on chronic hepatitis C treatment with peg-IFN and ribavirin. Eur. J. Dermatol. 16, 579-580.
8 Hong, S. Y., Lee, D. H., Lee, J. H., Haque, M. A. and Cho, K. M. 2021. Five surfactin isomers produced during cheonggukjang fermentation by Bacillus pumilus HY1 and their properties. Molecules 26, 4478.   DOI
9 Hu, S., Cao, X., Wu, Y., Mei, X., Xu, H., Wang, Y., Zhang, X., Gong, L. and Li, W. 2018. Effects of probiotic bacillus as an alternative of antibiotics on digestive enzymes activity and intestinal integrity of piglets. Front. Microbiol. 9, 2427.   DOI
10 Ismail, A. F. and El-Sonbaty, S. M. 2016. Fermentation enhances Ginkgo biloba protective role on gamma-irradiation induced neuroinflammatory gene expression and stress hormones in rat brain. J. Photochem. Photobiol. B. 158, 154-163.   DOI
11 Kibbie, J., Kines, K., Norris, D. and Dunnick, C. A. 2021. Oral tofacitinib for the treatment of alopecia areata in pediatric patients. Pediatr. Dermatol. doi.org/10.1111/pde.14855.   DOI
12 Aoki, E., Shibasaki, T. and Kawana, S. 2003. Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice. Exp. Dermatol. 12, 371-377.   DOI
13 Yang, C. H., Xu, J. H., Ren, Q. C., Duan, T., Mo, F. and Zhang, W. 2019. Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis. J. Pineal. Res. 67, e12569.   DOI
14 Liu, L., Ding, C., Tian, M., Yi, D., Wang, J., Zhao, J., Hu, Y. and Wang, C. 2019. Fermentation improves the potentiality of capsicum in decreasing high-fat diet-induced obesity in C57BL/6 mice by modulating lipid metabolism and hormone response. Food Res. Int. 124, 49-60.   DOI
15 Saido-Sakanaka, H., Ishibashi, J., Sagisaka, A., Momotani, E. and Yamakawa, M. 1999. Synthesis and characterization of bactericidal oligopeptides designed on the basis of an insect anti-bacterial peptide. Biochem. J. 338(Pt 1), 29-33.   DOI
16 Singh, V., Yeoh, B. S., Walker, R. E., Xiao, X., Saha, P., Golonka, R. M., Cai, J., Bretin, A. C. A., Cheng, X., Liu, Q., Flythe, M. D., Chassaing, B., Shearer, G. C., Patterson, A. D., Gewirtz, A. T. and Vijay-Kumar, M. 2019. Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation. Gut 68, 1801-1812.   DOI
17 Dey, D. K., Chang, S. N. and Kang, S. C. 2021. The inflammation response and risk associated with aflatoxin B1 contamination was minimized by insect peptide CopA3 treatment and act towards the beneficial health outcomes. Environ. Pollut. 268, 115713.   DOI
18 Liceaga, A. M., Aguilar-Toala, J. E., Vallejo-Cordoba, B., Gonzalez-Cordova, A. F. and Hernandez-Mendoza, A. 2021. Insects as an alternative protein source. Annu. Rev. Food. Sci. Technol. 13, 2.1-2.16.
19 Aguilera, Y., Pastrana, I., Rebollo-Hernanz, M., Benitez, V., Alvarez-Rivera, G., Viejo, J. L. and Martin-Cabrejas, M. A. 2021. Investigating edible insects as a sustainable food source: nutritional value and techno-functional and physiological properties. Food Funct. 12, 6309-6322.   DOI
20 Boyle, R. J., Elremeli, M., Hockenhull, J., Cherry, M. G., Bulsara, M. K., Daniels, M. and Oude Elberink, J. M. 2012. Venom immunotherapy for preventing allergic reactions to insect stings. Cochrane Database Syst. Rev. 10, CD008838.