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http://dx.doi.org/10.5352/JLS.2012.22.12.1729

Research Trends of Fermented Medicinal Herbs - Based on Their Clinical Efficacy and Safety Assessment  

Choi, Yun-Kyung (School of Korean Medicine, Pusan National University)
Sul, Jae-Uk (Chung-Youn Hospital)
Park, Seoul-Ki (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Yu, Sun-Nyoung (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Kim, Sang-Hun (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Rhee, Moon-Soo (Korea Research Institute of Bioscience & Biotechnology)
Ahn, Soon-Cheol (Department of Microbiology and Immunology, Pusan National University School of Medicine)
Shin, Mi-Sook (Department of Oriental Rehabilitation Medicine, School of Korean Medicine, Pusan National University)
Publication Information
Journal of Life Science / v.22, no.12, 2012 , pp. 1729-1739 More about this Journal
Abstract
The aim of this study was to evaluate the clinical efficacy and safety of fermented medicinal herbs. A search of the China National Knowledge Infrastructure (CNKI), PubMed databases and Korean Journal of Oriental Medicine in 2000-2011 located 11 randomized controlled trials (RCTs) that investigated the clinical efficacy of fermented medicinal herbs. Domestic RCTs reported clinical efficacy on improvement of immune responses and clinical safety on usage of fermented medicinal herbs in subjects suffering from cerebral hemodynamics. Countries other than Chinareported studies on the cause of esophageal cancer and on local inflammatory reactions. In China, studies were reported on the effectiveness of fermented medicinal herbs on scapulohumeral periarthritis of the stasis type, chronic superficial gastritis, dysuria induced by benign prostatic hyperplasia of deficiency of kidney yang, diabetic nephropathy, essential hypertension, and benign prostate hyperplasia. These results indicate that fermented medicinal herbs have obvious clinical effects in some diseases and no adverse reactions. Therefore, we need to initiate more fermentation research with useful bacteria, fungi, and mushrooms to produce fermented medicinal herbs. Both governments and research authorities should focus on research involving fermentation of medicinal herbs.
Keywords
Fermented herbs; fermentation; clinical efficacy; safety assessment;
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