Browse > Article
http://dx.doi.org/10.5352/JLS.2017.27.8.937

Hypolipidemic and Hypoinsulinemic Effects of Dietary Fiber from Agar in C57BL/6N Mice Fed a High-fat Diet  

Park, Jin Ju (Department of Biomaterials Science, College of Natural Resources & Life Science/Life and Industry Convergence Research Institute, Pusan National University)
Kim, Ji Eun (Department of Biomaterials Science, College of Natural Resources & Life Science/Life and Industry Convergence Research Institute, Pusan National University)
Yun, Woo Bin (Department of Biomaterials Science, College of Natural Resources & Life Science/Life and Industry Convergence Research Institute, Pusan National University)
Lee, Mi Lim (Department of Biomaterials Science, College of Natural Resources & Life Science/Life and Industry Convergence Research Institute, Pusan National University)
Choi, Jun Young (Department of Biomaterials Science, College of Natural Resources & Life Science/Life and Industry Convergence Research Institute, Pusan National University)
Song, Bo Ram (Department of Biomaterials Science, College of Natural Resources & Life Science/Life and Industry Convergence Research Institute, Pusan National University)
Kim, Dong Seob (Department of Foods Science & Technology, College of Natural Resources & Life Science/Life and Industry Convergence Research Institute, Pusan National University)
Lee, Chung Yeoul (Gangrim Organics)
Lee, Hee Seob (Department of Food Science & Nutrition, College of Human Ecology, Pusan National University)
Lim, Yong (Department of Clinical Laboratory Science, College of Nursing and Healthcare Science, Dong-Eui University)
Jung, Min Wook (Research Center, Miryang Agar-Agar Co., LTD)
Hwan, Dae Youn (Department of Biomaterials Science, College of Natural Resources & Life Science/Life and Industry Convergence Research Institute, Pusan National University)
Publication Information
Journal of Life Science / v.27, no.8, 2017 , pp. 937-944 More about this Journal
Abstract
To investigate the beneficial effects of fiber derived from agar on the lipid and glucose metabolism of obese model mice, changes in the fat accumulation, lipid content, and insulin concentration were measured in C57BL/6N mice fed a high-fat diet (HFD) and treated with a beverage containing agar (BCA) for 9 weeks. The feed efficiency ratio was significantly decreased in the HFD+BCA treatment group, although the body weight and food intake were maintained a constant level. Also, the fat accumulation in the fatty tissue and liver were lower in the HFD+BCA treatment group than in the HFD+Vehicle treatment group. Furthermore, a significant decrease was detected in the levels of total cholesterol (TC) and LDL after the BCA treatment, while a constant HDL level was maintained in the same group. Moreover, the serum insulin concentration was significantly decreased in the HFD+BCALo (Low concentration) and HFD+BCAMi (Middle concentration) groups compared to the HFD+Vehicle group. Therefore, the results suggest that the long-term administration of dietary fiber from agar can improve fat accumulation in the fatty tissue and liver, the serum lipid profile, and the insulin concentration in the blood. Also, the results provide evidence that the inclusion of agar fiber in beverages results in significant hypolipidemic and hypoinsulinemic effects.
Keywords
Anti-obesity; Agar; dietary fiber; high-fat diet; hypolipidemic effect;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Anderson, J. W., Baird, P., Davis, R. H. Jr., Ferreri, S., Knudtson, M., Koraym, A., Waters, V. and Williams, C. L. 2009. Health benefits of dietary fiber. Nutr. Rev. 67, 188-205.   DOI
2 Brenda, M. D. 2002. High-fiber oat cereal compared with wheat cereal consumption favorably alters LDL-cholesterol subclass and particle numbers in middle-aged and older men. Am. J. Clin. Nutr. 76, 351-358.   DOI
3 Byun, M. W., Yook, H. S., Lee, K. H., Lee, J. W. and Kim, D. H. 1999. Dietary fiber from marine products, refining process thereof and manufacture of functional food containing the dietary fiber. Patent pending 99-0043469.
4 Carr, T. P., Gallaher, D. D., Yang, C. H. and Hassel, C. A. 1996. Increased intestinal contents viscosity reduces cholesterol absorption efficiency in hamsters fed hydroxypropyl methylcellulose. J. Nutr. 126, 1463-1469.   DOI
5 David, J. A. J. 2002. Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. Am. J. Clin. Nutr. 75, 834-839.   DOI
6 Dahm, C. C., Keogh, R. H., Spencer, E. A., Greenwood, D. C., Key, T. J., Fentiman, I. S., Shipley, M. J., Brunner, E. J., Cade, J. E., Burley, V. J., Mishra, G., Stephen, A. M., Kuh, D., White, I. R., Luben, R., Lentjes, M. A., Khaw, K. T. and Rodwell, B. S. A. 2010. Dietary fiber and colorectal cancer risk: a nested case-control study using food diaries. J. Natl. Cancer Inst. 102, 614-626.   DOI
7 Bosmans, L., De, B. I., De, M. R., Rediers, H. and Lievens, B. 2016. Agar composition affects in vitro screening of biocontrol activity of antagonistic microorganisms. J. Microbiol. Methods 127, 7-9.   DOI
8 Dhingra, D., Michael, M., Rajput, H. and Patil, R. T. 2012. Dietary fibre in foods: a review. J. Food Sci. Technol. 49, 255-266.   DOI
9 Dongowski, G. and Ehwald, R. 1998. Properties of dietary preparations of the cellan-type, pp. 52-54. In: Guillon F et al (eds) Proceeding of the PROFIBRE Symposium, Functional properties of non digestible carbohydrates. Imprimerie Parentheses, Nantes.
10 Edrilin, A. L. 2000. Prune suppresses ovariectomy-induced hypercholesterolemia in rats. J. Nutr. Biochem. 11, 255-259.   DOI
11 Einat, N. 2002. Defatted avocado pulp reduces body weight and total hepatic fat but increases plasma cholesterol in male rats fed diets with cholesterol. Nut. Res. 22, 1319-1332.   DOI
12 Englyst, H. N. and Cummings, J. H. 1985. Digestion of the polysaccharides of some cereal foods in the human small intestine. Am. J. Clin. Nutr. 42, 778-787.   DOI
13 Kang, S. A. 2002. Status and application of functional food materials conscious fiber research. J. Kor. Soc. Food Sci. Nutr. 31, 788-795.   DOI
14 Gallaher, D. and Schneeman, B. O. 1986. Intestinal interaction of bile acids, phospholipids, dietary fiber and cholestylamine. Am. J. Physiol. 250, 420-426.
15 Garcia-Perez, F. J., Lario, Y., Fernandez-Lopez, J., Sayas, E., Perez-Alvarez, J. A. and Sendra, E. 2005. Effect of orange fibre addition on yogurt colour during fermentation and cold storage. Color Res. Appl. 30, 457-463.   DOI
16 Guillon, F. and Champ, M. 2000. Structural and physical properties of dietary fibres, and consequences of processing on human physiology. Food Res. Int. 33, 233-245   DOI
17 Hipsley, E. H. 1953. Dietary "Fibre" and pregnancy toxaemia. Br. Med. J. 2, 420-422.   DOI
18 Huhe, C., Akihiro, A., Miharu, U., Li, Y. X., Cheng, K. C., Li, J. B., Takahiro, Z., Mutsumi, T., Chie, T., Kaori, A., Takeo, S., Minglun, T., Haruka, A., Masahisa, H., Toru, T. and Akio, I. 2011. Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice. Exp. Ther. Med. 2, 369-373.   DOI
19 Jang, K. H. 2002. The effect of levan and insulin on the growth of lactic acid-producing bacteria and intestinal conditions in rats. Kor. J. Nutr. 35, 912-918.
20 Joanne, R. L. 2003. Dietary fiber and coronary disease: Does the evidence support an association? Curr. Atheroscler. Rep. 5, 500-505.   DOI
21 Kok, N. N. 1998. Insulin, Glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide and insulin-Like growth factor I as putative mediators of the hypolipidemic effect of oligofructose in rats 1,2. J. Nutr. 128, 1099-1103.   DOI
22 Kimmel, S. E. 2000. Effects of insoluble and soluble dietary fiber on glycemic control in dogs with naturally occurring insulin-dependent diabetes mellitus. J. Am. Vet. Med. Assoc. 216, 1076-1081.   DOI
23 Nelson, R. W. 2000. Effect of dietary insoluble fiber on control of glycemia in cats with naturally acquired diabetes mellitus. J. Am. Vet. Med. Assoc. 216, 1082-1088.   DOI
24 Schneeman, B. O. 1985. Effects of dietary fiber on digestive enzyme activity and bile acids in the small intestine, society for experimental biology and medicine symposium. 180, 409-414.
25 Raghavendra, S. N., Ramachandra, S. S. R., Rastogi, N. K., Raghavarao, K. S. M. S., Kumar, S. and Tharanathan, R. N. 2006. Grinding characteristics and hydration properties of coconut residue: a source of dietary fibre. J. Food Eng. 72, 281-286.   DOI
26 Rafael, A. C., Mario, R. and Garcia, P. 1990. Clinical Methods: The History, Physical, and Laboratory Examinations, pp. 153-160. In: Walker HK et al (eds) Chapter 31 Cholesterol, Triglycerides, and Associated Lipoproteins.
27 Saltzman, E. 2001. An oat-containing hypocaloric diet reduces systolic blood pressure and improves lipid profile beyond effects of weight loss in men and women. J. Nutr. 131, 1465-1470.   DOI
28 Sindurani, J. A. 2000. Effect of different levels of cococut fiber on blood glucose, serum insulin and minerals in rats. Indian J. Physiol. Pharmacol. 44, 97-100.
29 Stuart, P. W., Daniel, M., Manisha, D., Michael, R., Rudolph, I. L. and Anthony, W. F. 2003. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796-1808.   DOI
30 Ullrich, I. H. and Albrink, M. J. 1985. The effect of dietary fiber and other factors on insulin response: role in obesity. J. Environ. Pathol. Toxicol. Oncol. 5, 137-155.
31 Yeagle, P. L. 1991. Modulation of membrane function by cholesterol, Biochimie. 73, 1303-1310.   DOI
32 Yook, H. S. 2000. Rheological properties of wheat flour dough and qualities of bread prepared with dietary fiber purified from Ascidian (Halocynthia roretzi) Tunic. Kor. J. Food Sci. Technol. 32, 387-395.