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http://dx.doi.org/10.5352/JLS.2007.17.10.1381

Changes in Physiological Activities of Scutellariae baicalensis by Heating  

Choi, Myeong-Rak (Department of Biotechnology, Chonnam National University)
Lee, Jin-Seung (Department of Biotechnology, Chonnam National University)
Lim, Hyun-Soo (Department of Biotechnology, Chonnam National University)
Publication Information
Journal of Life Science / v.17, no.10, 2007 , pp. 1381-1386 More about this Journal
Abstract
To elucidate the changes in physiological activities of Scutellariae baicalensis by heating, composition analysis with HPLC and evaluation of physiological activities of extracts were conducted. HPLC analysis of CW(water extract at room temperature) and CHW(heat treated CW) indicated that two distinctive peaks in the HPLC chromatogram were disappeared after boiling and additional peak was newly observed. This observation suggested that certain chemical changed in the extract occurred by heat treatment. In the estimation of physiological activities, CW showed higher ACE inhibiting activity than CHW. In the case of cytotoxic activity against cancer cells, CW exhibited higher activity than CHW against CCL-185. On the other hand, CHW showed higher activity than CW against HeLa, SNU-601 and HepG2. In addition, CHW showed the inhibitory effect on melanogenesis (80% inhibition) while CW did not show any activity.
Keywords
Scutellariae baicalensis; peak analysis; antioxidative activity; cytotoxic activity; melanogenesis;
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