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http://dx.doi.org/10.5352/JLS.2010.20.9.1402

Enhancement of Anticarcinogenic Potentials of Submerged-Liquid Culture of Agaricus blazei Murill on Mouse Ascites Cancer by Rice Hull  

Kim, Young-S. (Division of Applied Life Science (BK21 programs))
Jang, Wook-J. (Division of Applied Life Science (BK21 programs))
Rakib, A. (Division of Applied Life Science (BK21 programs))
Kwon, Jung-M. (Division of Applied Life Science (BK21 programs))
Ahn, Chae-R. (Division of Applied Life Science (BK21 programs))
Kim, So-Y. (Department of Food Science, International University of Korea)
Cho, Yong-U. (Department of Pharmaceutical Engineering, Jinju National University)
Ha, Young-K. (HK Biotech. Co., Ltd.)
Kim, Jeong-O. (HK Biotech. Co., Ltd.)
Ha, Yeong-L. (Division of Applied Life Science (BK21 programs))
Publication Information
Journal of Life Science / v.20, no.9, 2010 , pp. 1402-1408 More about this Journal
Abstract
The effects of rice hull (RH) powder on the anticarcinogenic activity of submerged-liquid cultures of Agaricus blazei Murill (AB) were assessed for mouse ascites cancers induced by mouse Sarcoma S-180 (S-180) cancer cells. Optimal growth of AB mycelia in the basal liquid culture medium, containing soybean meal, was achieved by culturing at $25^{\circ}C$ for 5 days, when evaluated by $\beta$-glucan content, Brix, and mycelial weight, relative to other culture conditions. Hot-water extract (HWE) of the submergedliquid culture of AB mycelia grown at $25^{\circ}C$ for 5 days exhibited a stronger anticarcinogenic activity, relative to HWE from other culture conditions. No such effects were obtained from AB mycelial cultures by alternative temperature-controlling cultures. Both cytotoxicity for S-180 cells and anticarcinogenic potentials for mouse ascites cancer of the HWE from AB mycelia grown in the basal medium containing 1% RH powder for 5 days at $25^{\circ}C$ were significantly (p<0.05) enhanced, relative to HWE from the AB mycelia culture of the basal medium without RH powder. These results indicate that HWE of submerged-liquid culture of AB mycelia, incubated in media containing 1% RH powder at $25^{\circ}C$ for 5 days, enhanced anticarcinogenic activity against S-180 cell-induced mouse ascites cancer, and suggest that RH powder is an excellent ingredient for the improvement of the anticarcinogenic potentials of the submerged-liquid culture of mushroom mycelia.
Keywords
Agaricus blazei Murill (AB); $\beta$-glucan; mouse ascites cancer; rice hull;
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