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http://dx.doi.org/10.5352/JLS.2004.14.3.509

Inhibitory Activities of Edible and Medicinal Herbs Against Human Thrombin  

권정숙 (안동대학교 식품영양학과)
권윤숙 (안동대학교 식품영양학과)
김영숙 (안동대학교 식품영양학과)
권기석 (안동대학교 생명자원과학부)
진익렬 (경북대학교 미생물학과)
류기철 (㈜대평 천연물신소재 개발연구소)
손호용 (안동대학교 식품영양학과)
Publication Information
Journal of Life Science / v.14, no.3, 2004 , pp. 509-513 More about this Journal
Abstract
Inhibitory activities of 58 methanol extracts, which were prepared from different parts of 55 kinds of edible and medicinal plants, against human thrombin were evaluated. Analysis of the anti-coagulation activity determined by thrombin time enabled us to select 8 herb extracts as possible sources of anti-thrombosis agent. Further analysis of anti-thrombosis activity determined by activated partial thromboplastin time and fibrinolytic activity, and heat stability and inhibition against other proteolytic digestive enzymes provided new information that Pimpinella brachycarpa, Lysimachia clethroides, and Salix gracilistyla could be used as a potential anti-thrombosis agent. Our results suggest that edible and medicinal plants could be the potential source of thrombin inhibitor.
Keywords
thrombosis; thrombin time; anti-coagulation; medicinal and edible herbs.;
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Times Cited By KSCI : 5  (Citation Analysis)
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