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http://dx.doi.org/10.5352/JLS.2006.16.7.1104

The Enzymatic Regulatory Effects of Laninaria japonica Fucoidan Extract in Hepatotoxicity  

Kang, Kum-Suk (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University)
Nam, Chun-Suk (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University)
Park, Eun-Kyung (Central Research Institute, Binex Co., Ltd.)
Ha, Bae-Jin (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University)
Publication Information
Journal of Life Science / v.16, no.7, 2006 , pp. 1104-1108 More about this Journal
Abstract
The purpose of this study was to investigated the effects of Laminaria japonica fucoidan extract (LJFE) through the enzymatic regulation against the hepatotoxicity-inducing carbon tetrachloride $(CCl_4)$ in LJFE and $CCl_4-treated$ rats. LJFE of 100mg/kg concentration was intraperitoneally administered into rats at dose of 1.5m11kg for 14 days. On the day 15, 3.3ml/kg of $CCl_4$ dissolved in olive oil (1:1) was injected 12 hours before anesthetization. We examined the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) in serum of rats, superoxide dismutase(SOD) in mitochondrial fraction, and catalase(CAT), glutathione peroxidase(GPx) in liver homogenate. $CCl_4-treatment$ markedly increased the levels of GOT and GPT, and significantly decreased those of SOD, CAT and GPx. But LIFE pretreatment decreased the levels of GOT and GPT, by 40% and 64%, respectively and increased those of SOD, CAT and GPx, by 114%, 36.1% and 55.9%, respectively These results showed the LIFE had the enzymatic regulatory effects against the hepatotoxicity-inducing $CCl_4$ in the preventive way.
Keywords
Laminaria japonica; carbon tetrachloride; anti-oxidation enzyme; hepatotoxicity;
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